Endo Operations Drug Patent Portfolio

Endo Operations owns 12 orange book drugs protected by 77 US patents with Supprelin La having the least patent protection, holding only 1 patent. And Sumavel Dosepro with maximum patent protection, holding 16 patents. Given below is the list of Endo Operations's drug patents along with their expiration dates.

Drug Patent Number Drug Patent Title Drug Patent Expiry Status
US10869845 Ephedrine compositions and methods 22 Jan, 2040
Active
US12029710 Ephedrine compositions and methods 22 Jan, 2040
Active
US10653646 Epinephrine compositions and containers 21 Mar, 2039
Active
US11083698 Epinephrine compositions and containers 21 Mar, 2039
Active
US11207280 Epinephrine compositions and containers 21 Mar, 2039
Active
US10130592 Epinephrine formulations 13 Mar, 2035
Active
US9119876 Epinephrine formulations 13 Mar, 2035
Active
US9295657 Epinephrine formulations 13 Mar, 2035
Active
US10010575 Vasopressin formulations for use in treatment of hypotension 30 Jan, 2035
Active
US9375478 Vasopressin formulations for use in treatment of hypotension 30 Jan, 2035
Active
US9687526 Vasopressin formulations for use in treatment of hypotension 30 Jan, 2035
Active
US9744209 Vasopressin formulations for use in treatment of hypotension 30 Jan, 2035
Active
US9744239 Vasopressin formulations for use in treatment of hypotension 30 Jan, 2035
Active
US9750785 Vasopressin formulations for use in treatment of hypotension 30 Jan, 2035
Active
US9919026 Vasopressin formulations for use in treatment of hypotension 30 Jan, 2035
Active
US9925233 Vasopressin formulations for use in treatment of hypotension 30 Jan, 2035
Active
US9925234 Vasopressin formulations for use in treatment of hypotension 30 Jan, 2035
Active
US9937223 Vasopressin formulations for use in treatment of hypotension 30 Jan, 2035
Active
US9962422 Vasopressin formulations for use in treatment of hypotension 30 Jan, 2035
Active
US9968649 Vasopressin formulations for use in treatment of hypotension 30 Jan, 2035
Active
US9974827 Vasopressin formulations for use in treatment of hypotension 30 Jan, 2035
Active
US9981006 Vasopressin formulations for use in treatment of hypotension 30 Jan, 2035
Active
US8871779 Process for preparing morphinan-6-one products with low levels of α,β-unsaturated ketone compounds 22 Nov, 2029
Active
US8808737 Method of treating pain utilizing controlled release oxymorphone pharmaceutical compositions and instruction on dosing for renal impairment 21 Jun, 2027
Active
US8338395 Methods and pharmaceutical compositions for reliable achievement of acceptable serum testosterone levels 08 May, 2027
Active
US7718640 Methods and pharmaceutical compositions for reliable achievement of acceptable serum testosterone levels 14 Mar, 2027
Active
US7776007 Device for readying a needle free injector for delivery 22 Nov, 2026
Active
US7901385 Casing 31 Jul, 2026
Active
US8062652 Compositions and methods for treating precocious puberty 16 Jun, 2026
Active
US8241243 Needleless injector drug capsule and a method for filling thereof 25 Dec, 2025
Active
US7320968 Pharmaceutical composition 18 Jan, 2025
Active
US8287489 Device for readying a needle free injector for delivery 06 Dec, 2024
Active
US7229636 Cyanocobalamin low viscosity aqueous formulations for intranasal delivery 01 Aug, 2024 Expired
US7879349 Cyanocobalamin low viscosity aqueous formulations for intranasal delivery 01 Aug, 2024 Expired
