Carfilzomib Patent Expiration

Carfilzomib is Used for treating relapsed or refractory multiple myeloma in patients who have received one to three lines of therapy. It was first introduced by Onyx Pharmaceuticals Inc A Wholly Owned Sub Of Amgen Inc in its drug Kyprolis on Jul 20, 2012. 5 different companies have introduced drugs containing Carfilzomib.


Carfilzomib Patents

Given below is the list of patents protecting Carfilzomib, along with the drug name that holds that patent and the company name owning that drug.

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Drug Used in Drug Patent Number Drug Patent Title Drug Patent Expiry Drug Owner
Kyprolis US12636340

(Pediatric)

Methods Of Treating Multiple Myeloma Oct 29, 2041 Onyx Pharms Amgen
Kyprolis US12636340 Methods Of Treating Multiple Myeloma Apr 29, 2041 Onyx Pharms Amgen
Kyprolis US9493582

(Pediatric)

Alkylated cyclodextrin compositions and processes for preparing and using the same Aug 27, 2033 Onyx Pharms Amgen
Kyprolis US9493582 Alkylated cyclodextrin compositions and processes for preparing and using the same Feb 27, 2033 Onyx Pharms Amgen
Kyprolis USRE47954

(Pediatric)

Combination therapy with peptide epoxyketones Apr 21, 2030 Onyx Pharms Amgen
Kyprolis US9511109 Combination therapy with peptide epoxyketones Oct 21, 2029 Onyx Pharms Amgen
Kyprolis USRE47954 Combination therapy with peptide epoxyketones Oct 21, 2029 Onyx Pharms Amgen
Kyprolis US7737112

(Pediatric)

Composition for enzyme inhibition Jun 07, 2028 Onyx Pharms Amgen
Kyprolis US7737112 Composition for enzyme inhibition Dec 07, 2027 Onyx Pharms Amgen
Kyprolis US7417042

(Pediatric)

Compounds for enzyme inhibition Jan 20, 2027 Onyx Pharms Amgen
Kyprolis US7417042 Compounds for enzyme inhibition Jul 20, 2026

(Expired)

Onyx Pharms Amgen
Kyprolis US7232818 Compounds for enzyme inhibition Apr 14, 2025

(Expired)

Onyx Pharms Amgen
Kyprolis US7491704 Compounds for enzyme inhibition Apr 14, 2025

(Expired)

Onyx Pharms Amgen
Kyprolis US8129346 Compounds for enzyme inhibition Apr 14, 2025

(Expired)

Onyx Pharms Amgen
Kyprolis US8207125 Compounds for enzyme inhibition Apr 14, 2025

(Expired)

Onyx Pharms Amgen
Kyprolis US8207126 Compounds for enzyme inhibition Apr 14, 2025

(Expired)

Onyx Pharms Amgen
Kyprolis US8207127 Compounds for enzyme inhibition Apr 14, 2025

(Expired)

Onyx Pharms Amgen
Kyprolis US8207297 Compounds for enzyme inhibition Apr 14, 2025

(Expired)

Onyx Pharms Amgen



Carfilzomib's Family Patents

Family Patents

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Clinical Trials

Recent Clinical Trials on Carfilzomib:

Sometimes companies keep conducting clinical trials even after the drug's approval to discover new formulations, methods of use, or new treatment indications, so they could file for additional patents or receive regulatory exclusivity extensions, such as pediatric exclusivity, potentially delaying generic competition. Based on these recent clinical trials, generic companies need to consider the potential for new intellectual property or regulatory hurdles. These strategic moves by the drug owner might delay generic substitution or lead to additional sales of the brand drug, even after patent expiry.

