Temozolomide Patent Expiration

Temozolomide is Used for treating malignant neoplasms. It was first introduced by Merck Sharp And Dohme Corp in its drug Temodar on Aug 11, 1999. 18 different companies have introduced drugs containing Temozolomide.


Temozolomide Patents

Given below is the list of patents protecting Temozolomide, along with the drug name that holds that patent and the company name owning that drug.

Filter patents by

NEW
Drug Used in Drug Patent Number Drug Patent Title Drug Patent Expiry Drug Owner
Temodar US6987108 Pharmaceutical formulations of antineoplastic agents and processes of making and using the same Sep 08, 2023

(Expired)

Merck Sharp Dohme
Temodar US7786118 Pharmaceutical formulations of antineoplastic agents Feb 21, 2023

(Expired)

Merck Sharp Dohme
Temodar US8623868 Processes of making and using pharmaceutical formulations of antineoplastic agents Feb 21, 2023

(Expired)

Merck Sharp Dohme
Temodar US5260291

(Pediatric)

Tetrazine derivatives Feb 11, 2014

(Expired)

Merck Sharp Dohme
Temodar US5260291 Tetrazine derivatives Aug 11, 2013

(Expired)

Merck Sharp Dohme



A patent's expiry date may change depending upon legal activities going on that patent. Critical activities like abandoning of a patent, term extension of a patent or amendment of its claims can increase or decrease the life of a patent hence affecting its expiry date and in turn affecting the generic launch date of that drug. Tracking these ongoing activities on a patent application helps to keep an eye on the latest developments in the patent process of the drug which can give an idea of how early a drug's generic could be available. The next section provides a list of recent legal activities on Temozolomide's patents.

Given below is the list recent legal activities going on the following patents of Temozolomide.

Activity Date Patent Number
Patent litigations
Payment of Maintenance Fee, 12th Year, Large Entity 13 Jan, 2022 US7786118
Payment of Maintenance Fee, 8th Year, Large Entity 17 Jan, 2018 US7786118
Correspondence Address Change 26 Aug, 2011 US7786118
Correspondence Address Change 26 Aug, 2011 US6987108
Post Issue Communication - Certificate of Correction 09 Feb, 2011 US7786118
Recordation of Patent Grant Mailed 31 Aug, 2010 US7786118
Patent Issue Date Used in PTA Calculation 31 Aug, 2010 US7786118
Issue Notification Mailed 11 Aug, 2010 US7786118
Application Is Considered Ready for Issue 03 Aug, 2010 US7786118
Dispatch to FDC 03 Aug, 2010 US7786118


Temozolomide's Family Patents

Family Patents

Explore Our Curated Drug Screens

Drugs Generating Over $1 Billion in Annual Revenue
Explore the top-performing drugs that dominate the pharmaceutical industry
View List
NCE-1 Patent Expiry in the Next 1 Year
Identify opportunities as new chemical entity (NCE-1) patents approach expiry
View List
Recently Granted Patents in EP
Find the opportunity to file Oppositions
View List



Clinical Trials

Recent Clinical Trials on Temozolomide:

Sometimes companies keep conducting clinical trials even after the drug's approval to discover new formulations, methods of use, or new treatment indications, so they could file for additional patents or receive regulatory exclusivity extensions, such as pediatric exclusivity, potentially delaying generic competition. Based on these recent clinical trials, generic companies need to consider the potential for new intellectual property or regulatory hurdles. These strategic moves by the drug owner might delay generic substitution or lead to additional sales of the brand drug, even after patent expiry.