US8003353 Cyanocobalamin low viscosity aqueous formulations for intranasal delivery 01 Aug, 2024 Expired
US9415007 Cyanocobalamin low viscosity aqueous formulations for intranasal delivery 28 Jul, 2024 Expired
US7101576 Nanoparticulate megestrol formulations 22 Apr, 2024 Expired
US9040088 Nanoparticulate megestrol formulations 22 Apr, 2024 Expired
US9101540 Nanoparticulate megestrol formulations 22 Apr, 2024 Expired
US9101549 Nanoparticulate megestrol formulations 22 Apr, 2024 Expired
US9107827 Nanoparticulate megestrol formulations 22 Apr, 2024 Expired
US7404489 Cyanocobalamin low viscosity aqueous formulations for intranasal delivery 12 Mar, 2024 Expired
US8940714 Cyanocobalamin low viscosity aqueous formulations for intranasal delivery 26 Feb, 2024 Expired
US8118771 Needleless injector drug capsule and a method for filling thereof 10 Aug, 2023 Expired
US7608605 Pharmaceutical composition 21 Apr, 2023 Expired
US7608606 Pharmaceutical composition 21 Apr, 2023 Expired
US7608607 Pharmaceutical composition 21 Apr, 2023 Expired
US7608608 Pharmaceutical composition 21 Apr, 2023 Expired
US7608609 Pharmaceutical composition 21 Apr, 2023 Expired
US7608610 Pharmaceutical composition 21 Apr, 2023 Expired
US7935690 Pharmaceutical composition 21 Apr, 2023 Expired
US8063029 Pharmaceutical composition 21 Apr, 2023 Expired
US8178518 Pharmaceutical composition 21 Apr, 2023 Expired
US8267903 Casing 18 Mar, 2023 Expired
US7276250 Sustained release formulations of oxymorphone 04 Feb, 2023 Expired
US8309112 Coatings for implantable medical devices comprising hydrophilic substances and methods for fabricating the same 04 Feb, 2023 Expired
US8329216 Oxymorphone controlled release formulations 04 Feb, 2023 Expired
US8241244 Needleless injector drug capsule and a method for filling thereof 21 Nov, 2022 Expired
US8491524 Needleless injector drug capsule and a method for filling thereof 21 Nov, 2022 Expired
US8343130 Needleless injector 18 Oct, 2022 Expired
US6592903 Nanoparticulate dispersions comprising a synergistic combination of a polymeric surface stabilizer and dioctyl sodium sulfosuccinate 21 Sep, 2020 Expired
US6319913 Penetration enhancing and irritation reducing systems 09 Nov, 2018 Expired
US6579865 Penetration enhancing and irritation reducing systems 09 Nov, 2018 Expired
US6280410 Method of filling a drug capsule and article produced thereby 27 Mar, 2017 Expired
US6135979 Spring-powered dispensing device for medical purposes 21 Mar, 2017 Expired
US6251091 Needleless injector drug capsule and filling method 09 Dec, 2016 Expired
US5957886 Spring-Powered dispensing device 08 Mar, 2016 Expired
US6174304 Filling device for a needless injector cartridge 13 Dec, 2015 Expired
US6681810 Filling device for a needleless injector cartridge 13 Dec, 2015 Expired
US5464864 Use of tetrahydrocarbazone derivatives as 5HT1 receptor agonists 07 Nov, 2015 Expired
US5827871 Medicaments 1,2,3,4-tetrahydrocarbazoles and 5-HT1 agonist use thereof 27 Oct, 2015 Expired
US5891086 Needle-less injector 27 Jul, 2014 Expired
US5637611 Medicaments 10 Jun, 2014 Expired
US5616603 Enantiomers of carbazole derivatives as 5-HT1 -like agonists 01 Apr, 2014 Expired
US5962501 Enantiomer of carbazole derivative as 5-HT1-like agonists 16 Dec, 2013 Expired
US5662933 Controlled release formulation (albuterol) 09 Sep, 2013 Expired
US5958456 Controlled release formulation (albuterol) 09 Sep, 2013 Expired


