Latest Clinical Trials
Study Of Entrectinib (Rxdx-101) in Children and Adolescents With Locally Advanced Or Metastatic Solid Or Primary CNS Tumors And/Or Who Have No Satisfactory Treatment Options Hoffmann-La Roche NA
ACTIVE NOT RECRUITING
(Sep 1, 2026)
PHASE1, PHASE2 A Study to Evaluate the Efficacy and Safety of Multiple Targeted Therapies as Treatments for Participants With Non-Small Cell Lung Cancer (NSCLC) Hoffmann-La Roche NA
ACTIVE NOT RECRUITING
(Sep 1, 2026)
PHASE2, PHASE3 A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Patients With Metastatic or Locally Advanced Breast Cancer Hoffmann-La Roche NA
RECRUITING
(Sep 1, 2026)
PHASE1, PHASE2 A Study Evaluating the Efficacy and Safety of Inavolisib + Palbociclib + Fulvestrant vs Placebo + Palbociclib + Fulvestrant in Participants With PIK3CA-Mutant, Hormone Receptor-Positive, HER2-Negative, Locally Advanced or Metastatic Breast Cancer Hoffmann-La Roche NA
ACTIVE NOT RECRUITING
(Sep 1, 2026)
PHASE2, PHASE3 A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Mosunetuzumab + Lenalidomide (+Len), and the Safety, Tolerability, and Pharmacokinetics of SC Versus IV Mosunetuzumab + Len in Participants With Follicular Lymphoma Hoffmann-La Roche NA
ACTIVE NOT RECRUITING
(Sep 1, 2026)
PHASE1, PHASE2 A Study Evaluating the Efficacy and Safety of Giredestrant Compared With Physician's Choice of Endocrine Monotherapy in Participants With Previously Treated Estrogen Receptor-Positive, HER2-Negative Locally Advanced or Metastatic Breast Cancer (acelERA Breast Cancer) Hoffmann-La Roche NA
ACTIVE NOT RECRUITING
(Sep 1, 2026)
PHASE2 A Study to Evaluate the Efficacy and Safety of Fenebrutinib Compared With Teriflunomide in Relapsing Multiple Sclerosis (RMS) Hoffmann-La Roche NA
ACTIVE NOT RECRUITING
(Sep 1, 2026)
PHASE3 Study to Evaluate the Efficacy and Safety of Fenebrutinib Compared With Teriflunomide in Relapsing Multiple Sclerosis (RMS) Hoffmann-La Roche NA
ACTIVE NOT RECRUITING
(Sep 1, 2026)
PHASE3 Tumor-agnostic Precision Immuno-oncology and Somatic Targeting Rational for You (TAPISTRY) Platform Study Hoffmann-La Roche NA
ACTIVE NOT RECRUITING
(Sep 1, 2026)
PHASE2 Steroid Sparing Treatment With in Newly Diagnosed Transplant Ineligible Patients With Multiple Myeloma University of Rochester NA
ACTIVE NOT RECRUITING
(Sep 1, 2026)
PHASE2 Study of Atezolizumab Plus Carboplatin and Etoposide With or Without Tiragolumab in Participants With Untreated Extensive-Stage Small Cell Lung Cancer Hoffmann-La Roche NA
COMPLETED
(Sep 1, 2026)
PHASE3 A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Participants With Breast Cancer Hoffmann-La Roche NA
RECRUITING
(Sep 1, 2026)
PHASE1, PHASE2 A Study Evaluating the Safety and Efficacy of Targeted Therapies in Subpopulations of Patients With Metastatic Colorectal Cancer (INTRINSIC) Hoffmann-La Roche NA
RECRUITING
(Sep 1, 2026)
PHASE1 A Study Evaluating the Efficacy and Safety of Biomarker-Driven Therapies in Patients With Persistent or Recurrent Rare Epithelial Ovarian Tumors Hoffmann-La Roche NA
ACTIVE NOT RECRUITING
(Sep 1, 2026)
PHASE2 A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Obinutuzumab in Adolescents With Active Class III or IV Lupus Nephritis and the Safety and PK of Obinutuzumab in Pediatric Participants Hoffmann-La Roche NA
