Tiotropium Bromide Patent Expiration
Tiotropium Bromide is Used for long-term maintenance treatment of bronchospasm associated with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema. It was first introduced by Boehringer Ingelheim Pharmaceuticals Inc
Tiotropium Bromide Patents
Given below is the list of patents protecting Tiotropium Bromide, along with the drug name that holds that patent and the company name owning that drug.
| Drug Used in | Drug Patent Number | Drug Patent Title | Drug Patent Expiry | Drug Owner |
|---|---|---|---|---|
| Spiriva | US5478578 | Powders for inhalation |
Dec 26, 2012
(Expired) | Boehringer Ingelheim |
| Spiriva | US6777423 | Crystalline tiotropium bromide monohydrate, processes for the preparation thereof, and pharmaceutical compositions |
Sep 24, 2021
(Expired) | Boehringer Ingelheim |
| Spiriva |
US6777423 (Pediatric) | Crystalline tiotropium bromide monohydrate, processes for the preparation thereof, and pharmaceutical compositions |
Mar 24, 2022
(Expired) | Boehringer Ingelheim |
| Spiriva | US6908928 | Crystalline tiotropium bromide monohydrate, processes for the preparation thereof, and pharmaceutical compositions |
Sep 24, 2021
(Expired) | Boehringer Ingelheim |
| Spiriva |
US6908928 (Pediatric) | Crystalline tiotropium bromide monohydrate, processes for the preparation thereof, and pharmaceutical compositions |
Mar 24, 2022
(Expired) | Boehringer Ingelheim |
| Spiriva | US7070800 | Inhalable powder containing tiotropium |
Jan 22, 2022
(Expired) | Boehringer Ingelheim |
| Spiriva |
US7070800 (Pediatric) | Inhalable powder containing tiotropium |
Jul 22, 2022
(Expired) | Boehringer Ingelheim |
| Spiriva | US7309707 | Crystalline micronisate, process for the manufacture thereof and use thereof for the preparation of a medicament |
Sep 24, 2021
(Expired) | Boehringer Ingelheim |
| Spiriva |
US7309707 (Pediatric) | Crystalline micronisate, process for the manufacture thereof and use thereof for the preparation of a medicament |
Mar 24, 2022
(Expired) | Boehringer Ingelheim |
| Spiriva | US7642268 | Crystalline micronisate, process for the manufacture thereof and use thereof for the preparation of a medicament |
Sep 24, 2021
(Expired) | Boehringer Ingelheim |
| Spiriva |
US7642268 (Pediatric) | Crystalline micronisate, process for the manufacture thereof and use thereof for the preparation of a medicament |
Mar 24, 2022
(Expired) | Boehringer Ingelheim |
| Spiriva | US7694676 | Dry powder inhaler | Mar 12, 2027 | Boehringer Ingelheim |
| Spiriva |
US7694676 (Pediatric) | Dry powder inhaler | Sep 12, 2027 | Boehringer Ingelheim |
| Spiriva | US8022082 | Method for the administration of an anticholinergic by inhalation | Jan 19, 2026 | Boehringer Ingelheim |
| Spiriva |
US8022082 (Pediatric) | Method for the administration of an anticholinergic by inhalation | Jul 19, 2026 | Boehringer Ingelheim |
| Spiriva | US9010323 | Inhaler and sieve for an inhaler | Apr 19, 2030 | Boehringer Ingelheim |
| Spiriva | USRE38912 | Process for preparing powder formulations |
Oct 11, 2021
(Expired) | Boehringer Ingelheim |
| Spiriva |
USRE38912 (Pediatric) | Process for preparing powder formulations |
Apr 11, 2022
(Expired) | Boehringer Ingelheim |
| Spiriva | USRE39820 | Esters of thienyl carboxylic acids and amino alcohols and their quaternization products |
Jan 30, 2018
(Expired) | Boehringer Ingelheim |
| Spiriva |
USRE39820 (Pediatric) | Esters of thienyl carboxylic acids and amino alcohols and their quaternization products |
Jul 30, 2018
(Expired) | Boehringer Ingelheim |
| Spiriva Respimat | US5964416 | Device for producing high pressure in a fluid in miniature |
Oct 04, 2016
(Expired) | Boehringer Ingelheim |