Given below is the list of recent legal activities going on the following drug patents of Endo Operations.

Activity Date Patent Number
Patent litigations
Expire Patent 08 Jul, 2024 US8192722
Maintenance Fee Reminder Mailed 01 Jul, 2024 US8309060
Expire Patent 17 Jun, 2024 US8178518 (Litigated)
Payment of Maintenance Fee, 12th Year, Large Entity 12 Jun, 2024 US8338395
Payment of Maintenance Fee, 4th Year, Large Entity 05 Jun, 2024 US10869845 (Litigated)
Entity Status Set To Undiscounted (Initial Default Setting or Status Change) 30 May, 2024 US10869845 (Litigated)
Payment of Maintenance Fee, 12th Year, Large Entity 10 May, 2024 US8329216 (Litigated)
Payment of Maintenance Fee, 12th Year, Large Entity 11 Apr, 2024 US8309122 (Litigated)
Maintenance Fee Reminder Mailed 22 Jan, 2024 US8192722
Payment of Maintenance Fee, 8th Year, Large Entity 11 Jan, 2024 US9415007
Maintenance Fee Reminder Mailed 01 Jan, 2024 US8178518 (Litigated)
Expire Patent 25 Dec, 2023 US8063029 (Litigated)
Payment of Maintenance Fee, 8th Year, Large Entity 10 Nov, 2023 US9375478
Payment of Maintenance Fee, 4th Year, Large Entity 12 Oct, 2023 US10653646
Payment of Maintenance Fee, 12th Year, Large Entity 02 Aug, 2023 US8114383


Endo Operations's Drug Patent Litigations

Endo Operations's drugs have been subject to various legal proceedings, including patent litigations. The earliest legal proceeding was initiated on Aug 22, 2014, against patent number US8329216. The petitioner Amneal Pharmaceuticals, LLC, challenged the validity of this patent, with Endo Pharmaceuticals, Inc. as the respondent. Click below to track the latest information on how companies are challenging Endo Operations's patents.

Patent Proceeding Filing Date Status Respondent Petitioner
Patent litigations
US8329216 January, 2014 FWD Entered
(22 Jul, 2015)
Endo Pharmaceuticals, Inc. Amneal Pharmaceuticals, LLC
US8329216 August, 2014 FWD Entered
(22 Jul, 2015)
Endo Pharmaceuticals, Inc. Amneal Pharmaceuticals, LLC


Endo Operations Drug Patents' Oppositions Filed in EPO

Endo Operations drug patents have faced multiple oppositions in the European Patent Office. The earliest opposition was filed on Aug 10, 2010, by Straus, Alexander. This opposition was filed on patent number EP07751984A. Click below to reveal the latest opposition data.


Application Filing Date Opposition Party Legal Status
Patent litigations
EP05762243A Jan, 2016 Actavis Group PTC EHF Revoked
EP07751984A Aug, 2010 Straus, Alexander Revoked


Endo Operations's Family Patents

Endo Operations drugs have patent protection in a total of 45 countries. It's US patent count contributes only to 48.9% of its total global patent coverage. 13 countries have all of their patents expired or invalidated which has opened up potential generic launch opportunities in these countries. Click below to unlock the full patent family tree.

Family Patents



Endo Operations Drug List

Given below is the complete list of Endo Operations's drugs and the patents protecting them.


1. Adrenalin

Adrenalin is protected by 6 patents, out of which none have expired yet. Check out its patent list below.

Drug Patent Number Drug Patent Title Drug Patent Expiry Status
US10653646 Epinephrine compositions and containers 21 Mar, 2039
(14 years from now)
Active
US11083698 Epinephrine compositions and containers 21 Mar, 2039
(14 years from now)
Active
US11207280 Epinephrine compositions and containers 21 Mar, 2039
(14 years from now)
Active
US10130592 Epinephrine formulations 13 Mar, 2035
(10 years from now)
Active
US9119876 Epinephrine formulations 13 Mar, 2035
(10 years from now)
Active
US9295657 Epinephrine formulations 13 Mar, 2035
(10 years from now)
Active

Discover which of these patents contain the active ingredient(API) of the drug, their family patents, along with litigation and legal activity details of these patents on Adrenalin's drug page


2. Aveed

Aveed is protected by 2 patents, out of which none have expired yet. Check out its patent list below.

