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Brimonidine Tartrate; Timolol Maleate Patent Expiration

Brimonidine Tartrate; Timolol Maleate is used for lowering elevated intraocular pressure in patients with glaucoma or ocular hypertension. It was first introduced by Abbvie Inc in its drug Combigan on Oct 30, 2007. 11 different companies have introduced drugs containing Brimonidine Tartrate; Timolol Maleate.


Brimonidine Tartrate; Timolol Maleate Patents

Given below is the list of patents protecting Brimonidine Tartrate; Timolol Maleate, along with the drug name that holds that patent and the company name owning that drug.

Drug Used in Drug Patent Number Drug Patent Title Drug Patent Expiry Drug Owner
Combigan US7323463 Combination of brimonidine and timolol for topical ophthalmic use Jan 19, 2023

(Expired)

 Abbvie
Combigan US7030149 Combination of brimonidine timolol for topical ophthalmic use Apr 19, 2022

(Expired)

 Abbvie
Combigan US7320976 Combination of brimonidine and timolol for topical ophthalmic use Apr 19, 2022

(Expired)

 Abbvie
Combigan US7642258 Combination of brimonidine and timolol for topical ophthalmic use Apr 19, 2022

(Expired)

 Abbvie
Combigan US8133890 Combination of brimonidine and timolol for topical ophthalmic use Apr 19, 2022

(Expired)

 Abbvie
Combigan US8354409 Combination of brimonidine and timolol for topical ophthalmic use Apr 19, 2022

(Expired)

 Abbvie
Combigan US8748425 Combination of brimonidine and timolol for topical ophthalmic use Apr 19, 2022

(Expired)

 Abbvie
Combigan US9474751 Combination of brimonidine and timolol for topical ophthalmic use Apr 19, 2022

(Expired)

 Abbvie
Combigan US9770453 Combination of brimonidine and timolol for topical ophthalmic use Apr 19, 2022

(Expired)

 Abbvie
Combigan US9907801 Combination of brimonidine and timolol for topical ophthalmic use Apr 19, 2022

(Expired)

 Abbvie
Combigan US9907802 Combination of brimonidine and timolol for topical ophthalmic use Apr 19, 2022

(Expired)

 Abbvie



Brimonidine Tartrate; Timolol Maleate's Family Patents

Family Patents

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Brimonidine Tartrate; Timolol Maleate Generic API Manufacturers

Several generic applications have been filed for Brimonidine Tartrate; Timolol Maleate. The first generic version for Brimonidine Tartrate; Timolol Maleate was by Sandoz Inc and was approved on Apr 4, 2022. And the latest generic version is by Caplin Steriles Ltd and was approved on Feb 25, 2025.

Given below is the list of companies who have filed for Brimonidine Tartrate; Timolol Maleate generic, along with the locations of their manufacturing plants worldwide.


1. ALEMBIC

Alembic Pharmaceuticals Ltd has filed for 1 generic for Brimonidine Tartrate; Timolol Maleate. This 0.2%;eq 0.5% base version comes by the name BRIMONIDINE TARTRATE AND TIMOLOL MALEATE. Given below are the details of the strengths of this generic introduced by Alembic.

Strength Dosage Form Availability Application Pathway TE code Launch Date
0.2%; EQ 0.5% BASE

solution/drops Prescription OPHTHALMIC AB Aug 25, 2023


Manufacturing Plant Locations
New

Alembic's manufacturing plants are situated in 1 country - India. Given below are the details of these plant locations as well as the firm names of Alembic as present at those locations.

Country City Firm Name
India
Vadodara Alembic Pharmaceuticals Limited
Panchmahal Alembic Pharmaceuticals Limited
Vadodara Alembic Pharmaceuticals Ltd
Panchmahal Alembic Pharmaceuticals Limited (Units I and II)
Panelav Alembic Pharmaceuticals Limited
Vadodara Alembic Pharmaceuticals, Ltd
Vadodara Alembic Pharmaceuticals Ltd (API Division, Karakhadi)





2. AMNEAL

Amneal Eu Ltd has filed for 1 generic for Brimonidine Tartrate; Timolol Maleate. This 0.2%;eq 0.5% base version comes by the name BRIMONIDINE TARTRATE AND TIMOLOL MALEATE. Given below are the details of the strengths of this generic introduced by Amneal.