RECRUITING
(Sep 1, 2026)
PHASE2 A Study Evaluating the Safety, Efficacy, and Pharmacokinetics of Mosunetuzumab and a Combined Regimen of Mosunetuzumab and Venetoclax in Participants With Relapsed or Refractory Chronic Lymphocytic Leukemia Hoffmann-La Roche NA
RECRUITING
(Sep 1, 2026)
PHASE1 A Phase III, Open-Label Study of Maintenance Lurbinectedin in Combination With Atezolizumab Compared With Atezolizumab in Participants With Extensive-Stage Small-Cell Lung Cancer Hoffmann-La Roche NA
ACTIVE NOT RECRUITING
(Sep 1, 2026)
PHASE3 A Study to Investigate the Safety and Efficacy of RO7204239 in Combination With Risdiplam (RO7034067) in Participants With Spinal Muscular Atrophy Hoffmann-La Roche NA
ACTIVE NOT RECRUITING
(Sep 1, 2026)
PHASE2, PHASE3 Povidone Iodine Efficacy Study University of Rochester NA
ACTIVE NOT RECRUITING
(Sep 1, 2026)
PHASE2 A Study to Evaluate Glofitamab Monotherapy and Glofitamab + Chemoimmunotherapy in Pediatric and Young Adult Participants With Relapsed/Refractory Mature B-Cell Non-Hodgkin Lymphoma Hoffmann-La Roche NA
RECRUITING
(Sep 1, 2026)
PHASE1, PHASE2 A Study Evaluating the Safety and Efficacy of Multiple Treatments in Participants With Multiple Myeloma Hoffmann-La Roche NA
RECRUITING
(Sep 1, 2026)
PHASE1, PHASE2 A Study Evaluating the Safety, Activity, and Pharmacokinetics of Divarasib as a Single Agent or in Combination With Other Anti-Cancer Therapies in Participants With Previously Untreated Advanced or Metastatic Non-Small Cell Lung Cancer With a KRAS G12C Mutation Hoffmann-La Roche NA
RECRUITING
(Sep 1, 2026)
PHASE1, PHASE2 A Study of Tobemstomig + Nab-Paclitaxel Compared With Pembrolizumab + Nab-Paclitaxel in Participants With Previously Untreated, PD-L1-Positive, Locally-Advanced Unresectable or Metastatic Triple-Negative Breast Cancer Hoffmann-La Roche NA
ACTIVE NOT RECRUITING
(Sep 1, 2026)
PHASE2 A Rollover Study for Participants Previously Enrolled in a Genentech and/or F. Hoffman-La Roche Sponsored Study Hoffmann-La Roche NA
RECRUITING
(Sep 1, 2026)
PHASE3 A Study to Evaluate the Efficacy and Safety of Inavolisib in Combination With Phesgo Versus Placebo in Combination With Phesgo in Participants With PIK3CA-Mutated HER2-Positive Locally Advanced or Metastatic Breast Cancer Hoffmann-La Roche NA
RECRUITING
(Sep 1, 2026)
PHASE3 An Open-Label Study Comparing Glofitamab and Polatuzumab Vedotin + Rituximab, Cyclophosphamide, Doxorubicin, and Prednisone Versus Pola-R-CHP in Previously Untreated Patients With Large B-Cell Lymphoma Hoffmann-La Roche NA
ACTIVE NOT RECRUITING
(Sep 1, 2026)
PHASE3 A Study to Evaluate Efficacy and Safety of Giredestrant Compared With Fulvestrant (Plus a CDK4/6 Inhibitor), in Participants With ER-Positive, HER2-Negative Advanced Breast Cancer Resistant to Adjuvant Endocrine Therapy (pionERA Breast Cancer) Hoffmann-La Roche NA
ACTIVE NOT RECRUITING
(Sep 1, 2026)
PHASE3 A Study to Evaluate Glofitamab as a Single Agent vs. Investigator's Choice in Participants With Relapsed/Refractory Mantle Cell Lymphoma Hoffmann-La Roche NA
RECRUITING
(Sep 1, 2026)
PHASE3 A Surveillance Study of Susceptibility to Baloxavir Marboxil in Pediatric Participants With Influenza and Transmission of Influenza to Household Contacts Hoffmann-La Roche NA