Title Lead Sponsor Collaborators Status Phases
Clinical Trials
Phase I Trial of rhIL-15 Plus Dinutuximab Plus Irinotecan/Temozolomide for Children and Young Adults With Relapsed/Refractory Neuroblastoma National Cancer Institute (NCI) NA RECRUITING
(Sep 22, 2026)
PHASE1
Atezolizumab in Combination With Temozolomide and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma M.D. Anderson Cancer Center NA COMPLETED
(Sep 1, 2026)
PHASE1, PHASE2
Safety and Immunogenicity of Personalized Genomic Vaccine and Tumor Treating Fields (TTFields) to Treat Glioblastoma Adilia Hormigo NA ACTIVE NOT RECRUITING
(Sep 1, 2026)
PHASE1
Telaglenastat With Radiation Therapy and Temozolomide in Treating Patients With IDH-Mutated Diffuse Astrocytoma or Anaplastic Astrocytoma National Cancer Institute (NCI) NA ACTIVE NOT RECRUITING
(Sep 1, 2026)
PHASE1
OKN-007 in Combination With Adjuvant Temozolomide Chemoradiotherapy for Newly Diagnosed Glioblastoma University of Oklahoma NA ACTIVE NOT RECRUITING
(Sep 1, 2026)
PHASE1
Evaluate the Efficacy and Safety of ADCV01 as an Add-On Treatment for Primary Glioblastoma Multiforme (GBM) Patients Ever Supreme Bio Technology Co., Ltd. NA RECRUITING
(Sep 1, 2026)
PHASE2
NK Cells Infusions With Irinotecan, Temozolomide, and Dinutuximab Nationwide Children's Hospital NA ACTIVE NOT RECRUITING
(Sep 1, 2026)
PHASE1, PHASE2
Apatinib Mesylate Combined With IT Regimen for the Treatment of Recurrent or Refractory Neuroblastoma: A Single-arm, Phase I/II,Multi-center, Clinical Study. Sun Yat-sen University NA COMPLETED
(Sep 1, 2026)
PHASE1, PHASE2
A Dose Finding Study of [177Lu]Lu-DOTA-TATE in Newly Diagnosed Glioblastoma in Combination With Standard of Care and in Recurrent Glioblastoma as a Single Agent. Novartis Pharmaceuticals NA ACTIVE NOT RECRUITING
(Sep 1, 2026)
PHASE1
Azeliragon and Chemoradiotherapy in Newly Diagnosed Glioblastoma Cantex Pharmaceuticals NA COMPLETED
(Sep 1, 2026)
PHASE1, PHASE2
A Study of Temodar With Abexinostat (PCI-24781) for Patients With Recurrent Glioma University of Nebraska NA RECRUITING
(Sep 1, 2026)
PHASE1
A Study of Debio 0123 in Combination With Temozolomide in Adult Participants With Recurrent or Progressive Glioblastoma and of Debio 0123 in Combination With Temozolomide and Radiotherapy in Adult Participants With Newly Diagnosed Glioblastoma Debiopharm International SA NA RECRUITING
(Sep 1, 2026)
PHASE1, PHASE2
Safety and Efficacy of Bevacizumab in Combination With NaviFUS System for the Treatment of Recurrent Glioblastoma Multiforme (rGBM) NaviFUS Corporation NA SUSPENDED
(Sep 1, 2026)
PHASE1, PHASE2
Triapine in Combination With Temozolomide for the Treatment of Patients With Recurrent Glioblastoma Northwestern University NA RECRUITING
(Sep 1, 2026)
PHASE1
Silmitasertib (CX-4945) in Combination With Chemotherapy for Relapsed Refractory Solid Tumors Milton S. Hershey Medical Center NA RECRUITING
(Sep 1, 2026)
PHASE1, PHASE2
PEP-CMV + Nivolumab for Newly Diagnosed Diffuse Midline Glioma/High-grade Glioma and Recurrent Diffuse Midline Glioma/High-grade Glioma, Medulloblastoma, and Ependymoma Washington University School of Medicine NA SUSPENDED
