Glucagon Patent Expiration

Glucagon is Used for quickly raising blood sugar levels in cases of severe hypoglycemia. It was first introduced by Eli Lilly And Co in its drug Glucagon on Sep 11, 1998. Other drugs containing Glucagon are Gvoke Kit, Gvoke Pfs, Gvoke Vialdx, Baqsimi, Gvoke Hypopen. 6 different companies have introduced drugs containing Glucagon.


Glucagon Patents

Given below is the list of patents protecting Glucagon, along with the drug name that holds that patent and the company name owning that drug.

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Drug Used in Drug Patent Number Drug Patent Title Drug Patent Expiry Drug Owner
Baqsimi US10765602 Medication delivery systems and methods Sep 23, 2039 Amphastar Pharms Inc
Baqsimi US10894133 Device for dispensing a fluid product Jan 03, 2038 Amphastar Pharms Inc
Gvoke Hypopen US11590205 Methods for producing stable therapeutic glucagon formulations in aprotic polar solvents Apr 22, 2036 Xeris
Gvoke Hypopen US9649364 Methods for producing stable therapeutic formulations in aprotic polar solvents Apr 22, 2036 Xeris
Gvoke Kit US11590205 Methods for producing stable therapeutic glucagon formulations in aprotic polar solvents Apr 22, 2036 Xeris
Gvoke Pfs US11590205 Methods for producing stable therapeutic glucagon formulations in aprotic polar solvents Apr 22, 2036 Xeris
Gvoke Pfs US9649364 Methods for producing stable therapeutic formulations in aprotic polar solvents Apr 22, 2036 Xeris
Baqsimi US10213487 Nasal powder formulation for treatment of hypoglycemia Feb 16, 2036 Amphastar Pharms Inc
Baqsimi US12370241 Nasal Powder Formulation For Treatment Of Hypoglycemia Feb 16, 2036 Amphastar Pharms Inc
Baqsimi US6938798 Fluid or powdery product dispensing device Jan 03, 2022

(Expired)

Amphastar Pharms Inc



Glucagon's Family Patents

Family Patents

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Clinical Trials

Recent Clinical Trials on Glucagon:

Sometimes companies keep conducting clinical trials even after the drug's approval to discover new formulations, methods of use, or new treatment indications, so they could file for additional patents or receive regulatory exclusivity extensions, such as pediatric exclusivity, potentially delaying generic competition. Based on these recent clinical trials, generic companies need to consider the potential for new intellectual property or regulatory hurdles. These strategic moves by the drug owner might delay generic substitution or lead to additional sales of the brand drug, even after patent expiry.

