Pharsight

1. Auvelity patents expiration

Application	Filing Date	Opposition Party	Legal Status

EP15861189A	2021-05-31	Elkington and Fife LLP	Granted and Under Opposition

Drug Patent Number	Company	Drug Patent Title	Drug Patent Expiry
These drug patents focus on the other aspects of the active substance like dosage, mode of administration (oral, tablet, capsules, liquids etc).
US8569328	AXSOME	Compositions and methods comprising tilidine or related compounds and dextromethorphan	Oct, 2033 (10 years from now)
US11617747	AXSOME	Bupropion as a modulator of drug activity	Nov, 2034 (11 years from now)
US9314462	AXSOME	Compositions and methods for increasing dextromethorphan plasma levels and related pharmacodynamic effects	Nov, 2034 (11 years from now)
US10786496	AXSOME	Compositions and methods for increasing the metabolic lifetime of dextromethorphan and related pharmacodynamic effects	Nov, 2034 (11 years from now)
US11020389	AXSOME	Bupropion as a modulator of drug activity	Nov, 2034 (11 years from now)
US11185515	AXSOME	Bupropion as a modulator of drug activity	Nov, 2034 (11 years from now)
US10945973	AXSOME	Bupropion as a modulator of drug activity	Nov, 2034 (11 years from now)
US11285146	AXSOME	Bupropion as a modulator of drug activity	Nov, 2034 (11 years from now)
US11285118	AXSOME	Bupropion as a modulator of drug activity	Nov, 2034 (11 years from now)
US10874664	AXSOME	Bupropion as a modulator of drug activity	Nov, 2034 (11 years from now)
US11382874	AXSOME	Bupropion as a modulator of drug activity	Nov, 2034 (11 years from now)
US11364233	AXSOME	Bupropion as a modulator of drug activity	Nov, 2034 (11 years from now)
US9457025	AXSOME	Compositions and methods comprising bupropion or related compounds for sustained delivery of dextromethorphan	Nov, 2034 (11 years from now)
US10058518	AXSOME	Bupropion as a modulator of drug activity	Nov, 2034 (11 years from now)
US9278095	AXSOME	Bupropion as a modulator of drug activity	Nov, 2034 (11 years from now)
US9867819	AXSOME	Compositions and methods for increasing the metabolic lifetime of dextromethorphan and related pharmacodynamic effects	Nov, 2034 (11 years from now)
US9168234	AXSOME	Bupropion as a modulator of drug activity	Nov, 2034 (11 years from now)
US9861595	AXSOME	Compositions and methods for increasing the metabolic lifetime of dextromethorphan and related pharmacodynamic effects	Nov, 2034 (11 years from now)
US11197839	AXSOME	Bupropion as a modulator of drug activity	Nov, 2034 (11 years from now)
US11524007	AXSOME	Bupropion as a modulator of drug activity	Nov, 2034 (11 years from now)
US11517542	AXSOME	Bupropion as a modulator of drug activity	Nov, 2034 (11 years from now)
US11517543	AXSOME	Bupropion as a modulator of drug activity	Nov, 2034 (11 years from now)
US11541048	AXSOME	Bupropion as a modulator of drug activity	Nov, 2034 (11 years from now)
US11541021	AXSOME	Bupropion as a modulator of drug activity	Nov, 2034 (11 years from now)
US11534414	AXSOME	Bupropion as a modulator of drug activity	Nov, 2034 (11 years from now)
US11596627	AXSOME	Bupropion as a modulator of drug activity	Nov, 2034 (11 years from now)
US9700553	AXSOME	Compositions and methods for increasing the metabolic lifetime of dextromethorphan and related pharmacodynamic effects	Nov, 2034 (11 years from now)
US11357744	AXSOME	Bupropion as a modulator of drug activity	Nov, 2034 (11 years from now)
US11344544	AXSOME	Bupropion as a modulator of drug activity	Nov, 2034 (11 years from now)
US9486450	AXSOME	Hydroxybupropion and related compounds as modulators of drug plasma levels	Nov, 2034 (11 years from now)
US10596167	AXSOME	Compositions and methods comprising bupropion or related compounds for sustained delivery of dextromethorphan	Nov, 2034 (11 years from now)
US11439636	AXSOME	Bupropion as a modulator of drug activity	Nov, 2034 (11 years from now)
US9474731	AXSOME	Compositions and methods for increasing the metabolic lifetime of dextromethorphan and related pharmacodynamic effects	Nov, 2034 (11 years from now)
US9375429	AXSOME	Compositions and methods comprising erythrohydroxybupropion and related compounds for improving the efficacy of dextromethorphan	Nov, 2034 (11 years from now)
US9421176	AXSOME	Compositions and methods for increasing the metabolic lifetime of dextromethorphan and related pharmacodynamic effects	Nov, 2034 (11 years from now)
