Graft Versus Host Disease Therapeutics

1. Imbruvica patent expiration

Treatment: Treatment of marginal zone lymphoma; Treatment of mantle cell lymphoma; Treatment of chronic lymphocytic leukemia with 17p deletion; Treatment of adult patients with relapsed or refractory chronic lym...

IMBRUVICA's oppositions filed in EPO
IMBRUVICA IPR and PTAB Proceedings
Drug Patent Number Company Drug Patent Title Drug Patent Expiry Activity Alert
These drug patents protects the active chemical substance. Only drug patent owner can launch products that use this active substance.
US9296753 PHARMACYCLICS LLC Crystalline forms of a Bruton's tyrosine kinase inhibitor
Oct, 2033

(7 years from now)

US9181257 PHARMACYCLICS LLC Inhibitors of Bruton's tyrosine kinase
Dec, 2026

(11 months from now)

US8957079 PHARMACYCLICS LLC Inhibitors of Bruton's tyrosine kinase
Dec, 2026

(11 months from now)

US8735403 PHARMACYCLICS LLC Inhibitors of Bruton's tyrosine kinase
Dec, 2026

(11 months from now)

US7514444 PHARMACYCLICS LLC Inhibitors of bruton's tyrosine kinase
Dec, 2026

(11 months from now)

US10125140 PHARMACYCLICS LLC Crystalline forms of a bruton's tyrosine kinase inhibitor
Jun, 2033

(7 years from now)

US10106548 PHARMACYCLICS LLC Crystalline forms of a Bruton's tyrosine kinase inhibitor
Jun, 2033

(7 years from now)

US9725455 PHARMACYCLICS LLC Crystalline forms of a bruton's tyrosine kinase inhibitor
Jun, 2033

(7 years from now)

US8008309 PHARMACYCLICS LLC Inhibitors of bruton's tyrosine kinase
Nov, 2027

(1 year, 10 months from now)

US8697711 PHARMACYCLICS LLC Inhibitors of bruton'S tyrosine kinase
Dec, 2026

(11 months from now)

These drug patents focus on the other aspects of the active substance like dosage, mode of administration (oral, tablet, capsules, liquids etc).
US8563563

(Pediatric)

PHARMACYCLICS LLC Inhibitors of bruton's tyrosine kinase
Oct, 2027

(1 year, 9 months from now)

US9814721 PHARMACYCLICS LLC Use of inhibitors of bruton'S tyrosine kinase (BTK)
Jun, 2031

(5 years from now)

US10653696 PHARMACYCLICS LLC Use of inhibitors of bruton's tyrosine kinase (BTK)
Jun, 2031

(5 years from now)

US8999999 PHARMACYCLICS LLC Use of inhibitors of Bruton's tyrosine kinase (Btk)
Jun, 2031

(5 years from now)

US9814721

(Pediatric)

PHARMACYCLICS LLC Use of inhibitors of bruton'S tyrosine kinase (BTK)
Dec, 2031

(5 years from now)

US10653696

(Pediatric)

PHARMACYCLICS LLC Use of inhibitors of bruton's tyrosine kinase (BTK)
Dec, 2031

(5 years from now)

US10004746 PHARMACYCLICS LLC Use of inhibitors of Bruton's tyrosine kinase (Btk)
Jun, 2031

(5 years from now)

US10016435 PHARMACYCLICS LLC Use of inhibitors of Bruton's tyrosine kinase (Btk)
Jun, 2031

(5 years from now)

US9801881 PHARMACYCLICS LLC Use of inhibitors of bruton's tyrosine kinase (BTK)
Jun, 2031

(5 years from now)

US9801883 PHARMACYCLICS LLC Use of inhibitors of bruton's tyrosine kinase (Btk)
Jun, 2031

(5 years from now)

US9125889 PHARMACYCLICS LLC Use of inhibitors of Bruton's tyrosine kinase (Btk)
Jun, 2031

(5 years from now)

US8476284 PHARMACYCLICS LLC Inhibitors of Bruton's tyrosine kinase
Dec, 2026

(11 months from now)

US8754090 PHARMACYCLICS LLC Use of inhibitors of bruton's tyrosine kinase (Btk)
Jun, 2031

(5 years from now)

US10463668 PHARMACYCLICS LLC Methods of treating and preventing graft versus host disease
Oct, 2034

(8 years from now)

US10695350 PHARMACYCLICS LLC Methods of treating and preventing graft versus host disease
Oct, 2034

(8 years from now)

