Celecoxib Patent Expiration

Celecoxib is Used for reducing inflammation and treating various types of arthritis. It was first introduced by Upjohn Us 2 Llc in its drug Celebrex on Dec 31, 1998. Other drugs containing Celecoxib are Elyxyb, Vyscoxa. 29 different companies have introduced drugs containing Celecoxib.


Celecoxib Patents

Given below is the list of patents protecting Celecoxib, along with the drug name that holds that patent and the company name owning that drug.

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Drug Used in Drug Patent Number Drug Patent Title Drug Patent Expiry Drug Owner
Vyscoxa US12678405 Sep 17, 2045 Carwin Pharm Assoc
Elyxyb US10376527 Oral composition of celecoxib for treatment of pain May 27, 2036 Scilex Pharms
Elyxyb US10722456 Oral composition of celecoxib for treatment of pain May 27, 2036 Scilex Pharms
Elyxyb US10799517 Oral composition of celecoxib for treatment of pain May 27, 2036 Scilex Pharms
Elyxyb US9572819 Oral composition of celecoxib for treatment of pain May 27, 2036 Scilex Pharms
Elyxyb US9795620 Oral composition of celecoxib for treatment of pain May 27, 2036 Scilex Pharms
Elyxyb US9949990 Oral composition of celecoxib for treatment of pain May 27, 2036 Scilex Pharms
Celebrex US5760068

(Pediatric)

Substituted pyrazolyl benzenesulfonamides for the treatment of inflammation Dec 02, 2015

(Expired)

Upjohn
Celebrex USRE44048

(Pediatric)

4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-YL]benzenesulfonamide for the treatment of inflammation or an inflammation-associated disorder Dec 02, 2015

(Expired)

Upjohn
Celebrex US5760068 Substituted pyrazolyl benzenesulfonamides for the treatment of inflammation Jun 02, 2015

(Expired)

Upjohn
Celebrex USRE44048 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-YL]benzenesulfonamide for the treatment of inflammation or an inflammation-associated disorder Jun 02, 2015

(Expired)

Upjohn
Celebrex US5466823

(Pediatric)

Substituted pyrazolyl benzenesulfonamides May 30, 2014

(Expired)

Upjohn
Celebrex US5563165

(Pediatric)

Substituted pyrazolyl benzenesulfonamides for the treatment of inflammation May 30, 2014

(Expired)

Upjohn
Celebrex US5466823 Substituted pyrazolyl benzenesulfonamides Nov 30, 2013

(Expired)

Upjohn
Celebrex US5563165 Substituted pyrazolyl benzenesulfonamides for the treatment of inflammation Nov 30, 2013

(Expired)

Upjohn



Celecoxib's Family Patents

Family Patents

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Clinical Trials

Recent Clinical Trials on Celecoxib:

Sometimes companies keep conducting clinical trials even after the drug's approval to discover new formulations, methods of use, or new treatment indications, so they could file for additional patents or receive regulatory exclusivity extensions, such as pediatric exclusivity, potentially delaying generic competition. Based on these recent clinical trials, generic companies need to consider the potential for new intellectual property or regulatory hurdles. These strategic moves by the drug owner might delay generic substitution or lead to additional sales of the brand drug, even after patent expiry.

