Sorafenib Tosylate Patent Expiration

Sorafenib Tosylate is Used for treating advanced renal cell carcinoma, carcinoma of the thyroid, and unresectable hepatocellular carcinoma. It was first introduced by Bayer Healthcare Pharmaceuticals Inc in its drug Nexavar on Dec 20, 2005. 7 different companies have introduced drugs containing Sorafenib Tosylate.


Sorafenib Tosylate Patents

Given below is the list of patents protecting Sorafenib Tosylate, along with the drug name that holds that patent and the company name owning that drug.

Drug Used in Drug Patent Number Drug Patent Title Drug Patent Expiry Drug Owner
Nexavar US9737488 Pharmaceutical composition for the treatment of cancer Sep 10, 2028 Bayer Hlthcare
Nexavar US8877933 Thermodynamically stable form of a tosylate salt Dec 24, 2027 Bayer Hlthcare
Nexavar US8618141 Aryl ureas with angiogenesis inhibiting activity Feb 11, 2023

(Expired)

Bayer Hlthcare
Nexavar US7235576 Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors Jan 12, 2020

(Expired)

Bayer Hlthcare
Nexavar US7351834 ω-Carboxyaryl substituted diphenyl ureas as raf kinase inhibitors Jan 12, 2020

(Expired)

Bayer Hlthcare
Nexavar US7897623 ω-carboxyl aryl substituted diphenyl ureas as p38 kinase inhibitors Jan 12, 2020

(Expired)

Bayer Hlthcare
Nexavar US8124630 ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors Jan 12, 2020

(Expired)

Bayer Hlthcare
Nexavar US8841330 Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors Jan 12, 2020

(Expired)

Bayer Hlthcare



Sorafenib Tosylate's Family Patents

Family Patents

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Sorafenib Tosylate Generic API Manufacturers

Several generic applications have been filed for Sorafenib Tosylate. The first generic version for Sorafenib Tosylate was by Mylan Pharmaceuticals Inc and was approved on Sep 10, 2020. And the latest generic version is by Apotex Inc and was approved on Jan 27, 2025.

Given below is the list of companies who have filed for Sorafenib Tosylate generic, along with the locations of their manufacturing plants worldwide.