Tretinoin Patent Expiration

Tretinoin was first introduced by Valeant International Barbados Srl in its drug Retin-A on Approved Prior to Jan 1, 1982. Other drugs containing Tretinoin are Vesanoid, Altreno, Atralin, Retin-A Micro, Retin-A-Micro, Avita, Renova. 22 different companies have introduced drugs containing Tretinoin.


Tretinoin Patents

Given below is the list of patents protecting Tretinoin, along with the drug name that holds that patent and the company name owning that drug.

Drug Used in Drug Patent Number Drug Patent Title Drug Patent Expiry Drug Owner
Altreno US10653656 Topical pharmaceutical compositions for treating skin conditions Aug 22, 2038 Dow Pharm
Altreno US11324710 Topical pharmaceutical compositions for treating skin conditions Aug 22, 2038 Dow Pharm
Altreno US6517847 Topical gel delivery system Aug 03, 2020

(Expired)

Dow Pharm
Renova US6531141 Oil-in-water emulsion containing tretinoin Mar 07, 2020

(Expired)

Valeant Pharms North
Retin-a Micro US5955109 Methods and compositions for topical delivery of retinoic acid Sep 21, 2016

(Expired)

Bausch
Retin-a-micro US5955109 Methods and compositions for topical delivery of retinoic acid Sep 21, 2016

(Expired)

Bausch
Atralin US5670547 Moisturizing vehicle for topical application of vitamin A acid Sep 23, 2014

(Expired)

Dow Pharm



Tretinoin's Family Patents

Family Patents

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Tretinoin Generic API Manufacturers

Several generic applications have been filed for Tretinoin. The first generic version for Tretinoin was by Teva Pharmaceuticals Usa and was approved on Jun 19, 1998. And the latest generic version is by Encube Ethicals Private Ltd and was approved on Jul 10, 2025.

Given below is the list of companies who have filed for Tretinoin generic, along with the locations of their manufacturing plants worldwide.