Title Lead Sponsor Collaborators Status Phases
Clinical Trials
Glucagon-like Peptide-1 Metabolism and Acute Neprilysin Inhibition University of Pennsylvania NA WITHDRAWN
(Sep 1, 2026)
PHASE3
Evaluation of Long Term Safety and Efficacy of Glepaglutide in Treatment of SBS Zealand Pharma NA COMPLETED
(Sep 1, 2026)
PHASE3
Semaglutide for the Treatment of Glucose Intolerance in Women With Prior Gestational Diabetes Universitaire Ziekenhuizen KU Leuven NA RECRUITING
(Sep 1, 2026)
PHASE3
Acute Metabolic Effects of Tirzepatide in Type 1 Diabetes Victor Chang Cardiac Research Institute NA RECRUITING
(Sep 1, 2026)
PHASE2
A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight Without Type 2 Diabetes Hoffmann-La Roche NA RECRUITING
(Sep 1, 2026)
PHASE3
A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight and Type 2 Diabetes Hoffmann-La Roche NA RECRUITING
(Sep 1, 2026)
PHASE3
Interleukine-2 (IL-2) Plus Semaglutide in Alzheimer's Disease The Methodist Hospital Research Institute NA RECRUITING
(Sep 1, 2026)
PHASE1, PHASE2
A Study to Evaluate the Effects of Enicepatide in Participants With Obesity or Overweight, With or Without Type 2 Diabetes Hoffmann-La Roche NA RECRUITING
(Sep 1, 2026)
PHASE3
Supplementation of Gut-brain Axis (GLP-1)-Activating Carbohydrates for Increasing Satiety in Adolescents With Obesity Indiana University NA NOT YET RECRUITING
(Sep 1, 2026)
PHASE2
Semaglutide Therapy for Alcohol Reduction (STAR) National Institute on Drug Abuse (NIDA) NA ACTIVE NOT RECRUITING
(Aug 31, 2026)
PHASE2
Therapeutic Strategies for Microvascular Dysfunction in Type 1 Diabetes AdventHealth Translational Research Institute NA RECRUITING
(Aug 1, 2026)
PHASE2
Role of Semaglutide in Restoring Ovulation in Youth and Adults With Polycystic Ovary Syndrome University of Colorado, Denver NA RECRUITING
(Aug 1, 2026)
PHASE3
Effect of Liraglutide in Obese Women With Polycystic Ovary Syndrome Beni-Suef University NA COMPLETED
(Aug 1, 2026)
PHASE3
GLP-1 Receptor Agonists Post-Bariatric Surgery (GRABS) Pilot Trial Vanderbilt University Medical Center NA ACTIVE NOT RECRUITING
(Aug 1, 2026)
PHASE2, PHASE3
Avexitide for Treatment of Post-Bariatric Hypoglycemia Amylyx Pharmaceuticals Inc. NA ACTIVE NOT RECRUITING
(Aug 1, 2026)
PHASE3
Dorzagliatin in Pancreatic Insufficient Cystic Fibrosis Michael R. Rickels, MD, MS NA RECRUITING
(Aug 1, 2026)
PHASE1
Metabolic Interventions (Time-Restricted Eating, GLP1 Receptor Agonist, and Heart Healthy Diet) to Improve Cardiometabolic Health in Prostate Cancer Patients During Androgen Deprivation Therapy, IMPACT-ADT Trial City of Hope Medical Center NA RECRUITING
(Aug 1, 2026)
PHASE2
Studies of Insulin and Glucagon Action in the Liver Duke University NA NOT YET RECRUITING
(Aug 1, 2026)
PHASE1, PHASE2
A Study of Weight Loss Intervention With Tirzepatide and Progestin Intrauterine Device to Treat Endometrial Hyperplasia and Grade 1 Endometrial Cancer National Cancer Institute (NCI) NA NOT YET RECRUITING
(Aug 1, 2026)
PHASE2
Safety, Tolerability and Efficacy of Semaglutide Depot in Subjects With Type-2 Diabetes Mellitus Mapi Pharma Ltd. NA RECRUITING
(Aug 1, 2026)
PHASE1, PHASE2
A Study to Investigate the Efficacy and Safety of Apraglutide Compared With Placebo in Adult Participants With Short Bowel Syndrome Associated With Intestinal Failure (SBS-IF) VectivBio AG NA RECRUITING
(Aug 1, 2026)
PHASE3
A Clinical Trial Evaluating TQF3250 Capsules in Patients With Type 2 Diabetes Mellitus and Overweight/Obesity Chia Tai Tianqing Pharmaceutical Group Co., Ltd. NA RECRUITING
(Aug 1, 2026)
PHASE1
Impact of GLP-1 Receptor Agonist Therapy on Alcohol Pharmacokinetics University of Wisconsin, Madison NA NOT YET RECRUITING