(Sep 1, 2026)
PHASE1, PHASE2
Trial of Glioblastoma Immunotherapy Advancement With Nivolumab and Relatlimab Duke University NA RECRUITING
(Sep 1, 2026)
PHASE2
Study of ABBV-637 or ABBV-155 With ERAS-801 for People With Glioblastoma Memorial Sloan Kettering Cancer Center NA RECRUITING
(Sep 1, 2026)
PHASE1
IGNITE: Study of Tirabrutinib vs Rituximab/Temozolomide for Relapsed/Refractory Primary Central Nervous System Lymphoma (PCNSL) Ono Pharmaceutical Co., Ltd. NA RECRUITING
(Sep 1, 2026)
PHASE3
Testing Addition of an Anti-cancer Drug, Vorasidenib to Temozolomide, After Radiation for Advanced Brain Cancer Alliance for Clinical Trials in Oncology NA RECRUITING
(Sep 1, 2026)
PHASE3
Comparison of Cerebraca Wafer Plus Temozolomide Versus Temozolomide Alone in Recurrent Glioblastoma Everfront Biotech Co., Ltd. NA NOT YET RECRUITING
(Sep 1, 2026)
PHASE2, PHASE3
Combination ADI-PEG 20, TMZ, and RT for Treatment of Newly Diagnosed High-grade Glioma (HGG) Sabine Mueller, MD, PhD NA NOT YET RECRUITING
(Sep 1, 2026)
PHASE1, PHASE2
Temporally-Modulated Pulsed Radiation Therapy Versus Standard Radiation Therapy for the Treatment of Newly Diagnosed, IDH Wildtype, MGMT-Unmethylated Glioblastoma NRG Oncology NA RECRUITING
(Sep 1, 2026)
PHASE3
A Study of BMS-986504 Monotherapy and in Combination With Other Agents in Participants With Advanced and/or Metastatic Solid Tumors With Homozygous MTAP Deletion (MountainTAP-5) Bristol-Myers Squibb NA RECRUITING
(Sep 1, 2026)
PHASE2
Temozolomide, With or Without WSD0922-FU, for the Treatment of EGFR-Mutant, IDH-Wildtype Glioblastoma Mayo Clinic NA SUSPENDED
(Sep 1, 2026)
PHASE2
Trial of Temozolomide in BAP1 Mutated Patients With Advanced or Metastatic Cutaneous Melanoma Assistance Publique Hopitaux De Marseille NA NOT YET RECRUITING
(Sep 1, 2026)
PHASE2
Vorinostat and Temozolomide in Treating Patients With Malignant Gliomas National Cancer Institute (NCI) NA ACTIVE NOT RECRUITING
(Aug 1, 2026)
PHASE1
Bevacizumab Alone Versus Dose-dense Temozolomide Followed by Bevacizumab for Recurrent Glioblastoma, Phase III Kyorin University NA COMPLETED
(Aug 1, 2026)
PHASE3
Pembrolizumab and Standard Therapy in Treating Patients With Glioblastoma Mayo Clinic NA ACTIVE NOT RECRUITING
(Aug 1, 2026)
PHASE2
Nivolumab and Temozolomide in Treating Patients With Recurrent or Refractory Small-Cell Lung Cancer or Advanced Neuroendocrine Cancer Dwight Owen NA COMPLETED
(Aug 1, 2026)
PHASE2
A Study of NanO2™ Combined With Radiation and Temozolomide in Patients With Newly Diagnosed GBM NuvOx LLC NA ACTIVE NOT RECRUITING
(Aug 1, 2026)
PHASE2
BRiTE - Bispecific T Cell Engager for Patients With Glioblastoma Mustafa Khasraw, MBChB, MD, FRCP, FRACP NA RECRUITING
(Aug 1, 2026)
PHASE1
Preoperative Radiosurgery for the Treatment of High Grade Glioma, NeoGlioma Trial Mayo Clinic NA RECRUITING
(Aug 1, 2026)
PHASE1
PEP-CMV Vaccine Targeting CMV Antigen to Treat Newly Diagnosed Pediatric HGG and DIPG and Recurrent Medulloblastoma Nationwide Children's Hospital NA RECRUITING
(Aug 1, 2026)
PHASE2
SIGMA (Safusidenib in IDH1 Mutant Glioma Maintenance) Nuvation Bio Inc. NA RECRUITING
(Aug 1, 2026)
