Apixaban Patent Expiration

Apixaban is Used for reducing the risk of stroke and systemic embolism. It was first introduced by Bristol Myers Squibb Co Pharmaceutical Research Institute in its drug Eliquis on Dec 28, 2012. Another drug containing Apixaban is Eliquis Sprinkle. 15 different companies have introduced drugs containing Apixaban.


Apixaban Patents

Given below is the list of patents protecting Apixaban, along with the drug name that holds that patent and the company name owning that drug.

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Drug Used in Drug Patent Number Drug Patent Title Drug Patent Expiry Drug Owner
Eliquis Sprinkle US11896586

(Pediatric)

Apixaban formulations May 22, 2041 Bristol
Eliquis Sprinkle US11896586 Apixaban formulations Nov 22, 2040 Bristol
Eliquis US9326945

(Pediatric)

Apixaban formulations Aug 24, 2031 Bristol Myers Squibb
Eliquis US9326945 Apixaban formulations Feb 24, 2031 Bristol Myers Squibb
Eliquis US6967208

(Pediatric)

Lactam-containing compounds and derivatives thereof as factor Xa inhibitors May 21, 2027 Bristol Myers Squibb
Eliquis Sprinkle US6967208

(Pediatric)

Lactam-containing compounds and derivatives thereof as factor Xa inhibitors May 21, 2027 Bristol
Eliquis US6967208 Lactam-containing compounds and derivatives thereof as factor Xa inhibitors Nov 21, 2026 Bristol Myers Squibb
Eliquis Sprinkle US6967208 Lactam-containing compounds and derivatives thereof as factor Xa inhibitors Nov 21, 2026 Bristol
Eliquis US6413980 Nitrogen containing heterobicycles as factor Xa inhibitors Dec 22, 2019

(Expired)

Bristol Myers Squibb



Apixaban's Family Patents

Family Patents

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Clinical Trials

Recent Clinical Trials on Apixaban:

Sometimes companies keep conducting clinical trials even after the drug's approval to discover new formulations, methods of use, or new treatment indications, so they could file for additional patents or receive regulatory exclusivity extensions, such as pediatric exclusivity, potentially delaying generic competition. Based on these recent clinical trials, generic companies need to consider the potential for new intellectual property or regulatory hurdles. These strategic moves by the drug owner might delay generic substitution or lead to additional sales of the brand drug, even after patent expiry.

Title Lead Sponsor Collaborators Status Phases
Clinical Trials
Safety in Adult Participants With Atrial Fibrillation Who Are Treated With Anticoagulation Regeneron Pharmaceuticals NA RECRUITING
(Sep 1, 2026)
PHASE2
Stroke and Systemic Embolism Prevention in Adult Participants With Atrial Fibrillation Regeneron Pharmaceuticals NA RECRUITING
(Sep 1, 2026)
PHASE3
A Study of Milvexian Versus Apixaban in Participants With Atrial Fibrillation Janssen Research & Development, LLC NA ACTIVE NOT RECRUITING
(Aug 1, 2026)
PHASE3
SWITCH: Apixaban vs Vitamin K in HM3 Columbia University NA NOT YET RECRUITING
(Aug 1, 2026)
PHASE3
Treatment and Secondary Prevention of Venous Thromboembolism (VTE) in Adult Participants With Solid and Hematologic Cancers Regeneron Pharmaceuticals NA RECRUITING
(Aug 1, 2026)
PHASE3
Strategies for the Management of Atrial Fibrillation in patiEnts Receiving Dialysis 2 (SAFE-D2) Unity Health Toronto NA NOT YET RECRUITING
(Aug 1, 2026)
PHASE3
A Study to Investigate Andexanet Dosing and the Interaction Between Andexanet and Subsequent Enoxaparin in Healthy Participants AstraZeneca NA COMPLETED
(Jul 1, 2026)
PHASE1
Apixaban to Prevent Decompensation of Early Liver Cirrhosis Trial University College, London NA NOT YET RECRUITING
(Jul 1, 2026)
PHASE3
Study on Anti-Thrombotic Regimens for Secondary Prevention in Ischemic Stroke Patients With Possible Benefit From Anticoagulation Therapy Second Affiliated Hospital, Zhejiang University, School of Medicine NA NOT YET RECRUITING
(Jul 1, 2026)
PHASE3
AntiCoagulation Versus AcetylSalicylic Acid After Transcatheter Aortic Valve Implantation Oslo University Hospital NA COMPLETED
(Jun 1, 2026)
PHASE3
Timing to Restart Direct Oral Anticoagulants After Traumatic Intracranial Haemorrhage Walton Centre NHS Foundation Trust NA RECRUITING
(Jun 1, 2026)
PHASE3
Apixaban Versus Warfarin for Left Ventricular Thrombus University of Arizona NA RECRUITING
(Jun 1, 2026)
PHASE3
Anticoagulation in ICH Survivors for Stroke Prevention and Recovery Yale University NA RECRUITING
(May 1, 2026)
PHASE3
Avoiding Anticoagulation After IntraCerebral Haemorrhage University Hospital, Lille NA RECRUITING
(Apr 1, 2026)
PHASE3
AVAJAK: Apixaban/Rivaroxaban Versus Aspirin for Primary Prevention of Thrombo-embolic Complications in JAK2V617F-positive Myeloproliferative Neoplasms University Hospital, Brest NA RECRUITING
(Mar 1, 2026)
PHASE3
PFO Closure, Oral Anticoagulants or Antiplatelet Therapy After PFO-associated Stroke in Patients Aged 60 to 80 Years Assistance Publique - Hôpitaux de Paris NA RECRUITING
(Mar 1, 2026)
PHASE3


Apixaban Generic API Manufacturers

Several generic applications have been filed for Apixaban. The first generic version for Apixaban was by Mylan Pharmaceuticals Inc and was approved on Dec 23, 2019. And the latest generic version is by Macleods Pharmaceuticals Ltd and was approved on Feb 27, 2025.

Given below is the list of companies who have filed for Apixaban generic, along with the locations of their manufacturing plants worldwide.


Apixaban News

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