Dihydroergotamine Mesylate Patent Expiration

Dihydroergotamine Mesylate is used for acute treatment of migraine with or without aura. It was first introduced by Bausch Health Us Llc in its drug D.H.E. 45 on Approved Prior to Jan 1, 1982. Other drugs containing Dihydroergotamine Mesylate are Atzumi, Brekiya (Autoinjector), Migranal, Trudhesa. 14 different companies have introduced drugs containing Dihydroergotamine Mesylate.


Dihydroergotamine Mesylate Patents

Given below is the list of patents protecting Dihydroergotamine Mesylate, along with the drug name that holds that patent and the company name owning that drug.

Drug Used in Drug Patent Number Drug Patent Title Drug Patent Expiry Drug Owner
Atzumi US11744967 Intranasal delivery devices Oct 12, 2041 Satsuma Pharms
Atzumi US12102754 Intranasal delivery devices Oct 12, 2041 Satsuma Pharms
Atzumi US10758532 Compositions, devices, and methods for treating or preventing headaches Dec 11, 2039 Satsuma Pharms
Atzumi US12263162 Compositions, devices, and methods for treating or preventing headaches Dec 11, 2039 Satsuma Pharms
Brekiya (autoinjector) US10532049 Parenteral unit dosage form of dihydroergotamine Feb 26, 2039 Amneal
Brekiya (autoinjector) US11304942 Parenteral unit dosage form of dihydroergotamine Feb 26, 2039 Amneal
Brekiya (autoinjector) US11819501 Parenteral unit dosage form of dihydroergotamine Feb 26, 2039 Amneal
Trudhesa US11185497 Intranasal delivery of dihydroergotamine by precision olfactory device Jan 04, 2039 Impel Pharms
Atzumi US10792253 Pharmaceutical compositions Aug 04, 2037 Satsuma Pharms
Atzumi US11872314 Pharmaceutical compositions Aug 04, 2037 Satsuma Pharms
Trudhesa US11266799 In-line nasal delivery device Nov 05, 2036 Impel Pharms
Trudhesa US9919117 Nozzles for nasal drug delivery Mar 17, 2033 Impel Pharms
Trudhesa US10940278 Nozzles for nasal drug delivery Jan 23, 2033 Impel Pharms
Trudhesa US10507295 Nasal drug delivery device Dec 25, 2032 Impel Pharms
Trudhesa US9550036 Nasal drug delivery device Sep 05, 2032 Impel Pharms



A patent's expiry date may change depending upon legal activities going on that patent. Critical activities like abandoning of a patent, term extension of a patent or amendment of its claims can increase or decrease the life of a patent hence affecting its expiry date and in turn affecting the generic launch date of that drug. Tracking these ongoing activities on a patent application helps to keep an eye on the latest developments in the patent process of the drug which can give an idea of how early a drug's generic could be available. The next section provides a list of recent legal activities on Dihydroergotamine Mesylate's patents.

Given below is the list recent legal activities going on the following patents of Dihydroergotamine Mesylate.

Activity Date Patent Number
Patent litigations
Payment of Maintenance Fee, 8th Yr, Small Entity 11 Jul, 2024 US9550036
Payment of Maintenance Fee, 4th Yr, Small Entity 11 Jul, 2024 US10940278
Change in Power of Attorney (May Include Associate POA) 02 Apr, 2024 US11185497
Email Notification 02 Apr, 2024 US11185497
Change in Power of Attorney (May Include Associate POA) 01 Apr, 2024 US9550036
Email Notification 01 Apr, 2024 US9550036
Email Notification 29 Mar, 2024 US10940278
Change in Power of Attorney (May Include Associate POA) 29 Mar, 2024 US10940278
Email Notification 28 Mar, 2024 US11266799
Change in Power of Attorney (May Include Associate POA) 28 Mar, 2024 US11266799


Dihydroergotamine Mesylate's Family Patents

Family Patents

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Dihydroergotamine Mesylate Generic API Manufacturers

Several generic applications have been filed for Dihydroergotamine Mesylate. The first generic version for Dihydroergotamine Mesylate was by Padagis Us Llc and was approved on Apr 28, 2003. And the latest generic version is by Aggrega Pharma Llc and was approved on Feb 26, 2025.

Given below is the list of companies who have filed for Dihydroergotamine Mesylate generic, along with the locations of their manufacturing plants worldwide.