Major Depressive Disorder Therapeutics

1. Abilify patent expiration

Treatment: Treatment of irritability associated with autistic disorder; Treatment of schizophrenia including maintaining stability in patients with schizophrenia; Treatment of schizophrenia; Treatment of

ABILIFY's oppositions filed in EPO
ABILIFY IPR and PTAB Proceedings
Drug Patent Number Company Drug Patent Title Drug Patent Expiry Activity Alert
These drug patents protects the active chemical substance. Only drug patent owner can launch products that use this active substance.
US9359302 OTSUKA Low hygroscopic aripiprazole drug substance and processes for the preparation thereof
Sep, 2022

(3 years ago)

US8642760 OTSUKA Low hygroscopic aripiprazole drug substance and processes for the preparation thereof
Sep, 2022

(3 years ago)

US8580796 OTSUKA Low hygroscopic aripiprazole drug substance and processes for the preparation thereof
Sep, 2022

(3 years ago)

These drug patents focus on the other aspects of the active substance like dosage, mode of administration (oral, tablet, capsules, liquids etc).
US8642600 OTSUKA Method of treating autism
Jan, 2022

(3 years ago)

US5006528 OTSUKA Carbostyril derivatives
Oct, 2014

(11 years ago)

US9089567 OTSUKA Method of treating cognitive impairments and schizophrenias
Jan, 2022

(3 years ago)

US7053092 OTSUKA 5-HT1a receptor subtype agonist
Jan, 2022

(3 years ago)

US9387182 OTSUKA Carbostyril derivatives and serotonin reuptake inhibitors for treatment of mood disorders
Dec, 2023

(2 years ago)

US8642600

(Pediatric)

OTSUKA Method of treating autism
Jul, 2022

(3 years ago)

US8759350 OTSUKA Carbostyril derivatives and serotonin reuptake inhibitors for treatment of mood disorders
Mar, 2027

(1 year, 1 month from now)

US8518421 OTSUKA Flashmelt oral dosage formulation
Jan, 2021

(4 years ago)

US6977257 OTSUKA Aripiprazole oral solution
Apr, 2022

(3 years ago)

US9125939 OTSUKA Carbostyril derivatives and mood stabilizers for treating mood disorders
Jul, 2026

(6 months from now)

US5006528

(Pediatric)

OTSUKA Carbostyril derivatives
Apr, 2015

(10 years ago)

US8518421

(Pediatric)

OTSUKA Flashmelt oral dosage formulation
Jul, 2021

(4 years ago)

US9358207 OTSUKA Flashmelt oral dosage formulation
Apr, 2020

(5 years ago)

US8642760

(Pediatric)

OTSUKA Low hygroscopic aripiprazole drug substance and processes for the preparation thereof
Mar, 2023

(2 years ago)

US8580796

(Pediatric)

OTSUKA Low hygroscopic aripiprazole drug substance and processes for the preparation thereof
Mar, 2023

(2 years ago)

US6977257

(Pediatric)

OTSUKA Aripiprazole oral solution
Oct, 2022

(3 years ago)

US8017615 OTSUKA Low hygroscopic aripiprazole drug substance and processes for the preparation thereof
Jun, 2024

(1 year, 6 months ago)

US8017615

(Pediatric)

OTSUKA Low hygroscopic aripiprazole drug substance and processes for the preparation thereof
Dec, 2024

(1 year, 23 days ago)

US7115587 OTSUKA Aripiprazole complex formulation and method
Jul, 2024

(1 year, 5 months ago)

US7550445 OTSUKA Aripiprazole complex formulation and method
Jul, 2024

(1 year, 5 months ago)

US7115587

(Pediatric)

OTSUKA Aripiprazole complex formulation and method
Jan, 2025

(11 months ago)

US7550445

(Pediatric)

OTSUKA Aripiprazole complex formulation and method
Jan, 2025

(11 months ago)




