Selinexor Patent Expiration

Selinexor is Used for treating relapsed or refractory Diffuse Large B-Cell Lymphoma (DLBCL) and Multiple Myeloma in adults. It was first introduced by Karyopharm Therapeutics Inc in its drug Xpovio on Jul 3, 2019.


Selinexor Patents

Given below is the list of patents protecting Selinexor, along with the drug name that holds that patent and the company name owning that drug.

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Drug Used in Drug Patent Number Drug Patent Title Drug Patent Expiry Drug Owner
Xpovio US10519139 Polymorphs of Selinexor Aug 14, 2035 Karyopharm Theraps
Xpovio US11746102 Polymorphs of selinexor Aug 14, 2035 Karyopharm Theraps
Xpovio US11753401 Polymorphs of Selinexor Aug 14, 2035 Karyopharm Theraps
Xpovio US11807629 Polymorphs of Selinexor Aug 14, 2035 Karyopharm Theraps
Xpovio US8999996 Hydrazide containing nuclear transport modulators and uses thereof Jul 03, 2033 Karyopharm Theraps
Xpovio US10544108 Hydrazide containing nuclear transport modulators and uses thereof Jul 26, 2032 Karyopharm Theraps
Xpovio US11034660 Hydrazide containing nuclear transport modulators and uses thereof Jul 26, 2032 Karyopharm Theraps
Xpovio US11787771 Hydrazide containing nuclear transport modulators and uses thereof Jul 26, 2032 Karyopharm Theraps
Xpovio US12291508 Hydrazide containing nuclear transport modulators and uses thereof Jul 26, 2032 Karyopharm Theraps
Xpovio US9079865 Hydrazide containing nuclear transport modulators and uses thereof Jul 26, 2032 Karyopharm Theraps
Xpovio US9714226 Hydrazide containing nuclear transport modulators and uses thereof Jul 26, 2032 Karyopharm Theraps



A patent's expiry date may change depending upon legal activities going on that patent. Critical activities like abandoning of a patent, term extension of a patent or amendment of its claims can increase or decrease the life of a patent hence affecting its expiry date and in turn affecting the generic launch date of that drug. Tracking these ongoing activities on a patent application helps to keep an eye on the latest developments in the patent process of the drug which can give an idea of how early a drug's generic could be available. The next section provides a list of recent legal activities on Selinexor's patents.

Given below is the list recent legal activities going on the following patents of Selinexor.

Activity Date Patent Number
Patent litigations
Payment of Maintenance Fee, 8th Year, Large Entity 11 Apr, 2025 US9714226
7.5 yr surcharge - late pmt w/in 6 mo, Large Entity 11 Apr, 2025 US9714226
Maintenance Fee Reminder Mailed 17 Mar, 2025 US9714226
Payment of Maintenance Fee, 4th Year, Large Entity 16 Dec, 2024 US11034660
Recordation of Patent Grant Mailed 07 Nov, 2023 US11807629
Patent Issue Date Used in PTA Calculation 07 Nov, 2023 US11807629
Mail Patent eGrant Notification 07 Nov, 2023 US11807629
Email Notification 07 Nov, 2023 US11807629
Patent eGrant Notification 07 Nov, 2023 US11807629
Recordation of Patent eGrant 07 Nov, 2023 US11807629


Selinexor's Family Patents

Family Patents

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Clinical Trials

Recent Clinical Trials on Selinexor:

Sometimes companies keep conducting clinical trials even after the drug's approval to discover new formulations, methods of use, or new treatment indications, so they could file for additional patents or receive regulatory exclusivity extensions, such as pediatric exclusivity, potentially delaying generic competition. Based on these recent clinical trials, generic companies need to consider the potential for new intellectual property or regulatory hurdles. These strategic moves by the drug owner might delay generic substitution or lead to additional sales of the brand drug, even after patent expiry.

