Nitric Oxide Patent Expiration

Nitric Oxide is Used for treating pulmonary hypertension or hypoxia through nitric oxide delivery to the patient. It was first introduced by Mallinckrodt Hosp Products Ip Ltd in its drug Inomax on Dec 23, 1999. Another drug containing Nitric Oxide is Genosyl. 4 different companies have introduced drugs containing Nitric Oxide.


Nitric Oxide Patents

Given below is the list of patents protecting Nitric Oxide, along with the drug name that holds that patent and the company name owning that drug.

Drug Used in Drug Patent Number Drug Patent Title Drug Patent Expiry Drug Owner
Genosyl US11672938 Start-up protocols for nitric oxide delivery device Jul 22, 2040 Vero Biotech Inc
Inomax US9770570

(Pediatric)

Apparatus and method for monitoring nitric oxide delivery Nov 03, 2036 Mallinckrodt Hosp
Inomax US9770570 Apparatus and method for monitoring nitric oxide delivery May 03, 2036 Mallinckrodt Hosp
Genosyl US10213572 Nitrogen dioxide storage cassette Feb 12, 2036 Vero Biotech Inc
Genosyl US10737051 Nitrogen dioxide storage device Oct 20, 2035 Vero Biotech Inc
Inomax US9279794

(Pediatric)

Systems and methods for compensating long term sensitivity drift of electrochemical gas sensors exposed to nitric oxide Aug 19, 2034 Mallinckrodt Hosp
Inomax US9279794 Systems and methods for compensating long term sensitivity drift of electrochemical gas sensors exposed to nitric oxide Feb 19, 2034 Mallinckrodt Hosp
Inomax US8291904

(Pediatric)

Gas delivery device and system Jul 06, 2031 Mallinckrodt Hosp
Inomax US8573209

(Pediatric)

Gas delivery device and system Jul 06, 2031 Mallinckrodt Hosp
Inomax US8573210

(Pediatric)

Nitric oxide delivery device Jul 06, 2031 Mallinckrodt Hosp
Inomax US8776794

(Pediatric)

Nitric oxide delivery device Jul 06, 2031 Mallinckrodt Hosp
Inomax US8776795

(Pediatric)

Gas delivery device and system Jul 06, 2031 Mallinckrodt Hosp
Inomax US9265911

(Pediatric)

Gas delivery device and system Jul 06, 2031 Mallinckrodt Hosp
Inomax US9295802

(Pediatric)

Gas delivery device and system Jul 06, 2031 Mallinckrodt Hosp
Inomax US9408993

(Pediatric)

Nitric oxide delivery device Jul 06, 2031 Mallinckrodt Hosp
Inomax US8291904 Gas delivery device and system Jan 06, 2031 Mallinckrodt Hosp
Inomax US8573209 Gas delivery device and system Jan 06, 2031 Mallinckrodt Hosp
Inomax US8573210 Nitric oxide delivery device Jan 06, 2031 Mallinckrodt Hosp
Inomax US8776794 Nitric oxide delivery device Jan 06, 2031 Mallinckrodt Hosp
Inomax US8776795 Gas delivery device and system Jan 06, 2031 Mallinckrodt Hosp
Inomax US9265911 Gas delivery device and system Jan 06, 2031 Mallinckrodt Hosp
Inomax US9295802 Gas delivery device and system Jan 06, 2031 Mallinckrodt Hosp
Inomax US9408993 Nitric oxide delivery device Jan 06, 2031 Mallinckrodt Hosp
Genosyl US8607785 Systems and devices for generating nitric oxide Jul 14, 2030 Vero Biotech Inc
Genosyl US11103669 Nitric oxide therapies Jun 21, 2030 Vero Biotech Inc
Inomax US8282966

(Pediatric)

Methods of reducing the risk of occurrence of pulmonary edema in children in need of treatment with inhaled nitric oxide Dec 30, 2029 Mallinckrodt Hosp
Inomax US8293284

(Pediatric)

Methods of reducing the risk of occurrence of pulmonary edema in term or near-term neonates in need of treatment with inhaled nitric oxide Dec 30, 2029 Mallinckrodt Hosp
Inomax US8431163

