Propofol Patent Expiration

Propofol is Used for preventing microbial growth, administering over a longer period, and inducing anesthesia. It was first introduced by Fresenius Kabi Usa Llc in its drug Diprivan on Oct 2, 1989. 13 different companies have introduced drugs containing Propofol.


Propofol Patents

Given below is the list of patents protecting Propofol, along with the drug name that holds that patent and the company name owning that drug.

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Drug Used in Drug Patent Number Drug Patent Title Drug Patent Expiry Drug Owner
Diprivan US8476010

(Pediatric)

Propofol formulations with non-reactive container closures Jun 01, 2025

(Expired)

Fresenius Kabi Usa
Diprivan US8476010 Propofol formulations with non-reactive container closures Dec 01, 2024

(Expired)

Fresenius Kabi Usa
Diprivan US5714520

(Pediatric)

Propofol compostion containing edetate Sep 22, 2015

(Expired)

Fresenius Kabi Usa
Diprivan US5731355

(Pediatric)

Pharmaceutical compositions of propofol and edetate Sep 22, 2015

(Expired)

Fresenius Kabi Usa
Diprivan US5731356

(Pediatric)

Pharmaceutical compositions of propofol and edetate Sep 22, 2015

(Expired)

Fresenius Kabi Usa
Diprivan US5908869

(Pediatric)

Propofol compositions containing edetate Sep 22, 2015

(Expired)

Fresenius Kabi Usa
Diprivan US5714520 Propofol compostion containing edetate Mar 22, 2015

(Expired)

Fresenius Kabi Usa
Diprivan US5731355 Pharmaceutical compositions of propofol and edetate Mar 22, 2015

(Expired)

Fresenius Kabi Usa
Diprivan US5731356 Pharmaceutical compositions of propofol and edetate Mar 22, 2015

(Expired)

Fresenius Kabi Usa
Diprivan US5908869 Propofol compositions containing edetate Mar 22, 2015

(Expired)

Fresenius Kabi Usa



About Veterinary Propofol

Propofol is used in drugs marketed by 3 different companies: Zoetis Inc, Ivaoes Inc Dba Ivaoes Animal Health, Parnell Technologies Pty Ltd.

Other drugs containing Propofol are: Rapanofal , Propoflo, propoflo 28 , Propoclear , Propofolvet multidose .

Veterinary Propofol Patents

Given below is the list of patents protecting Propofol, along with the drug name that holds that patent and the company owning that drug.

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Drug Used In Drug Patent Number Drug Patent Expiry Drug Owner
Patent Data
PropoClear US7550155 ZOETIS INC.

Propofol Petitions

Details of Propofol's suitability petitions are listed below.

Petitioner Action Date of Action Description
Suitability Petitions
Veterinary Research Associates, Inc. Denied
IVX Animal Health, Inc. Denied

Propofol's Family Patents

Family Patents

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Clinical Trials

Recent Clinical Trials on Propofol:

Sometimes companies keep conducting clinical trials even after the drug's approval to discover new formulations, methods of use, or new treatment indications, so they could file for additional patents or receive regulatory exclusivity extensions, such as pediatric exclusivity, potentially delaying generic competition. Based on these recent clinical trials, generic companies need to consider the potential for new intellectual property or regulatory hurdles. These strategic moves by the drug owner might delay generic substitution or lead to additional sales of the brand drug, even after patent expiry.

