Tacrolimus is Used for preventing organ rejection in transplant patients. It was first introduced by Astellas Pharma Us Inc in its drug Prograf on Apr 8, 1994. Other drugs containing Tacrolimus are Protopic, Astagraf Xl, Envarsus Xr. 21 different companies have introduced drugs containing Tacrolimus.

Tacrolimus Patents

Given below is the list of patents protecting Tacrolimus, along with the drug name that holds that patent and the company name owning that drug.

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Drug Used in	Drug Patent Number	Drug Patent Title	Drug Patent Expiry	Drug Owner
Envarsus Xr	US8644239	Method and apparatus for allocating and processing sequences in communication system	Aug 30, 2028	Veloxis Pharms Inc
Envarsus Xr	US8664239	Tacrolimus for improved treatment of transplant patients	Aug 30, 2028	Veloxis Pharms Inc
Envarsus Xr	US8685998	Tacrolimus for improved treatment of transplant patients	Aug 30, 2028	Veloxis Pharms Inc
Envarsus Xr	US10166190	Stabilized tacrolimus composition	May 30, 2028	Veloxis Pharms Inc
Envarsus Xr	US10864199	Tacrolimus for improved treatment of transplant patients	May 30, 2028	Veloxis Pharms Inc
Envarsus Xr	US11110081	Tacrolimus for improved treatment of transplant patients	May 30, 2028	Veloxis Pharms Inc
Envarsus Xr	US11123331	Tacrolimus for improved treatment of transplant patients	May 30, 2028	Veloxis Pharms Inc
Envarsus Xr	US11419823	Stabilized tacrolimus composition	May 30, 2028	Veloxis Pharms Inc
Envarsus Xr	US12083103	Tacrolimus for improved treatment of transplant patients	May 30, 2028	Veloxis Pharms Inc
Envarsus Xr	US9549918	Stabilized tacrolimus composition	May 30, 2028	Veloxis Pharms Inc
Envarsus Xr	US10548880	Solid dispersions comprising tacrolimus	Aug 30, 2024 (Expired)	Veloxis Pharms Inc
Envarsus Xr	US11077096	Modified release compositions comprising tacrolimus	Aug 30, 2024 (Expired)	Veloxis Pharms Inc
Envarsus Xr	US7994214	Solid dispersions comprising tacrolimus	Aug 30, 2024 (Expired)	Veloxis Pharms Inc
Envarsus Xr	US8486993	Solid dispersions comprising tacrolimus	Aug 30, 2024 (Expired)	Veloxis Pharms Inc
Envarsus Xr	US8586084	Modified release compositions comprising tacrolimus	Aug 30, 2024 (Expired)	Veloxis Pharms Inc
Envarsus Xr	US8591946	Modified release compositions comprising tacrolimus	Aug 30, 2024 (Expired)	Veloxis Pharms Inc
Envarsus Xr	US8617599	Modified release compositions comprising tacrolimus	Aug 30, 2024 (Expired)	Veloxis Pharms Inc
Envarsus Xr	US8623410	Modified release compositions comprising tacrolimus	Aug 30, 2024 (Expired)	Veloxis Pharms Inc
Envarsus Xr	US8623411	Modified release compositions comprising tacrolimus	Aug 30, 2024 (Expired)	Veloxis Pharms Inc
Envarsus Xr	US8889185	Modified release compositions comprising tacrolimus	Aug 30, 2024 (Expired)	Veloxis Pharms Inc
Envarsus Xr	US8889186	Modified release compositions comprising tacrolimus	Aug 30, 2024 (Expired)	Veloxis Pharms Inc
Envarsus Xr	US9161907	Modified release compositions comprising tacrolimus	Aug 30, 2024 (Expired)	Veloxis Pharms Inc
Envarsus Xr	US9757362	Modified release compositions comprising tacrolimus	Aug 30, 2024 (Expired)	Veloxis Pharms Inc
Envarsus Xr	US9763920	Solid dispersions comprising tacrolimus	Aug 30, 2024 (Expired)	Veloxis Pharms Inc
Astagraf Xl	US6440458	Sustained release preparations	Mar 25, 2019 (Expired)	Astellas
Astagraf Xl	US6576259	Sustained release formulations containing tacrolimus	Mar 25, 2019 (Expired)	Astellas
Astagraf Xl	US6884433	Sustained release formulation containing tacrolimus	Mar 25, 2019 (Expired)	Astellas
Astagraf Xl	US8551522	Sustained-release formulation	Mar 25, 2019 (Expired)	Astellas
Protopic	US5665727	Use of 11,28-dioxa-4-azatricyclo[22.3.1.04,9 ]octacos-18-ene derivatives and pharmaceutical compositions containing them	Sep 09, 2014 (Expired)	Leo Pharma As

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Tacrolimus's Family Patents

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Tacrolimus Generic API Manufacturers

Several generic applications have been filed for Tacrolimus. The first generic version for Tacrolimus was by Sandoz Inc and was approved on Aug 10, 2009. And the latest generic version is by Nexus Pharmaceuticals Llc and was approved on Feb 12, 2025.

Given below is the list of companies who have filed for Tacrolimus generic, along with the locations of their manufacturing plants worldwide.