Entacapone Patent Expiration

Entacapone is Used for treating Parkinson's disease. It was first introduced by Orion Pharma in its drug Comtan on Oct 19, 1999. 9 different companies have introduced drugs containing Entacapone.


Entacapone Patents

Given below is the list of patents protecting Entacapone, along with the drug name that holds that patent and the company name owning that drug.

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Drug Used in Drug Patent Number Drug Patent Title Drug Patent Expiry Drug Owner
Comtan US6599530 Oral compacted composition comprising catechol derivatives Sep 14, 2018

(Expired)

Orion Pharma
Comtan US5446194 Pharmacologically active catechol derivatives Oct 19, 2013

(Expired)

Orion Pharma



Entacapone's Family Patents

Family Patents

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Clinical Trials

Recent Clinical Trials on Entacapone:

Sometimes companies keep conducting clinical trials even after the drug's approval to discover new formulations, methods of use, or new treatment indications, so they could file for additional patents or receive regulatory exclusivity extensions, such as pediatric exclusivity, potentially delaying generic competition. Based on these recent clinical trials, generic companies need to consider the potential for new intellectual property or regulatory hurdles. These strategic moves by the drug owner might delay generic substitution or lead to additional sales of the brand drug, even after patent expiry.

Title Lead Sponsor Collaborators Status Phases
Clinical Trials
Entacapone Plus Bevacizumab for Glioblastoma at First Recurrence First Affiliated Hospital of Wenzhou Medical University NA NOT YET RECRUITING
(Sep 1, 2026)
PHASE1, PHASE2


Entacapone Generic API Manufacturers

Several generic applications have been filed for Entacapone. The first generic version for Entacapone was by Sun Pharmaceutical Industries Ltd and was approved on Jul 16, 2012. And the latest generic version is by Alembic Pharmaceuticals Ltd and was approved on Jan 4, 2022.

Given below is the list of companies who have filed for Entacapone generic, along with the locations of their manufacturing plants worldwide.