Melphalan Hydrochloride Patent Expiration

Melphalan Hydrochloride was first introduced by Apotex Inc in its drug Alkeran on Nov 18, 1992. Other drugs containing Melphalan Hydrochloride are Hepzato, Ivra, Evomela. 19 different companies have introduced drugs containing Melphalan Hydrochloride.


Melphalan Hydrochloride Patents

Given below is the list of patents protecting Melphalan Hydrochloride, along with the drug name that holds that patent and the company name owning that drug.

Drug Used in Drug Patent Number Drug Patent Title Drug Patent Expiry Drug Owner
Ivra US10537520 Stable liquid formulations of melphalan Jun 29, 2036 Apotex
Hepzato US9707331 Apparatus for removing chemotherapy compounds from blood Sep 17, 2034 Delcath Systems Inc
Hepzato US9314561 Filter and frame apparatus and method of use Feb 07, 2034 Delcath Systems Inc
Evomela US10040872 Alkylated cyclodextrin compositions and processes for preparing and using the same Jan 30, 2034 Acrotech Biopharma
Evomela US9493582 Alkylated cyclodextrin compositions and processes for preparing and using the same Feb 27, 2033 Acrotech Biopharma
Hepzato US10195334 Filter and frame apparatus and method of use Jan 16, 2033 Delcath Systems Inc
Hepzato US11083831 Filter and frame apparatus and method of use Dec 30, 2032 Delcath Systems Inc
Hepzato US11833286 Filter and frame apparatus and method of use Dec 30, 2032 Delcath Systems Inc
Hepzato US10098997 Apparatus for removing chemotherapy compounds from blood Nov 07, 2032 Delcath Systems Inc
Hepzato US10369264 Apparatus for removing chemotherapy compounds from blood Nov 07, 2032 Delcath Systems Inc
Hepzato US10569004 Apparatus for removing chemotherapy compounds from blood Nov 07, 2032 Delcath Systems Inc
Hepzato US11241522 Apparatus for removing chemotherapy compounds from blood Nov 07, 2032 Delcath Systems Inc
Hepzato US11633528 Apparatus for removing chemotherapy compounds from blood Nov 07, 2032 Delcath Systems Inc
Evomela US10940128 Injectable melphalan compositions comprising a cyclodextrin derivative and methods of making and using the same Jun 14, 2030 Acrotech Biopharma
Evomela US10864183 Injectable nitrogen mustard compositions comprising a cyclodextrin derivative and methods of making and using the same May 28, 2030 Acrotech Biopharma
Evomela US11020363 Injectable nitrogen mustard compositions comprising a cyclodextrin derivative and methods of making and using the same May 28, 2030 Acrotech Biopharma
Evomela US8410077 Sulfoalkyl ether cyclodextrin compositions Mar 13, 2029 Acrotech Biopharma
Evomela US9200088 Sulfoalkyl ether cyclodextrin compositions Mar 13, 2029 Acrotech Biopharma



A patent's expiry date may change depending upon legal activities going on that patent. Critical activities like abandoning of a patent, term extension of a patent or amendment of its claims can increase or decrease the life of a patent hence affecting its expiry date and in turn affecting the generic launch date of that drug. Tracking these ongoing activities on a patent application helps to keep an eye on the latest developments in the patent process of the drug which can give an idea of how early a drug's generic could be available. The next section provides a list of recent legal activities on Melphalan Hydrochloride's patents.

Given below is the list recent legal activities going on the following patents of Melphalan Hydrochloride.

Activity Date Patent Number
Patent litigations
Payment of Maintenance Fee, 4th Yr, Small Entity 23 Jan, 2023 US10537520
Post Issue Communication - Certificate of Correction 31 Jan, 2020 US10537520
Recordation of Patent Grant Mailed 21 Jan, 2020 US10537520
Patent Issue Date Used in PTA Calculation 21 Jan, 2020 US10537520
Issue Notification Mailed 01 Jan, 2020 US10537520
Dispatch to FDC 16 Dec, 2019 US10537520
Application Is Considered Ready for Issue 16 Dec, 2019 US10537520
Issue Fee Payment Received 03 Dec, 2019 US10537520
Issue Fee Payment Verified 03 Dec, 2019 US10537520
Printer Rush- No mailing 02 Dec, 2019 US10537520


Melphalan Hydrochloride's Family Patents

Family Patents

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Melphalan Hydrochloride Generic API Manufacturers

Several generic applications have been filed for Melphalan Hydrochloride. The first generic version for Melphalan Hydrochloride was by Mylan Institutional Llc and was approved on Jun 9, 2009. And the latest generic version is by Avet Lifesciences Private Ltd and was approved on Oct 29, 2024.

Given below is the list of companies who have filed for Melphalan Hydrochloride generic, along with the locations of their manufacturing plants worldwide.