Drug Patent Number Drug Patent Title Drug Patent Expiry Status
US8338395 Methods and pharmaceutical compositions for reliable achievement of acceptable serum testosterone levels 08 May, 2027
(2 years from now)
Active
US7718640 Methods and pharmaceutical compositions for reliable achievement of acceptable serum testosterone levels 14 Mar, 2027
(2 years from now)
Active

Discover which of these patents contain the active ingredient(API) of the drug, their family patents, along with litigation and legal activity details of these patents on Aveed's drug page


3. Ephedrine Sulfate

Ephedrine Sulfate is protected by 2 patents, out of which none have expired yet. Check out its patent list below.

Drug Patent Number Drug Patent Title Drug Patent Expiry Status
US10869845 Ephedrine compositions and methods 22 Jan, 2040
(15 years from now)
Active
US12029710 Ephedrine compositions and methods 22 Jan, 2040
(15 years from now)
Active

Discover which of these patents contain the active ingredient(API) of the drug, their family patents, along with litigation and legal activity details of these patents on Ephedrine Sulfate's drug page


4. Fortesta

Fortesta is protected by 2 patents, out of which all have expired. Check out its patent list below.

Drug Patent Number Drug Patent Title Drug Patent Expiry Status
US6319913 Penetration enhancing and irritation reducing systems 09 Nov, 2018
(5 years ago)
Expired
US6579865 Penetration enhancing and irritation reducing systems 09 Nov, 2018
(5 years ago)
Expired

Discover which of these patents contain the active ingredient(API) of the drug, their family patents, along with litigation and legal activity details of these patents on Fortesta's drug page


5. Frova

Frova is protected by 5 patents, out of which all have expired. Check out its patent list below.

Drug Patent Number Drug Patent Title Drug Patent Expiry Status
US5464864 Use of tetrahydrocarbazone derivatives as 5HT1 receptor agonists 07 Nov, 2015
(8 years ago)
Expired
US5827871 Medicaments 1,2,3,4-tetrahydrocarbazoles and 5-HT1 agonist use thereof 27 Oct, 2015
(8 years ago)
Expired
US5637611 Medicaments 10 Jun, 2014
(10 years ago)
Expired
US5616603 Enantiomers of carbazole derivatives as 5-HT1 -like agonists 01 Apr, 2014
(10 years ago)
Expired
US5962501 Enantiomer of carbazole derivative as 5-HT1-like agonists 16 Dec, 2013
(10 years ago)
Expired

Discover which of these patents contain the active ingredient(API) of the drug, their family patents, along with litigation and legal activity details of these patents on Frova's drug page


Explore Our Curated Drug Screens

Drugs Generating Over $1 Billion in Annual Revenue
Explore the top-performing drugs that dominate the pharmaceutical industry
View List
NCE-1 Patent Expiry in the Next 1 Year
Identify opportunities as new chemical entity (NCE-1) patents approach expiry
View List
Recently Granted Patents in EP
Find the opportunity to file Oppositions
View List

6. Megace Es

Megace Es is protected by 6 patents, out of which all have expired. Check out its patent list below.

Drug Patent Number Drug Patent Title Drug Patent Expiry Status
US7101576 Nanoparticulate megestrol formulations 22 Apr, 2024
(5 months ago)
Expired
US9040088 Nanoparticulate megestrol formulations 22 Apr, 2024
(5 months ago)
Expired
US9101540 Nanoparticulate megestrol formulations 22 Apr, 2024
(5 months ago)
Expired
US9101549 Nanoparticulate megestrol formulations 22 Apr, 2024
(5 months ago)
Expired
US9107827 Nanoparticulate megestrol formulations 22 Apr, 2024
(5 months ago)
Expired
US6592903 Nanoparticulate dispersions comprising a synergistic combination of a polymeric surface stabilizer and dioctyl sodium sulfosuccinate 21 Sep, 2020
(4 years ago)
Expired

Discover which of these patents contain the active ingredient(API) of the drug, their family patents, along with litigation and legal activity details of these patents on Megace Es's drug page


7. Nascobal

Nascobal is protected by 6 patents, out of which all have expired. Check out its patent list below.