(Aug 1, 2026)
PHASE1
A Clinical Trial of TQF3250 Capsules in Overweight/Obese Trial Participants With Poor Weight Control Through Simple Lifestyle Intervention Chia Tai Tianqing Pharmaceutical Group Co., Ltd. NA NOT YET RECRUITING
(Aug 1, 2026)
PHASE1
An Exploratory Study of Single-Dose and Multiple-Doses IBI3042 in Healthy, Overweight, or Obese Participants Hongwei Jiang NA NOT YET RECRUITING
(Aug 1, 2026)
PHASE1
Tirzepatide s Dopaminergic Effects in Alcohol Use Disorders (AUD) National Institute on Alcohol Abuse and Alcoholism (NIAAA) NA RECRUITING
(Jul 22, 2026)
PHASE1
Extension Trial Evaluating the Long-term Safety and Efficacy of Dasiglucagon in Children With Congenital Hyperinsulinism Zealand Pharma NA COMPLETED
(Jul 1, 2026)
PHASE3
Semaglutide Treatment in the Real-world for Fibrosis Due to NAFLD in Obesity and T2DM University of California, San Diego NA ACTIVE NOT RECRUITING
(Jul 1, 2026)
PHASE2
Examination of How the Duration of Fasting and Temporary Stopping of GLP-1 Medications Affect the Amount of Food Left in the Stomach in People Using Liraglutide (Injected), Semaglutide (Taken by Mouth) or Semaglutide (Injected) Novo Nordisk A/S NA RECRUITING
(Jul 1, 2026)
PHASE1
CLF065 for Chronic Pouchitis Calibr, a division of Scripps Research NA SUSPENDED
(Jul 1, 2026)
PHASE2
Investigating the Impact of GLP-1 RA Therapy on Osteosarcopenia in Older Female Adults With Diabetes Emory University NA RECRUITING
(Jul 1, 2026)
PHASE3
Pre-hepatectomy Rehabilitation in Obese MASLD-Complicated Living Liver Donors With Mazdutide (PRIME) West China Hospital NA NOT YET RECRUITING
(Jul 1, 2026)
PHASE2, PHASE3
Tirzepatide in Thrombectomy-Treated Acute Ischemic Stroke: A Randomized Trial yifang zhu NA NOT YET RECRUITING
(Jul 1, 2026)
PHASE2, PHASE3
Evaluation of the Efficacy and Safety of Tirzepatide, a Dual GLP-1/GIP Agonist, on Functional Capacity in Reduced Ejection Fraction Heart Failure Patients With Obesity Shahid Beheshti University of Medical Sciences NA NOT YET RECRUITING
(Jul 1, 2026)
PHASE3
GLP-1 Agonists for Lung Function Improvement and Muscle Restoration in COPD The Cleveland Clinic NA NOT YET RECRUITING
(Jul 1, 2026)
PHASE2
Lifestyle Counseling and Medication for Adolescent Weight Management University of Minnesota NA ACTIVE NOT RECRUITING
(Jun 1, 2026)
PHASE2
GLP-1 Analogue in Preventing Progression of Small Vessel Disease (GAPP-SVD) Chinese University of Hong Kong NA RECRUITING
(Jun 1, 2026)
PHASE2
Safety and Efficacy of Bimagrumab and Semaglutide in Adults Who Are Overweight or Obese Eli Lilly and Company NA COMPLETED
(Jun 1, 2026)
PHASE2
Combination Adjunctive Therapy to Address Multiple Metabolic Imbalances in Type 1 Diabetes University of California, San Diego NA ACTIVE NOT RECRUITING
(Jun 1, 2026)
PHASE1, PHASE2
Effect of Weight Loss on Physical and Cardiac Performance in People With Obesity and Heart Failure Jens D Hove, MD,PHD NA RECRUITING
(Jun 1, 2026)
PHASE2, PHASE3
Brain Plasticity and GLP-1 Receptor Agonist Treatment for Obesity University of Colorado, Denver NA NOT YET RECRUITING
(Jun 1, 2026)
PHASE3
Semaglutide (Wegovy) Treatment for Trichotillomania University of Chicago NA NOT YET RECRUITING
(Jun 1, 2026)
PHASE2
Evaluation of the Tolerability of Cagrilintide in Participants Not Tolerating GLP-1-RA Therapies Due to Gastrointestinal Adverse Events Novo Nordisk A/S NA RECRUITING
(Jun 1, 2026)
PHASE1
Glucagon-Like Peptide-1 Receptor Agonists to Attenuate Metabolic Risk in Individuals With Duchenne Muscular Dystrophy Vanderbilt University Medical Center NA NOT YET RECRUITING
(Jun 1, 2026)
PHASE1, PHASE2