Title Lead Sponsor Collaborators Status Phases
Clinical Trials
Neural and Antidepressant Effects of Propofol University of Utah NA COMPLETED
(Sep 1, 2026)
PHASE2, PHASE3
Total Intravenous Anesthesia and Recurrence Free Survival The Cleveland Clinic NA RECRUITING
(Sep 1, 2026)
PHASE3
Comparative Efficacy and Safety of Propofol-Ketamine Combination Versus Propofol Monotherapy in Geriatric Patients Under Invasive Ventilation Helwan University NA RECRUITING
(Sep 1, 2026)
PHASE3
A Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of KL0011034 Injection Administered by Continuous Infusion in Healthy Adult Subjects Hunan Kelun Pharmaceutical Co., Ltd. NA NOT YET RECRUITING
(Sep 1, 2026)
PHASE1
Use of S+Ketamine During Target-Controlled Intravenous Anaesthesia After Abdominal Hysterectomy KK Women's and Children's Hospital NA COMPLETED
(Aug 1, 2026)
PHASE2
Prevention of Post-Operative Nausea and Vomiting With Propofol Infusion Milton S. Hershey Medical Center NA COMPLETED
(Aug 1, 2026)
PHASE2
Slow Wave Induction by Propofol to Eliminate Depression (SWIPED) Stage II Washington University School of Medicine NA RECRUITING
(Aug 1, 2026)
PHASE2
Assessing Covert Consciousness During Dexmedetomidine and Ketamine Sedation: An fMRI Study University of Michigan NA ENROLLING BY INVITATION
(Aug 1, 2026)
PHASE2
Propofol-Dexmedetomine Adjunction in Balanced Anesthesia for Minimally Invasive Cardiac Valve Surgery :Effect on Anesthetic Consumption ,Perioperative Outcomes,and Early Recovery Kafrelsheikh University NA NOT YET RECRUITING
(Aug 1, 2026)
PHASE1, PHASE2
buRst-supprESsion TO Stop Refractory Status Epilepticus Post-cardiac Arrest University of California, San Francisco NA RECRUITING
(Jul 1, 2026)
PHASE2
Xenon Compared to Sevoflurane and Total Intravenous Anaesthesia for Coronary Artery Bypass Graft Surgery Air Liquide Santé International NA COMPLETED
(Jun 1, 2026)
PHASE3
Providing "Good Sleep" for ICU Sedation University of California, San Francisco NA TERMINATED
(Jun 1, 2026)
PHASE1
A Trial of Remimazolam for Intraoperative Sedation in Pediatric and Adolescent Patients Jiangsu HengRui Medicine Co., Ltd. NA COMPLETED
(Jun 1, 2026)
PHASE2, PHASE3
Induction of Dreaming With EEG and Anesthesia in Healthy Adults Stanford University NA ENROLLING BY INVITATION
(Jun 1, 2026)
PHASE1
Dexmedetomidine Versus Propofol Sedation for Drug-Induced Sleep Endoscopy in Pediatric Obstructive Sleep Apnea Erin Kirkham NA RECRUITING
(May 1, 2026)
PHASE2
Effects of Dexmedetomidine Versus Ketamine on Inflammatory Response and Hemodynamic in Patients New Valley University NA RECRUITING
(May 1, 2026)
PHASE1, PHASE2
Ketamine Augmentation of ECT in Treatment-Resistant Depression Università Vita-Salute San Raffaele NA RECRUITING
(May 1, 2026)
PHASE3
Electrophysiological Analysis of Gamma-Hydroxybutyrate-induced Sleep in Intensive Care Patients Assistance Publique - Hôpitaux de Paris NA NOT YET RECRUITING
(May 1, 2026)
PHASE2
Ketofol Versus Ketodex for POD Prophylaxis in Elderly Cancer Surgery Cairo University NA RECRUITING
(May 1, 2026)
PHASE3
a Comparive Study of Ketamine-Propofol Versus Dexmedetomidine-Propofol Sedation in Pediatric Patients Undergoing Cardiac Catheterization for Device Closure of Simple Left-to-right Shunts Ain Shams University NA RECRUITING
(May 1, 2026)
PHASE1
Slow Wave Induction by Propofol to Eliminate Depression (SWIPED) I Washington University School of Medicine NA COMPLETED
(Apr 1, 2026)
PHASE1
Study of Psilocybin Under Anesthesia Controlled by EEG Stanford University NA NOT YET RECRUITING
(Apr 1, 2026)
PHASE2


Propofol Generic API Manufacturers

Several generic applications have been filed for Propofol. The first generic version for Propofol was by Sagent Pharmaceuticals Inc and was approved on Jan 4, 1999. And the latest generic version is by Anthea Pharma Private Ltd and was approved on Jul 14, 2026.

Given below is the list of companies who have filed for Propofol generic, along with the locations of their manufacturing plants worldwide.