RECRUITING
(Sep 1, 2026)
PHASE3 The Effects of Disulfiram (Antabuse®) on Visual Acuity in Patients With Retinal Degeneration University of Rochester NA
RECRUITING
(Sep 1, 2026)
PHASE1 A Study Evaluating the Efficacy and Safety of Divarasib Versus Sotorasib or Adagrasib in Participants With Previously Treated KRAS G12C-positive Advanced or Metastatic Non-Small Cell Lung Cancer Hoffmann-La Roche NA
ACTIVE NOT RECRUITING
(Sep 1, 2026)
PHASE3 A Study Evaluating the Safety and Efficacy of Glofitamab + Gemcitabine + Oxaliplatin in U.S. Patients With Relapsed or Refractory Diffuse Large B-Cell Lymphoma Hoffmann-La Roche NA
RECRUITING
(Sep 1, 2026)
PHASE1 A Study Evaluating the Efficacy and Safety of Inavolisib Plus CDK4/6 Inhibitor and Letrozole vs Placebo + CDK4/6i and Letrozole in Participants With Endocrine-Sensitive PIK3CA-Mutated, Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer Hoffmann-La Roche NA
RECRUITING
(Sep 1, 2026)
PHASE3 A Study Evaluating the Efficacy and Safety of Divarasib and Pembrolizumab Versus Pembrolizumab and Pemetrexed and Carboplatin or Cisplatin in Participants With Previously Untreated, KRAS G12C-Mutated, Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer Hoffmann-La Roche NA
RECRUITING
(Sep 1, 2026)
PHASE3 Evaluate Optimization of CRS Profile for Glofit Monotherapy and Glofit+GemOx in R/R Aggressive B-NHL Hoffmann-La Roche NA
RECRUITING
(Sep 1, 2026)
PHASE2 A Study to Assess Efficacy, Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of RO7204239 in Combination With Tirzepatide in Participants With Obesity or Overweight With At Least One Weight-related Comorbidity Hoffmann-La Roche NA
ACTIVE NOT RECRUITING
(Sep 1, 2026)
PHASE2 A Study to Evaluate the Efficacy and Safety of Intravenous (IV) Prasinezumab in Participants With Early-Stage Parkinson's Disease Hoffmann-La Roche NA
RECRUITING
(Sep 1, 2026)
PHASE3 A Study to Test Inavolisib Treatment in Participants With Metastatic Castration-Resistant Prostate Cancer Hoffmann-La Roche NA
RECRUITING
(Sep 1, 2026)
PHASE2 A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight Without Type 2 Diabetes Hoffmann-La Roche NA
RECRUITING
(Sep 1, 2026)
PHASE3 A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight and Type 2 Diabetes Hoffmann-La Roche NA
RECRUITING
(Sep 1, 2026)
PHASE3 To Study the Effect of Inavolisib in Combination With Fulvestrant in Participants With Breast Cancer Hoffmann-La Roche NA
RECRUITING
(Sep 1, 2026)
PHASE2 A Phase II Study Evaluating the Efficacy and Safety of Inavolisib Plus Ribociclib Plus Fulvestrant Versus Placebo Plus Ribociclib Plus Fulvestrant in Participants With Advanced Breast Cancer Hoffmann-La Roche NA
RECRUITING
(Sep 1, 2026)
PHASE2 RO7771950 Versus Tucatinib in Combination With Trastuzumab and Capecitabine in People With Locally Advanced or Metastatic Breast Cancer That is Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Hoffmann-La Roche NA
RECRUITING
(Sep 1, 2026)
PHASE2, PHASE3 A Study to Evaluate the Efficacy and Safety of Divarasib Compared With Investigator's Choice of Immunotherapy or Observation in Participants With Resected Stage II-III KRAS G12C-Positive Non-Small Cell Lung Cancer (NSCLC) Hoffmann-La Roche NA