(Pediatric)

Methods of reducing the risk of occurrence of pulmonary edema associated with inhalation of nitric oxide gas Dec 30, 2029 Mallinckrodt Hosp
Inomax US8795741

(Pediatric)

Methods for treating patients who are candidates for inhaled nitric oxide treatment Dec 30, 2029 Mallinckrodt Hosp
Inomax US8846112

(Pediatric)

Methods of distributing a pharmaceutical product comprising nitric oxide gas for inhalation Dec 30, 2029 Mallinckrodt Hosp
Inomax US11931377

(Pediatric)

Methods of administering inhaled nitric oxide gas Dec 03, 2029 Mallinckrodt Hosp
Genosyl US11511252 Conversion of nitrogen dioxide (NO2) to nitric oxide (NO) Sep 21, 2029 Vero Biotech Inc
Genosyl US10926054 Systems and devices for generating nitric oxide Aug 13, 2029 Vero Biotech Inc
Genosyl US8944049 Systems and devices for generating nitric oxide Aug 13, 2029 Vero Biotech Inc
Genosyl US9604028 Systems and devices for generating nitric oxide Aug 13, 2029 Vero Biotech Inc
Inomax US8282966 Methods of reducing the risk of occurrence of pulmonary edema in children in need of treatment with inhaled nitric oxide Jun 30, 2029 Mallinckrodt Hosp
Inomax US8293284 Methods of reducing the risk of occurrence of pulmonary edema in term or near-term neonates in need of treatment with inhaled nitric oxide Jun 30, 2029 Mallinckrodt Hosp
Inomax US8431163 Methods of reducing the risk of occurrence of pulmonary edema associated with inhalation of nitric oxide gas Jun 30, 2029 Mallinckrodt Hosp
Inomax US8795741 Methods for treating patients who are candidates for inhaled nitric oxide treatment Jun 30, 2029 Mallinckrodt Hosp
Inomax US8846112 Methods of distributing a pharmaceutical product comprising nitric oxide gas for inhalation Jun 30, 2029 Mallinckrodt Hosp
Inomax US11931377 Methods of administering inhaled nitric oxide gas Jun 03, 2029 Mallinckrodt Hosp
Genosyl US9701538 Conversion of nitrogen dioxide (NO2) to nitric oxide (NO) Jan 28, 2029 Vero Biotech Inc
Genosyl US7560076 Conversion of nitrogen dioxide (NO2) to nitric oxide (NO) Apr 21, 2027 Vero Biotech Inc
Genosyl US7618594 Conversion of nitrogen dioxide (NO2) to nitric oxide (NO) Oct 17, 2026 Vero Biotech Inc
Genosyl US7947227 Kit for the conversion of nitrogen dioxide (NO2) to nitric oxide (NO) Oct 17, 2026 Vero Biotech Inc
Genosyl US8057742 Conversion of nitrogen dioxide (NO2) to nitric oxide (NO) Jan 18, 2026 Vero Biotech Inc
Genosyl US10814092 Conversion of nitrogen dioxide (NO2) to nitric oxide (NO) Oct 17, 2025 Vero Biotech Inc
Genosyl US10124142 Conversion of nitrogen dioxide (NO2) to nitric oxide (NO) Aug 18, 2025 Vero Biotech Inc
Genosyl US11291793 Conversion of nitrogen dioxide (NO2) to nitric oxide (NO) Aug 18, 2025 Vero Biotech Inc
Genosyl US11383059 Conversion of nitrogen dioxide (NO2) to nitric oxide (NO) Aug 18, 2025 Vero Biotech Inc
Genosyl US11554241 Conversion of nitrogen dioxide (NO2) to nitric oxide (NO) Aug 18, 2025 Vero Biotech Inc
Genosyl US8226916 Conversion of nitrogen dioxide (NO2) to nitric oxide (NO) Aug 18, 2025 Vero Biotech Inc
Genosyl US8609028 Conversion of nitrogen dioxide (NO2) to nitric oxide (NO) Aug 18, 2025 Vero Biotech Inc
Genosyl US8821801 Conversion of nitrogen dioxide (NO2) to nitric oxide (NO) Aug 18, 2025 Vero Biotech Inc
Genosyl US9522249 Conversion of nitrogen dioxide (NO2) to nitric oxide (NO) Aug 18, 2025 Vero Biotech Inc
Genosyl US9956373 Conversion of nitrogen dioxide (NO2) to nitric oxide (NO) Aug 18, 2025 Vero Biotech Inc
Genosyl US6758214 Simple nitric oxide generator for ambulatory and/or bedside inhaled no treatment Feb 23, 2022

