Insulin Recombinant Human is Used for treating diabetes mellitus through inhalation of a dry powder medicament containing insulin. It was first introduced by Eli Lilly And Co in its drug Humulin R on Oct 28, 1982. Other drugs containing Insulin Recombinant Human are Humulin Br, Novolin R, Velosulin Br, Humulin R Pen, Afrezza, Exubera. 4 different companies have introduced drugs containing Insulin Recombinant Human.

Insulin Recombinant Human Patents

Given below is the list of patents protecting Insulin Recombinant Human, along with the drug name that holds that patent and the company name owning that drug.

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Drug Used in	Drug Patent Number	Drug Patent Title	Drug Patent Expiry	Drug Owner
Afrezza	US8636001	Dry powder inhaler and system for drug delivery	Jul 12, 2032	Mannkind
Afrezza	US8499757	Dry powder inhaler and system for drug delivery	Feb 19, 2032	Mannkind
Afrezza	US8424518	Dry powder inhaler and system for drug delivery	Oct 17, 2031	Mannkind
Afrezza	US9597374	Use of ultrarapid acting insulin	Oct 08, 2031	Mannkind
Afrezza	US8227409	Diketopiperazine microparticles with defined isomer contents	Mar 08, 2031	Mannkind
Afrezza	US9358352	Dry powder drug delivery system and methods	Feb 15, 2031	Mannkind
Afrezza	US10500159	Apparatus and method for cryogranulating a pharmaceutical composition	Nov 02, 2030	Mannkind
Afrezza	US10201672	Dry powder inhaler and system for drug delivery	Aug 02, 2030	Mannkind
Afrezza	US8551528	Diketopiperazine microparticles with defined specific surface areas	Jun 11, 2030	Mannkind
Afrezza	US8734845	Diketopiperazine microparticles with defined specific surface areas	Jun 11, 2030	Mannkind
Afrezza	US8778403	Diketopiperazine microparticles with defined specific surface areas	Jun 11, 2030	Mannkind
Afrezza	US8485180	Dry powder drug delivery system	Mar 25, 2030	Mannkind
Afrezza	US9511198	Dry powder inhaler and system for drug delivery	Feb 16, 2030	Mannkind
Afrezza	US9339615	Dry powder inhaler and system for drug delivery	Oct 20, 2029	Mannkind
Afrezza	US8623817	Method of treating diabetes type 2 by administering ultrarapid acting insulin	Sep 18, 2029	Mannkind
Afrezza	US10046031	Use of ultrarapid acting insulin	Aug 11, 2029	Mannkind
Afrezza	US8119593	Method of treating diabetes type 2 by metformin and an ultrarapid acting insulin	Aug 11, 2029	Mannkind
Afrezza	US8258095	Method of controlling glycemia by ultrarapid acting insulin without adjusting an insulin dose for meal content	Aug 11, 2029	Mannkind
Afrezza	US9943571	Use of ultrarapid acting insulin	Aug 11, 2029	Mannkind
Afrezza	US9393372	Dry powder drug delivery system	Jul 04, 2029	Mannkind
Afrezza	US10342938	Dry powder drug delivery system	Jun 12, 2029	Mannkind
Afrezza	US8912193	Dry powder inhaler and system for drug delivery	Jun 12, 2029	Mannkind
Afrezza	US9192675	Dry powder inhaler and system for drug delivery	Jun 12, 2029	Mannkind
Afrezza	US9446133	Dry powder inhaler and system for drug delivery	Jun 12, 2029	Mannkind
Afrezza	US9662461	Dry powder drug delivery system and methods	Jun 12, 2029	Mannkind
Afrezza	US8729019	Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents	Dec 26, 2028	Mannkind
Afrezza	US9283193	Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents	Sep 14, 2026	Mannkind
Afrezza	US9717689	Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents	Sep 14, 2026	Mannkind
Afrezza	US7943572	Superior control of blood glucose in diabetes treatment	Aug 10, 2026	Mannkind