RECRUITING
(Sep 1, 2026)
PHASE3 Cevostamab in Combination With Pomalidomide and Dexamethasone Versus Standard of Care in Participants With Previously Treated Multiple Myeloma Hoffmann-La Roche NA
RECRUITING
(Sep 1, 2026)
PHASE3 An Early-Stage Study in Multiple Clinics of How Afimkibart May Affect the Body's Processing of Medicines That Rely on Cytochrome P450 Enzymes in Participants With Ulcerative Colitis Hoffmann-La Roche NA
RECRUITING
(Sep 1, 2026)
PHASE1 A Study to Evaluate the Effects of Enicepatide in Participants With Obesity or Overweight, With or Without Type 2 Diabetes Hoffmann-La Roche NA
RECRUITING
(Sep 1, 2026)
PHASE3 A Study Evaluating the Safety of Inavolisib and Fulvestrant With or Without Palbociclib in Participants With Advanced Breast Cancer (ABC) and Type 2 Diabetes Hoffmann-La Roche NA
NOT YET RECRUITING
(Sep 1, 2026)
PHASE2 Study to Test Effects and Safety of RO7568282 in Early Parkinson's Disease Hoffmann-La Roche NA
NOT YET RECRUITING
(Sep 1, 2026)
PHASE1, PHASE2 Cevostamab in Combination With Pomalidomide and Dexamethasone After BCMA- Targeting CAR T-Cell Therapy in Participants With Previously Treated Multiple Myeloma Hoffmann-La Roche NA
RECRUITING
(Sep 1, 2026)
PHASE2 A Study to Learn How Well Participants With a Specific Type of Early Breast Cancer (ER-Positive, HER2-Negative) Tolerate and Stay on Treatment With Giredestrant and How They Feel During Treatment Hoffmann-La Roche NA
NOT YET RECRUITING
(Sep 1, 2026)
PHASE3 A Study to Confirm Efficacy of a Single Dose of Baloxavir Marboxil in the Post-exposure Prophylaxis (PEP) of Influenza Virus Infection in Chinese Participants Hoffmann-La Roche NA
NOT YET RECRUITING
(Sep 1, 2026)
PHASE3 Basket Study of Entrectinib (RXDX-101) for the Treatment of Patients With Solid Tumors Harboring NTRK 1/2/3 (Trk A/B/C), ROS1, or ALK Gene Rearrangements (Fusions) Hoffmann-La Roche NA
ACTIVE NOT RECRUITING
(Aug 1, 2026)
PHASE2 A Study of Atezolizumab Plus Tiragolumab in Combination With Paclitaxel and Cisplatin Compared With Paclitaxel and Cisplatin as First-Line Treatment in Participants With Unresectable Locally Advanced, Unresectable Recurrent, or Metastatic Esophageal Carcinoma Hoffmann-La Roche NA
COMPLETED
(Aug 1, 2026)
PHASE3 A Study Evaluating the Efficacy and Safety of Giredestrant Combined With Palbociclib Compared With Letrozole Combined With Palbociclib in Participants With Estrogen Receptor-Positive, HER2-Negative Locally Advanced or Metastatic Breast Cancer (persevERA Breast Cancer) Hoffmann-La Roche NA
ACTIVE NOT RECRUITING
(Aug 1, 2026)
PHASE3 A Study to Compare the Efficacy and Safety of Entrectinib and Crizotinib in Participants With Advanced or Metastatic ROS1 Non-small Cell Lung Cancer (NSCLC) With and Without Central Nervous System (CNS) Metastases Hoffmann-La Roche NA
ACTIVE NOT RECRUITING
(Aug 1, 2026)
PHASE3 A Study of Atezolizumab and Trastuzumab in Combination With Capecitabine and Oxaliplatin in Patients With HER2 Positive Locally Advanced Resectable Gastric Cancer of Adenocarcinoma of Gastroesophageal Junction Hoffmann-La Roche NA
COMPLETED
(Aug 1, 2026)
PHASE2 A Study Evaluating the Efficacy and Safety of Multiple Therapies in Cohorts of Participants With Locally Advanced, Unresectable, Stage III Non-Small Cell Lung Cancer (NSCLC) Hoffmann-La Roche NA