US9408815	AXSOME	Bupropion as a modulator of drug activity	Nov, 2034 (11 years from now)
US9763932	AXSOME	Compositions and methods for increasing the metabolic lifetime of dextromethorphan and related pharmacodynamic effects	Nov, 2034 (11 years from now)
US11311534	AXSOME	Bupropion as a modulator of drug activity	Nov, 2034 (11 years from now)
US9205083	AXSOME	Compositions and methods comprising erythrohydroxybupropion and related compounds for improving the efficacy of dextromethorphan	Nov, 2034 (11 years from now)
US9707191	AXSOME	Compositions and methods for increasing the metabolic lifetime of dextromethorphan and related pharmacodynamic effects	Nov, 2034 (11 years from now)
US10898453	AXSOME	Bupropion as a modulator of drug activity	Nov, 2034 (11 years from now)
US11433067	AXSOME	Bupropion as a modulator of drug activity	Nov, 2034 (11 years from now)
US9700528	AXSOME	Compositions and methods for increasing the metabolic lifetime of dextromethorphan and related pharmacodynamic effects	Nov, 2034 (11 years from now)
US9370513	AXSOME	Compositions and methods for increasing the metabolic lifetime of dextromethorphan and related pharmacodynamic effects	Nov, 2034 (11 years from now)
US9457023	AXSOME	Compositions and methods for increasing the metabolic lifetime of dextromethorphan and related pharmacodynamic effects	Nov, 2034 (11 years from now)
US9238032	AXSOME	Compositions and methods comprising bupropion or related compounds for sustained delivery of dextromethorphan	Nov, 2034 (11 years from now)
US11096937	AXSOME	Bupropion as a modulator of drug activity	Nov, 2034 (11 years from now)
US11298352	AXSOME	Bupropion as a modulator of drug activity	Nov, 2034 (11 years from now)
US10966941	AXSOME	Bupropion as a modulator of drug activity	Nov, 2034 (11 years from now)
US11298351	AXSOME	Bupropion as a modulator of drug activity	Nov, 2034 (11 years from now)
US11090300	AXSOME	Bupropion as a modulator of drug activity	Nov, 2034 (11 years from now)
US10894047	AXSOME	Bupropion as a modulator of drug activity	Nov, 2034 (11 years from now)
US10064857	AXSOME	Bupropion as a modulator of drug activity	Nov, 2034 (11 years from now)
US11291665	AXSOME	Bupropion as a modulator of drug activity	Nov, 2034 (11 years from now)
US11291638	AXSOME	Bupropion as a modulator of drug activity	Nov, 2034 (11 years from now)
US10786469	AXSOME	Compositions and methods for increasing the metabolic lifetime of dextromethorphan and related pharmacodynamic effects	Nov, 2034 (11 years from now)
US11253492	AXSOME	Bupropion as a modulator of drug activity	Nov, 2034 (11 years from now)
US10881657	AXSOME	Bupropion as a modulator of drug activity	Nov, 2034 (11 years from now)
US10874663	AXSOME	Bupropion as a modulator of drug activity	Nov, 2034 (11 years from now)
US10463634	AXSOME	Compositions and methods for increasing the metabolic lifetime of dextromethorphan and related pharmacodynamic effects	Nov, 2034 (11 years from now)
US10799497	AXSOME	Combination of dextromethorphan and bupropion for treating depression	Nov, 2034 (11 years from now)
US11058648	AXSOME	Bupropion as a modulator of drug activity	Nov, 2034 (11 years from now)
US11273133	AXSOME	Bupropion as a modulator of drug activity	Nov, 2034 (11 years from now)
US10864209	AXSOME	Bupropion as a modulator of drug activity	Nov, 2034 (11 years from now)
US10806710	AXSOME	Bupropion as a modulator of drug activity	Nov, 2034 (11 years from now)
US10881624	AXSOME	Compositions and methods for increasing the metabolic lifetime of dextromethorphan and related pharmacodynamic effects	Nov, 2034 (11 years from now)
US9198905	AXSOME	Compositions and methods for reducing dextrorphan plasma levels and related pharmacodynamic effects	Nov, 2034 (11 years from now)
US11426401	AXSOME	Bupropion as a modulator of drug activity	Nov, 2034 (11 years from now)
US11426370	AXSOME	Bupropion as a modulator of drug activity	Nov, 2034 (11 years from now)
US11419867	AXSOME	Bupropion as a modulator of drug activity	Nov, 2034 (11 years from now)
US10772850	AXSOME	Bupropion as a modulator of drug activity	Nov, 2034 (11 years from now)
US11273134	AXSOME	Bupropion as a modulator of drug activity	Nov, 2034 (11 years from now)
US11253491	AXSOME	Bupropion as a modulator of drug activity	Nov, 2034 (11 years from now)