Humulin R	US7291132	Medication dispensing apparatus with triple screw threads for mechanical advantage	Aug 09, 2024 (Expired)	Lilly
Afrezza	US8146588	Unit dose capsules and dry powder inhaler	Apr 24, 2023 (Expired)	Mannkind
Afrezza	US7464706	Unit dose cartridge and dry powder inhaler	Mar 02, 2023 (Expired)	Mannkind
Afrezza	US7305986	Unit dose capsules for use in a dry powder inhaler	Jan 16, 2023 (Expired)	Mannkind
Afrezza	US8156936	Unit dose capsules and dry powder inhaler	Jan 16, 2023 (Expired)	Mannkind
Afrezza	US8215300	Unit dose cartridge and dry powder inhaler	Nov 24, 2022 (Expired)	Mannkind
Afrezza	US8950397	Unit dose cartridge and dry powder inhaler	Jul 20, 2021 (Expired)	Mannkind
Afrezza	US6444226	Purification and stabilization of peptide and protein pharmaceutical agents	Jun 29, 2020 (Expired)	Mannkind
Afrezza	US6652885	Purification and stabilization of peptide and protein pharmaceutical agents	Jun 29, 2020 (Expired)	Mannkind
Afrezza	US7648960	Method for delivery of monomeric or dimeric insulin complexed to diketopiperazine microparticles	Jun 29, 2020 (Expired)	Mannkind
Afrezza	US7943178	Methods and compositions for delivering peptides	Jun 29, 2020 (Expired)	Mannkind
Afrezza	US8389470	Methods and compositions for delivering peptides	Jun 29, 2020 (Expired)	Mannkind
Afrezza	US8889099	Methods and compositions for delivering peptides	Jun 29, 2020 (Expired)	Mannkind
Exubera	US6582728	Spray drying of macromolecules to produce inhaleable dry powders	Jun 24, 2020 (Expired)	Pfizer
Exubera	US6257233	Dry powder dispersing apparatus and methods for their use	May 14, 2019 (Expired)	Pfizer
Exubera	US6546929	Dry powder dispersing apparatus and methods for their use	May 14, 2019 (Expired)	Pfizer
Exubera	US6685967	Methods and compositions for pulmonary delivery of insulin	Sep 11, 2018 (Expired)	Pfizer
Afrezza	US6071497	Microparticles for lung delivery comprising diketopiperazine	May 15, 2015 (Expired)	Mannkind
Afrezza	US6428771	Method for drug delivery to the pulmonary system	May 15, 2015 (Expired)	Mannkind
Afrezza	US8394414	Method for drug delivery to the pulmonary system	May 15, 2015 (Expired)	Mannkind
Exubera	US5740794	Apparatus and methods for dispersing dry powder medicaments	Apr 21, 2015 (Expired)	Pfizer
Afrezza	US6663898	Carbon-substituted diketopiperazine delivery systems	Sep 30, 2014 (Expired)	Mannkind
Afrezza	US6906030	Carbon-substituted diketopiperazine delivery systems	Sep 30, 2014 (Expired)	Mannkind
Afrezza	US7276534	Carbon-substituted diketopiperazine delivery systems	Sep 30, 2014 (Expired)	Mannkind
Afrezza	US8133514	Carbon-substituted diketopiperazine delivery systems	Sep 30, 2014 (Expired)	Mannkind
Exubera	US6543448	Apparatus and methods for dispersing dry powder medicaments	Sep 21, 2014 (Expired)	Pfizer
Exubera	US5997848	Methods and compositions for pulmonary delivery of insulin	Mar 07, 2014 (Expired)	Pfizer
Exubera	US6051256	Dispersible macromolecule compositions and methods for their preparation and use	Mar 07, 2014 (Expired)	Pfizer
Exubera	US6423344	Dispersible macromolecule compositions and methods for their preparation and use	Mar 07, 2014 (Expired)	Pfizer
Exubera	US6592904	Dispersible macromolecule compositions and methods for their preparation and use	Mar 07, 2014 (Expired)	Pfizer
Exubera	US6737045	Methods and compositions for the pulmonary delivery insulin	Mar 07, 2014 (Expired)	Pfizer

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