Lidocaine Patent Expiration

Lidocaine is Used for managing pain associated with post-herpetic neuralgia. It was first introduced by Astrazeneca Lp in its drug Xylocaine on Approved Prior to Jan 1, 1982. Other drugs containing Lidocaine are Bondlido, Ztlido, Dentipatch, Lidoderm. 33 different companies have introduced drugs containing Lidocaine.


Lidocaine Patents

Given below is the list of patents protecting Lidocaine, along with the drug name that holds that patent and the company name owning that drug.

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Drug Used in Drug Patent Number Drug Patent Title Drug Patent Expiry Drug Owner
Ztlido US10765640 Non-aqueous patch May 10, 2031 Scilex Pharms
Ztlido US10765749 Non-aqueous patch May 10, 2031 Scilex Pharms
Ztlido US11278623 Non-aqueous patch May 10, 2031 Scilex Pharms
Ztlido US11786455 Non-aqueous patch May 10, 2031 Scilex Pharms
Ztlido US11793766 Non-aqueous patch for the relief of pain May 10, 2031 Scilex Pharms
Ztlido US9283174 Non-aqueous patch May 10, 2031 Scilex Pharms
Ztlido US9925264 Non-aqueous patch May 10, 2031 Scilex Pharms
Ztlido US9931403 Non-aqueous patch May 10, 2031 Scilex Pharms
Bondlido US8722065 Lidocaine Tape Preparation Nov 10, 2028 Medrx Usa
Lidoderm US5827529 External preparation for application to the skin containing lidocaine Oct 27, 2015

(Expired)

Teikoku Pharma Usa
Lidoderm US5741510 Adhesive patch for applying analgesic medication to the skin Mar 30, 2014

(Expired)

Teikoku Pharma Usa



A patent's expiry date may change depending upon legal activities going on that patent. Critical activities like abandoning of a patent, term extension of a patent or amendment of its claims can increase or decrease the life of a patent hence affecting its expiry date and in turn affecting the generic launch date of that drug. Tracking these ongoing activities on a patent application helps to keep an eye on the latest developments in the patent process of the drug which can give an idea of how early a drug's generic could be available. The next section provides a list of recent legal activities on Lidocaine's patents.

Given below is the list recent legal activities going on the following patents of Lidocaine.

Activity Date Patent Number
Patent litigations
Payment of Maintenance Fee, 8th Year, Large Entity 17 Sep, 2025 US9931403
Payment of Maintenance Fee, 4th Year, Large Entity 10 Sep, 2025 US11278623
Payment of Maintenance Fee, 8th Year, Large Entity 10 Sep, 2025 US9925264
Email Notification 10 Jan, 2025 US11793766
Change in Power of Attorney (May Include Associate POA) 10 Jan, 2025 US10765749
Change in Power of Attorney (May Include Associate POA) 10 Jan, 2025 US11278623
Change in Power of Attorney (May Include Associate POA) 10 Jan, 2025 US11786455
Email Notification 10 Jan, 2025 US11278623
Email Notification 10 Jan, 2025 US10765749
Email Notification 10 Jan, 2025 US11786455


Lidocaine's Family Patents

Family Patents

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Clinical Trials

Recent Clinical Trials on Lidocaine:

Sometimes companies keep conducting clinical trials even after the drug's approval to discover new formulations, methods of use, or new treatment indications, so they could file for additional patents or receive regulatory exclusivity extensions, such as pediatric exclusivity, potentially delaying generic competition. Based on these recent clinical trials, generic companies need to consider the potential for new intellectual property or regulatory hurdles. These strategic moves by the drug owner might delay generic substitution or lead to additional sales of the brand drug, even after patent expiry.