Drug Patent Number Drug Patent Title Drug Patent Expiry Status
US7229636 Cyanocobalamin low viscosity aqueous formulations for intranasal delivery 01 Aug, 2024
(2 months ago)
Expired
US7879349 Cyanocobalamin low viscosity aqueous formulations for intranasal delivery 01 Aug, 2024
(2 months ago)
Expired
US8003353 Cyanocobalamin low viscosity aqueous formulations for intranasal delivery 01 Aug, 2024
(2 months ago)
Expired
US9415007 Cyanocobalamin low viscosity aqueous formulations for intranasal delivery 28 Jul, 2024
(2 months ago)
Expired
US7404489 Cyanocobalamin low viscosity aqueous formulations for intranasal delivery 12 Mar, 2024
(7 months ago)
Expired
US8940714 Cyanocobalamin low viscosity aqueous formulations for intranasal delivery 26 Feb, 2024
(7 months ago)
Expired

Discover which of these patents contain the active ingredient(API) of the drug, their family patents, along with litigation and legal activity details of these patents on Nascobal's drug page


8. Opana Er

Opana Er is protected by 7 patents, out of which 5 have expired. Check out its patent list below.

Drug Patent Number Drug Patent Title Drug Patent Expiry Status
US8871779 Process for preparing morphinan-6-one products with low levels of α,β-unsaturated ketone compounds 22 Nov, 2029
(5 years from now)
Active
US8808737 Method of treating pain utilizing controlled release oxymorphone pharmaceutical compositions and instruction on dosing for renal impairment 21 Jun, 2027
(2 years from now)
Active
US7276250 Sustained release formulations of oxymorphone 04 Feb, 2023
(1 year, 8 months ago)
Expired
US8309112 Coatings for implantable medical devices comprising hydrophilic substances and methods for fabricating the same 04 Feb, 2023
(1 year, 8 months ago)
Expired
US8329216 Oxymorphone controlled release formulations 04 Feb, 2023
(1 year, 8 months ago)
Expired
US5662933 Controlled release formulation (albuterol) 09 Sep, 2013
(11 years ago)
Expired
US5958456 Controlled release formulation (albuterol) 09 Sep, 2013
(11 years ago)
Expired

Discover which of these patents contain the active ingredient(API) of the drug, their family patents, along with litigation and legal activity details of these patents on Opana Er's drug page


9. Sumavel Dosepro

Sumavel Dosepro is protected by 16 patents, out of which 12 have expired. Check out its patent list below.

Drug Patent Number Drug Patent Title Drug Patent Expiry Status
US7776007 Device for readying a needle free injector for delivery 22 Nov, 2026
(2 years from now)
Active
US7901385 Casing 31 Jul, 2026
(1 year, 9 months from now)
Active
US8241243 Needleless injector drug capsule and a method for filling thereof 25 Dec, 2025
(1 year, 2 months from now)
Active
US8287489 Device for readying a needle free injector for delivery 06 Dec, 2024
(a month from now)
Active
US8118771 Needleless injector drug capsule and a method for filling thereof 10 Aug, 2023
(1 year, 2 months ago)
Expired
US8267903 Casing 18 Mar, 2023
(1 year, 6 months ago)
Expired
US8241244 Needleless injector drug capsule and a method for filling thereof 21 Nov, 2022
(1 year, 10 months ago)
Expired
US8491524 Needleless injector drug capsule and a method for filling thereof 21 Nov, 2022
(1 year, 10 months ago)
Expired
US8343130 Needleless injector 18 Oct, 2022
(1 year, 11 months ago)
Expired
US6280410 Method of filling a drug capsule and article produced thereby 27 Mar, 2017
(7 years ago)
Expired
US6135979 Spring-powered dispensing device for medical purposes 21 Mar, 2017
(7 years ago)
Expired
US6251091 Needleless injector drug capsule and filling method 09 Dec, 2016
(7 years ago)
Expired
US5957886 Spring-Powered dispensing device 08 Mar, 2016
(8 years ago)
Expired
US6174304 Filling device for a needless injector cartridge 13 Dec, 2015
(8 years ago)
Expired
US6681810 Filling device for a needleless injector cartridge 13 Dec, 2015
(8 years ago)
Expired
US5891086 Needle-less injector 27 Jul, 2014
(10 years ago)
Expired

Discover which of these patents contain the active ingredient(API) of the drug, their family patents, along with litigation and legal activity details of these patents on Sumavel Dosepro's drug page


10. Supprelin La

Supprelin La is protected by 1 patent, which is still active. Check out its patent list below.

