Drugs Opening to Patent Challenges in 2026

As we look ahead to 2026, significant shifts in the pharmaceutical landscape are coming. This year is crucial for several high-profile drugs as they approach their NCE-1 dates, opening the door to potential patent challenges. These challenges could pave the way for generic competition, lowering costs and increasing accessibility for patients. On this page, we highlight the drugs whose NCE-1 date lies in 2026, making them eligible for generic manufacturers to begin the process of seeking approval for alternatives. Explore the key players set to face competition and what it could mean for the market.

1. AMVUTTRA

Amvuttra is a brand drug owned by Alnylam Pharmaceuticals Inc. It is Used for treating the polyneuropathy of hereditary transthyretin-mediated amyloidosis in adults. It was approved for market use on Jun 13, 2022. Amvuttra uses Vutrisiran Sodium as an active ingredient.

Total Patents: 13
Expired Patents: 0

Amvuttra's NCE-1 date is Jun 13, 2026 which is when its patents will be open to challenges.

Check the entire list of patents and their expiration dates for Amvuttra

2. BAXDELA

Baxdela is a brand drug owned by Melinta Subsidiary Corp. It is used for treating acute bacterial skin infections in adults. It was approved for market use on Jun 19, 2017. Baxdela uses Delafloxacin Meglumine as an active ingredient.

Total Patents: 16
Expired Patents: 3

Baxdela's NCE-1 date is Jun 19, 2026 which is when its patents will be open to challenges.

Check the entire list of patents and their expiration dates for Baxdela

3. BLUDIGO

Bludigo is a brand drug owned by Provepharm Sas. It was approved for market use on Jul 8, 2022. Bludigo uses Indigotindisulfonate Sodium as an active ingredient.

Total Patents: 3
Expired Patents: 0

Bludigo's NCE-1 date is Jul 08, 2026 which is when its patents will be open to challenges.

Check the entire list of patents and their expiration dates for Bludigo

4. BOSULIF

Bosulif is a brand drug owned by Pf Prism Cv. It is used for treating BCR-ABL positive leukemia resistant to imatinib, including patients with specific BCR-ABL mutations and various phases of CML. It was approved for market use on Sep 4, 2012. Bosulif uses Bosutinib Monohydrate as an active ingredient.

Total Patents: 11
Expired Patents: 5

Bosulif's NCE-1 date is Mar 26, 2026 which is when its patents will be open to challenges.

Check the entire list of patents and their expiration dates for Bosulif

5. CAMZYOS

Camzyos is a brand drug owned by Bristol Myers Squibb Co. It is Used for improving functional capacity and symptoms in adults with symptomatic obstructive hypertrophic cardiomyopathy (HCM) in NYHA class II-III. It was approved for market use on Apr 28, 2022. Camzyos uses Mavacamten as an active ingredient.

Total Patents: 3
Expired Patents: 0

Camzyos's NCE-1 date is Apr 28, 2026 which is when its patents will be open to challenges.

Check the entire list of patents and their expiration dates for Camzyos

6. CIBINQO

Cibinqo is a brand drug owned by Pfizer Inc. It is Used for treating adults with refractory, moderate-to-severe atopic dermatitis not adequately controlled with other systemic drug products. It was approved for market use on Jan 14, 2022. Cibinqo uses Abrocitinib as an active ingredient.

Total Patents: 3
Expired Patents: 0

Cibinqo's NCE-1 date is Jan 14, 2026 which is when its patents will be open to challenges.

Check the entire list of patents and their expiration dates for Cibinqo

7. EDURANT

Edurant is a brand drug owned by Janssen Products Lp. It is Used for treating HIV-1 infection in treatment-naive adult patients with low viral load. It was approved for market use on May 20, 2011. Edurant uses Rilpivirine Hydrochloride as an active ingredient.

Total Patents: 7
Expired Patents: 7

Edurant's NCE-1 date is Sep 15, 2026 which is when its patents will be open to challenges.

Check the entire list of patents and their expiration dates for Edurant

8. ELUCIREM

Elucirem is a brand drug owned by Guerbet. It was approved for market use on Sep 21, 2022. Elucirem uses Gadopiclenol as an active ingredient.

Total Patents: 3
Expired Patents: 0

Elucirem's NCE-1 date is Sep 21, 2026 which is when its patents will be open to challenges.

Check the entire list of patents and their expiration dates for Elucirem

9. EPCLUSA

Epclusa is a brand drug owned by Gilead Sciences Inc. It is Used for treating hepatitis C. It was approved for market use on Mar 19, 2020. Epclusa uses Sofosbuvir; Velpatasvir as an active ingredient.

Total Patents: 30
Expired Patents: 0

Epclusa's NCE-1 date is Sep 19, 2026 which is when its patents will be open to challenges.

Check the entire list of patents and their expiration dates for Epclusa

10. FARXIGA

Farxiga is a brand drug owned by Astrazeneca Ab. It is used for treating heart failure and type 2 diabetes. It was approved for market use on Jan 8, 2014. Farxiga uses Dapagliflozin as an active ingredient.

Total Patents: 44
Expired Patents: 11

Farxiga's NCE-1 date is Dec 12, 2026 which is when its patents will be open to challenges.

Check the entire list of patents and their expiration dates for Farxiga

Download full list of 40+ drugs as PDF

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