Title Lead Sponsor Collaborators Status Phases
Clinical Trials
HCMT/MM2401: Ph2 Study of Selinexor + Bispecific Antibody for RRMM Duke University NA RECRUITING
(Sep 1, 2026)
PHASE2
Testing the Addition of an Anti-cancer Drug, Selinexor, to the Usual Chemotherapy Treatment (Temozolomide) for Brain Tumors That Have Returned After Previous Treatment National Cancer Institute (NCI) NA RECRUITING
(Aug 1, 2026)
PHASE1, PHASE2
Selinexor in Maintenance Therapy After Systemic Therapy for Participants With p53 Wild-Type, Advanced or Recurrent Endometrial Carcinoma Karyopharm Therapeutics Inc NA ACTIVE NOT RECRUITING
(Aug 1, 2026)
PHASE3
A Study of the Drug Selinexor With Radiation Therapy in Patients With Newly-Diagnosed Diffuse Intrinsic Pontine (DIPG) Glioma and High-Grade Glioma (HGG) National Cancer Institute (NCI) NA RECRUITING
(Jul 1, 2026)
PHASE1, PHASE2
Testing Atezolizumab With Selinexor in People ≥ 12 Years Old With Alveolar Soft Part Sarcoma, AXIOM Trial National Cancer Institute (NCI) NA RECRUITING
(Jul 1, 2026)
PHASE2
Selinexor (KPT-330) in Patients With Relapsed/Refractory Diffuse Large B-Cell Lymphoma (DLBCL) Karyopharm Therapeutics Inc NA ACTIVE NOT RECRUITING
(Jun 1, 2026)
PHASE2
A Study of Rituximab-Gemcitabine-Dexamethasone-Platinum (R-GDP) With or Without Selinexor in Patients With Relapsed/Refractory Diffuse Large B-cell Lymphoma Karyopharm Therapeutics Inc NA ACTIVE NOT RECRUITING
(Jun 1, 2026)
PHASE2, PHASE3
Selinexor Maintenance Post CAR-T Cell Therapy for Multiple Myeloma Washington University School of Medicine NA RECRUITING
(Jun 1, 2026)
PHASE1
Selinexor in Myelofibrosis Refractory or Intolerant to JAK1/2 Inhibitors University of Utah NA TERMINATED
(May 1, 2026)
PHASE2
Low-Dose Selinexor and Choline Salicylate for Non-Hodgkin or Hodgkin Lymphoma, Histiocytic/Dendritic Cell Neoplasm, or Relapsed or Refractory Multiple Myeloma Mayo Clinic NA COMPLETED
(May 1, 2026)
PHASE1
A Study of Selinexor in People With Wilms Tumors and Other Solid Tumors Memorial Sloan Kettering Cancer Center NA RECRUITING
(May 1, 2026)
PHASE2
A Phase II Study of Sintilimab, Pegaspargase and Selinexor Followed by Radiotherapy in Newly Diagnosed Stage I/II Extranodal NK/T-Cell Lymphoma Sun Yat-sen University NA NOT YET RECRUITING
(May 1, 2026)
PHASE2
Maintenance With Selinexor/Placebo After Combination Chemotherapy in Participants With Endometrial Cancer [SIENDO] Karyopharm Therapeutics Inc NA COMPLETED
(Apr 1, 2026)
PHASE3
Study of Selinexor in Combination With Ruxolitinib in Myelofibrosis Karyopharm Therapeutics Inc NA ACTIVE NOT RECRUITING
(Apr 1, 2026)
PHASE3
A Study to Evaluate Safety , Efficacy and Pharmacokinetics of WJ01024 Tablets Combined With Ruxolitinib in Patients With Myelofibrosis Suzhou Junjing BioSciences Co., Ltd. NA ACTIVE NOT RECRUITING
(Mar 1, 2026)
PHASE1, PHASE2
Selinexor and Pacritinib in JAK Inhibitor-naïve MF Patients With Cytopenias John Mascarenhas NA NOT YET RECRUITING
(Mar 1, 2026)
PHASE2


Selinexor Generic API Manufacturers

Given below is the list of companies who have filed for Selinexor generic, along with the locations of their manufacturing plants worldwide.