PHASE3
Study of AZD9574 as Monotherapy and in Combination With Anti-cancer Agents in Participants With Advanced Solid Malignancies AstraZeneca NA RECRUITING
(Aug 1, 2026)
PHASE1, PHASE2
To Evaluate the Efficacy and Safety of Naxitamab in Patients With Refractory Ewing's Sarcoma (Butterfly) Anna Raciborska NA RECRUITING
(Aug 1, 2026)
PHASE2
Temozolomide and Survivin Long Peptide Vaccine (SurVaxM) for the Treatment of Patients With Progressing Metastatic Neuroendocrine Carcinomas Roswell Park Cancer Institute NA SUSPENDED
(Aug 1, 2026)
PHASE2
Glioma Adaptive Radiotherapy With Development of an Artificial Intelligence Workflow Tata Memorial Centre NA RECRUITING
(Aug 1, 2026)
PHASE2
A Phase II Study With a Safety Run-In of the Addition of N-803 to a Chemoimmunotherapy Backbone for the Treatment of Patients With Relapsed or Refractory Neuroblastoma St. Jude Children's Research Hospital NA RECRUITING
(Aug 1, 2026)
PHASE2
Liothyronine in Combination With BIT Regimen for Medulloblastoma With or Without Minimal Residual Disease Sabine Mueller, MD, PhD NA RECRUITING
(Aug 1, 2026)
PHASE1, PHASE2
Adebrelimab Plus Temozolomide ± Hyperbaric Oxygen for Primary Glioblastoma Wei Jiang NA NOT YET RECRUITING
(Aug 1, 2026)
PHASE2
SurVaxM Vaccine Therapy and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma Roswell Park Cancer Institute NA ACTIVE NOT RECRUITING
(Jul 1, 2026)
PHASE2
Safety and Efficacy Study in Recurrent or Progressive Grade III or IV IDH1 Mutated Glioma Neonc Technologies, Inc. NA ACTIVE NOT RECRUITING
(Jul 1, 2026)
PHASE1, PHASE2
Proton Beam or Intensity-Modulated Radiation Therapy in Preserving Brain Function in Patients With IDH Mutant Grade II or III Glioma NRG Oncology NA ACTIVE NOT RECRUITING
(Jul 1, 2026)
PHASE2
Temozolomide (TMZ) In Advanced Succinate Dehydrogenase (SDH)-Mutant/Deficient Gastrointestinal Stromal Tumor (GIST) Adam Burgoyne, MD, PhD NA COMPLETED
(Jul 1, 2026)
PHASE2
Flavored, Oral Irinotecan VAL-413 (Orotecan®) Given With Temozolomide for Treatment of Recurrent Pediatric Solid Tumors Valent Technologies, LLC NA ACTIVE NOT RECRUITING
(Jul 1, 2026)
PHASE1
A Phase 2b Clinical Study With a Combination Immunotherapy in Newly Diagnosed Patients With Glioblastoma Imvax NA ACTIVE NOT RECRUITING
(Jul 1, 2026)
PHASE2
Phase I Trial of DNA-PK Inhibitor (PEPOSERTIB ) in Combination With Radiation and Adjuvant Temozolomide in Newly Diagnosed MGMT Unmethylated and Recurrent Glioblastoma M.D. Anderson Cancer Center NA ACTIVE NOT RECRUITING
(Jul 1, 2026)
PHASE1
Chemotherapy and Radiation Therapy for the Treatment of IDH Wildtype Gliomas or Non-histological (Molecular) Glioblastomas M.D. Anderson Cancer Center NA RECRUITING
(Jul 1, 2026)
PHASE2
Short Course Radiotherapy for the Treatment of Patients With Glioblastoma, SAGA Study Mayo Clinic NA ACTIVE NOT RECRUITING
(Jul 1, 2026)
PHASE2
An Open, Single-center Clinical Study of Surufatinib Combined With Temozolomide and S-1 in the First-line Treatment of Advanced Neuroendocrine Tumors Cancer Institute and Hospital, Chinese Academy of Medical Sciences NA RECRUITING
(Jul 1, 2026)
PHASE1, PHASE2