Drug Exclusivity Drug Exclusivity Expiration
Pediatric Exclusivity(PED) Aug 27, 2011
New Indication(I-616) Nov 19, 2012
New Indication(I-633) Feb 16, 2014
M(M-137) Jun 09, 2017
New Indication(I-700) Dec 12, 2017
Orphan Drug Exclusivity(ODE) Dec 12, 2021
Orphan Drug Exclusivity(ODE-80) Dec 12, 2021

Drugs and Companies using ARIPIPRAZOLE ingredient

Market Authorisation Date: 15 November, 2002

Dosage: TABLET; TABLET, ORALLY DISINTEGRATING; INJECTABLE; SOLUTION

How can I launch a generic of ABILIFY before it's drug patent expiration?
More Information on Dosage

ABILIFY family patents

Family Patents

2. Cymbalta patent expiration

Treatment: Management of fibromyalgia (fm); Method of treating anxiety

Drug Patent Number Company Drug Patent Title Drug Patent Expiry Activity Alert
These drug patents focus on the other aspects of the active substance like dosage, mode of administration (oral, tablet, capsules, liquids etc).
US6596756

(Pediatric)

LILLY Treatment of fibromyalgia
Mar, 2020

(5 years ago)

US5508276 LILLY Duloxetine enteric pellets
Jul, 2014

(11 years ago)

US6596756 LILLY Treatment of fibromyalgia
Sep, 2019

(6 years ago)

US5023269 LILLY 3-aryloxy-3-substituted propanamines
Jun, 2013

(12 years ago)

US5023269

(Pediatric)

LILLY 3-aryloxy-3-substituted propanamines
Dec, 2013

(12 years ago)

US5508276

(Pediatric)

LILLY Duloxetine enteric pellets
Jan, 2015

(10 years ago)




Drug Exclusivity Drug Exclusivity Expiration
New Indication(I-617) Nov 19, 2012
New Indication(I-632) Nov 04, 2013
Pediatric Exclusivity(PED) Apr 18, 2016
M(M-61) Oct 18, 2015
New Patient Population(NPP) Apr 20, 2023

Drugs and Companies using DULOXETINE HYDROCHLORIDE ingredient

Market Authorisation Date: 03 August, 2004

Dosage: CAPSULE, DELAYED REL PELLETS

How can I launch a generic of CYMBALTA before it's drug patent expiration?
More Information on Dosage

CYMBALTA family patents

Family Patents

Stay ahead of others in designing the generic launch strategy of these 5 blockbuster drugs expiring in next 5 years.

Get the exclusive patent insights now. Don't be the last to know.

3. Exxua patent expiration

Treatment: Treatment of subjects with major depression with sexual dysfunction caused by either major depression or prior treatments, or treatment of subjects with major depression without the risk of sexual dys...

Drug Patent Number Company Drug Patent Title Drug Patent Expiry Activity Alert
These drug patents focus on the other aspects of the active substance like dosage, mode of administration (oral, tablet, capsules, liquids etc).
US7538116 FABRE KRAMER Treatment of sexual disorders
Sep, 2030

(4 years from now)




Drug Exclusivity Drug Exclusivity Expiration
New Chemical Entity Exclusivity(NCE) Sep 22, 2028

Drugs and Companies using GEPIRONE HYDROCHLORIDE ingredient

NCE-1 date: 23 September, 2027

Market Authorisation Date: 22 September, 2023

Dosage: TABLET, EXTENDED RELEASE

More Information on Dosage

EXXUA family patents

Family Patents

4. Pristiq patent expiration

Treatment: For the approved uses and conditions of use, including depression; Maintenance treatment of major depressive disorder (mdd)

PRISTIQ's oppositions filed in EPO
PRISTIQ IPR and PTAB Proceedings
Drug Patent Number Company Drug Patent Title Drug Patent Expiry Activity Alert
These drug patents protects the active chemical substance. Only drug patent owner can launch products that use this active substance.
US6673838 PF PRISM CV Succinate salt of O-desmethyl-venlafaxine
Mar, 2022

(3 years ago)

