Metformin Hydrochloride; Pioglitazone Hydrochloride is used for improving glycemic control in patients with type 2 diabetes already on a combination of pioglitazone and metformin or a thiazolidinedione (TZD) and metformin. It was first introduced by Takeda Pharmaceuticals Usa Inc in its drug Actoplus Met on Aug 29, 2005. Another drug containing Metformin Hydrochloride; Pioglitazone Hydrochloride is Actoplus Met Xr. 7 different companies have introduced drugs containing Metformin Hydrochloride; Pioglitazone Hydrochloride.

Metformin Hydrochloride; Pioglitazone Hydrochloride Patents

Given below is the list of patents protecting Metformin Hydrochloride; Pioglitazone Hydrochloride, along with the drug name that holds that patent and the company name owning that drug.

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Drug Used in	Drug Patent Number	Drug Patent Title	Drug Patent Expiry	Drug Owner
Actoplus Met	US9320714	Tablet	Feb 03, 2029	Takeda Pharms Usa
Actoplus Met	US9101660	Solid preparation	Jan 22, 2027	Takeda Pharms Usa
Actoplus Met Xr	US7785627	Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative	Jul 31, 2026	Takeda Pharms Usa
Actoplus Met Xr	US7959946	Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative	Jul 31, 2026	Takeda Pharms Usa
Actoplus Met Xr	US8470368	Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative	Sep 19, 2023 (Expired)	Takeda Pharms Usa
Actoplus Met Xr	US8668931	Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative	Sep 19, 2023 (Expired)	Takeda Pharms Usa
Actoplus Met Xr	US9060941	Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative	Sep 19, 2023 (Expired)	Takeda Pharms Usa
Actoplus Met Xr	US6790459	Methods for treating diabetes via administration of controlled release metformin	Mar 17, 2021 (Expired)	Takeda Pharms Usa
Actoplus Met Xr	US6866866	Controlled release metformin compositions	Mar 17, 2021 (Expired)	Takeda Pharms Usa
Actoplus Met Xr	US6099859	Controlled release oral tablet having a unitary core	Mar 20, 2018 (Expired)	Takeda Pharms Usa
Actoplus Met Xr	US6495162	Controlled release oral tablet having a unitary core	Mar 20, 2018 (Expired)	Takeda Pharms Usa
Actoplus Met Xr	US7919116	Controlled release metformin formulations	Mar 20, 2018 (Expired)	Takeda Pharms Usa
Actoplus Met Xr	US8475841	Controlled release metformin formulations	Mar 20, 2018 (Expired)	Takeda Pharms Usa
Actoplus Met	US5965584	Pharmaceutical composition	Jun 19, 2016 (Expired)	Takeda Pharms Usa
Actoplus Met	US6166042	Pharmaceutical composition	Jun 19, 2016 (Expired)	Takeda Pharms Usa
Actoplus Met	US6166043	Pharmaceutical composition	Jun 19, 2016 (Expired)	Takeda Pharms Usa
Actoplus Met	US6172090	Pharmaceutical composition	Jun 19, 2016 (Expired)	Takeda Pharms Usa
Actoplus Met Xr	US5965584	Pharmaceutical composition	Jun 19, 2016 (Expired)	Takeda Pharms Usa
Actoplus Met Xr	US6166042	Pharmaceutical composition	Jun 19, 2016 (Expired)	Takeda Pharms Usa
Actoplus Met Xr	US6166043	Pharmaceutical composition	Jun 19, 2016 (Expired)	Takeda Pharms Usa
Actoplus Met Xr	US6172090	Pharmaceutical composition	Jun 19, 2016 (Expired)	Takeda Pharms Usa

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Metformin Hydrochloride; Pioglitazone Hydrochloride's Family Patents

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Metformin Hydrochloride; Pioglitazone Hydrochloride Generic API Manufacturers

Several generic applications have been filed for Metformin Hydrochloride; Pioglitazone Hydrochloride. The first generic version for Metformin Hydrochloride; Pioglitazone Hydrochloride was by Norvium Bioscience Llc and was approved on Feb 25, 2011. And the latest generic version is by Macleods Pharmaceuticals Ltd and was approved on Nov 5, 2015.

Given below is the list of companies who have filed for Metformin Hydrochloride; Pioglitazone Hydrochloride generic, along with the locations of their manufacturing plants worldwide.