PH Weighted Chemical Exchange Saturation Transfer MRI-Based Surgical Resection to Improve Survival in Patients With Glioblastoma Jonsson Comprehensive Cancer Center NA NOT YET RECRUITING
(Jul 1, 2026)
PHASE3
Vorasidenib in Combination With Temozolomide (TMZ) in IDH-mutant Glioma Institut de Recherches Internationales Servier NA ACTIVE NOT RECRUITING
(Jul 1, 2026)
PHASE1, PHASE2
PEEL-224, Vincristine and Temozolomide in Pediatric Solid Tumors Theodore Laetsch NA RECRUITING
(Jul 1, 2026)
PHASE1, PHASE2
Study of NMS-03305293 in Adult Patient With Relapsed Small Cell Lung Cancer Nerviano Medical Sciences NA RECRUITING
(Jul 1, 2026)
PHASE1
CART-EGFR-IL13Ra2 in Newly Diagnosed GBM Following Initial Radiotherapy University of Pennsylvania NA ACTIVE NOT RECRUITING
(Jul 1, 2026)
PHASE1
Ruxolitinib With Radiation and Temozolomide Compared to Radiation and Temozolomide for Newly Diagnosed Glioblastoma Baptist Health South Florida NA RECRUITING
(Jul 1, 2026)
PHASE2
Feasibility Study of Prolonged Administration of Naxitamab, Irinotecan, and Temozolomide for Patients With Relapsed or Refractory Neuroblastoma Steven DuBois, MD NA RECRUITING
(Jul 1, 2026)
PHASE1
Adjuvant Temozolomide ± 5-Aminolevulinic Acid + Low Intensity Diffuse Ultrasound Sonodynamic Therapy System for Newly Diagnosed Glioblastoma Alpheus Medical, Inc. NA RECRUITING
(Jul 1, 2026)
PHASE2
Illuminate: A Clinical Study Evaluating CAR T Immune Cell Therapy (BCB-276) for Patients With Diffuse Intrinsic Pontine Glioma (DIPG). BrainChild Bio, Inc NA RECRUITING
(Jul 1, 2026)
PHASE2
Nimotuzumab Combined With the Stupp Regimen for Postoperative Residual Glioblastoma Tianjin First Central Hospital NA NOT YET RECRUITING
(Jul 1, 2026)
PHASE2
Preoperative Proton Irradiation for High-grade Brain Gliomas. National Medical Research Radiological Centre of the Ministry of Health of Russia NA RECRUITING
(Jul 1, 2026)
PHASE1
Survivin-Targeted Dendritic Cell (DC) Cell Injection for Newly Diagnosed Glioblastoma Beijing Tricision Biotherapeutics Inc NA NOT YET RECRUITING
(Jul 1, 2026)
PHASE2
Trial of NLG802 Indoximod Prodrug Plus Temozolomide for Patients With Progressive Pediatric Brain Cancer Lumos Pharma NA NOT YET RECRUITING
(Jul 1, 2026)
PHASE1
Phase II Study Incorporating Pegylated Interferon In the Treatment For Children With High-Risk Melanoma St. Jude Children's Research Hospital NA ACTIVE NOT RECRUITING
(Jun 1, 2026)
PHASE2
Subventricular Zone (SVZ) and Temozolomide in Glioblastoma Multiforme Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins NA ACTIVE NOT RECRUITING
(Jun 1, 2026)
PHASE2
Dose-Escalated Photon IMRT or Proton Beam Radiation Therapy Versus Standard-Dose Radiation Therapy and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma NRG Oncology NA ACTIVE NOT RECRUITING
(Jun 1, 2026)
PHASE2
Adjuvant Dendritic Cell-immunotherapy Plus Temozolomide in Glioblastoma Patients University Hospital, Antwerp NA ACTIVE NOT RECRUITING
(Jun 1, 2026)
PHASE1, PHASE2
PEP-CMV in Recurrent MEdulloblastoma/Malignant Glioma Daniel Landi NA ACTIVE NOT RECRUITING
(Jun 1, 2026)
PHASE1
Ruxolitinib With Radiation and Temozolomide for Grade III Gliomas and Glioblastoma Case Comprehensive Cancer Center NA COMPLETED