US8563563 PHARMACYCLICS LLC Inhibitors of bruton's tyrosine kinase
Apr, 2027

(1 year, 3 months from now)

US8703780 PHARMACYCLICS LLC Inhibitors of Bruton's tyrosine kinase
Dec, 2026

(11 months from now)

US8952015 PHARMACYCLICS LLC Inhibitors of Bruton's tyrosine kinase
Dec, 2026

(11 months from now)

US11672803 PHARMACYCLICS LLC Use of inhibitors of Brutons tyrosine kinase (Btk)
Jun, 2031

(5 years from now)

US8497277 PHARMACYCLICS LLC Inhibitors of Bruton's tyrosine kinase
Dec, 2026

(11 months from now)

US10478439 PHARMACYCLICS LLC Use of inhibitors of bruton's tyrosine kinase (Btk)
Jun, 2031

(5 years from now)

US10751342 PHARMACYCLICS LLC Use of inhibitors of Bruton's tyrosine kinase (Btk)
Jun, 2031

(5 years from now)

US10961251 PHARMACYCLICS LLC Crystalline forms of a Bruton's tyrosine kinase inhibitor
Jun, 2033

(7 years from now)

US8754090

(Pediatric)

PHARMACYCLICS LLC Use of inhibitors of bruton's tyrosine kinase (Btk)
Dec, 2031

(5 years from now)

US9795604 PHARMACYCLICS LLC Methods of treating and preventing graft versus host disease
Oct, 2034

(8 years from now)

US9540382 PHARMACYCLICS LLC Crystalline forms of a Bruton's tyrosine kinase inhibitor
Aug, 2033

(7 years from now)

US8754091 PHARMACYCLICS LLC Inhibitors of bruton's tyrosine kinase
Dec, 2026

(11 months from now)

US10010507 PHARMACYCLICS LLC Pharmaceutical formulations of a bruton's tyrosine kinase inhibitor
Mar, 2036

(10 years from now)

US10213386 PHARMACYCLICS LLC Pharmaceutical formulations of a Bruton's tyrosine kinase inhibitor
Mar, 2036

(10 years from now)

US10752634 PHARMACYCLICS LLC Crystalline forms of a brutons tyrosine kinase inhibitor
Jun, 2033

(7 years from now)

US9713617 PHARMACYCLICS LLC Crystalline forms of a Bruton's tyrosine kinase inhibitor
Jun, 2033

(7 years from now)

US10294231 PHARMACYCLICS LLC Crystalline forms of a Bruton's tyrosine kinase inhibitor
Jun, 2033

(7 years from now)

US10294232 PHARMACYCLICS LLC Crystalline forms of a Bruton's tyrosine kinase inhibitor
Jun, 2033

(7 years from now)

US9655857 PHARMACYCLICS LLC Pharmaceutical formulations of a Bruton's tyrosine kinase inhibitor
Mar, 2036

(10 years from now)

US10828259 PHARMACYCLICS LLC Pharmaceutical formulations of a Bruton's tyrosine kinase inhibitor
Mar, 2036

(10 years from now)

US12364698 PHARMACYCLICS LLC NA
Apr, 2036

(10 years from now)

US12201690 PHARMACYCLICS LLC Formulations/compositions comprising ibrutinib
Jun, 2039

(13 years from now)

US8008309

(Pediatric)

PHARMACYCLICS LLC Inhibitors of bruton's tyrosine kinase
May, 2028

(2 years from now)

US7514444

(Pediatric)

PHARMACYCLICS LLC Inhibitors of bruton's tyrosine kinase
Jun, 2027

(1 year, 5 months from now)

US8476284

(Pediatric)

PHARMACYCLICS LLC Inhibitors of Bruton's tyrosine kinase
Jun, 2027

(1 year, 5 months from now)

US8497277

(Pediatric)

PHARMACYCLICS LLC Inhibitors of Bruton's tyrosine kinase
Jun, 2027

(1 year, 5 months from now)

US8754091

(Pediatric)

PHARMACYCLICS LLC Inhibitors of bruton's tyrosine kinase
Jun, 2027

(1 year, 5 months from now)

US8697711

(Pediatric)

PHARMACYCLICS LLC Inhibitors of bruton'S tyrosine kinase
Jun, 2027

(1 year, 5 months from now)

US8703780

(Pediatric)

PHARMACYCLICS LLC Inhibitors of Bruton's tyrosine kinase
Jun, 2027

(1 year, 5 months from now)

US8735403

(Pediatric)

PHARMACYCLICS LLC Inhibitors of Bruton's tyrosine kinase
Jun, 2027

(1 year, 5 months from now)

