Tramadol Hydrochloride Patent Expiration

Tramadol Hydrochloride was first introduced by Janssen Pharmaceuticals Inc in its drug Ultram on Mar 3, 1995. Other drugs containing Tramadol Hydrochloride are Ultram Er, Ryzolt, Conzip, Rybix Odt, Qdolo. 34 different companies have introduced drugs containing Tramadol Hydrochloride.


Tramadol Hydrochloride Patents

Given below is the list of patents protecting Tramadol Hydrochloride, along with the drug name that holds that patent and the company name owning that drug.

Drug Used in Drug Patent Number Drug Patent Title Drug Patent Expiry Drug Owner
Qdolo US11103452 Tramadol hydrochloride solution Sep 01, 2040 Athena
Qdolo US11752103 Tramadol hydrochloride solution Sep 01, 2040 Athena
Ryzolt US7988998 Sustained-release tramadol formulations with 24-hour efficacy Oct 27, 2023

(Expired)

Purdue Pharma
Conzip US7858118 Extended release composition containing Tramadol Apr 11, 2022

(Expired)

Cipher Pharms Inc
Ryzolt US6607748 Cross-linked high amylose starch for use in controlled-release pharmaceutical formulations and processes for its manufacture Jun 29, 2020

(Expired)

Purdue Pharma
Ultram US6339105

(Pediatric)

Analgesic regimen Apr 12, 2020

(Expired)

Janssen Pharms
Ultram US6339105 Analgesic regimen Oct 12, 2019

(Expired)

Janssen Pharms
Rybix Odt US6106861 Multiparticulate tablet disintegrating in less than 40 seconds in the mouth Dec 05, 2017

(Expired)

Shionogi Inc
Ryzolt US5591452 Controlled release formulation May 10, 2014

(Expired)

Purdue Pharma
Ryzolt US6254887 Controlled release tramadol May 10, 2014

(Expired)

Purdue Pharma
Rybix Odt US5464632 Rapidly disintegratable multiparticular tablet Mar 22, 2013

(Expired)

Shionogi Inc



A patent's expiry date may change depending upon legal activities going on that patent. Critical activities like abandoning of a patent, term extension of a patent or amendment of its claims can increase or decrease the life of a patent hence affecting its expiry date and in turn affecting the generic launch date of that drug. Tracking these ongoing activities on a patent application helps to keep an eye on the latest developments in the patent process of the drug which can give an idea of how early a drug's generic could be available. The next section provides a list of recent legal activities on Tramadol Hydrochloride's patents.

Given below is the list recent legal activities going on the following patents of Tramadol Hydrochloride.

Activity Date Patent Number
Patent litigations
Email Notification 12 Sep, 2023 US11752103
Mail Patent eGrant Notification 12 Sep, 2023 US11752103
Recordation of Patent Grant Mailed 12 Sep, 2023 US11752103
Patent Issue Date Used in PTA Calculation 12 Sep, 2023 US11752103
Recordation of Patent eGrant 12 Sep, 2023 US11752103
Patent eGrant Notification 12 Sep, 2023 US11752103
Email Notification 24 Aug, 2023 US11752103
Issue Notification Mailed 23 Aug, 2023 US11752103
Application Is Considered Ready for Issue 10 Aug, 2023 US11752103
Dispatch to FDC 10 Aug, 2023 US11752103


Tramadol Hydrochloride's Family Patents

Family Patents

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Tramadol Hydrochloride Generic API Manufacturers

Several generic applications have been filed for Tramadol Hydrochloride. The first generic version for Tramadol Hydrochloride was by Actavis Elizabeth Llc and was approved on Jun 19, 2002. And the latest generic version is by Macleods Pharmaceuticals Ltd and was approved on Jan 31, 2025.

Given below is the list of companies who have filed for Tramadol Hydrochloride generic, along with the locations of their manufacturing plants worldwide.