(Jun 1, 2026)
PHASE1
Hyperpolarized Imaging in Diagnosing Participants With Glioma Susan Chang NA RECRUITING
(Jun 1, 2026)
PHASE1
Adjuvant Dendritic Cell Immunotherapy for Pediatric Patients With High-grade Glioma or Diffuse Intrinsic Pontine Glioma University Hospital, Antwerp NA COMPLETED
(Jun 1, 2026)
PHASE1, PHASE2
Testing the Combination of the Anti-Cancer Drugs Temozolomide and M1774 to Evaluate Their Safety and Effectiveness National Cancer Institute (NCI) NA RECRUITING
(Jun 1, 2026)
PHASE1, PHASE2
New Adjuvant Vaccine in Glioblastoma, a Phase 1/2a Study Assistance Publique - Hôpitaux de Paris NA RECRUITING
(Jun 1, 2026)
PHASE1, PHASE2
A Study of 177Lu-PSMA-617 in People With Gliomas Memorial Sloan Kettering Cancer Center NA RECRUITING
(Jun 1, 2026)
PHASE1
SM-1 Combined With Temozolomide in Subjects With Refractory or Recurrent High-Grade Gliomas Shenzhen Zhenxing Medical Technology Co., Ltd NA COMPLETED
(Jun 1, 2026)
PHASE1
INO-5401 and INO-9012 Delivered by Electroporation (EP) in Combination With Cemiplimab (REGN2810) in Newly-Diagnosed Glioblastoma (GBM) Inovio Pharmaceuticals NA ACTIVE NOT RECRUITING
(May 1, 2026)
PHASE1, PHASE2
DC Migration Study to Evaluate TReg Depletion In GBM Patients With and Without Varlilumab Annick Desjardins, MD NA ACTIVE NOT RECRUITING
(May 1, 2026)
PHASE2
VITAS: Atezolizumab in Combination With Chemotherapy for Pediatric Relapsed/Refractory Solid Tumors University of Texas Southwestern Medical Center NA RECRUITING
(May 1, 2026)
PHASE1, PHASE2
Study of Onivyde With Talazoparib or Temozolomide in Children With Recurrent Solid Tumors and Ewing Sarcoma St. Jude Children's Research Hospital NA RECRUITING
(May 1, 2026)
PHASE1, PHASE2
A Pilot Study of SurVaxM in Children Progressive or Relapsed Medulloblastoma, High Grade Glioma, Ependymoma and Newly Diagnosed Diffuse Intrinsic Pontine Glioma Children's Oncology Group NA ACTIVE NOT RECRUITING
(May 1, 2026)
PHASE1
Dose Finding Study of [177Lu]Lu-NeoB in Newly Diagnosed Glioblastoma and in Recurrent Glioblastoma Novartis Pharmaceuticals NA ACTIVE NOT RECRUITING
(May 1, 2026)
PHASE1
A Phase Ib Trial of Eribulin in Combination With Irinotecan and Temozolamide in Children With Relapsed or Refractory Solid Tumors M.D. Anderson Cancer Center NA RECRUITING
(May 1, 2026)
PHASE1
Combination of Tarlatamab and Temozolomide in Patients With Central Nervous System Tumors Centre Leon Berard NA RECRUITING
(May 1, 2026)
PHASE1, PHASE2
Study of Silevertinib With Temozolomide for the Treatment of Newly Diagnosed GBM With Unmethylated MGMT and EGFRvIII Black Diamond Therapeutics, Inc. NA RECRUITING
(May 1, 2026)
PHASE2
A Phase I First-in-human Trial of Bvax (B-cell Vaccination) in Addition to Standard of Care Chemoradiotherapy for Newly Diagnosed Glioblastoma Catalina Lee Chang NA NOT YET RECRUITING
(May 1, 2026)
PHASE1
A Rollover Study of NBM-BMX in Combination With Temozolomide in Patients With Newly Diagnosed Glioblastoma Novelwise Pharmaceutical Corporation NA RECRUITING
(May 1, 2026)
PHASE1, PHASE2