Strength Dosage Form Availability Application Pathway TE code Launch Date
0.2%; EQ 0.5% BASE

solution/drops Discontinued OPHTHALMIC N/A Dec 30, 2024


Manufacturing Plant Locations
New

Amneal's manufacturing plants are situated in 2 countries - United States, India. Given below are the details of these plant locations as well as the firm names of Amneal as present at those locations.

Country City Firm Name
United States
Glasgow Amneal Pharmaceuticals LLC
Piscataway Amneal Pharmaceuticals, LLC
Branchburg Amneal Pharmaceuticals, LLC
Brookhaven Amneal Pharmaceuticals of New York, LLC
Hauppauge Amneal Pharmaceuticals of New York, LLC
Bridgewater Amneal Complex Products Research LLC
East Hanover Amneal Pharmaceuticals LLC
Paterson Amneal Pharmaceuticals, Llc
India
Hyderabad Amneal Oncology Private Limited
Matoda Amneal Pharmaceuticals Private Ltd.
Tal Bavla, Ahmedabad Amneal Pharmaceuticals Pvt. Ltd.
Ahmedabad Amneal Pharmaceuticals Private Ltd.





3. APOTEX

Apotex Inc has filed for 1 generic for Brimonidine Tartrate; Timolol Maleate. This 0.2%;eq 0.5% base version comes by the name BRIMONIDINE TARTRATE AND TIMOLOL MALEATE. Given below are the details of the strengths of this generic introduced by Apotex.

Strength Dosage Form Availability Application Pathway TE code Launch Date
0.2%; EQ 0.5% BASE

solution/drops Prescription OPHTHALMIC AB Apr 20, 2022


Manufacturing Plant Locations
New

Apotex's manufacturing plants are situated in 3 countries - United States, Canada, India. Given below are the details of these plant locations as well as the firm names of Apotex as present at those locations.

Country City Firm Name
United States
Weston Apotex Corp.
Canada
Toronto Apotex Inc.
Etobicoke Apotex, Inc.
Richmond Hill Apotex Inc.
Winnipeg Apotex Fermentation Inc.
Brantford Apotex Pharmachem Inc.
North York Apotex Inc.
India
Bangalore Apotex Research Private Limited - Bioequivalence Centre
Bangalore Apotex Pharmachem India Pvt Ltd.
Bengaluru Apotex Research Private Limited





4. CAPLIN

Caplin Steriles Ltd has filed for 1 generic for Brimonidine Tartrate; Timolol Maleate. This 0.2%;eq 0.5% base version comes by the name BRIMONIDINE TARTRATE AND TIMOLOL MALEATE. Given below are the details of the strengths of this generic introduced by Caplin.

Strength Dosage Form Availability Application Pathway TE code Launch Date
0.2%; EQ 0.5% BASE

solution/drops Prescription OPHTHALMIC AB Feb 25, 2025


Manufacturing Plant Locations
New

Caplin's manufacturing plants are situated in 2 countries - United States, India. Given below are the details of these plant locations as well as the firm names of Caplin as present at those locations.

Country City Firm Name
United States
Creve Coeur Caplin, Dr David
India
Gummidipoondi Caplin Steriles Limited





5. FLORIDA

Florida Pharmaceutical Products Llc has filed for 1 generic for Brimonidine Tartrate; Timolol Maleate. This 0.2%;eq 0.5% base version comes by the name BRIMONIDINE TARTRATE AND TIMOLOL MALEATE. Given below are the details of the strengths of this generic introduced by Florida.

