Tipiracil Hydrochloride; Trifluridine is Used for treating metastatic colorectal cancer in patients previously treated with specific chemotherapy combinations. It was first introduced by Taiho Oncology Inc in its drug Lonsurf on Sep 22, 2015. 3 different companies have introduced drugs containing Tipiracil Hydrochloride; Trifluridine.

Tipiracil Hydrochloride; Trifluridine Patents

Given below is the list of patents protecting Tipiracil Hydrochloride; Trifluridine, along with the drug name that holds that patent and the company name owning that drug.

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Drug Used in	Drug Patent Number	Drug Patent Title	Drug Patent Expiry	Drug Owner
Lonsurf	US10456399	Method for treating cancer patients with severe renal impairment	Feb 03, 2037	Taiho Oncology
Lonsurf	US10960004	Method for treating cancer patients with severe renal impairment	Feb 03, 2037	Taiho Oncology
Lonsurf	US9943537	Antitumor agent and antitumor effect enhancer	Sep 05, 2034	Taiho Oncology
Lonsurf	US10457666	Stable crystal form of tipiracil hydrochloride and crystallization method for the same	Jun 17, 2034	Taiho Oncology
Lonsurf	US9527833	Stable crystal form of tipiracil hydrochloride and crystallization method for the same	Jun 17, 2034	Taiho Oncology
Lonsurf	USRE46284	Method of administrating an anticancer drug containing α, α, α-trifluorothymidine and thymidine phosphorylase inhibitor	Sep 22, 2029	Taiho Oncology
Lonsurf	US7799783	Method of administrating an anticancer drug containing α, α, α-trifluorothymidine and thymidine phosphorylase inhibitor	Dec 16, 2026	Taiho Oncology
Lonsurf	US6479500	Agents for alleviating side effects	Mar 16, 2020 (Expired)	Taiho Oncology
Lonsurf	US5744475	Uracil derivatives, and antitumor effect potentiator and antitumor agent containing the same	Mar 28, 2016 (Expired)	Taiho Oncology

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Tipiracil Hydrochloride; Trifluridine's Family Patents

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Tipiracil Hydrochloride; Trifluridine Generic API Manufacturers

Several generic applications have been filed for Tipiracil Hydrochloride; Trifluridine. The first generic version for Tipiracil Hydrochloride; Trifluridine was by Natco Pharma Ltd and was approved on Jun 13, 2023. And the latest generic version is by Msn Laboratories Private Ltd and was approved on Jan 8, 2025.

Given below is the list of companies who have filed for Tipiracil Hydrochloride; Trifluridine generic, along with the locations of their manufacturing plants worldwide.