Insulin Recombinant Human Patent Expiration

Insulin Recombinant Human is Used for treating diabetes mellitus through inhalation of a dry powder medicament containing insulin. It was first introduced by Eli Lilly And Co in its drug Humulin R on Oct 28, 1982. Other drugs containing Insulin Recombinant Human are Humulin Br, Humulin R Pen, Afrezza, Novolin R, Velosulin Br, Exubera. 4 different companies have introduced drugs containing Insulin Recombinant Human.


Insulin Recombinant Human Patents

Given below is the list of patents protecting Insulin Recombinant Human, along with the drug name that holds that patent and the company name owning that drug.

Drug Used in Drug Patent Number Drug Patent Title Drug Patent Expiry Drug Owner
Afrezza US10046031 Use of ultrarapid acting insulin Aug 11, 2029 Mannkind
Afrezza US10201672 Dry powder inhaler and system for drug delivery Aug 02, 2030 Mannkind
Afrezza US10342938 Dry powder drug delivery system Jun 12, 2029 Mannkind
Afrezza US10500159 Apparatus and method for cryogranulating a pharmaceutical composition Nov 02, 2030 Mannkind
Afrezza US6071497 Microparticles for lung delivery comprising diketopiperazine May 15, 2015

(Expired)

Mannkind
Afrezza US6428771 Method for drug delivery to the pulmonary system May 15, 2015

(Expired)

Mannkind
Afrezza US6444226 Purification and stabilization of peptide and protein pharmaceutical agents Jun 29, 2020

(Expired)

Mannkind
Afrezza US6652885 Purification and stabilization of peptide and protein pharmaceutical agents Jun 29, 2020

(Expired)

Mannkind
Afrezza US6663898 Carbon-substituted diketopiperazine delivery systems Sep 30, 2014

(Expired)

Mannkind
Afrezza US6906030 Carbon-substituted diketopiperazine delivery systems Sep 30, 2014

(Expired)

Mannkind
Afrezza US7276534 Carbon-substituted diketopiperazine delivery systems Sep 30, 2014

(Expired)

Mannkind
Afrezza US7305986 Unit dose capsules for use in a dry powder inhaler Jan 16, 2023

(Expired)

Mannkind
Afrezza US7464706 Unit dose cartridge and dry powder inhaler Mar 02, 2023

(Expired)

Mannkind
Afrezza US7648960 Method for delivery of monomeric or dimeric insulin complexed to diketopiperazine microparticles Jun 29, 2020

(Expired)

Mannkind
Afrezza US7943178 Methods and compositions for delivering peptides Jun 29, 2020

(Expired)

Mannkind
Afrezza US7943572 Superior control of blood glucose in diabetes treatment Aug 10, 2026 Mannkind
Afrezza US8119593 Method of treating diabetes type 2 by metformin and an ultrarapid acting insulin Aug 11, 2029 Mannkind
Afrezza US8133514 Carbon-substituted diketopiperazine delivery systems Sep 30, 2014

(Expired)

Mannkind
Afrezza US8146588 Unit dose capsules and dry powder inhaler Apr 24, 2023

(Expired)

Mannkind
Afrezza US8156936 Unit dose capsules and dry powder inhaler Jan 16, 2023

(Expired)

Mannkind
Afrezza US8215300 Unit dose cartridge and dry powder inhaler Nov 24, 2022

(Expired)

Mannkind
Afrezza US8227409 Diketopiperazine microparticles with defined isomer contents Mar 08, 2031 Mannkind
Afrezza US8258095 Method of controlling glycemia by ultrarapid acting insulin without adjusting an insulin dose for meal content Aug 11, 2029 Mannkind
Afrezza US8389470 Methods and compositions for delivering peptides Jun 29, 2020

(Expired)

Mannkind
Afrezza US8394414 Method for drug delivery to the pulmonary system May 15, 2015

(Expired)