Strength Dosage Form Availability Application Pathway TE code Launch Date
0.2%; EQ 0.5% BASE

solution/drops Prescription OPHTHALMIC AB Oct 4, 2022





6. GLENMARK PHARMS LTD

Glenmark Pharmaceuticals Ltd has filed for 1 generic for Brimonidine Tartrate; Timolol Maleate. This 0.2%;eq 0.5% base version comes by the name BRIMONIDINE TARTRATE AND TIMOLOL MALEATE. Given below are the details of the strengths of this generic introduced by Glenmark Pharms Ltd.

Strength Dosage Form Availability Application Pathway TE code Launch Date
0.2%; EQ 0.5% BASE

solution/drops Prescription OPHTHALMIC AB May 16, 2024





7. SANDOZ

Sandoz Inc has filed for 1 generic for Brimonidine Tartrate; Timolol Maleate. This 0.2%;eq 0.5% base version comes by the name BRIMONIDINE TARTRATE AND TIMOLOL MALEATE. Given below are the details of the strengths of this generic introduced by Sandoz.

Strength Dosage Form Availability Application Pathway TE code Launch Date
0.2%; EQ 0.5% BASE

solution/drops Prescription OPHTHALMIC AB Apr 4, 2022


Manufacturing Plant Locations
New

Sandoz's manufacturing plants are situated in 4 countries - Austria, United States, Spain, India. Given below are the details of these plant locations as well as the firm names of Sandoz as present at those locations.

Country City Firm Name
Austria
Kundl Sandoz GmbH
Langkampfen Sandoz GmbH
United States
Princeton Sandoz Inc
East Hanover Sandoz Incorporated
Spain
Les Franqueses Del Valles Sandoz Industrial Products S.A.
Palafolls Sandoz Industrial Products, S.A.
India
Navi Mumbai Sandoz Private Limited





8. SENTISS

Sentiss Ag has filed for 1 generic for Brimonidine Tartrate; Timolol Maleate. This 0.2%;eq 0.5% base version comes by the name BRIMONIDINE TARTRATE AND TIMOLOL MALEATE. Given below are the details of the strengths of this generic introduced by Sentiss.

Strength Dosage Form Availability Application Pathway TE code Launch Date
0.2%; EQ 0.5% BASE

solution/drops Prescription OPHTHALMIC AB Oct 31, 2022


Manufacturing Plant Locations
New

Sentiss's manufacturing plants are situated in 1 country - India. Given below are the details of these plant locations as well as the firm names of Sentiss as present at those locations.

Country City Firm Name
India
District Solan Sentiss Pharma Pvt. Ltd.





9. SOMERSET

Somerset Therapeutics Llc has filed for 1 generic for Brimonidine Tartrate; Timolol Maleate. This 0.2%;eq 0.5% base version comes by the name BRIMONIDINE TARTRATE AND TIMOLOL MALEATE. Given below are the details of the strengths of this generic introduced by Somerset.

Strength Dosage Form Availability Application Pathway TE code Launch Date
0.2%; EQ 0.5% BASE

solution/drops Prescription OPHTHALMIC AB Sep 10, 2024


Manufacturing Plant Locations
New

Somerset's manufacturing plants are situated in 2 countries - United States, India. Given below are the details of these plant locations as well as the firm names of Somerset as present at those locations.

Country City Firm Name
United States
Fairfield Somerset Auction Company, LLC
Somerville Somerset Medical Center IRB
India
Bengaluru Somerset Therapeutics Limited





10. UPSHER SMITH LABS

Upsher Smith Laboratories Llc has filed for 1 generic for Brimonidine Tartrate; Timolol Maleate. This 0.2%;eq 0.5% base version comes by the name BRIMONIDINE TARTRATE AND TIMOLOL MALEATE. Given below are the details of the strengths of this generic introduced by Upsher Smith Labs.

Strength Dosage Form Availability Application Pathway TE code Launch Date
0.2%; EQ 0.5% BASE

solution/drops Prescription OPHTHALMIC AB Dec 12, 2022