ACTIVE NOT RECRUITING
(Aug 1, 2026)
PHASE3 A Study Evaluating Efficacy and Safety of Mosunetuzumab in Combination With Polatuzumab Vedotin Compared to Rituximab in Combination With Gemcitabine Plus Oxaliplatin in Participants With Relapsed or Refractory Aggressive B-Cell Non-Hodgkin's Lymphoma Hoffmann-La Roche NA
ACTIVE NOT RECRUITING
(Aug 1, 2026)
PHASE3 A Study Evaluating the Efficacy and Safety of Inavolisib Plus Fulvestrant Compared With Alpelisib Plus Fulvestrant in Participants With HR-Positive, HER2-Negative, PIK3CA Mutated, Locally Advanced or Metastatic Breast Cancer Post CDK4/6i and Endocrine Combination Therapy Hoffmann-La Roche NA
RECRUITING
(Aug 1, 2026)
PHASE3 A Study of Immune Checkpoint Inhibitor Combinations With Axitinib in Participants With Untreated Locally Advanced Unresectable or Metastatic Renal Cell Carcinoma Hoffmann-La Roche NA
ACTIVE NOT RECRUITING
(Aug 1, 2026)
PHASE2 A Study Evaluating Single-agent Inavolisib, Inavolisib Plus Atezolizumab in PIK3CA-Mutated Cancers Hoffmann-La Roche NA
ACTIVE NOT RECRUITING
(Aug 1, 2026)
PHASE1 A Study to See How Well and How Safely Different Treatments Work in a Group of Participants With Non-Small Cell Lung Cancer (NSCLC) Hoffmann-La Roche NA
COMPLETED
(Aug 1, 2026)
PHASE3 A Study to Test Inavolisib Treatments in Participants With Early-Stage, PIK3CA-Mutated Breast Cancer Hoffmann-La Roche NA
RECRUITING
(Aug 1, 2026)
PHASE2 A Phase 2 Study of Methylene Blue Photodynamic Therapy for Treatment of Breast Abscesses University of Rochester NA
NOT YET RECRUITING
(Aug 1, 2026)
PHASE2 Study to Assess Safety and Efficacy of Atezolizumab (MPDL3280A) Compared to Best Supportive Care Following Chemotherapy in Patients With Lung Cancer [IMpower010] Hoffmann-La Roche NA
ACTIVE NOT RECRUITING
(Jul 1, 2026)
PHASE3 A Study of Multiple Immunotherapy-Based Treatment Combinations in Patients With Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction Cancer (G/GEJ) or Esophageal Cancer (Morpheus-Gastric and Esophageal Cancer) Hoffmann-La Roche NA
TERMINATED
(Jul 1, 2026)
PHASE1, PHASE2 A Study Comparing Adjuvant Alectinib Versus Adjuvant Platinum-Based Chemotherapy in Patients With ALK Positive Non-Small Cell Lung Cancer Hoffmann-La Roche NA
ACTIVE NOT RECRUITING
(Jul 1, 2026)
PHASE3 A Study in Patients Previously Enrolled in a Genentech and/or F. Hoffmann-La Roche Ltd Sponsored Atezolizumab Study Hoffmann-La Roche NA
ACTIVE NOT RECRUITING
(Jul 1, 2026)
PHASE3 A Study of Risdiplam in Infants With Genetically Diagnosed and Presymptomatic Spinal Muscular Atrophy Hoffmann-La Roche NA
ACTIVE NOT RECRUITING
(Jul 1, 2026)
PHASE2 Study Evaluating the Efficacy and Safety of Multiple Immunotherapy-Based Treatments and Combinations in Patients With Urothelial Carcinoma (MORPHEUS-UC) Hoffmann-La Roche NA
TERMINATED
(Jul 1, 2026)
PHASE1, PHASE2 A Study to Evaluate the Efficacy and Safety of Obinutuzumab in Participants With ISN/RPS 2003 Class III or IV Lupus Nephritis Hoffmann-La Roche NA
ACTIVE NOT RECRUITING
(Jul 1, 2026)
PHASE3 A Phase III Study Evaluating Glofitamab in Combination With Gemcitabine + Oxaliplatin vs Rituximab in Combination With Gemcitabine + Oxaliplatin in Participants With Relapsed/Refractory Diffuse Large B-Cell Lymphoma Hoffmann-La Roche NA