US8269040 PF PRISM CV Derivatives of venlafaxine and methods of preparing and using the same
Jul, 2027

(1 year, 5 months from now)

These drug patents focus on the other aspects of the active substance like dosage, mode of administration (oral, tablet, capsules, liquids etc).
US6673838 PF PRISM CV Succinate salt of O-desmethyl-venlafaxine
Feb, 2022

(3 years ago)




Drug Exclusivity Drug Exclusivity Expiration
New Chemical Entity Exclusivity(NCE) Mar 01, 2013
New Indication(I-675) Feb 14, 2016
M(M-222) Feb 06, 2021

Drugs and Companies using DESVENLAFAXINE SUCCINATE ingredient

NCE-1 date: 01 March, 2012

Market Authorisation Date: 20 August, 2014

Dosage: TABLET, EXTENDED RELEASE

How can I launch a generic of PRISTIQ before it's drug patent expiration?
More Information on Dosage

PRISTIQ family patents

Family Patents

5. Rexulti patent expiration

Treatment: Adjunctive treatment of major depressive disorder (mdd); Treatment of schizophrenia; Treatment of schizophrenia in adults and pediatric pati...

REXULTI's oppositions filed in EPO
Drug Patent Number Company Drug Patent Title Drug Patent Expiry Activity Alert
These drug patents protects the active chemical substance. Only drug patent owner can launch products that use this active substance.
US7888362 OTSUKA Piperazine-substituted benzothiophenes for treatment of mental disorders
Apr, 2026

(3 months from now)

USRE48059 OTSUKA Piperazine-substituted benzothiophenes for treatment of mental disorders
Dec, 2028

(2 years from now)

These drug patents focus on the other aspects of the active substance like dosage, mode of administration (oral, tablet, capsules, liquids etc).
US8349840 OTSUKA Piperazine-substituted benzothiophenes for treatment of mental disorders
Apr, 2026

(3 months from now)

US9839637 OTSUKA Piperazine-substituted benzothiophenes for treatment of mental disorders
Apr, 2026

(3 months from now)

US8618109 OTSUKA Piperazine-substituted benzothiophenes for treatment of mental disorders
Apr, 2026

(3 months from now)

US10307419 OTSUKA Tablet comprising 7-[4-(4-benzo[b]thiopen-4-yl-piperazin-1-yl)butoxy]-1H-quinolin-2-one or a salt thereof
Oct, 2032

(6 years from now)

US9839637

(Pediatric)

OTSUKA Piperazine-substituted benzothiophenes for treatment of mental disorders
Oct, 2026

(9 months from now)

US8618109

(Pediatric)

OTSUKA Piperazine-substituted benzothiophenes for treatment of mental disorders
Oct, 2026

(9 months from now)

US7888362

(Pediatric)

OTSUKA Piperazine-substituted benzothiophenes for treatment of mental disorders
Oct, 2026

(9 months from now)

US8349840

(Pediatric)

OTSUKA Piperazine-substituted benzothiophenes for treatment of mental disorders
Oct, 2026

(9 months from now)

USRE48059

(Pediatric)

OTSUKA Piperazine-substituted benzothiophenes for treatment of mental disorders
Jun, 2029

(3 years from now)

US10307419

(Pediatric)

OTSUKA Tablet comprising 7-[4-(4-benzo[b]thiopen-4-yl-piperazin-1-yl)butoxy]-1H-quinolin-2-one or a salt thereof
Apr, 2033

(7 years from now)




Drug Exclusivity Drug Exclusivity Expiration
M(M-186) Sep 23, 2019
New Chemical Entity Exclusivity(NCE) Jul 10, 2020
New Patient Population(NPP) Dec 27, 2024
New Indication(I-913) May 10, 2026
Pediatric Exclusivity(PED) Nov 10, 2026
M(M-14) May 08, 2027
M(M-315) May 09, 2028

Drugs and Companies using BREXPIPRAZOLE ingredient

NCE-1 date: 10 November, 2025

Market Authorisation Date: 10 July, 2015

Dosage: TABLET

How can I launch a generic of REXULTI before it's drug patent expiration?
More Information on Dosage

REXULTI family patents

Family Patents

6. Trintellix patent expiration

Treatment: Method of treating an affective disorder such as depression; Method of treating depression or major depressive disorder; Use in the treatmen...

