Latest Clinical Trials
Comparison of Fulvestrant (FASLODEX™) 250 mg and 500 mg in Postmenopausal Women With Oestrogen Receptor Positive Advanced Breast Cancer Progressing or Relapsing After Previous Endocrine Therapy. AstraZeneca NA
ACTIVE NOT RECRUITING
(Sep 1, 2026)
PHASE3 To Evaluate the Safety, Tolerability, and Pharmacokinetics of Inavolisib Single Agent in Participants With Solid Tumors and in Combination With Endocrine and Targeted Therapies in Participants With Breast Cancer Genentech, Inc. NA
ACTIVE NOT RECRUITING
(Sep 1, 2026)
PHASE1 A Study Evaluating the Efficacy and Safety of Inavolisib + Palbociclib + Fulvestrant vs Placebo + Palbociclib + Fulvestrant in Participants With PIK3CA-Mutant, Hormone Receptor-Positive, HER2-Negative, Locally Advanced or Metastatic Breast Cancer Hoffmann-La Roche NA
ACTIVE NOT RECRUITING
(Sep 1, 2026)
PHASE2, PHASE3 A Study Evaluating the Efficacy and Safety of Giredestrant Compared With Physician's Choice of Endocrine Monotherapy in Participants With Previously Treated Estrogen Receptor-Positive, HER2-Negative Locally Advanced or Metastatic Breast Cancer (acelERA Breast Cancer) Hoffmann-La Roche NA
ACTIVE NOT RECRUITING
(Sep 1, 2026)
PHASE2 Study for Participants Continuing From Pfizer-sponsored Palbociclib (a Study Medicine) Studies Pfizer NA
ACTIVE NOT RECRUITING
(Sep 1, 2026)
PHASE2 A Study to Learn About the Study Medicine (Called PF-07220060 in Combination With PF-07104091) In Participants With Breast Cancer and Solid Tumors Pfizer NA
ACTIVE NOT RECRUITING
(Sep 1, 2026)
PHASE1, PHASE2 [177Lu]Lu-NeoB in Combination With Ribociclib and Fulvestrant in Participants With ER+, HER2- and GRPR+ Advanced Breast Cancer Novartis Pharmaceuticals NA
ACTIVE NOT RECRUITING
(Sep 1, 2026)
PHASE1 BGB-43395 Alone or as Part of Combination Therapies in Participants With Breast Cancer and Other Advanced Solid Tumors BeOne Medicines NA
RECRUITING
(Sep 1, 2026)
PHASE1 The CDK4/6 Inhibitor Dosing Knowledge (CDK) Study American Society of Clinical Oncology NA
RECRUITING
(Sep 1, 2026)
PHASE3 Open-Label Study of BBO-10203 in Subjects With Advanced Solid Tumors TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics) NA
RECRUITING
(Sep 1, 2026)
PHASE1 A Study of Mirdametinib in Combination With Palbociclib in People With Liposarcoma Memorial Sloan Kettering Cancer Center NA
RECRUITING
(Sep 1, 2026)
PHASE1, PHASE2 A Study of BG-75098 Alone and in Combination With Other Agents in Adults With Advanced Solid Tumors BeOne Medicines NA
RECRUITING
(Sep 1, 2026)
PHASE1 To Study the Effect of Inavolisib in Combination With Fulvestrant in Participants With Breast Cancer Hoffmann-La Roche NA
RECRUITING
(Sep 1, 2026)
PHASE2 A Phase II Study Evaluating the Efficacy and Safety of Inavolisib Plus Ribociclib Plus Fulvestrant Versus Placebo Plus Ribociclib Plus Fulvestrant in Participants With Advanced Breast Cancer Hoffmann-La Roche NA
RECRUITING
(Sep 1, 2026)
PHASE2 Study of IEV407 as Single Agent or in Combination in Patients With Advanced HR+/HER2- Breast Cancer Novartis Pharmaceuticals NA
RECRUITING
(Sep 1, 2026)
PHASE1 A Study Evaluating the Safety of Inavolisib and Fulvestrant With or Without Palbociclib in Participants With Advanced Breast Cancer (ABC) and Type 2 Diabetes Hoffmann-La Roche NA
NOT YET RECRUITING
(Sep 1, 2026)
PHASE2 A Phase 2 Bridging Study of Elacestrant Monotherapy in Advanced or Metastatic Breast Cancer Stemline Therapeutics, Inc. NA
RECRUITING
(Sep 1, 2026)
PHASE2 Alisertib With or Without Fulvestrant in Treating Patients With Locally Advanced or Metastatic, Endocrine-Resistant Breast Cancer Mayo Clinic NA