A Phase 1/2 Study of Safety and Tolerability of MT-125 With Chemoradiation in Patients With Newly Diagnosed MGMT Methylated Glioblastoma Myosin Therapeutics Inc. NA NOT YET RECRUITING
(May 1, 2026)
PHASE1, PHASE2
FG001 Near-Infrared Fluorescence Imaging During Tumor Resection in Newly Diagnosed High-Grade Glioma FluoGuide A/S NA NOT YET RECRUITING
(May 1, 2026)
PHASE2
Association of Peripheral Blood Immunologic Response to Therapeutic Response to Adjuvant Treatment With Immune Checkpoint Inhibition (ICI) in Patients With Newly Diagnosed Glioblastoma or Gliosarcoma National Cancer Institute (NCI) NA COMPLETED
(Apr 15, 2026)
PHASE2
Phase III Study Comparing 2 Brain Conformational Radiotherapy in Combination With Chemotherapy in the Treatment of Glioblastoma Institut Claudius Regaud NA TERMINATED
(Apr 1, 2026)
PHASE3
Temozolomide With or Without Veliparib in Treating Patients With Newly Diagnosed Glioblastoma Multiforme National Cancer Institute (NCI) NA ACTIVE NOT RECRUITING
(Apr 1, 2026)
PHASE2, PHASE3
Personalized NeoAntigen Cancer Vaccine w RT Plus Pembrolizumab for Patients With Newly Diagnosed GBM Dana-Farber Cancer Institute NA ACTIVE NOT RECRUITING
(Apr 1, 2026)
PHASE1
Ketogenic Diet in Combination With Standard-of-care Radiation and Temozolomide for Patients With Glioblastoma Jethro Hu NA COMPLETED
(Apr 1, 2026)
PHASE1
Cabozantinib and Temozolomide for the Treatment of Unresectable or Metastatic Leiomyosarcoma or Other Soft Tissue Sarcoma City of Hope Medical Center NA ACTIVE NOT RECRUITING
(Apr 1, 2026)
PHASE2
Testing the Use of the Immunotherapy Drugs Ipilimumab and Nivolumab Plus Radiation Therapy Compared to the Usual Treatment (Temozolomide and Radiation Therapy) for Newly Diagnosed MGMT Unmethylated Glioblastoma National Cancer Institute (NCI) NA COMPLETED
(Apr 1, 2026)
PHASE2, PHASE3
Temozolomide and Atezolizumab for Subsequent Line for the Treatment of Metastatic or Recurrent Small Cell Lung Cancer Dwight Owen NA RECRUITING
(Apr 1, 2026)
PHASE2
Radiation/Temozolomide and Immunotherapy With Daratumumab to Improve Antitumor Efficacy in Glioblastoma West Virginia University NA ACTIVE NOT RECRUITING
(Apr 1, 2026)
PHASE1, PHASE2
Safety & Efficacy of DC Vaccine and TMZ for the Treatment of Newly-diagnosed Glioblastoma After Surgery Beijing Tiantan Hospital NA COMPLETED
(Apr 1, 2026)
PHASE1
ETAPA I: Peptide-based Tumor Associated Antigen Vaccine in GBM Mustafa Khasraw, MBChB, MD, FRCP, FRACP NA ACTIVE NOT RECRUITING
(Apr 1, 2026)
PHASE1
UNITy-BasED MR-Linac Adaptive Simultaneous Integrated Hypofractionated Boost Trial for High Grade Glioma in the Elderly Sunnybrook Health Sciences Centre NA ACTIVE NOT RECRUITING
(Apr 1, 2026)
PHASE2
Natural Killer Cell Therapy (UD TGFbetai NK Cells) and Temozolomide for the Treatment of Stage IV Melanoma Metastatic to the Brain Kari Kendra NA RECRUITING
(Apr 1, 2026)
PHASE1, PHASE2
ARISTOCRAT: Blinded Trial of Temozolomide +/- Cannabinoids University of Birmingham NA RECRUITING
(Apr 1, 2026)
PHASE2
The Efficacy and Safety of Temozolomide in SDH-deficient GIST Asan Medical Center NA RECRUITING
(Apr 1, 2026)
PHASE2
NBM-BMX Administered Orally to Patients With Solid Tumors or Newly Diagnosed Glioblastoma Novelwise Pharmaceutical Corporation NA RECRUITING