TRINTELLIX's oppositions filed in EPO
Drug Patent Number Company Drug Patent Title Drug Patent Expiry Activity Alert
These drug patents protects the active chemical substance. Only drug patent owner can launch products that use this active substance.
US7144884 TAKEDA PHARMS USA Phenyl-piperazine derivatives as serotonin reuptake inhibitors
Jun, 2026

(5 months from now)

US8722684 TAKEDA PHARMS USA 1-[2-(2,4-dimethylphenylsulfanyl)-phenyl] piperazine as a compound with combined serotonin reuptake, 5-HT3 and 5-HT1A activity for the treatment of cognitive impairment
Jun, 2031

(5 years from now)

These drug patents focus on the other aspects of the active substance like dosage, mode of administration (oral, tablet, capsules, liquids etc).
US8476279 TAKEDA PHARMS USA Phenyl-piperazine derivatives as serotonin reuptake inhibitors
Oct, 2022

(3 years ago)

US8969355 TAKEDA PHARMS USA 1-[2-(2,4 dimethylphenylsulfanyl)-phenyl]piperazine as a compound with combined serotonin reuptake, 5-HT3 and 5-HT1a activity for the treatment of cognitive impairment
Jun, 2027

(1 year, 5 months from now)

US9125910 TAKEDA PHARMS USA 1-[2-(2,4 dimethylphenylsulfanyl)-phenyl]piperazine as a compound with combined serotonin reuptake, 5-HT3 and 5-HT1A activity for the treatment of cognitive impairment
Jun, 2027

(1 year, 5 months from now)

US9227946 TAKEDA PHARMS USA 1-[2-(2,4 dimethylphenylsulfanyl)-phenyl]piperazine as a compound with combined serotonin reuptake, 5-HT3 and 5-HT1a activity for the treatment of cognitive impairment
Jun, 2027

(1 year, 5 months from now)

US11458134 TAKEDA PHARMS USA 1-[2-(2,4-dimeihylphenylsulfanyl)-phenyl]piperazine as a compound with combined serotonin reuptake, 5-HT3 and 5-HT1A activity for the treatment of cognitive impairment
Jun, 2027

(1 year, 5 months from now)

US9125909 TAKEDA PHARMS USA 1-[2-(2,4 dimethylphenylsulfanyl)-phenyl]piperazine as a compound with combined serotonin reuptake, 5-HT3 and 5-HT1A activity for the treatment of cognitive impairment
Jun, 2027

(1 year, 5 months from now)

US9125908 TAKEDA PHARMS USA 1-[2-(2,4-dimethylphenylsulfanyl)-phenyl]piperazine as a compound with combined serotonin reuptake, 5-HT3 and 5-HT1A activity for the treatment of cognitive impairment
Jun, 2027

(1 year, 5 months from now)

US9861630 TAKEDA PHARMS USA 1-[2-(2,4-dimethylphenylsulfanyl)-phenyl]piperazine as a compound with combined serotonin reuptake, 5-HT3 and 5-HT1A activity for the treatment of cognitive impairment
Jun, 2027

(1 year, 5 months from now)

US9278096 TAKEDA PHARMS USA Therapeutic uses of compounds having combined SERT, 5-HT3 and 5-HT1A activity
Mar, 2032

(6 years from now)

US8722684

(Pediatric)

TAKEDA PHARMS USA 1-[2-(2,4-dimethylphenylsulfanyl)-phenyl] piperazine as a compound with combined serotonin reuptake, 5-HT3 and 5-HT1A activity for the treatment of cognitive impairment
Dec, 2031

(5 years from now)

US7144884

(Pediatric)