Title Lead Sponsor Collaborators Status Phases
Clinical Trials
A Phase 1/2 Study of Intravenous Gene Transfer With an AAV9 Vector Expressing Human Beta-galactosidase in Type I and Type II GM1 Gangliosidosis National Human Genome Research Institute (NHGRI) NA RECRUITING
(Sep 17, 2026)
PHASE1, PHASE2
Injections of Botulinic Toxin in Plantar Lesions of Localized Epidermolysis Bullosa Simplex University Hospital, Toulouse NA COMPLETED
(Sep 1, 2026)
PHASE2, PHASE3
The SToICAL Study - The Soft Tissue Injection of Corticosteroid And Local Anaesthetic Study University Hospital Plymouth NHS Trust NA TERMINATED
(Sep 1, 2026)
PHASE3
Effectiveness of Platelet-rich Plasma Treatment of Knee Osteoarthritis Universidad Nacional de Entre Rios NA COMPLETED
(Sep 1, 2026)
PHASE2
Lidocaine for Opioid Sparing in Vaso-occlusive Crisis of Sickle Cell Disease Nantes University Hospital NA RECRUITING
(Sep 1, 2026)
PHASE3
Localized Injection of Lidocaine Via the Middle Meningeal Artery for Headache Treatment Daniel A Tonetti, MD NA RECRUITING
(Sep 1, 2026)
PHASE2
Intralesional Gardasil-9 for the Treatment of Recalcitrant Warts Rush University Medical Center NA ACTIVE NOT RECRUITING
(Sep 1, 2026)
PHASE2
MMA Infusion of Lidocaine for Treatment of Headache in Patients With Aneurysmal SAH Rigshospitalet, Denmark NA NOT YET RECRUITING
(Sep 1, 2026)
PHASE2
Long-term Outcomes of Lidocaine Infusions for Post-Operative Pain (LOLIPOP) Trial Monash University NA RECRUITING
(Aug 1, 2026)
PHASE3
JUVÉDERM® VOLITE™ XC Injectable Gel for Improvement in Neck Appearance AbbVie NA COMPLETED
(Aug 1, 2026)
PHASE3
Oral Ketorolac for IUD Pain Reduction University of North Carolina, Chapel Hill NA ENROLLING BY INVITATION
(Aug 1, 2026)
PHASE2
Efficacy and Safety of Intravenous Lidocaine Versus Placebo in Patients Receiving Morphine-rachi Analgesia GCS Ramsay Santé pour l'Enseignement et la Recherche NA NOT YET RECRUITING
(Aug 1, 2026)
PHASE3
DaxibotulinumtoxinA for Blepharospasm University of Pennsylvania NA NOT YET RECRUITING
(Aug 1, 2026)
PHASE2
Visual Instillation of Sphenopalatine-block Intervention for ONgoing Migraine Association of Migraine Disorders NA NOT YET RECRUITING
(Aug 1, 2026)
PHASE2
Study to Assess Adverse Events and How Effective NOA LIFT is Compared to JUVÉDERM VOLIFT With Lidocaine for the Correction of Nasolabial Folds in Adults AbbVie NA RECRUITING
(Aug 1, 2026)
PHASE3
Effectiveness of Medical and Environmental Interventions to Reduce Cystoscopy Discomfort (CystoDiscomfort) Florian Schroeck NA NOT YET RECRUITING
(Aug 1, 2026)
PHASE3
Bladder Directed vs. Pelvic Floor Therapy in IC/BPS Corewell Health East NA ACTIVE NOT RECRUITING
(Jul 1, 2026)
PHASE2
To Assess the Efficacy and Safety of Ceftriaxone in Patients With Mild to Moderate Parkinson's Disease Dementia BrainX Corporation NA COMPLETED
(Jul 1, 2026)
PHASE2
Coconut Oil to Prevent Mouth Sores in Pediatric Patients Receiving High Dose Chemotherapy Wake Forest University Health Sciences NA RECRUITING
(Jul 1, 2026)
PHASE2
Temporary Inactivation of Strong Muscle Sensation to Improve Rehabilitation Interventions in SCI University of Texas Rio Grande Valley NA COMPLETED
(Jul 1, 2026)
PHASE1
Analgesic Ear Drops for Children With Acute Otitis Media UMC Utrecht NA TERMINATED
(Jul 1, 2026)
PHASE3
Evaluation of Botulinum TOXin Type A in the Treatment of Buerger's Disease University Hospital, Toulouse NA NOT YET RECRUITING
(Jul 1, 2026)
PHASE3
Mifepristone vs Misoprostol Montefiore Medical Center NA RECRUITING
(Jul 1, 2026)
PHASE1
IA Lidocaine and Methylprednisolone for Headache Associated With Subarachnoid Hemorrhage Daniel Raper, MBBS NA RECRUITING
(Jul 1, 2026)
PHASE2
Pain Control for Cervical Ripening Balloon Beth Israel Deaconess Medical Center NA RECRUITING
(Jul 1, 2026)
PHASE2
Intravenous Lidocaine to Prevent Post-Fundal Pressure Headache During Cesarean Section Tanta University NA RECRUITING
(Jul 1, 2026)
PHASE3
Lidocaine Patch vs Intradermal Lidocaine for Epidural Needle Insertion Pain Ohio State University NA RECRUITING