US9125889

(Pediatric)

PHARMACYCLICS LLC Use of inhibitors of Bruton's tyrosine kinase (Btk)
Dec, 2031

(5 years from now)

US8957079

(Pediatric)

PHARMACYCLICS LLC Inhibitors of Bruton's tyrosine kinase
Jun, 2027

(1 year, 5 months from now)

US9181257

(Pediatric)

PHARMACYCLICS LLC Inhibitors of Bruton's tyrosine kinase
Jun, 2027

(1 year, 5 months from now)

US9296753

(Pediatric)

PHARMACYCLICS LLC Crystalline forms of a Bruton's tyrosine kinase inhibitor
Apr, 2034

(8 years from now)

US9795604

(Pediatric)

PHARMACYCLICS LLC Methods of treating and preventing graft versus host disease
Apr, 2035

(9 years from now)

US10004746

(Pediatric)

PHARMACYCLICS LLC Use of inhibitors of Bruton's tyrosine kinase (Btk)
Dec, 2031

(5 years from now)

US9801883

(Pediatric)

PHARMACYCLICS LLC Use of inhibitors of bruton's tyrosine kinase (Btk)
Dec, 2031

(5 years from now)

US9801881

(Pediatric)

PHARMACYCLICS LLC Use of inhibitors of bruton's tyrosine kinase (BTK)
Dec, 2031

(5 years from now)

US8952015

(Pediatric)

PHARMACYCLICS LLC Inhibitors of Bruton's tyrosine kinase
Jun, 2027

(1 year, 5 months from now)

US8999999

(Pediatric)

PHARMACYCLICS LLC Use of inhibitors of Bruton's tyrosine kinase (Btk)
Dec, 2031

(5 years from now)

US9540382

(Pediatric)

PHARMACYCLICS LLC Crystalline forms of a Bruton's tyrosine kinase inhibitor
Feb, 2034

(8 years from now)

US9713617

(Pediatric)

PHARMACYCLICS LLC Crystalline forms of a Bruton's tyrosine kinase inhibitor
Dec, 2033

(7 years from now)

US9725455

(Pediatric)

PHARMACYCLICS LLC Crystalline forms of a bruton's tyrosine kinase inhibitor
Dec, 2033

(7 years from now)

US10016435

(Pediatric)

PHARMACYCLICS LLC Use of inhibitors of Bruton's tyrosine kinase (Btk)
Dec, 2031

(5 years from now)

US10106548

(Pediatric)

PHARMACYCLICS LLC Crystalline forms of a Bruton's tyrosine kinase inhibitor
Dec, 2033

(7 years from now)

US10125140

(Pediatric)

PHARMACYCLICS LLC Crystalline forms of a bruton's tyrosine kinase inhibitor
Dec, 2033

(7 years from now)

US10294232

(Pediatric)

PHARMACYCLICS LLC Crystalline forms of a Bruton's tyrosine kinase inhibitor
Dec, 2033

(7 years from now)

US10294231

(Pediatric)

PHARMACYCLICS LLC Crystalline forms of a Bruton's tyrosine kinase inhibitor
Dec, 2033

(7 years from now)

US10751342

(Pediatric)

PHARMACYCLICS LLC Use of inhibitors of Bruton's tyrosine kinase (Btk)
Dec, 2031

(5 years from now)

US10752634

(Pediatric)

PHARMACYCLICS LLC Crystalline forms of a brutons tyrosine kinase inhibitor
Dec, 2033

(7 years from now)

US10478439

(Pediatric)

PHARMACYCLICS LLC Use of inhibitors of bruton's tyrosine kinase (Btk)
Dec, 2031

(5 years from now)

US10961251

(Pediatric)

PHARMACYCLICS LLC Crystalline forms of a Bruton's tyrosine kinase inhibitor
Dec, 2033

(7 years from now)

US10463668

(Pediatric)

PHARMACYCLICS LLC Methods of treating and preventing graft versus host disease
Apr, 2035

(9 years from now)

US10695350

(Pediatric)

PHARMACYCLICS LLC Methods of treating and preventing graft versus host disease
Apr, 2035

(9 years from now)

US9655857

(Pediatric)

PHARMACYCLICS LLC Pharmaceutical formulations of a Bruton's tyrosine kinase inhibitor
Sep, 2036

(10 years from now)

US10010507

(Pediatric)

PHARMACYCLICS LLC Pharmaceutical formulations of a bruton's tyrosine kinase inhibitor
Sep, 2036

(10 years from now)