TAKEDA PHARMS USA Phenyl-piperazine derivatives as serotonin reuptake inhibitors
Dec, 2026

(11 months from now)

US8969355

(Pediatric)

TAKEDA PHARMS USA 1-[2-(2,4 dimethylphenylsulfanyl)-phenyl]piperazine as a compound with combined serotonin reuptake, 5-HT3 and 5-HT1a activity for the treatment of cognitive impairment
Dec, 2027

(1 year, 11 months from now)

US9227946

(Pediatric)

TAKEDA PHARMS USA 1-[2-(2,4 dimethylphenylsulfanyl)-phenyl]piperazine as a compound with combined serotonin reuptake, 5-HT3 and 5-HT1a activity for the treatment of cognitive impairment
Dec, 2027

(1 year, 11 months from now)

US9125908

(Pediatric)

TAKEDA PHARMS USA 1-[2-(2,4-dimethylphenylsulfanyl)-phenyl]piperazine as a compound with combined serotonin reuptake, 5-HT3 and 5-HT1A activity for the treatment of cognitive impairment
Dec, 2027

(1 year, 11 months from now)

US9125909

(Pediatric)

TAKEDA PHARMS USA 1-[2-(2,4 dimethylphenylsulfanyl)-phenyl]piperazine as a compound with combined serotonin reuptake, 5-HT3 and 5-HT1A activity for the treatment of cognitive impairment
Dec, 2027

(1 year, 11 months from now)

US9125910

(Pediatric)

TAKEDA PHARMS USA 1-[2-(2,4 dimethylphenylsulfanyl)-phenyl]piperazine as a compound with combined serotonin reuptake, 5-HT3 and 5-HT1A activity for the treatment of cognitive impairment
Dec, 2027

(1 year, 11 months from now)

US9861630

(Pediatric)

TAKEDA PHARMS USA 1-[2-(2,4-dimethylphenylsulfanyl)-phenyl]piperazine as a compound with combined serotonin reuptake, 5-HT3 and 5-HT1A activity for the treatment of cognitive impairment
Dec, 2027

(1 year, 11 months from now)

US9278096

(Pediatric)

TAKEDA PHARMS USA Therapeutic uses of compounds having combined SERT, 5-HT3 and 5-HT1A activity
Sep, 2032

(6 years from now)

US11458134

(Pediatric)

TAKEDA PHARMS USA 1-[2-(2,4-dimeihylphenylsulfanyl)-phenyl]piperazine as a compound with combined serotonin reuptake, 5-HT3 and 5-HT1A activity for the treatment of cognitive impairment
Dec, 2027

(1 year, 11 months from now)




Drug Exclusivity Drug Exclusivity Expiration
New Chemical Entity Exclusivity(NCE) Sep 30, 2018
M(M-227) May 02, 2021
M(M-234) Oct 19, 2021
M(M-267) Nov 13, 2023
M(M-187) Jan 22, 2024
M(M-232) Aug 23, 2026
Pediatric Exclusivity(PED) Feb 23, 2027

Drugs and Companies using VORTIOXETINE HYDROBROMIDE ingredient

NCE-1 date: 23 February, 2026

Market Authorisation Date: 30 September, 2013

Dosage: TABLET

How can I launch a generic of TRINTELLIX before it's drug patent expiration?
More Information on Dosage

TRINTELLIX family patents

Family Patents

7. Viibryd patent expiration

Treatment: Treatment of major depressive disorder (mdd)

VIIBRYD IPR and PTAB Proceedings
Drug Patent Number Company Drug Patent Title Drug Patent Expiry Activity Alert
These drug patents protects the active chemical substance. Only drug patent owner can launch products that use this active substance.
US8673921 ABBVIE Polymorphic forms of 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoylbenzofuran-5-yl) piperazine hydrochloride
Jun, 2022

(3 years ago)

These drug patents focus on the other aspects of the active substance like dosage, mode of administration (oral, tablet, capsules, liquids etc).
US5532241 ABBVIE Piperidines and piperazines
Sep, 2014