COMPLETED
(Aug 1, 2026)
PHASE2 Palbociclib After CDK and Endocrine Therapy (PACE) Dana-Farber Cancer Institute NA
ACTIVE NOT RECRUITING
(Aug 1, 2026)
PHASE2 Determinants of Resistance to Endocrine Therapy and a Cyclin-dependent Kinases 4 and 6 (CDK4/6) Inhibitor for HR+ MBC Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins NA
ACTIVE NOT RECRUITING
(Aug 1, 2026)
PHASE2 AKT Inhibitor, Ipatasertib, With Endocrine and CDK 4/6 Inhibitor for Patients With Metastatic Breast Cancer (TAKTIC) Massachusetts General Hospital NA
ACTIVE NOT RECRUITING
(Aug 1, 2026)
PHASE1 A Study to Investigate Efficacy and Safety With Oral AZD9833 Compared With Intramuscular Fulvestrant in Post-menopausal Women at Least 18 Years of Age With Advanced ER-positive HER2 Negative Breast Cancer AstraZeneca NA
ACTIVE NOT RECRUITING
(Aug 1, 2026)
PHASE2 Phase 2a Study of ZW25 in Combination With Palbociclib Plus Fulvestrant Jazz Pharmaceuticals NA
COMPLETED
(Aug 1, 2026)
PHASE2 Basket Study of Tucatinib and Trastuzumab in Solid Tumors With HER2 Alterations Seagen, a wholly owned subsidiary of Pfizer NA
ACTIVE NOT RECRUITING
(Aug 1, 2026)
PHASE2 Phase 1b/2 Study of TTI-101 in Combination for Patients With Metastatic Hormone Receptor-Positive and HER2-Negative Breast Cancer Tvardi Therapeutics, Incorporated NA
TERMINATED
(Aug 1, 2026)
PHASE1 Phase I Study of BEBT-209 in Women With Advanced Breast Cancer BeBetter Med Inc NA
COMPLETED
(Aug 1, 2026)
PHASE1 Study of ECI830 Single Agent or in Combination in Patients With Advanced HR+/HER2- Breast Cancer and in Patients With Other Advanced Solid Tumors Novartis Pharmaceuticals NA
RECRUITING
(Aug 1, 2026)
PHASE1, PHASE2 A Study With NKT5097 for Adults With Advanced/Metastatic Solid Tumors NiKang Therapeutics, Inc. NA
RECRUITING
(Aug 1, 2026)
PHASE1 A Phase 1 Study of ATV-1601 in Patients With Advanced Cancer That Have AKT1 E17K Mutations Atavistik Bio, Inc NA
ACTIVE NOT RECRUITING
(Aug 1, 2026)
PHASE1 JYP0035 Capsules Plus Fulvestrant in PIK3CA-Mutant HR+/HER2- Advanced Breast Cancer Chengdu JOYO pharma Co., Ltd. NA
NOT YET RECRUITING
(Aug 1, 2026)
PHASE3 A Study of LAE118 as Monotherapy and in Combination With Antitumor Agents in Advanced Solid Tumors Laekna Limited NA
NOT YET RECRUITING
(Aug 1, 2026)
PHASE1 Durvalumab, With Olaparib and Fulvestrant in Advanced ER+, HER2- Breast Cancer Patients. UNICANCER NA
ACTIVE NOT RECRUITING
(Jul 1, 2026)
PHASE2 DNA-guided Second Line Adjuvant Therapy for High Residual Risk, Estrogen Receptor Positive, HER-2 Negative Breast Cancer (DARE) Criterium, Inc. NA
ACTIVE NOT RECRUITING
(Jul 1, 2026)
PHASE2 Study of INCB123667 in Subjects With Advanced Solid Tumors Incyte Corporation NA
ACTIVE NOT RECRUITING
(Jul 1, 2026)
PHASE1 A Study of Lenvatinib, Pembrolizumab, and Fulvestrant in People With Breast Cancer Memorial Sloan Kettering Cancer Center NA
RECRUITING
(Jul 1, 2026)
PHASE1, PHASE2 First-in-Human Study of OKI-219 in Advanced Solid Tumors and Advanced Breast Cancer OnKure, Inc. NA
ACTIVE NOT RECRUITING
(Jul 1, 2026)
PHASE1 Futibatinib in Patients Previously Enrolled in an Antecedent Futibatinib as Monotherapy or Combination Therapy. Taiho Oncology, Inc. NA
ACTIVE NOT RECRUITING
(Jul 1, 2026)
PHASE2, PHASE3 A Trial of HRS-6209 in Combination With Fulvestrant, Letrozole, HRS-8080, or HRS-1358 in Breast Cancer Patients Jiangsu HengRui Medicine Co., Ltd. NA
RECRUITING
(Jul 1, 2026)
PHASE1, PHASE2 Study of 68Ga-R10602 Radionetics Oncology NA
COMPLETED