| Spiriva Respimat |
US5964416 (Pediatric) | Device for producing high pressure in a fluid in miniature |
Apr 04, 2017
(Expired) | Boehringer Ingelheim |
| Spiriva Respimat | US6149054 | Mechanical counter for a metering apparatus |
Dec 16, 2016
(Expired) | Boehringer Ingelheim |
| Spiriva Respimat |
US6149054 (Pediatric) | Mechanical counter for a metering apparatus |
Jun 16, 2017
(Expired) | Boehringer Ingelheim |
| Spiriva Respimat | US6176242 | Method of treating manic depression by brain infusion |
May 31, 2016
(Expired) | Boehringer Ingelheim |
| Spiriva Respimat | US6176442 | Device for mounting a component exposed to a pressurized fluid |
May 31, 2016
(Expired) | Boehringer Ingelheim |
| Spiriva Respimat |
US6176442 (Pediatric) | Device for mounting a component exposed to a pressurized fluid |
Dec 01, 2016
(Expired) | Boehringer Ingelheim |
| Spiriva Respimat | US6453795 | Locking mechanism for a spring-actuated device |
Dec 05, 2016
(Expired) | Boehringer Ingelheim |
| Spiriva Respimat |
US6453795 (Pediatric) | Locking mechanism for a spring-actuated device |
Jun 05, 2017
(Expired) | Boehringer Ingelheim |
| Spiriva Respimat | US6726124 | Device for producing high pressure in a fluid in miniature |
Oct 04, 2016
(Expired) | Boehringer Ingelheim |
| Spiriva Respimat |
US6726124 (Pediatric) | Device for producing high pressure in a fluid in miniature |
Apr 04, 2017
(Expired) | Boehringer Ingelheim |
| Spiriva Respimat | US6846413 | Microstructured filter |
Aug 28, 2018
(Expired) | Boehringer Ingelheim |
| Spiriva Respimat |
US6846413 (Pediatric) | Microstructured filter |
Feb 28, 2019
(Expired) | Boehringer Ingelheim |
| Spiriva Respimat | US6977042 | Microstructured filter |
Aug 28, 2018
(Expired) | Boehringer Ingelheim |
| Spiriva Respimat |
US6977042 (Pediatric) | Microstructured filter |
Feb 28, 2019
(Expired) | Boehringer Ingelheim |
| Spiriva Respimat | US6988496 | Cartridge for a liquid |
Feb 23, 2020
(Expired) | Boehringer Ingelheim |
| Spiriva Respimat |
US6988496 (Pediatric) | Cartridge for a liquid |
Aug 23, 2020
(Expired) | Boehringer Ingelheim |
| Spiriva Respimat | US7104470 | Device for producing high pressure in a fluid in miniature |
Oct 04, 2016
(Expired) | Boehringer Ingelheim |
| Spiriva Respimat |
US7104470 (Pediatric) | Device for producing high pressure in a fluid in miniature |
Apr 04, 2017
(Expired) | Boehringer Ingelheim |
| Spiriva Respimat | US7246615 | Atomising nozzle and filter and spray generating device |
May 31, 2016
(Expired) | Boehringer Ingelheim |
| Spiriva Respimat |
US7246615 (Pediatric) | Atomising nozzle and filter and spray generating device |
Dec 01, 2016
(Expired) | Boehringer Ingelheim |
| Spiriva Respimat | US7284474 | Piston-pumping system having o-ring seal properties | Aug 26, 2024 | Boehringer Ingelheim |
| Spiriva Respimat |
US7284474 (Pediatric) | Piston-pumping system having o-ring seal properties | Feb 26, 2025 | Boehringer Ingelheim |
| Spiriva Respimat | US7396341 | Blocking device for a locking stressing mechanism having a spring-actuated output drive device | Oct 10, 2026 | Boehringer Ingelheim |
| Spiriva Respimat |
US7396341 (Pediatric) | Blocking device for a locking stressing mechanism having a spring-actuated output drive device | Apr 10, 2027 | Boehringer Ingelheim |
| Spiriva Respimat | US7802568 | Cartridge for a liquid |
Feb 26, 2019
(Expired) | Boehringer Ingelheim |
| Spiriva Respimat |
US7802568 (Pediatric) | Cartridge for a liquid |
Aug 26, 2019
(Expired) | Boehringer Ingelheim |
| Spiriva Respimat | US7837235 | Device for clamping a fluidic component | Mar 13, 2028 | Boehringer Ingelheim |
| Spiriva Respimat |