(Jul 1, 2026)
PHASE2
Intraperitoneal Irrigation of Ondansteron in Combination With Lidocaine in Acute Postoperative Pain Assiut University NA RECRUITING
(Jul 1, 2026)
PHASE1, PHASE2
500-mg Versus 1000-mg Ceftriaxone for Uncomplicated Gonorrhea Infection National Taiwan University Hospital NA RECRUITING
(Jul 1, 2026)
PHASE3
Pulsed Electromagnetic Field on Chronic Anal Fissure Healing Galala University NA COMPLETED
(Jul 1, 2026)
PHASE3
The Effect of Inhalation Aromatherapy on Intraoperative Fear in Patients Undergoing Lower Blepharoplasty Under Local Anesthesia: A Randomized Controlled Trial Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University NA NOT YET RECRUITING
(Jul 1, 2026)
PHASE2
Prevention of Persistent Pain With LidocAine iNfusions in Breast Cancer Surgery (PLAN) University Health Network, Toronto NA RECRUITING
(Jun 1, 2026)
PHASE3
A Study to Evaluate Safety and Effectiveness of NOA VOLUME Injectable Gel in Adult Participants Compared to JUVÉDERM VOLUMA XC for Improvement of Mid-Face Volume AbbVie NA RECRUITING
(Jun 1, 2026)
PHASE3
Efficacy of Temocillin Compared to Standard of Care in the Treatment of Neisseria Gonorrhoeae Infections Assistance Publique - Hôpitaux de Paris NA NOT YET RECRUITING
(Jun 1, 2026)
PHASE3
The ASPIRE Trial: AchilleS tendinoPathy Treated With cortIcosteRoid injEctions Erasmus Medical Center NA RECRUITING
(Jun 1, 2026)
PHASE3
A Study to Assess Adverse Events and Change in Disease Activity of HArmonyCa Lidocaine Injectable Gel for Mid Face Soft Tissue Augmentation in Adult Participants Allergan NA COMPLETED
(May 1, 2026)
PHASE3
In-office Repair of Chronic Tympanic Membrane Perforations D. Bradley Welling, MD, PhD NA ACTIVE NOT RECRUITING
(May 1, 2026)
PHASE1, PHASE2
Intratumoral Lidocaine Injection Before Oropharyngeal Cancer Surgery Ryan Carey NA RECRUITING
(May 1, 2026)
PHASE1
Bilateral Middle Meningeal Artery Lidocaine Infusion for Chronic Debilitating Migraines Northwell Health NA RECRUITING
(May 1, 2026)
PHASE2
A Phase IIb/III Clinical Study to Evaluate the Efficacy and Safety of APC101 in Patients With Postherpetic Neuralgia. Andros Pharmaceuticals Co., Ltd. NA NOT YET RECRUITING
(May 1, 2026)
PHASE2, PHASE3
Safety and Feasibility Study of Methylene Blue Photodynamic Therapy to Sterilize Deep Tissue Abscess Cavities University of Rochester NA COMPLETED
(Apr 1, 2026)
PHASE1
Ondansetron as a Strategy for Reducing Propofol Injection Pain in Pediatrics: a Randomized Controlled Trial Emory University NA TERMINATED
(Apr 1, 2026)
PHASE2
Bioequivalence Study of Lidocaine and Prilocaine Cream in Healthy Chinese Subjects Haisco Pharmaceutical Group Co., Ltd. NA COMPLETED
(Apr 1, 2026)
PHASE1
"Comparison of Buffered Versus Non-Buffered Local Anesthetic in Patients With Inflamed Tissues for Pain Perception, Onset, Duration and Adverse Effects" King Edward Medical University NA NOT YET RECRUITING
(Apr 1, 2026)
PHASE3
Cardiac Index and General Anesthesia Without Opioid. Centre Hospitalier de Montauban NA COMPLETED
(Mar 1, 2026)
PHASE2, PHASE3
A Randomized, Controlled Study of Repeat Dose Sustained Release Lidocaine for Treatment of Chronic Scrotal Pain Sustained Therapeutics Inc. NA COMPLETED
(Mar 1, 2026)
PHASE2
EMLA Topical Cream for Treatment of Pain in Patients Receiving Intra-Dermal Technetium 99 Injections for Lymphoscintigraphy for Skin Cancers Ohio State University Comprehensive Cancer Center NA RECRUITING
(Mar 1, 2026)
PHASE2
Intraoperative Nebulization of Lidocaine and Postoperative Pulmonary Complications Jun Zhang NA COMPLETED
(Mar 1, 2026)
PHASE3


Lidocaine Generic API Manufacturers

Several generic applications have been filed for Lidocaine. The first generic version for Lidocaine was by Sun Pharma Canada Inc and was approved on Approved Prior to Jan 1, 1982. And the latest generic version is by Uspharma Ltd and was approved on Feb 9, 2026.

Given below is the list of companies who have filed for Lidocaine generic, along with the locations of their manufacturing plants worldwide.