(Jul 1, 2026)
PHASE1 An Open-Label, Bayesian Adaptive Phase II Clinical Study in HR+/HER2- Advanced Breast Cancer After Progression on Standard Therapy Fudan University NA
RECRUITING
(Jul 1, 2026)
PHASE2 Study of GVV858 as a Single Agent or in Combination With Endocrine Therapy in Patients With HR+/HER2- Breast Cancer and Other Advanced Solid Tumors Novartis Pharmaceuticals NA
RECRUITING
(Jul 1, 2026)
PHASE1, PHASE2 Clinical Trial Evaluating the Biological Activity of a New Drug Identified as Prifetrastat (PF-07248144), Combined With Fulvestrant for the Treatment of Patients With Hormone Receptor Positive (HR+) and HER2 Negative (HER2-) Breast Cancer Extended to Other Organs. UNICANCER NA
NOT YET RECRUITING
(Jul 1, 2026)
PHASE2 Reversing InGuinal Hernia Trial: The Evaluation of Sex Hormones to Reverse Inguinal Hernias in Males Northwestern University NA
RECRUITING
(Jul 1, 2026)
PHASE1 T-DXd Based Therapy Followed by Endocrine Therapy Plus Dual HER2 Blockade in First-line HER2+/ HR+ Metastatic Breast Cancer and Retreatment With T-DXd Daiichi Sankyo NA
NOT YET RECRUITING
(Jul 1, 2026)
PHASE3 Culmerciclib in HR+/HER2+ Advanced Breast Cancer Sun Yat-sen University NA
RECRUITING
(Jul 1, 2026)
PHASE2 Palbociclib With Fulvestrant for Metastatic Breast Cancer After Treatment With Palbociclib and an Aromatase Inhibitor Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins NA
ACTIVE NOT RECRUITING
(Jun 1, 2026)
PHASE2 A Study of Investigational Drug CFI-402257 in Patients With Advanced Solid Tumors University Health Network, Toronto NA
COMPLETED
(Jun 1, 2026)
PHASE1 Cetuximab Plus Dalpicilib in Patients With HPV Negative, PD-1 Resistant R/M HNSCC Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University NA
COMPLETED
(Jun 1, 2026)
PHASE2 BGB-43395 Alone or as Part of Combination Therapies in Chinese Participants With HR+/HER2- Breast Cancer and Other Advanced Solid Tumors BeOne Medicines NA
COMPLETED
(Jun 1, 2026)
PHASE1 A Study to Examine the Safety of Different Doses of BG-68501 Given to Participants With Advanced-Stage Tumors BeiGene NA
ACTIVE NOT RECRUITING
(Jun 1, 2026)
PHASE1 Nab-Sirolimus and Endocrine Therapy in Recurrent Low Grade Serous Ovarian Cancer (NARETO) University of Oklahoma NA
ACTIVE NOT RECRUITING
(Jun 1, 2026)
PHASE2 Phase 1/2 Study of ETX-636 in Participants With Advanced Solid Tumors Ensem Therapeutics NA
RECRUITING
(Jun 1, 2026)
PHASE1, PHASE2 Study of ERW316 as a Single Agent or in Combination With Endocrine Therapy in Patients With HR+/HER2- Breast Cancer and Other Advanced Solid Tumors Novartis Pharmaceuticals NA
WITHDRAWN
(Jun 1, 2026)
PHASE1, PHASE2 A Phase II Clinical Study of the Efficacy and Safety of Culmerciclib Rechallenge in HR-positive, HER2-negative Breast Cancer Patients With Resistance to First-line Endocrine Therapy. Fudan University NA
RECRUITING
(Jun 1, 2026)
PHASE2 Efficacy and Safety of 500mg of Fulvestrant Beth Israel Deaconess Medical Center NA
ACTIVE NOT RECRUITING
(May 1, 2026)
PHASE2 Modular Study to Evaluate CT7001 Alone in Cancer Patients With Advanced Malignancies Carrick Therapeutics Limited NA
COMPLETED
(May 1, 2026)
PHASE1, PHASE2 PF-07104091 as a Single Agent and in Combination Therapy Pfizer NA
ACTIVE NOT RECRUITING
(May 1, 2026)
PHASE2 Liquid-biopsy Informed Platform Trial to Evaluate CDK4/6-inhibitor Resistant ER+/HER2- Metastatic Breast Cancer Canadian Cancer Trials Group NA
RECRUITING
(May 1, 2026)
PHASE2 Phase 3 Study of Gedatolisib as First-Line Treatment for Patients With HR-Positive, HER2-Negative Advanced Breast Cancer (VIKTORIA-2) Celcuity Inc NA