US7837235 (Pediatric) | Device for clamping a fluidic component | Sep 13, 2028 | Boehringer Ingelheim |
| Spiriva Respimat | US7896264 | Microstructured high pressure nozzle with built-in filter function | May 26, 2025 | Boehringer Ingelheim |
| Spiriva Respimat |
US7896264 (Pediatric) | Microstructured high pressure nozzle with built-in filter function | Nov 26, 2025 | Boehringer Ingelheim |
| Spiriva Respimat | US7988001 | Container provided with a pressure equalization opening |
Aug 04, 2021
(Expired) | Boehringer Ingelheim |
| Spiriva Respimat |
US7988001 (Pediatric) | Container provided with a pressure equalization opening |
Feb 04, 2022
(Expired) | Boehringer Ingelheim |
| Spiriva Respimat | US8733341 | Atomizer and method of atomizing fluid with a nozzle rinsing mechanism | Oct 16, 2030 | Boehringer Ingelheim |
| Spiriva Respimat |
US8733341 (Pediatric) | Atomizer and method of atomizing fluid with a nozzle rinsing mechanism | Apr 16, 2031 | Boehringer Ingelheim |
| Spiriva Respimat | US9027967 | Device for clamping a fluidic component | Mar 31, 2027 | Boehringer Ingelheim |
| Spiriva Respimat |
US9027967 (Pediatric) | Device for clamping a fluidic component | Oct 01, 2027 | Boehringer Ingelheim |
| Spiriva Respimat | USRE39820 | Esters of thienyl carboxylic acids and amino alcohols and their quaternization products |
Jan 30, 2018
(Expired) | Boehringer Ingelheim |
| Spiriva Respimat |
USRE39820 (Pediatric) | Esters of thienyl carboxylic acids and amino alcohols and their quaternization products |
Jul 30, 2018
(Expired) | Boehringer Ingelheim |
A patent's expiry date may change depending upon legal activities going on that patent. Critical activities like abandoning of a patent, term extension of a patent or amendment of its claims can increase or decrease the life of a patent hence affecting its expiry date and in turn affecting the generic launch date of that drug. Tracking these ongoing activities on a patent application helps to keep an eye on the latest developments in the patent process of the drug which can give an idea of how early a drug's generic could be available. The next section provides a list of recent legal activities on Tiotropium Bromide's patents.
Latest Legal Activities on Tiotropium Bromide's Patents
Given below is the list recent legal activities going on the following patents of Tiotropium Bromide.
| Event | Date | Patent/Publication |
|---|---|---|
 | ||
| Payment of Maintenance Fee, 12th Year, Large Entity | 15 Mar, 2023 | US8022082 |
| Payment of Maintenance Fee, 8th Year, Large Entity | 12 Oct, 2022 | US9010323 |
| Payment of Maintenance Fee, 12th Year, Large Entity | 05 Oct, 2021 | US7694676 |
| Payment of Maintenance Fee, 12th Year, Large Entity | 30 Jun, 2021 | US7642268 |
| Email Notification | 09 Feb, 2021 | US7694676 |
| Mail Certificate of Correction Memo | 08 Feb, 2021 | US7694676 |
| Certificate of Correction Memo | 08 Feb, 2021 | US7694676 |
| Post Issue Communication - Certificate of Correction | 08 Feb, 2021 | US7694676 |
| Email Notification | 01 Aug, 2019 | US7694676 |
| Change in Power of Attorney (May Include Associate POA) | 01 Aug, 2019 | US7694676 |
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Tiotropium Bromide Generics
Only one generic application has been filed for Tiotropium Bromide.
Given below is the list of companies who have filed for Tiotropium Bromide generic.
1. LUPIN
Lupin Inc has filed for 1 generic for Tiotropium Bromide. Given below are the details of the strengths of this generic introduced by Lupin.
| Strength | Dosage Form | Availability | Application Pathway | TE code | Launch Date |
|---|---|---|---|---|---|
| EQ 0.018MG BASE/INH | powder | Prescription | INHALATION | AB | Jun 20, 2023 |