Brigatinib Patent Expiration

Brigatinib is Used for treating anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC). It was first introduced by Takeda Pharmaceuticals Usa Inc in its drug Alunbrig on Apr 28, 2017.


Brigatinib Patents

Given below is the list of patents protecting Brigatinib, along with the drug name that holds that patent and the company name owning that drug.

Filter patents by

NEW
Drug Used in Drug Patent Number Drug Patent Title Drug Patent Expiry Drug Owner
Alunbrig US10385078 Crystalline forms of 5-chloro-N4-[-2-(dimethylphosphoryl)phenyl]-N2-{2-methoxy-4-[4-(4-methylpiperazin-1-YL) piperidin-1-YL]phenyl}pyrimidine-2,4-diamine Nov 10, 2035 Takeda Pharms Usa
Alunbrig US9611283 Methods for inhibiting cell proliferation in ALK-driven cancers Apr 10, 2034 Takeda Pharms Usa
Alunbrig US9012462 Phosphorous derivatives as kinase inhibitors Apr 28, 2031 Takeda Pharms Usa
Alunbrig US9273077 Phosphorus derivatives as kinase inhibitors May 21, 2029 Takeda Pharms Usa



Brigatinib's Family Patents

Family Patents

Explore Our Curated Drug Screens

Drugs Generating Over $1 Billion in Annual Revenue
Explore the top-performing drugs that dominate the pharmaceutical industry
View List
NCE-1 Patent Expiry in the Next 1 Year
Identify opportunities as new chemical entity (NCE-1) patents approach expiry
View List
Recently Granted Patents in EP
Find the opportunity to file Oppositions
View List



Clinical Trials

Recent Clinical Trials on Brigatinib:

Sometimes companies keep conducting clinical trials even after the drug's approval to discover new formulations, methods of use, or new treatment indications, so they could file for additional patents or receive regulatory exclusivity extensions, such as pediatric exclusivity, potentially delaying generic competition. Based on these recent clinical trials, generic companies need to consider the potential for new intellectual property or regulatory hurdles. These strategic moves by the drug owner might delay generic substitution or lead to additional sales of the brand drug, even after patent expiry.

Title Lead Sponsor Collaborators Status Phases
Clinical Trials
OBSERVE: A Pilot Study Of Omission Of Brain Metastasis Stereotactic Radiosurgery Following Resection With CNS-Active Systemic Therapy M.D. Anderson Cancer Center NA RECRUITING
(Sep 1, 2026)
PHASE1
A Multicenter Exploratory Clinical Study of Iruplaltinib Combined With Pemetrexed as Neoadjuvant Therapy for Resectable ALK-Positive Non-Squamous Non-Small Cell Lung Cancer First Affiliated Hospital of Fujian Medical University NA NOT YET RECRUITING
(Aug 1, 2026)
PHASE2
Advancing Brigatinib Properties in ALK+ NSCLC Patients by Deep Phenotyping Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest NA COMPLETED
(Jun 1, 2026)
PHASE2
Innovative Trial for Understanding the Impact of Targeted Therapies in NF2-Related Schwannomatosis (INTUITT-NF2) Scott R. Plotkin, MD, PhD NA RECRUITING
(Jun 1, 2026)
PHASE2
A Study of Neladalkib (NVL-655) in Patients With Advanced NSCLC and Other Solid Tumors Harboring ALK Rearrangement or Activating ALK Mutation (ALKOVE-1) Nuvalent Inc. NA RECRUITING
(May 1, 2026)
PHASE1, PHASE2
Trial for Local Ablative Treatment (LAT) Optimization in Patients With Advanced Non-Small Cells Lung Cancer (NSCLC) Presenting an Anaplastic Lymphoma Kinase (ALK) Rearrangement Treated by Brigatinib Groupe Francais De Pneumo-Cancerologie NA RECRUITING
(Apr 1, 2026)
PHASE2
Targeted Treatment for ALK Positive Patients Who Have Previously Been Treated for Non-squamous Non-small Cell Lung Cancer National Cancer Institute (NCI) NA TERMINATED
(Mar 1, 2026)
PHASE2


Brigatinib Generic API Manufacturers

Given below is the list of companies who have filed for Brigatinib generic, along with the locations of their manufacturing plants worldwide.