Drugs Opening to Patent Challenges in 2026

As we look ahead to 2026, significant shifts in the pharmaceutical landscape are coming. This year is crucial for several high-profile drugs as they approach their NCE-1 dates, opening the door to potential patent challenges. These challenges could pave the way for generic competition, lowering costs and increasing accessibility for patients. On this page, we highlight the drugs whose NCE-1 date lies in 2026, making them eligible for generic manufacturers to begin the process of seeking approval for alternatives. Explore the key players set to face competition and what it could mean for the market.

1. AMVUTTRA

Amvuttra is a brand drug owned by Alnylam Pharmaceuticals Inc. It is Used for treating the polyneuropathy of hereditary transthyretin-mediated amyloidosis in adults. It was approved for market use on Jun 13, 2022. Amvuttra uses Vutrisiran Sodium as an active ingredient.

Total Patents: 13
Expired Patents: 0

Amvuttra's NCE-1 date is Jun 13, 2026 which is when its patents will be open to challenges.

Check the entire list of patents and their expiration dates for Amvuttra

2. AQVESME

Aqvesme is a brand drug owned by Agios Pharmaceuticals Inc. It was approved for market use on Dec 23, 2025. Aqvesme uses Mitapivat Sulfate as an active ingredient.

Total Patents: 6
Expired Patents: 0

Aqvesme's NCE-1 date is Feb 17, 2026 which is when its patents will be open to challenges.

Check the entire list of patents and their expiration dates for Aqvesme

3. BLUDIGO

Bludigo is a brand drug owned by Provepharm Sas. It was approved for market use on Jul 8, 2022. Bludigo uses Indigotindisulfonate Sodium as an active ingredient.

Total Patents: 3
Expired Patents: 0

Bludigo's NCE-1 date is Jul 08, 2026 which is when its patents will be open to challenges.

Check the entire list of patents and their expiration dates for Bludigo

4. CAMZYOS

Camzyos is a brand drug owned by Bristol Myers Squibb Co. It is Used for improving functional capacity and symptoms in adults with symptomatic obstructive hypertrophic cardiomyopathy (HCM) in NYHA class II-III. It was approved for market use on Apr 28, 2022. Camzyos uses Mavacamten as an active ingredient.

Total Patents: 3
Expired Patents: 0

Camzyos's NCE-1 date is Apr 28, 2026 which is when its patents will be open to challenges.

Check the entire list of patents and their expiration dates for Camzyos

5. CIBINQO

Cibinqo is a brand drug owned by Pfizer Inc. It is Used for treating adults with refractory, moderate-to-severe atopic dermatitis not adequately controlled with other systemic drug products. It was approved for market use on Jan 14, 2022. Cibinqo uses Abrocitinib as an active ingredient.

Total Patents: 3
Expired Patents: 0

Cibinqo's NCE-1 date is Jan 14, 2026 which is when its patents will be open to challenges.

Check the entire list of patents and their expiration dates for Cibinqo

6. ELUCIREM

Elucirem is a brand drug owned by Guerbet. It was approved for market use on Sep 21, 2022. Elucirem uses Gadopiclenol as an active ingredient.

Total Patents: 3
Expired Patents: 0

Elucirem's NCE-1 date is Sep 21, 2026 which is when its patents will be open to challenges.

Check the entire list of patents and their expiration dates for Elucirem

7. KRAZATI

Krazati is a brand drug owned by Bristol Myers Squibb Co. It is Used for treating locally advanced or metastatic non-small cell lung cancer in adult patients with a specific KRAS mutation who have already undergone prior systemic therapy. It was approved for market use on Dec 12, 2022. Krazati uses Adagrasib as an active ingredient.

Total Patents: 4
Expired Patents: 0

Krazati's NCE-1 date is Dec 12, 2026 which is when its patents will be open to challenges.

Check the entire list of patents and their expiration dates for Krazati

8. LYTGOBI

Lytgobi is a brand drug owned by Taiho Oncology Inc. It is used for treating intrahepatic cholangiocarcinoma. It was approved for market use on Sep 30, 2022. Lytgobi uses Futibatinib as an active ingredient.

Total Patents: 3
Expired Patents: 0

Lytgobi's NCE-1 date is Sep 30, 2026 which is when its patents will be open to challenges.

Check the entire list of patents and their expiration dates for Lytgobi

9. MOUNJARO

Mounjaro is a brand drug owned by Eli Lilly And Co. It is used for improving glycemic control in adults with type 2 diabetes mellitus. It was approved for market use on Jul 28, 2023. Mounjaro uses Tirzepatide as an active ingredient.

Total Patents: 6
Expired Patents: 0

Mounjaro's NCE-1 date is May 13, 2026 which is when its patents will be open to challenges.

Check the entire list of patents and their expiration dates for Mounjaro

10. MOUNJARO (AUTOINJECTOR)

Mounjaro (autoinjector) is a brand drug owned by Eli Lilly And Co. It is Used for improving glycemic control in adults with type 2 diabetes mellitus as an adjunct to diet and exercise. It was approved for market use on May 13, 2022. Mounjaro (autoinjector) uses Tirzepatide as an active ingredient.

Total Patents: 8
Expired Patents: 0

Mounjaro (autoinjector)'s NCE-1 date is May 13, 2026 which is when its patents will be open to challenges.

Check the entire list of patents and their expiration dates for Mounjaro (autoinjector)

Download full list of 40+ drugs as PDF

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