Madrigal Drug Patent Portfolio

Madrigal owns 1 orange book drug protected by 6 US patents Given below is the list of Madrigal's drug patents along with their expiration dates.

Drug Patent Number Drug Patent Title Drug Patent Expiry Status
US12377104 04 Feb, 2045
Active
US10376517 Methods of synthesizing thyroid hormone analogs and polymorphs thereof 17 Sep, 2033
Active
US11564926 Methods of synthesizing thyroid hormone analogs and polymorphs thereof 17 Sep, 2033
Active
US11986481 Method of synthesizing thyroid hormone analogs and polymorphs thereof 17 Sep, 2033
Active
US9266861 Method of synthesizing thyroid hormone analogs and polymorphs thereof 17 Sep, 2033
Active
US7452882 Thyroid hormone analogs 12 Sep, 2026
Active


Given below is the list of recent legal activities going on the following drug patents of Madrigal.

Activity Date Patent Number
Patent litigations
Second letter to regulating agency to determine regulatory review period 19 Aug, 2025 US7452882
Second letter to regulating agency to determine regulatory review period 19 Aug, 2025 US9266861
Information Disclosure Statement (IDS) Filed 12 Aug, 2025 US7452882
Recordation of Patent Grant Mailed 12 Aug, 2025 US12377104
Letter from FDA or Dept of Agriculture re PTE application 12 Aug, 2025 US9266861
Letter from FDA or Dept of Agriculture re PTE application 12 Aug, 2025 US7452882
Email Notification 07 Aug, 2025 US12377104
PG-Pub Issue Notification 07 Aug, 2025 US12377104
Email Notification 05 Aug, 2025 US12377104
Patent eGrant Notification 05 Aug, 2025 US12377104
Patent Issue Date Used in PTA Calculation 05 Aug, 2025 US12377104
Mail Patent eGrant Notification 05 Aug, 2025 US12377104
Recordation of Patent eGrant 05 Aug, 2025 US12377104
Email Notification 24 Jul, 2025 US12377104
Issue Notification Mailed 23 Jul, 2025 US12377104


Madrigal's Family Patents


Family Patents



Madrigal Drug List

Given below is the complete list of Madrigal's drugs and the patents protecting them.


1. Rezdiffra

Rezdiffra is protected by 6 patents, out of which none have expired yet. Check out its patent list below.

Drug Patent Number Drug Patent Title Drug Patent Expiry Status
US12377104 04 Feb, 2045
(18 years from now)
Active
US10376517 Methods of synthesizing thyroid hormone analogs and polymorphs thereof 17 Sep, 2033
(7 years from now)
Active
US11564926 Methods of synthesizing thyroid hormone analogs and polymorphs thereof 17 Sep, 2033
(7 years from now)
Active
US11986481 Method of synthesizing thyroid hormone analogs and polymorphs thereof 17 Sep, 2033
(7 years from now)
Active
US9266861 Method of synthesizing thyroid hormone analogs and polymorphs thereof 17 Sep, 2033
(7 years from now)
Active
US7452882 Thyroid hormone analogs 12 Sep, 2026
(5 months from now)
Active

Discover which of these patents contain the active ingredient(API) of the drug, their family patents, along with litigation and legal activity details of these patents on Rezdiffra's drug page


Explore Our Curated Drug Screens

Drugs Generating Over $1 Billion in Annual Revenue
Explore the top-performing drugs that dominate the pharmaceutical industry
View List
NCE-1 Patent Expiry in the Next 1 Year
Identify opportunities as new chemical entity (NCE-1) patents approach expiry
View List
Recently Granted Patents in EP
Find the opportunity to file Oppositions
View List

Madrigal News

Biopharmaceutical Investments Yield Superior Returns as Valuations Rebound

11 Dec, 2025

Galmed Reveals Approval of New Use Patents for the Aramchol Combination with ...

04 Dec, 2025

Madrigal Receives Conditional Approval for MASH Medication Rezdiffra in Europe - TradingView

20 Aug, 2025

Madrigal's Rezdiffra: A Patent-Guarded Success with Growth in Europe and Future Developments...

05 Aug, 2025

See More