ACTIVE NOT RECRUITING
(Jul 1, 2026)
PHASE3 A Study to Evaluate the Efficacy, Safety and Pharmacokinetics (PK) of a Higher Dose of Ocrelizumab in Adults With Relapsing Multiple Sclerosis (RMS) Hoffmann-La Roche NA
ACTIVE NOT RECRUITING
(Jul 1, 2026)
PHASE3 A Study Evaluating the Efficacy and Safety of Obinutuzumab in Participants With Primary Membranous Nephropathy Hoffmann-La Roche NA
ACTIVE NOT RECRUITING
(Jul 1, 2026)
PHASE3 A Study Evaluating the Efficacy and Safety of Mosunetuzumab in Combination With Lenalidomide in Comparison to Rituximab in Combination With Lenalidomide With a US Extension of Mosunetuzumab in Combination With Lenalidomide in Participants With Follicular Lymphoma Hoffmann-La Roche NA
ACTIVE NOT RECRUITING
(Jul 1, 2026)
PHASE3 A Study to Evaluate the Safety and Efficacy of Glofitamab in Combination With Rituximab (R) Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (CHOP) in Circulating Tumor (ct)DNA High-Risk Patients With Untreated Diffuse Large B-Cell Lymphoma Hoffmann-La Roche NA
ACTIVE NOT RECRUITING
(Jul 1, 2026)
PHASE2 A Study of Atezolizumab With or Without Tiragolumab Following Neoadjuvant Chemoradiotherapy in Participants With Locally Advanced Rectal Cancer Hoffmann-La Roche NA
ACTIVE NOT RECRUITING
(Jul 1, 2026)
PHASE2 An Extension Study in Participants Previously Enrolled in a Genentech and/or F. Hoffmann-La Roche Ltd Sponsored Atezolizumab Study (IMbrella C) Hoffmann-La Roche NA
ACTIVE NOT RECRUITING
(Jul 1, 2026)
PHASE3 A Study to Evaluate the Efficacy and Safety of Giredestrant in Combination With Phesgo (Pertuzumab, Trastuzumab, and Hyaluronidase-zzxf) Versus Phesgo in Participants With Locally Advanced or Metastatic Breast Cancer (heredERA Breast Cancer) Hoffmann-La Roche NA
ACTIVE NOT RECRUITING
(Jul 1, 2026)
PHASE3 A Study to Compare Different Doses of RO7795081 With a Placebo or Semaglutide in People With Type 2 Diabetes Hoffmann-La Roche NA
ACTIVE NOT RECRUITING
(Jul 1, 2026)
PHASE2 Caffeine Optimization for Oxygen Saturation Index in ELBW Infants University of Rochester NA
RECRUITING
(Jul 1, 2026)
PHASE2 A Study to Evaluate and Compare the Efficacy and Safety of Alectinib Versus Crizotinib and to Evaluate the Pharmacokinetics of Alectinib in Asian Participants With Treatment-Naive Anaplastic Lymphoma Kinase (ALK)-Positive Advanced Non-Small Cell Lung Cancer (NSCLC) Hoffmann-La Roche NA
COMPLETED
(Jun 1, 2026)
PHASE3 A Rollover Study of Alectinib in Patients With Anaplastic Lymphoma Kinase (ALK)-Positive or Rearranged During Transfection (RET)-Positive Cancer Hoffmann-La Roche NA
COMPLETED
(Jun 1, 2026)
PHASE3 Neoadjuvant FOLFOX Therapy With Short Course Radiation and Active Surveillance in Locally Advanced Rectal Cancer University of Rochester NA
ACTIVE NOT RECRUITING
(Jun 1, 2026)
PHASE2 Study of Pembrolizumab and Single Agent Chemotherapy as First Line Treatment for Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer With Eastern Cooperative Oncology Group (ECOG) Performance Status of 2 University of Rochester NA
RECRUITING
(Jun 1, 2026)
PHASE1 A Study to Evaluate the Efficacy, Safety and Pharmacokinetics (PK) of a Higher Dose of Ocrelizumab in Adults With Primary Progressive Multiple Sclerosis (PPMS) Hoffmann-La Roche NA