(Expired)

Vero Biotech Inc
Inomax US6125846

(Pediatric)

Purge system for nitric oxide administration apparatus Nov 16, 2017

(Expired)

Mallinckrodt Hosp
Inomax US5732693

(Pediatric)

Pause control of nitric oxide therapy Jun 13, 2017

(Expired)

Mallinckrodt Hosp
Inomax US5752504

(Pediatric)

System for monitoring therapy during calibration Jun 13, 2017

(Expired)

Mallinckrodt Hosp
Inomax US6125846 Purge system for nitric oxide administration apparatus May 16, 2017

(Expired)

Mallinckrodt Hosp
Inomax US5732693 Pause control of nitric oxide therapy Dec 13, 2016

(Expired)

Mallinckrodt Hosp
Inomax US5752504 System for monitoring therapy during calibration Dec 13, 2016

(Expired)

Mallinckrodt Hosp
Inomax US5558083

(Pediatric)

Nitric oxide delivery system May 22, 2014

(Expired)

Mallinckrodt Hosp
Inomax US5558083 Nitric oxide delivery system Nov 22, 2013

(Expired)

Mallinckrodt Hosp
Inomax US5485827

(Pediatric)

Methods and devices for treating plumonary vasoconstriction and asthma Jul 23, 2013

(Expired)

Mallinckrodt Hosp
Inomax US5873359

(Pediatric)

Methods and devices for treating pulmonary vasoconstriction and asthma Jul 23, 2013

(Expired)

Mallinckrodt Hosp
Inomax US5485827 Methods and devices for treating plumonary vasoconstriction and asthma Jan 23, 2013

(Expired)

Mallinckrodt Hosp
Inomax US5873359 Methods and devices for treating pulmonary vasoconstriction and asthma Jan 23, 2013

(Expired)

Mallinckrodt Hosp



Nitric Oxide's Family Patents

Family Patents

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Nitric Oxide Generic API Manufacturers

Several generic applications have been filed for Nitric Oxide. The first generic version for Nitric Oxide was by Linde Gas And Equipment Inc and was approved on Oct 2, 2018. And the latest generic version is by Airgas Therapeutics Llc and was approved on Jul 27, 2023.

Given below is the list of companies who have filed for Nitric Oxide generic, along with the locations of their manufacturing plants worldwide.


1. AIRGAS THERAP

Airgas Therapeutics Llc has filed for 1 generic for Nitric Oxide. This 800ppm version comes by the name ULSPIRA. Given below are the details of the strengths of this generic introduced by Airgas Therap.

Strength Dosage Form Availability Application Pathway TE code Launch Date
800PPM

gas Prescription INHALATION AA Jul 27, 2023


Manufacturing Plant Locations
New

Airgas Therap's manufacturing plants are situated in 1 country - United States. Given below are the details of these plant locations as well as the firm names of Airgas Therap as present at those locations.

Country City Firm Name
United States
Plumsteadville Airgas Therapeutics Llc





2. LINDE GAS EQUIP

Linde Gas And Equipment Inc has filed for 2 different strengths of generic version for Nitric Oxide. All of these versions come by the name NOXIVENT. Given below are the details of the strengths of this generic introduced by Linde Gas Equip.

Strength Dosage Form Availability Application Pathway TE code Launch Date
100PPM

(reference standard)

gas Prescription INHALATION N/A Oct 2, 2018
800PPM

gas Prescription INHALATION AA Oct 2, 2018


Manufacturing Plant Locations
New

Linde Gas Equip's manufacturing plants are situated in 1 country - United States. Given below are the details of these plant locations as well as the firm names of Linde Gas Equip as present at those locations.

Country City Firm Name
United States
Albuquerque Linde Gas Equipment Inc.