Drug Patent Number Drug Patent Title Drug Patent Expiry Status
US8062652 Compositions and methods for treating precocious puberty 16 Jun, 2026
(1 year, 7 months from now)
Active

Discover which of these patents contain the active ingredient(API) of the drug, their family patents, along with litigation and legal activity details of these patents on Supprelin La's drug page


11. Testim

Testim is protected by 10 patents, out of which 9 have expired. Check out its patent list below.

Drug Patent Number Drug Patent Title Drug Patent Expiry Status
US7320968 Pharmaceutical composition 18 Jan, 2025
(3 months from now)
Active
US7608605 Pharmaceutical composition 21 Apr, 2023
(1 year, 5 months ago)
Expired
US7608606 Pharmaceutical composition 21 Apr, 2023
(1 year, 5 months ago)
Expired
US7608607 Pharmaceutical composition 21 Apr, 2023
(1 year, 5 months ago)
Expired
US7608608 Pharmaceutical composition 21 Apr, 2023
(1 year, 5 months ago)
Expired
US7608609 Pharmaceutical composition 21 Apr, 2023
(1 year, 5 months ago)
Expired
US7608610 Pharmaceutical composition 21 Apr, 2023
(1 year, 5 months ago)
Expired
US7935690 Pharmaceutical composition 21 Apr, 2023
(1 year, 5 months ago)
Expired
US8063029 Pharmaceutical composition 21 Apr, 2023
(1 year, 5 months ago)
Expired
US8178518 Pharmaceutical composition 21 Apr, 2023
(1 year, 5 months ago)
Expired

Discover which of these patents contain the active ingredient(API) of the drug, their family patents, along with litigation and legal activity details of these patents on Testim's drug page


12. Vasostrict

Vasostrict is protected by 14 patents, out of which none have expired yet. Check out its patent list below.

Drug Patent Number Drug Patent Title Drug Patent Expiry Status
US10010575 Vasopressin formulations for use in treatment of hypotension 30 Jan, 2035
(10 years from now)
Active
US9375478 Vasopressin formulations for use in treatment of hypotension 30 Jan, 2035
(10 years from now)
Active
US9687526 Vasopressin formulations for use in treatment of hypotension 30 Jan, 2035
(10 years from now)
Active
US9744209 Vasopressin formulations for use in treatment of hypotension 30 Jan, 2035
(10 years from now)
Active
US9744239 Vasopressin formulations for use in treatment of hypotension 30 Jan, 2035
(10 years from now)
Active
US9750785 Vasopressin formulations for use in treatment of hypotension 30 Jan, 2035
(10 years from now)
Active
US9919026 Vasopressin formulations for use in treatment of hypotension 30 Jan, 2035
(10 years from now)
Active
US9925233 Vasopressin formulations for use in treatment of hypotension 30 Jan, 2035
(10 years from now)
Active
US9925234 Vasopressin formulations for use in treatment of hypotension 30 Jan, 2035
(10 years from now)
Active
US9937223 Vasopressin formulations for use in treatment of hypotension 30 Jan, 2035
(10 years from now)
Active
US9962422 Vasopressin formulations for use in treatment of hypotension 30 Jan, 2035
(10 years from now)
Active
US9968649 Vasopressin formulations for use in treatment of hypotension 30 Jan, 2035
(10 years from now)
Active
US9974827 Vasopressin formulations for use in treatment of hypotension 30 Jan, 2035
(10 years from now)
Active
US9981006 Vasopressin formulations for use in treatment of hypotension 30 Jan, 2035
(10 years from now)
Active

Discover which of these patents contain the active ingredient(API) of the drug, their family patents, along with litigation and legal activity details of these patents on Vasostrict's drug page