US10213386

(Pediatric)

PHARMACYCLICS LLC Pharmaceutical formulations of a Bruton's tyrosine kinase inhibitor
Sep, 2036

(10 years from now)

US10828259

(Pediatric)

PHARMACYCLICS LLC Pharmaceutical formulations of a Bruton's tyrosine kinase inhibitor
Sep, 2036

(10 years from now)




Drug Exclusivity Drug Exclusivity Expiration
New Indication(I-680) Feb 12, 2017
New Indication(I-689) Jul 28, 2017
New Indication(I-702) Jan 29, 2018
New Chemical Entity Exclusivity(NCE) Nov 13, 2018
New Indication(I-729) Mar 04, 2019
New Dosing Schedule(D-165) May 06, 2019
New Indication(I-736) May 06, 2019
New Indication(I-737) May 06, 2019
New Indication(I-741) Jan 18, 2020
New Indication(I-753) Aug 02, 2020
Orphan Drug Exclusivity(ODE-55) Nov 13, 2020
Orphan Drug Exclusivity(ODE-60) Feb 12, 2021
Orphan Drug Exclusivity(ODE-72) Jul 28, 2021
New Dosing Schedule(D-176) Aug 24, 2021
M(M-236) Jan 25, 2022
Orphan Drug Exclusivity(ODE-86) Jan 29, 2022
Orphan Drug Exclusivity(ODE-109) Mar 04, 2023
Orphan Drug Exclusivity(ODE-117) May 06, 2023
Orphan Drug Exclusivity(ODE-128) Jan 18, 2024
Orphan Drug Exclusivity(ODE) Aug 02, 2024
ODE*(ODE*) Aug 02, 2024
Orphan Drug Exclusivity(ODE-152) Aug 02, 2024
M(M-14) Aug 24, 2025
New Product(NP) Aug 24, 2025
New Patient Population(NPP) Aug 24, 2025
Pediatric Exclusivity(PED) Feb 24, 2026
Orphan Drug Exclusivity(ODE-405) Aug 24, 2029

Drugs and Companies using IBRUTINIB ingredient

NCE-1 date: 24 February, 2025

Market Authorisation Date: 16 February, 2018

Dosage: TABLET; CAPSULE; SUSPENSION

How can I launch a generic of IMBRUVICA before it's drug patent expiration?
More Information on Dosage

IMBRUVICA family patents

Family Patents

2. Jakafi patent expiration

Treatment: For treatment of intermediate or high-risk myelofibrosis (mf), including primary mf, post-polycythemia vera mf and post-essential thrombocythemia mf; For treatment of steroid-refractory acute graft-ve...

JAKAFI's oppositions filed in EPO
JAKAFI IPR and PTAB Proceedings
Drug Patent Number Company Drug Patent Title Drug Patent Expiry Activity Alert
These drug patents protects the active chemical substance. Only drug patent owner can launch products that use this active substance.
US9662335 INCYTE CORP Heteroaryl substituted pyrrolo[2,3-B] pyridines and pyrrolo[2,3-B] pyrimidines as janus kinase inhibitors
Dec, 2026

(11 months from now)

US7598257 INCYTE CORP Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as janus kinase inhibitors
Dec, 2027

(1 year, 11 months from now)

US8722693 INCYTE CORP Salts of the Janus kinase inhibitor (R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile
Jun, 2028

(2 years from now)

US8415362 INCYTE CORP Pyrazolyl substituted pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors
Dec, 2027

(1 year, 11 months from now)

These drug patents focus on the other aspects of the active substance like dosage, mode of administration (oral, tablet, capsules, liquids etc).
US8829013 INCYTE CORP Salts of the Janus kinase inhibitor (R)-3-(4-(7H-pyrrolo[2,3-D]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile
Jun, 2028

(2 years from now)

US9079912 INCYTE CORP Heteroaryl substituted pyrrolo[2,3-B] pyridines and pyrrolo[2,3-B] pyrimidines as Janus kinase inhibitors
Dec, 2026

(11 months from now)

US9814722 INCYTE CORP Heteroaryl substituted pyrrolo[2,3-B] pyridines and pyrrolo[2,3-B] pyrimidines as janus kinase inhibitors
Dec, 2026

(11 months from now)

US10016429 INCYTE CORP Salts of the janus kinase inhibitor (R)-3-(4-(7H-pyrrolo[2,3-D]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile
Jun, 2028

(2 years from now)

US8822481 INCYTE CORP Salts of the janus kinase inhibitor (R)-3-(4-(7H-pyrrolo[2,3-d] pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile
Jun, 2028