ACTIVE NOT RECRUITING
(Jun 1, 2026)
PHASE3 A Study Evaluating the Efficacy and Safety of Adjuvant Giredestrant Compared With Physician's Choice of Adjuvant Endocrine Monotherapy in Participants With Estrogen Receptor-Positive, HER2-Negative Early Breast Cancer (lidERA Breast Cancer) Hoffmann-La Roche NA
ACTIVE NOT RECRUITING
(Jun 1, 2026)
PHASE3 A Study of Tobemstomig Plus Platinum-Based Chemotherapy vs Pembrolizumab Plus Platinum-Based Chemotherapy in Participants With Previously Untreated Non-Small Cell Lung Cancer Hoffmann-La Roche NA
COMPLETED
(Jun 1, 2026)
PHASE2 A Study to Investigate the Pharmacokinetics and Safety of Risdiplam in Infants With Spinal Muscular Atrophy Hoffmann-La Roche NA
COMPLETED
(Jun 1, 2026)
PHASE2 A Study Comparing Alectinib With Crizotinib in Treatment-Naive Anaplastic Lymphoma Kinase-Positive Advanced Non-Small Cell Lung Cancer Participants Hoffmann-La Roche NA
COMPLETED
(May 1, 2026)
PHASE3 A Study Comparing the Efficacy and Safety of Polatuzumab Vedotin With Rituximab-Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Rituximab-Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Participants With Diffuse Large B-Cell Lymphoma Hoffmann-La Roche NA
COMPLETED
(May 1, 2026)
PHASE3 A Study of Tiragolumab in Combination With Atezolizumab Plus Pemetrexed and Carboplatin/Cisplatin Versus Pembrolizumab Plus Pemetrexed and Carboplatin/Cisplatin in Participants With Previously Untreated Advanced Non-Squamous Non-Small Cell Lung Cancer Hoffmann-La Roche NA
COMPLETED
(May 1, 2026)
PHASE2, PHASE3 A Study to Evaluate the Efficacy and Safety of Obinutuzumab in Participants With Systemic Lupus Erythematosus Hoffmann-La Roche NA
ACTIVE NOT RECRUITING
(May 1, 2026)
PHASE3 The Role of Brain Dopamine in Chronic Pain University of Rochester NA
RECRUITING
(May 1, 2026)
PHASE2 Safety and Feasibility Study of Methylene Blue Photodynamic Therapy to Sterilize Deep Tissue Abscess Cavities University of Rochester NA
COMPLETED
(Apr 1, 2026)
PHASE1 A Study Of Multiple Immunotherapy-Based Treatment Combinations In Participants With Metastatic Non-Small Cell Lung Cancer (Morpheus- Non-Small Cell Lung Cancer) Hoffmann-La Roche NA
TERMINATED
(Apr 1, 2026)
PHASE1, PHASE2 Reducing Frailty for Older Cancer Survivors Using Supplements University of Rochester NA
COMPLETED
(Apr 1, 2026)
PHASE2 An Umbrella Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Patients With Gastric or Gastroesophageal Junction Carcinoma Hoffmann-La Roche NA
TERMINATED
(Apr 1, 2026)
PHASE1, PHASE2 Study to Assess the Safety, Pharmacokinetics, and Efficacy of Baloxavir Marboxil in Chinese Pediatric Participants 1 to <12 Years of Age With Influenza Symptoms Hoffmann-La Roche NA
COMPLETED
(Apr 1, 2026)
PHASE3 Ketamine-Assisted Psychotherapy for Treatment-Resistant Depression University of Rochester NA
NOT YET RECRUITING
(Apr 1, 2026)
PHASE2 A Study Evaluating the Safety and Efficacy of Neoadjuvant and Adjuvant Tiragolumab Plus Atezolizumab, With or Without Platinum-Based Chemotherapy, in Participants With Previously Untreated Locally Advanced Resectable Stage II, IIIA, or Select IIIB Non-Small Cell Lung Cancer Hoffmann-La Roche NA
TERMINATED
(Mar 1, 2026)
PHASE2 