Title Lead Sponsor Collaborators Status Phases
Clinical Trials
Antiangiogenic Therapy for Children With Recurrent Medulloblastoma, Ependymoma, ATRT and Rare CNS Tumors Medical University of Vienna NA RECRUITING
(Sep 1, 2026)
PHASE2
Treating Immuno-metabolic Depression With Anti-inflammatory Drugs Amsterdam UMC, location VUmc NA COMPLETED
(Sep 1, 2026)
PHASE3
A Phase Ib Study to Evaluate the Efficacy and Safety of HRS-2129 in Patients With Knee Osteoarthritis Shandong Suncadia Medicine Co., Ltd. NA COMPLETED
(Sep 1, 2026)
PHASE1
Ivosidenib Plus mFOLFOXIRI and Celecoxib for BRAF-targeted Therapy-refractory BRAF V600E-mutant Colorectal Cancer Patients Sun Yat-sen University NA RECRUITING
(Sep 1, 2026)
PHASE2
A Trial in Healthy Participants to Assess Drug Interaction Potential of BGB-43395 BeOne Medicines NA NOT YET RECRUITING
(Sep 1, 2026)
PHASE1
PET Imaging of Cyclooxygenase in Participants With Major Depressive Disorder (MDD) National Institute of Mental Health (NIMH) NA RECRUITING
(Aug 14, 2026)
PHASE1
Rintatolimod, Celecoxib and Interferon Alpha 2b With Pembrolizumab For the Treatment of Patients With Metastatic or Unresectable Triple Negative Breast Cancer Roswell Park Cancer Institute NA TERMINATED
(Aug 1, 2026)
PHASE1, PHASE2
Intensive Locoregional Chemoimmunotherapy for Recurrent Ovarian Cancer Plus Intranodal DC Vaccines Roswell Park Cancer Institute NA WITHDRAWN
(Jul 1, 2026)
PHASE1, PHASE2
Evaluation of Superiority of Valsartan+Celecoxib+Metformin Over Metformin Alone in Type 2 Diabetes Patients ARKAY Therapeutics NA WITHDRAWN
(Jul 1, 2026)
PHASE1, PHASE2
Celecoxib for ENT Pain Management University of Wisconsin, Madison NA RECRUITING
(Jul 1, 2026)
PHASE2
TriGlytza®-01 Versus Metformin in Overweight and Obese Adults With Type 2 Diabetes and Inadequate Glycaemic Control Despite Metformin Therapy Myopharm Limited NA NOT YET RECRUITING
(Jul 1, 2026)
PHASE2
Celecoxib Plus R-CHOP vs R-CHOP in Newly Diagnosed Advanced CD5+ DLBCL Sun Yat-sen University NA RECRUITING
(Jul 1, 2026)
PHASE2
Celecoxib With Chemotherapy in Localized, Muscle-Invasive Bladder Cancer Baylor College of Medicine NA COMPLETED
(Jun 1, 2026)
PHASE1
Safety of F14 Following Total Knee Replacement Arthritis Innovation Corporation NA SUSPENDED
(Jun 1, 2026)
PHASE2, PHASE3
A Multicenter, Prospective, Randomized, Open-label Phase Ib/II Study of Celecoxib Plus Pembrolizumab and Gemcitabine/Cisplatin Versus Pembrolizumab and Gemcitabine/Cisplatin in Patients With CK5/6-High Unresectable Locally Advanced or Metastatic Intrahepatic Cholangiocarcinoma Shanghai 6th People's Hospital NA NOT YET RECRUITING
(Jun 1, 2026)
PHASE1, PHASE2
Intensive Locoregional Chemoimmunotherapy, Intradermal Autologous Alpha-DC1 Vaccines, and Systemic Pembrolizumab for Advanced-Stage Ovarian Cancer Kalinski, Pawel, MD, PhD NA NOT YET RECRUITING
(Jun 1, 2026)
PHASE2
Efficacy of Intravenous Dexamethasone in Prolonging the Duration of Spinal Anesthesia With Chloroprocaine in Knee Arthroscopy CMC Ambroise Paré NA NOT YET RECRUITING
(Jun 1, 2026)
PHASE3
Toripalimab Plus Celecoxib for dMMR/MSI-H Locally Advanced Colorectal Cancer Sun Yat-sen University NA RECRUITING
(May 1, 2026)
PHASE2
Methotrexate, Erlotinib, and Celecoxib for the Treatment of Recurrent/Metastatic Head and Neck Cancer in a Rural Midwest United States Population Mayo Clinic NA RECRUITING
(May 1, 2026)
PHASE2
Safety and Efficacy of Allogeneic Bone Marrow MSCs in Ankylosing Spondylitis Eighth Affiliated Hospital, Sun Yat-sen University NA NOT YET RECRUITING
(May 1, 2026)
PHASE1
Efficacy & Safety of rAd-IFN Administered With Celecoxib & Gemcitabine in Patients With Malignant Pleural Mesothelioma Ferring Ventures Limited NA COMPLETED
(Apr 1, 2026)
PHASE3
A Phase 2, Randomized, Prospective Double-Blind, Single-Center, Placebo-controlled Study to Evaluate Safety, Tolerability, Target Engagement, and Efficacy of PrimeC in Patients With Mild to Moderate Alzheimer's Disease. NeuroSense Therapeutics Ltd. NA TERMINATED
(Apr 1, 2026)
PHASE2
Efficacy and Safety of TRD205 Tablets for Postoperative Analgesia in Unilateral Total Hip Arthroplasty (Phase IIb) Beijing Tide Pharmaceutical Co., Ltd NA RECRUITING
(Apr 1, 2026)
PHASE2
Efficacy of Selective COX-2 Inhibitors in Relieving Orthodontic Pain Sharif Medical Research Center NA ACTIVE NOT RECRUITING
(Apr 1, 2026)
PHASE1
Metformin Safety and Efficacy in Osteoarthritis. Mostafa Bahaa NA RECRUITING
(Mar 1, 2026)
PHASE3
Study to Assess the Safety and Pharmacokinetics of AVD275 Injection in Patients With Osteoarthritis of the Knee Avidence Therapeutics NA RECRUITING
(Mar 1, 2026)
PHASE1


Celecoxib Generic API Manufacturers

Several generic applications have been filed for Celecoxib. The first generic version for Celecoxib was by Teva Pharmaceuticals Usa Inc and was approved on May 30, 2014. And the latest generic version is by Zydus Pharmaceuticals Usa Inc and was approved on Jul 14, 2025.

Given below is the list of companies who have filed for Celecoxib generic, along with the locations of their manufacturing plants worldwide.


Celecoxib News

Patent Extensions Result in $3.5 Billion Loss in Potential Generic Savings for the US

22 Aug, 2025

NeuroSense Therapeutics is nearing a significant pharmaceutical agreement with its ALS treatment...

24 Apr, 2025

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