(2 years from now)

US7598257

(Pediatric)

INCYTE CORP Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as janus kinase inhibitors
Jun, 2028

(2 years from now)

US8415362

(Pediatric)

INCYTE CORP Pyrazolyl substituted pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors
Jun, 2028

(2 years from now)

US8722693

(Pediatric)

INCYTE CORP Salts of the Janus kinase inhibitor (R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile
Dec, 2028

(2 years from now)

US8822481

(Pediatric)

INCYTE CORP Salts of the janus kinase inhibitor (R)-3-(4-(7H-pyrrolo[2,3-d] pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile
Dec, 2028

(2 years from now)

US8829013

(Pediatric)

INCYTE CORP Salts of the Janus kinase inhibitor (R)-3-(4-(7H-pyrrolo[2,3-D]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile
Dec, 2028

(2 years from now)

US9079912

(Pediatric)

INCYTE CORP Heteroaryl substituted pyrrolo[2,3-B] pyridines and pyrrolo[2,3-B] pyrimidines as Janus kinase inhibitors
Jun, 2027

(1 year, 5 months from now)

US9814722

(Pediatric)

INCYTE CORP Heteroaryl substituted pyrrolo[2,3-B] pyridines and pyrrolo[2,3-B] pyrimidines as janus kinase inhibitors
Jun, 2027

(1 year, 5 months from now)

US10016429

(Pediatric)

INCYTE CORP Salts of the janus kinase inhibitor (R)-3-(4-(7H-pyrrolo[2,3-D]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile
Dec, 2028

(2 years from now)




Drug Exclusivity Drug Exclusivity Expiration
New Chemical Entity Exclusivity(NCE) Nov 16, 2016
New Indication(I-699) Dec 04, 2017
Orphan Drug Exclusivity(ODE) Nov 16, 2018
Orphan Drug Exclusivity(ODE-19) Nov 16, 2018
Orphan Drug Exclusivity(ODE-79) Dec 04, 2021
New Indication(I-799) May 24, 2022
New Indication(I-872) Sep 22, 2024
M(M-285) Dec 19, 2025
Orphan Drug Exclusivity(ODE-238) May 24, 2026
Orphan Drug Exclusivity(ODE-373) Sep 22, 2028
Pediatric Exclusivity(PED) Mar 22, 2029

Drugs and Companies using RUXOLITINIB PHOSPHATE ingredient

NCE-1 date: 22 March, 2028

Market Authorisation Date: 16 November, 2011

Dosage: TABLET

How can I launch a generic of JAKAFI before it's drug patent expiration?
More Information on Dosage

JAKAFI family patents

Family Patents

Stay ahead of others in designing the generic launch strategy of these 5 blockbuster drugs expiring in next 5 years.

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3. Rezurock patent expiration

Treatment: Treatment of chronic graft-versus-host disease (chronic gvhd) after failure of at least two prior lines of systemic therapy in adult and pediatric patients 12 years and older with a grade 3 infection ...

REZUROCK's oppositions filed in EPO
Drug Patent Number Company Drug Patent Title Drug Patent Expiry Activity Alert
These drug patents protects the active chemical substance. Only drug patent owner can launch products that use this active substance.
US8357693 KADMON PHARMS LLC Pharmacokinetically improved compounds
Jun, 2034

(8 years from now)

These drug patents focus on the other aspects of the active substance like dosage, mode of administration (oral, tablet, capsules, liquids etc).
US12097202 KADMON PHARMS LLC Methods of administering Belumosudil for treatment of chronic graft versus host disease
Jul, 2042

(16 years from now)

US11311541 KADMON PHARMS LLC Treatment of GVHD
Apr, 2035

(9 years from now)

US10696660 KADMON PHARMS LLC Rho kinase inhibitors
Oct, 2033

(7 years from now)

US10183931 KADMON PHARMS LLC Rho kinase inhibitors
Oct, 2033

(7 years from now)

US9815820 KADMON PHARMS LLC Rho kinase inhibitors
Oct, 2033

(7 years from now)




Drug Exclusivity Drug Exclusivity Expiration
New Chemical Entity Exclusivity(NCE) Jul 16, 2026
Orphan Drug Exclusivity(ODE-362) Jul 16, 2028

Drugs and Companies using BELUMOSUDIL MESYLATE ingredient

NCE-1 date: 16 July, 2025

Market Authorisation Date: 16 July, 2021

Dosage: TABLET

More Information on Dosage

REZUROCK family patents

Family Patents