US11234946	AXSOME	Bupropion as a modulator of drug activity	Nov, 2034 (11 years from now)
US10548857	AXSOME	Compositions and methods for increasing the metabolic lifetime of dextromethorphan and related pharmacodynamic effects	Nov, 2034 (11 years from now)
US11229640	AXSOME	Combination of dextromethorphan and bupropion for treating depression	Nov, 2034 (11 years from now)
US10874665	AXSOME	Bupropion as a modulator of drug activity	Nov, 2034 (11 years from now)
US10933034	AXSOME	Bupropion as a modulator of drug activity	Nov, 2034 (11 years from now)
US10251879	AXSOME	Bupropion as a modulator of drug activity	Nov, 2034 (11 years from now)
US10092561	AXSOME	Compositions and methods comprising bupropion or related compounds for sustained delivery of dextromethorphan	Nov, 2034 (11 years from now)
US10894046	AXSOME	Bupropion as a modulator of drug activity	Nov, 2034 (11 years from now)
US11191739	AXSOME	Bupropion as a modulator of drug activity	Nov, 2034 (11 years from now)
US10080727	AXSOME	Compositions and methods for increasing the metabolic lifetime of dextromethorphan and related pharmacodynamic effects	Nov, 2034 (11 years from now)
US11617728	AXSOME	Bupropion as a modulator of drug activity	Nov, 2034 (11 years from now)
US11147808	AXSOME	Method of decreasing the fluctuation index of dextromethorphan	Nov, 2034 (11 years from now)
US11207281	AXSOME	Bupropion as a modulator of drug activity	Nov, 2034 (11 years from now)
US11141416	AXSOME	Bupropion as a modulator of drug activity	Nov, 2034 (11 years from now)
US11141388	AXSOME	Bupropion as a modulator of drug activity	Nov, 2034 (11 years from now)
US11213521	AXSOME	Bupropion as a modulator of drug activity	Nov, 2034 (11 years from now)
US11129826	AXSOME	Bupropion as a modulator of drug activity	Nov, 2034 (11 years from now)
US11123343	AXSOME	Bupropion as a modulator of drug activity	Nov, 2034 (11 years from now)
US10966974	AXSOME	Bupropion as a modulator of drug activity	Nov, 2034 (11 years from now)
US10512643	AXSOME	Compositions and methods for increasing the metabolic lifetime of dextromethorphan and related pharmacodynamic effects	Nov, 2034 (11 years from now)
US10105361	AXSOME	Compositions and methods for increasing the metabolic lifetime of dextromethorphan and related pharmacodynamic effects	Nov, 2034 (11 years from now)
US10105327	AXSOME	Compositions and methods for increasing the metabolic lifetime of dextromethorphane and related pharmacodynamic effects	Nov, 2034 (11 years from now)
US10092560	AXSOME	Compositions and methods for increasing the metabolic lifetime of dextromethorphan and related pharmacodynamic effects	Nov, 2034 (11 years from now)
US9968568	AXSOME	Compositions and methods for increasing the metabolic lifetime of dextromethorphan and related pharmacodynamic effects	Nov, 2034 (11 years from now)
US11510918	AXSOME	NA	Nov, 2034 (11 years from now)
US11478468	AXSOME	Bupropion as a modulator of drug activity	Nov, 2034 (11 years from now)
US11497721	AXSOME	NA	Nov, 2034 (11 years from now)
US11524008	AXSOME	Bupropion as a modulator of drug activity	Nov, 2034 (11 years from now)
US10780066	AXSOME	Compositions and methods for increasing the metabolic lifetime of dextromethorphan and related pharmacodynamic effects	Nov, 2034 (11 years from now)
US10925842	AXSOME	Bupropion as a modulator of drug activity	Jan, 2040 (16 years from now)
US10940124	AXSOME	Bupropion as a modulator of drug activity	Jan, 2040 (16 years from now)
US10966942	AXSOME	Bupropion as a modulator of drug activity	Jan, 2040 (16 years from now)
US10780064	AXSOME	Bupropion as a modulator of drug activity	Jan, 2040 (16 years from now)
US11717518	AXSOME	Bupropion dosage forms with reduced food and alcohol dosing effects	Jan, 2043 (19 years from now)
US11730706	AXSOME	Treatment of depression in certain patient populations	Jan, 2043 (19 years from now)

Drug Exclusivity	Drug Exclusivity Expiration
New Product (NP)	Aug 18, 2025

Drugs and Companies using BUPROPION HYDROCHLORIDE; DEXTROMETHORPHAN HYDROBROMIDE ingredient

Market Authorisation Date: 18 August, 2022

Treatment: Dextromethorphan and bupropion in combination to treat major depressive disorder; Dextromethorphan and bupropion in combination to increase dextromethorphan plasma levels; Dextromethorphan and bupropr...

Dosage: TABLET, EXTENDED RELEASE;ORAL