Mannkind
Afrezza US8424518 Dry powder inhaler and system for drug delivery Oct 17, 2031 Mannkind
Afrezza US8485180 Dry powder drug delivery system Mar 25, 2030 Mannkind
Afrezza US8499757 Dry powder inhaler and system for drug delivery Feb 19, 2032 Mannkind
Afrezza US8551528 Diketopiperazine microparticles with defined specific surface areas Jun 11, 2030 Mannkind
Afrezza US8623817 Method of treating diabetes type 2 by administering ultrarapid acting insulin Sep 18, 2029 Mannkind
Afrezza US8636001 Dry powder inhaler and system for drug delivery Jul 12, 2032 Mannkind
Afrezza US8729019 Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents Dec 26, 2028 Mannkind
Afrezza US8734845 Diketopiperazine microparticles with defined specific surface areas Jun 11, 2030 Mannkind
Afrezza US8778403 Diketopiperazine microparticles with defined specific surface areas Jun 11, 2030 Mannkind
Afrezza US8889099 Methods and compositions for delivering peptides Jun 29, 2020

(Expired)

Mannkind
Afrezza US8912193 Dry powder inhaler and system for drug delivery Jun 12, 2029 Mannkind
Afrezza US8950397 Unit dose cartridge and dry powder inhaler Jul 20, 2021

(Expired)

Mannkind
Afrezza US9192675 Dry powder inhaler and system for drug delivery Jun 12, 2029 Mannkind
Afrezza US9283193 Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents Sep 14, 2026 Mannkind
Afrezza US9339615 Dry powder inhaler and system for drug delivery Oct 20, 2029 Mannkind
Afrezza US9358352 Dry powder drug delivery system and methods Feb 15, 2031 Mannkind
Afrezza US9393372 Dry powder drug delivery system Jul 04, 2029 Mannkind
Afrezza US9446133 Dry powder inhaler and system for drug delivery Jun 12, 2029 Mannkind
Afrezza US9511198 Dry powder inhaler and system for drug delivery Feb 16, 2030 Mannkind
Afrezza US9597374 Use of ultrarapid acting insulin Oct 08, 2031 Mannkind
Afrezza US9662461 Dry powder drug delivery system and methods Jun 12, 2029 Mannkind
Afrezza US9717689 Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents Sep 14, 2026 Mannkind
Afrezza US9943571 Use of ultrarapid acting insulin Aug 11, 2029 Mannkind
Exubera US5740794 Apparatus and methods for dispersing dry powder medicaments Apr 21, 2015

(Expired)

Pfizer
Exubera US5997848 Methods and compositions for pulmonary delivery of insulin Mar 07, 2014

(Expired)

Pfizer
Exubera US6051256 Dispersible macromolecule compositions and methods for their preparation and use Mar 07, 2014

(Expired)

Pfizer
Exubera US6257233 Dry powder dispersing apparatus and methods for their use May 14, 2019

(Expired)

Pfizer
Exubera US6423344 Dispersible macromolecule compositions and methods for their preparation and use Mar 07, 2014

(Expired)

Pfizer
Exubera US6543448 Apparatus and methods for dispersing dry powder medicaments Sep 21, 2014

(Expired)

Pfizer
Exubera US6546929 Dry powder dispersing apparatus and methods for their use May 14, 2019

(Expired)

Pfizer
Exubera US6582728 Spray drying of macromolecules to produce inhaleable dry powders Jun 24, 2020

(Expired)

Pfizer
Exubera US6592904 Dispersible macromolecule compositions and methods for their preparation and use Mar 07, 2014

(Expired)

Pfizer
Exubera US6685967 Methods and compositions for pulmonary delivery of insulin Sep 11, 2018

(Expired)

Pfizer
Exubera US6737045 Methods and compositions for the pulmonary delivery insulin Mar 07, 2014

(Expired)

Pfizer
Humulin R US7291132 Medication dispensing apparatus with triple screw threads for mechanical advantage Aug 09, 2024 Lilly


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