Discontinuation One Week Recommendations for GLP-1 Receptor Agonists Prior to Esophagogastroduodenoscopy. Fu Jen Catholic University Hospital NA RECRUITING
(Jun 1, 2026)
PHASE3
GLP-1 Agonist Therapy in Cystic Fibrosis-Related Glucose Intolerance University of Pennsylvania NA RECRUITING
(May 1, 2026)
PHASE2
The Effects of Glucagon on Hepatic Metabolism in People With Type 2 Diabetes After Caloric Restriction Adrian Vella NA RECRUITING
(May 1, 2026)
PHASE2
Effect of Aqueous Extracts of Cissus Quadrangularis and Dichrostachys Glomerata on GLP-1 Concentration and DPP-4 Activity in Overweight and Obese Adults University of Yaounde 1 NA ACTIVE NOT RECRUITING
(May 1, 2026)
PHASE1, PHASE2
Semaglutide for Smoking Cessation in Patients With Diabetes Ottawa Heart Institute Research Corporation NA RECRUITING
(May 1, 2026)
PHASE3
The Role of Glucagon in Glucose Metabolism in Humans With and Without Bariatric Surgery The University of Texas Health Science Center at San Antonio NA RECRUITING
(May 1, 2026)
PHASE1
GLP-1 Receptor Agonist in Primary Intracerebral Hemorrhage: A Phase 2 Randomized Trial Chinese University of Hong Kong NA NOT YET RECRUITING
(May 1, 2026)
PHASE2
SHIELD-T1D: Shingrix and GLP-1 Agonist for Beta-Cell Preservation in Recent-Onset Type 1 Diabetes. Ministry of Health, Saudi Arabia NA NOT YET RECRUITING
(May 1, 2026)
PHASE2
The Effects of Glucagon on Hepatic Metabolism Adrian Vella NA COMPLETED
(Apr 1, 2026)
PHASE1, PHASE2
A Study of the Effect of ZT-01 on Night-time Hypoglycemia in Type 1 Diabetes Zucara Therapeutics Inc. NA RECRUITING
(Apr 1, 2026)
PHASE2
A Study to Evaluate DD01 in Overweight/Obese Subjects With MASLD/MASH Neuraly, Inc. NA COMPLETED
(Apr 1, 2026)
PHASE2
Tailoring Obesity Treatment Trial Esbjerg Hospital - University Hospital of Southern Denmark NA WITHDRAWN
(Apr 1, 2026)
PHASE2, PHASE3
A Study to Estimate Early Clinical Efficacy Signals of GLP-1 Agonist Administration in Conjunction With Levonorgestrel Intrauterine Device in Obese Patients With Endometrioid Intraepithelial Neoplasia University of Florida NA RECRUITING
(Apr 1, 2026)
PHASE2
The Role of Phosphodiesterase Inhibitors in Incretin Secretion National Institute on Aging (NIA) NA COMPLETED
(Mar 11, 2026)
PHASE1
To Determine Tolerability to Glucagon Infusion in Obese Subjects AdventHealth Translational Research Institute NA ACTIVE NOT RECRUITING
(Mar 1, 2026)
PHASE1
Loxenatide Plus LNG-IUS in Endometrial Atypical Hyperplasia Fudan University NA COMPLETED
(Mar 1, 2026)
PHASE2, PHASE3
Repurposing Semaglutide for the Treatment of Cocaine Use Disorder The University of Texas Health Science Center, Houston NA RECRUITING
(Mar 1, 2026)
PHASE2


Glucagon Generic API Manufacturers

Several generic applications have been filed for Glucagon. The first generic version for Glucagon was by Amphastar Pharmaceuticals Inc and was approved on Dec 28, 2020. And the latest generic version is by Cipla Ltd and was approved on Sep 15, 2025.

Given below is the list of companies who have filed for Glucagon generic, along with the locations of their manufacturing plants worldwide.


Glucagon News

Pharmalittle: Lilly unveils findings on obesity medication, U.K. reduces trial durations - STAT News

17 Apr, 2026

New Weight Loss Medications Provide Significant Results - NYC Today

12 Mar, 2026

DCGI instructs pharmaceutical companies to halt advertising campaigns promoting GLP-1 for obesity awareness - Drugscontrol

12 Mar, 2026

GLP-1 diabetes medications associated with lower likelihood of addiction and fatalities related to substances.

05 Mar, 2026

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