Megestrol Acetate Patent Expiration

Megestrol Acetate is Used for treating anorexia, cachexia, or unexplained significant weight loss in AIDS patients. It was first introduced by Bristol Myers Squibb in its drug Megace on Approved Prior to Jan 1, 1982. Another drug containing Megestrol Acetate is Megace Es. 12 different companies have introduced drugs containing Megestrol Acetate.


Megestrol Acetate Patents

Given below is the list of patents protecting Megestrol Acetate, along with the drug name that holds that patent and the company name owning that drug.

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Drug Used in Drug Patent Number Drug Patent Title Drug Patent Expiry Drug Owner
Megace Es US7101576 Nanoparticulate megestrol formulations Apr 22, 2024

(Expired)

Endo Operations
Megace Es US9040088 Nanoparticulate megestrol formulations Apr 22, 2024

(Expired)

Endo Operations
Megace Es US9101540 Nanoparticulate megestrol formulations Apr 22, 2024

(Expired)

Endo Operations
Megace Es US9101549 Nanoparticulate megestrol formulations Apr 22, 2024

(Expired)

Endo Operations
Megace Es US9107827 Nanoparticulate megestrol formulations Apr 22, 2024

(Expired)

Endo Operations
Megace Es US6592903 Nanoparticulate dispersions comprising a synergistic combination of a polymeric surface stabilizer and dioctyl sodium sulfosuccinate Sep 21, 2020

(Expired)

Endo Operations



About Veterinary Megestrol Acetate

Megestrol Acetate is used in a drug marketed by 1 company: Intervet Inc.

Other drugs containing Megestrol Acetate are: Ovaban tablets 20 mg, ovaban tablets 5 mg .

Megestrol Acetate's Family Patents

Family Patents

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Clinical Trials

Recent Clinical Trials on Megestrol Acetate:

Sometimes companies keep conducting clinical trials even after the drug's approval to discover new formulations, methods of use, or new treatment indications, so they could file for additional patents or receive regulatory exclusivity extensions, such as pediatric exclusivity, potentially delaying generic competition. Based on these recent clinical trials, generic companies need to consider the potential for new intellectual property or regulatory hurdles. These strategic moves by the drug owner might delay generic substitution or lead to additional sales of the brand drug, even after patent expiry.

Title Lead Sponsor Collaborators Status Phases
Clinical Trials
Megestrol Acetate for Fatigue Management in T-DXd Treated Breast Cancer Sun Yat-sen University NA RECRUITING
(Aug 1, 2026)
PHASE3
Olanzapine Versus Megestrol Acetate for the Treatment of Loss of Appetite Among Advanced Cancer Patients Alliance for Clinical Trials in Oncology NA ACTIVE NOT RECRUITING
(Jul 1, 2026)
PHASE3
Testing the Addition of the AKT Inhibitor, Ipatasertib, to Treatment With the Hormonal Agent Megestrol Acetate for Recurrent or Metastatic Endometrial Cancers National Cancer Institute (NCI) NA ACTIVE NOT RECRUITING
(Jun 1, 2026)
PHASE1, PHASE2
Progestins for the Treatment of Endometrial Cancer or Precancers of the Uterus Before Surgery, The Pro-Window Trial New Mexico Cancer Research Alliance NA RECRUITING
(Jun 1, 2026)
PHASE2
Megestrol Acetate With or Without Pterostilbene in Treating Patients With Endometrial Cancer Undergoing Hysterectomy City of Hope Medical Center NA ACTIVE NOT RECRUITING
(May 1, 2026)
PHASE2
A Clinical Study of Nanocrystalline Megestrol Acetate in Concurrent Chemoradiotherapy for Locally Advanced Cervical Cancer Second Xiangya Hospital of Central South University NA RECRUITING
(Apr 1, 2026)
PHASE1
Nanocrystalline Megestrol Acetate Versus Placebo for Anorexia in Patients With Unresectable Hepatocellular Carcinoma Receiving TACE Combined With Targeted and Immunotherapy Nanfang Hospital, Southern Medical University NA NOT YET RECRUITING
(Apr 1, 2026)
PHASE2
Megestrol Acetate for First-Line Treatment of Malnourished Non-Small Cell Lung Cancer Hunan Province Tumor Hospital NA NOT YET RECRUITING
(Mar 1, 2026)
PHASE3


Megestrol Acetate Generic API Manufacturers

Several generic applications have been filed for Megestrol Acetate. The first generic version for Megestrol Acetate was by Usl Pharma Inc and was approved on Oct 2, 1987. And the latest generic version is by Chartwell Life Molecules Llc and was approved on Dec 1, 2017.

Given below is the list of companies who have filed for Megestrol Acetate generic, along with the locations of their manufacturing plants worldwide.