(Apr 1, 2026)
PHASE1, PHASE2
PH Sensitive MRI Based Resections of Glioblastoma University of California, Los Angeles NA RECRUITING
(Apr 1, 2026)
PHASE1
A Prospective Pivotal Study to Evaluate the Efficacy and Safety of Avastin® Bevacizumab (BEV) With or Without Microbubble-mediated Focused Ultrasound (FUS-MB) Using NaviFUS System in Recurrent Glioblastoma Multiforme Patients NaviFUS Corporation NA RECRUITING
(Apr 1, 2026)
PHASE3
G-CSF After Chemo-radiation in Patients With Glioblastoma Massachusetts General Hospital NA RECRUITING
(Apr 1, 2026)
PHASE2
DOC1021 Dendritic Cell Immunotherapy for Treatment of Newly Diagnosed Adult Glioblastoma (GBM) Diakonos Oncology Corporation NA RECRUITING
(Apr 1, 2026)
PHASE2
A Phase 1/2 Study of the Safety and Tolerability of MT-125 in GBM Patients Myosin Therapeutics Inc. NA RECRUITING
(Apr 1, 2026)
PHASE1, PHASE2
A Clinical Trial Testing the Safety of the Investigational Drug Pumitamig (BNT327) and How Well it Works in Patients With Recurrent Glioblastoma BioNTech SE NA RECRUITING
(Apr 1, 2026)
PHASE2
Focused Ultrasound Blood-Brain Barrier Opening in Pontine Diffuse Midline Glioma to Enhance Temozolomide Therapy: Pilot Feasibility Study (FIDES) UMC Utrecht NA NOT YET RECRUITING
(Apr 1, 2026)
PHASE1, PHASE2
A Prospective, Single-arm Clinical Study on the Safety and Efficacy of Ivoximab Combined With Temozolomide in the Treatment of Relapsed/Refractory Glioma The First Affiliated Hospital of Zhengzhou University NA RECRUITING
(Apr 1, 2026)
PHASE1, PHASE2
Temozolomide With or Without Veliparib in Treating Patients With Relapsed or Refractory Small Cell Lung Cancer National Cancer Institute (NCI) NA ACTIVE NOT RECRUITING
(Mar 1, 2026)
PHASE2
BGB-290 and Temozolomide in Treating Isocitrate Dehydrogenase (IDH)1/2-Mutant Grade I-IV Gliomas University of California, San Francisco NA ACTIVE NOT RECRUITING
(Mar 1, 2026)
PHASE1
Multiparametric MR-Guided High Dose Adaptive Radiotherapy With Concurrent Temozolomide in Patients With Newly Diagnosed Glioblastoma University of Michigan Rogel Cancer Center NA ACTIVE NOT RECRUITING
(Mar 1, 2026)
PHASE2
DB107-RRV, DB107-FC, and Radiation Therapy With or Without Temozolomide (TMZ) for High Grade Glioma University of California, San Francisco NA RECRUITING
(Mar 1, 2026)
PHASE1, PHASE2
Integrating Biology for Safe Intensification of Glioblastoma Hypofractionated Treatment on the MR-Linac NYU Langone Health NA NOT YET RECRUITING
(Mar 1, 2026)
PHASE1
Neoadjuvant Pucotenlimab Combined With Lenvatinib and Temozolomide in Resectable Stage IIB/III Acral Melanoma Shanghai Zhongshan Hospital NA NOT YET RECRUITING
(Mar 1, 2026)
PHASE2


Temozolomide Generic API Manufacturers

Several generic applications have been filed for Temozolomide. The first generic version for Temozolomide was by Heritage Pharma Labs Inc Dba Avet Pharma Labs Inc and was approved on Mar 1, 2010. And the latest generic version is by Hetero Labs Ltd Unit V and was approved on Aug 23, 2024.

Given below is the list of companies who have filed for Temozolomide generic, along with the locations of their manufacturing plants worldwide.