(11 years ago)

US8193195

(Pediatric)

ABBVIE Polymorphic forms of 1-'4-(5-cyanoindol-3-yl) butyl-4-(2-carbamoylbenzofuran-5-yl) piperazine hydrochloride
Dec, 2022

(3 years ago)

US7834020 ABBVIE Polymorphic forms of 1-′4-(5-cyanoindol-3-yl)butyl-4-(2-carbamoylbenzofuran-5-yl) piperazine hydrochloride
Jun, 2022

(3 years ago)

US8193195 ABBVIE Polymorphic forms of 1-'4-(5-cyanoindol-3-yl) butyl-4-(2-carbamoylbenzofuran-5-yl) piperazine hydrochloride
Jun, 2022

(3 years ago)

US8236804 ABBVIE Polymorphic forms of 1-′4-(5-cyanoindol-3-yl)butyl-4-(2-carbamoylbenzofuran-5-yl)piperazine hydrochloride
Jun, 2022

(3 years ago)

US7834020

(Pediatric)

ABBVIE Polymorphic forms of 1-′4-(5-cyanoindol-3-yl)butyl-4-(2-carbamoylbenzofuran-5-yl) piperazine hydrochloride
Dec, 2022

(3 years ago)

US8236804

(Pediatric)

ABBVIE Polymorphic forms of 1-′4-(5-cyanoindol-3-yl)butyl-4-(2-carbamoylbenzofuran-5-yl)piperazine hydrochloride
Dec, 2022

(3 years ago)

US8673921

(Pediatric)

ABBVIE Polymorphic forms of 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoylbenzofuran-5-yl) piperazine hydrochloride
Dec, 2022

(3 years ago)




Drug Exclusivity Drug Exclusivity Expiration
New Chemical Entity Exclusivity(NCE) Jan 21, 2016
New Dosing Schedule(D-146) Mar 16, 2018
M(M-254) Jan 31, 2023
Pediatric Exclusivity(PED) Jul 31, 2023

Drugs and Companies using VILAZODONE HYDROCHLORIDE ingredient

NCE-1 date: 31 July, 2022

Market Authorisation Date: 21 January, 2011

Dosage: TABLET

How can I launch a generic of VIIBRYD before it's drug patent expiration?
More Information on Dosage

VIIBRYD family patents

Family Patents

8. Zurzuvae patent expiration

Treatment: Method of treating postpartum depression

Drug Patent Number Company Drug Patent Title Drug Patent Expiry Activity Alert
These drug patents protects the active chemical substance. Only drug patent owner can launch products that use this active substance.
US9512165 BIOGEN INC 19-nor C3, 3-disubstituted C21-N-pyrazolyl steroids and methods of use thereof
Apr, 2034

(8 years from now)

US11236121 BIOGEN INC Crystalline 19-nor C3,3-disubstituted C21-N-pyrazolyl steroid
Aug, 2037

(11 years from now)

These drug patents focus on the other aspects of the active substance like dosage, mode of administration (oral, tablet, capsules, liquids etc).
US11884696 BIOGEN INC Crystalline 19-nor C3,3-disubstituted C21-n-pyrazolyl steroid
Aug, 2037

(11 years from now)

US10342810 BIOGEN INC 19-nor C3, 3-disubstituted C21-N-pyrazolyl steroids and methods of use thereof
Apr, 2034

(8 years from now)

US10172871 BIOGEN INC 19-nor C3, 3-disubstituted C21-N-pyrazolyl steroids and methods of use thereof
Apr, 2034

(8 years from now)




Drug Exclusivity Drug Exclusivity Expiration
New Chemical Entity Exclusivity(NCE) Oct 31, 2028

Drugs and Companies using ZURANOLONE ingredient

NCE-1 date: 01 November, 2027

Market Authorisation Date: 31 October, 2023

Dosage: CAPSULE

More Information on Dosage

ZURZUVAE family patents

Family Patents