Encorafenib Patent Expiration

Encorafenib is Used for treating metastatic non-small cell lung cancer, metastatic colorectal cancer, and melanoma with BRAF mutations. It was first introduced by Array Biopharma Inc in its drug Braftovi on Jun 27, 2018.


Encorafenib Patents

Given below is the list of patents protecting Encorafenib, along with the drug name that holds that patent and the company name owning that drug.

Filter patents by

NEW
Drug Used in Drug Patent Number Drug Patent Title Drug Patent Expiry Drug Owner
Braftovi US9474754 Pharmaceutical combinations comprising a B-RAF inhibitor, and EGFR inhibitor and optionally a PI3K-α inhibitor Aug 05, 2033 Array Biopharma Inc
Braftovi US10258622 Method of treating colorectal cancer by administration of pharmaceutical formulations of (S)-methyl (1-((4-(3-(5-chloro-2-fluoro-3-(methylsulfonamido)pheny1)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-yl)amino)propan-2-yl) carbamate Nov 21, 2032 Array Biopharma Inc
Braftovi US9387208 Pharmaceutical formulations of (S)-methyl (1-((4-(3-(5-chloro-2-fluoro-3-(methylsulfonamido)phenyl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-yl)amino)propan-2-yl)carbamate Nov 21, 2032 Array Biopharma Inc
Braftovi US9763941 Method of treating melanoma by administration of pharmaceutical formulations of (S)-methyl (1-((4-(3-(5-chloro-2-fluoro-3-(methylsulfonamido)phenyl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-yl)amino)propan-2-yl)carbamate Nov 21, 2032 Array Biopharma Inc
Braftovi US9314464 Compounds and compositions as protein kinase inhibitors Jul 04, 2031 Array Biopharma Inc
Braftovi US8501758 Compounds and compositions as protein kinase inhibitors Mar 04, 2031 Array Biopharma Inc
Braftovi US10005761 Compounds and compositions as protein kinase inhibitors Aug 27, 2030 Array Biopharma Inc
Braftovi US8501758 Compounds and compositions as protein kinase inhibitors Aug 27, 2030 Array Biopharma Inc
Braftovi US9593099 Compounds and compositions as protein kinase inhibitors Aug 27, 2030 Array Biopharma Inc
Braftovi US9593100 Compounds and compositions as protein kinase inhibitors Aug 27, 2030 Array Biopharma Inc
Braftovi US9850229 Compounds and compositions as protein kinase inhibitors Aug 27, 2030 Array Biopharma Inc
Braftovi US9850230 Compounds and compositions as protein kinase inhibitors Aug 27, 2030 Array Biopharma Inc
Braftovi USRE49556 Compounds and compositions as protein kinase inhibitors Feb 27, 2030 Array Biopharma Inc
Braftovi US8541575 3,4-diarylpyrazoles as protein kinase inhibitors Feb 26, 2030 Array Biopharma Inc
Braftovi US8946250 3,4-diarylpyrazoles as protein kinase inhibitors Jul 23, 2029 Array Biopharma Inc



Encorafenib's Family Patents

Family Patents

Explore Our Curated Drug Screens

Drugs Generating Over $1 Billion in Annual Revenue
Explore the top-performing drugs that dominate the pharmaceutical industry
View List
NCE-1 Patent Expiry in the Next 1 Year
Identify opportunities as new chemical entity (NCE-1) patents approach expiry
View List
Recently Granted Patents in EP
Find the opportunity to file Oppositions
View List



Clinical Trials

Recent Clinical Trials on Encorafenib:

Sometimes companies keep conducting clinical trials even after the drug's approval to discover new formulations, methods of use, or new treatment indications, so they could file for additional patents or receive regulatory exclusivity extensions, such as pediatric exclusivity, potentially delaying generic competition. Based on these recent clinical trials, generic companies need to consider the potential for new intellectual property or regulatory hurdles. These strategic moves by the drug owner might delay generic substitution or lead to additional sales of the brand drug, even after patent expiry.

Title Lead Sponsor Collaborators Status Phases
Clinical Trials
Open-label Phase 1b Study of Ulixertinib and Cetuximab or Ulixertinib in Combination With Cetuximab and Encorafenib in Patients With Unresectable or Metastatic Colorectal Cancer Who Have Previously Received EGFR or BRAF-directed Therapy M.D. Anderson Cancer Center NA RECRUITING
(Sep 1, 2026)
PHASE1
Testing the Addition of Anti-cancer Drug, ZEN003694, to the Usual Chemotherapy Treatment, Cetuximab Plus Encorafenib, for Colorectal Cancer National Cancer Institute (NCI) NA RECRUITING
(Sep 1, 2026)
PHASE1
Phase II Study of ctDNA-guided Encorafenib Plus Cetuximab Retreatment in Patients BRAF V600E Mutated mCRC Gruppo Oncologico del Nord-Ovest NA ACTIVE NOT RECRUITING
(Sep 1, 2026)
PHASE2
A Study of Encorafenib Plus Cetuximab Taken Together With Pembrolizumab Compared to Pembrolizumab Alone in People With Previously Untreated Metastatic Colorectal Cancer Pfizer NA ACTIVE NOT RECRUITING
(Jul 1, 2026)
PHASE2
Efficacy and Safety of Tunlametinib Combination Therapy in the Treatment of Second-line and Above Metastatic Colorectal Cancer Sun Yat-sen University NA NOT YET RECRUITING
(Jul 1, 2026)
PHASE2
Encorafenib, Cetuximab, and Nivolumab in Treating Patients With Microsatellite Stable, BRAFV600E Mutated Unresectable or Metastatic Colorectal Cancer M.D. Anderson Cancer Center NA ACTIVE NOT RECRUITING
(Jun 1, 2026)
PHASE1, PHASE2
Testing the Addition of Nivolumab to Standard Treatment for Patients With Metastatic or Unresectable Colorectal Cancer That Have a BRAF Mutation National Cancer Institute (NCI) NA ACTIVE NOT RECRUITING
(Jun 1, 2026)
PHASE2
Hydroxychloroquine in Combination With Encorafenib and Cetuximab or Panitumumab in the Treatment of Metastatic BRAF-mutated Colorectal Cancer Refractory Northwestern University NA TERMINATED
(Jun 1, 2026)
PHASE2
A Single-Arm, Phase II, Multicenter Clinical Study of Neoadjuvant Encorafenib Plus Cetuximab N01 and mFOLFOX6 in Patients With Locally Advanced BRAF V600E-Mutant Colorectal Cancer With or Without Resectable Metastases Zhejiang University NA RECRUITING
(Jun 1, 2026)
PHASE2
A Study of ERAS-007 in Patients With Advanced Gastrointestinal Malignancies Erasca, Inc. NA COMPLETED
(Mar 1, 2026)
PHASE1, PHASE2


Encorafenib Generic API Manufacturers

Given below is the list of companies who have filed for Encorafenib generic, along with the locations of their manufacturing plants worldwide.