RECRUITING
(May 1, 2026)
PHASE3 A Study to Investigate the Safety, Pharmacokinetics, and Preliminary Efficacy of IDE574 Therapy in Adult Participants With Advanced Solid Tumors IDEAYA Biosciences NA
RECRUITING
(May 1, 2026)
PHASE1 Efficacy and Safety of Dalpiciclib Combined With Endocrine Adjuvant Therapy for Early HR +/HER2- Breast Cancer: a Multicenter, Prospective Clinical Study Fujian Cancer Hospital NA
RECRUITING
(May 1, 2026)
PHASE2 A Phase ll, Interventional, Single-arm Study Evaluating the Efficacy and Safety of Inavolisib Plus Ribociclib and Fulvestrant in Chinese Patients With PIK3CA-mutant, HR-positive, HER2-negative Locally Advanced or Metastatic Breast Cancer. Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University NA
NOT YET RECRUITING
(May 1, 2026)
PHASE2 A Phase II Study of Zongertinib Plus Fulvestrant in Participants With HR-positive/HER2-negative Advanced Breast Cancer Harboring HER2 Mutations. MedSIR NA
NOT YET RECRUITING
(May 1, 2026)
PHASE2 Palbociclib and Letrozole or Fulvestrant in Treating Patients With Estrogen Receptor Positive, HER2 Negative Metastatic Breast Cancer Alliance for Clinical Trials in Oncology NA
COMPLETED
(Apr 1, 2026)
PHASE2 Phase 1/1b/2 Study of Oral PMD-026 in Patients With Metastatic Breast Cancer Phoenix Molecular Designs NA
ACTIVE NOT RECRUITING
(Apr 1, 2026)
PHASE1, PHASE2 Study of PF-07248144 in Advanced or Metastatic Solid Tumors Pfizer NA
RECRUITING
(Apr 1, 2026)
PHASE2 A Study of TQB3616 Capsules Combined With Fulvestrant Injection in Subjects With Advanced Breast Cancer Chia Tai Tianqing Pharmaceutical Group Co., Ltd. NA
COMPLETED
(Apr 1, 2026)
PHASE2 TQB3616 Capsules Plus Fulvestrant Compared to Placebo Plus Fulvestrant in Previously Treated Breast Cancer in Clinical Trail Chia Tai Tianqing Pharmaceutical Group Co., Ltd. NA
COMPLETED
(Apr 1, 2026)
PHASE3 A Study to Evaluate the Safety and Tolerability of TOS-358 in Women With HR+ HER2- Breast Cancer Totus Medicines NA
RECRUITING
(Apr 1, 2026)
PHASE1 Evaluation of TQB3616 Capsules in a Phase II Clinical Trial for Recurrent/Metastatic Breast Cancer Chia Tai Tianqing Pharmaceutical Group Co., Ltd. NA
ACTIVE NOT RECRUITING
(Apr 1, 2026)
PHASE2 Artificial Intelligence and Machine Learning to Guide CDK4/6 Inhibitor Rechallenge in Breast Cancer. University of California, San Diego NA
RECRUITING
(Apr 1, 2026)
PHASE2 A Study of SH3765 Tablets in Combination With Fulvestrant in Patients With HR+/HER2- Advanced Breast Cancer. Nanjing Sanhome Pharmaceutical, Co., Ltd. NA
ACTIVE NOT RECRUITING
(Apr 1, 2026)
PHASE1 Sapanisertib and Serabelisib (PIKTOR) in Various Combinations in Patients With HR+/HER2- Advanced/Metastatic Breast Cancer Faeth Therapeutics NA
RECRUITING
(Apr 1, 2026)
PHASE1, PHASE2 Ipatasertib + Pertuzumab +Trastuzumab in Advanced HER2+ PI3KCA-mutant Breast Cancer Patients SOLTI Breast Cancer Research Group NA
COMPLETED
(Mar 1, 2026)
PHASE1 Phase II Study of Tazemetostat in Solid Tumors Harboring an ARID1A Mutation Prisma Health-Upstate NA
TERMINATED
(Mar 1, 2026)
PHASE2 A Study of HRS-6208 in Combination With HRS-8080, or Fulvestrant, or Letrozole, With or Without HRS-6209 in Patients With Advanced Unresectable or Metastatic Breast Cancer Shandong Suncadia Medicine Co., Ltd. NA
RECRUITING
(Mar 1, 2026)
PHASE1, PHASE2 Phase I Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of HLX97 (a KAT6A/B Inhibitor) in Patients With Advanced/Metastatic Solid Tumor Shanghai Henlius Biotech NA
NOT YET RECRUITING
(Mar 1, 2026)
PHASE1