Title Lead Sponsor Collaborators Status Phases
Clinical Trials
Subcutaneous Daratumumab, Once Weekly Carfilzomib, and Dexamethasone (DKd) in Patients With High-Risk Smoldering Multiple Myeloma National Cancer Institute (NCI) NA ACTIVE NOT RECRUITING
(Sep 16, 2026)
PHASE2
Carfilzomib Based Chemotherapy Mobilization for Autologous Stem Cell Transplants in Multiple Myeloma Hackensack Meridian Health NA RECRUITING
(Sep 1, 2026)
PHASE1
A Trial That Compare Two Treatments in Newly Diagnosed Myeloma Patients Not Eligible for Transplant Fondazione EMN Italy Onlus NA ACTIVE NOT RECRUITING
(Sep 1, 2026)
PHASE3
A Study of Selinexor, in Combination With Carfilzomib, Daratumumab or Pomalidomide in Patients With Multiple Myeloma Hackensack Meridian Health NA RECRUITING
(Sep 1, 2026)
PHASE2
Isatuximab, Carfilzomib, Pomalidomide, and Dexamethasone for the Treatment of Relapsed or Refractory Multiple Myeloma University of Washington NA ACTIVE NOT RECRUITING
(Sep 1, 2026)
PHASE2
A Trial for Relapsed Multiple Myeloma Patients (Isatuximab-dexamethasone) EMN Trial Office S.r.l. Impresa Sociale NA ACTIVE NOT RECRUITING
(Sep 1, 2026)
PHASE2
A Phase 1b/2 Study of Sonrotoclax (BGB-11417) as Monotherapy and in Various Combinations With Dexamethasone Plus Carfilzomib, Dexamethasone Plus Daratumumab, and Dexamethasone Plus Pomalidomide in Multiple Myeloma BeOne Medicines NA RECRUITING
(Sep 1, 2026)
PHASE1, PHASE2
A Study to Evaluate Mezigdomide in Combination With Carfilzomib and Dexamethasone (MeziKD) Versus Carfilzomib and Dexamethasone (Kd) in Participants With Relapsed or Refractory Multiple Myeloma (SUCCESSOR-2) Bristol-Myers Squibb NA ACTIVE NOT RECRUITING
(Sep 1, 2026)
PHASE3
Study of Belantamab Mafodotin With Carfilzomib, Pomalidomide, and Dexamethasone in Relapsed Multiple Myeloma University of Chicago NA RECRUITING
(Sep 1, 2026)
PHASE2
Testing the Investigational Medication Combination of Daratumumab and Teclistamab Compared to the Usual Treatment (Daratumumab, Pomalidomide, Dexamethasone or Daratumumab, Carfilzomib, Dexamethasone) for Patients With High-risk Multiple Myeloma Refractory or in First Relapse National Cancer Institute (NCI) NA RECRUITING
(Sep 1, 2026)
PHASE2
A Study to Compare Linvoseltamab Monotherapy and Linvoseltamab + Carfilzomib Combination Therapy With Standard-of-Care Combination Regimens in Adult Participants With Relapsed/Refractory Multiple Myeloma (RRMM) Regeneron Pharmaceuticals NA RECRUITING
(Sep 1, 2026)
PHASE3
Cevostamab in Combination With Pomalidomide and Dexamethasone Versus Standard of Care in Participants With Previously Treated Multiple Myeloma Hoffmann-La Roche NA RECRUITING
(Sep 1, 2026)
PHASE3
Hepatic Artery Infusion of Carfilzomib in Participants With Liver Metastatic Disease Previously Treated With Hepatic Artery Infusion Pump Therapy National Cancer Institute (NCI) NA NOT YET RECRUITING
(Aug 26, 2026)
PHASE1
Selinexor, Daratumumab, Carfilzomib and Dexamethasone for the Treatment of High-Risk, Recurrent or Refractory Multiple Myeloma Academic and Community Cancer Research United NA ACTIVE NOT RECRUITING
(Aug 1, 2026)
PHASE2
A Study of Talquetamab With Other Anticancer Therapies in Participants With Multiple Myeloma Janssen Research & Development, LLC NA ACTIVE NOT RECRUITING
(Aug 1, 2026)
PHASE1
A Study of Daratumumab Janssen Research & Development, LLC NA ACTIVE NOT RECRUITING
(Aug 1, 2026)
PHASE3
A Study of an MMSET Inhibitor in Patients With Relapsed and Refractory Multiple Myeloma K36 Therapeutics, Inc. NA RECRUITING
(Aug 1, 2026)
PHASE1
A Clinical Trial of Four Medicines (Elranatamab Plus Carfilzomib and Dexamethasone or Maplirpacept) in People With Relapsed Refractory Multiple Myeloma Pfizer NA ACTIVE NOT RECRUITING
(Aug 1, 2026)
PHASE1
SX-682 in Combination With Carfilzomib, Daratumumab-Hyaluronidase, and Dexamethasone in Patients With Relapsed or Refractory Multiple Myeloma Roswell Park Cancer Institute NA RECRUITING
(Aug 1, 2026)
PHASE1
Mezigdomide, Carfilzomib, and Dexamethasone for the Treatment of Relapsed or Refractory Multiple Myeloma in Patients With Extramedullary Disease Roswell Park Cancer Institute NA RECRUITING
(Aug 1, 2026)
PHASE2
Treatment of Antibody-Mediated Rejection (ABMR) With CarBel National Institute of Allergy and Infectious Diseases (NIAID) NA RECRUITING
(Aug 1, 2026)
PHASE1
A Phase 1 Clinical Trial of Siltuximab for the Treatment of Antibody-Mediated Rejection After Lung Transplantation Washington University School of Medicine NA RECRUITING
(Aug 1, 2026)
PHASE1
Testing the Investigational Medication Combination of Teclistamab and Pomalidomide Compared to the Usual Treatment (Carfilzomib, Pomalidomide, and Dexamethasone) for Patients With Multiple Myeloma Who Have Relapsed Shortly After Treatment National Cancer Institute (NCI) NA RECRUITING
(Aug 1, 2026)
PHASE1, PHASE2
Study of Selinexor With Carfilzomib, Isatuximab and Dexamethasone for Patients With Relapsed and/or Refractory Multiple Myeloma Natalie Callander NA RECRUITING
(Aug 1, 2026)
PHASE1, PHASE2
Testing an Experimental Approach to Treat Patients With Plasma Cell Leukemia, The QUANTUM Trial National Cancer Institute (NCI) NA RECRUITING
(Aug 1, 2026)
PHASE2
Inobrodib, Pomalidomide and Dexamethasone Versus Standard Available Therapy in Relapsed or Refractory Multiple Myeloma CellCentric Ltd. NA RECRUITING
(Aug 1, 2026)
PHASE3
CB-839 HCl in Combination With Carfilzomib and Dexamethasone in Treating Patients With Recurrent or Refractory Multiple Myeloma National Cancer Institute (NCI) NA ACTIVE NOT RECRUITING
(Jul 1, 2026)
PHASE1
Isa-KRd vs KRd in Newly Diagnosed Multiple Myeloma Patients Eligible for Autologous Stem Cell Transplantation (IsKia TRIAL) European Myeloma Network B.V. NA ACTIVE NOT RECRUITING
(Jul 1, 2026)
PHASE3
Study of Carfilzomib, Lenalidomide, Dexamethasone and Belantamab Mafodotin in Multiple Myeloma Wake Forest University Health Sciences NA ACTIVE NOT RECRUITING
(Jul 1, 2026)
PHASE1, PHASE2
Carfilzomib, Iberdomide (CC-220) and Dexamethasone (KID) in Transplant Eligible Multiple Myeloma Hackensack Meridian Health NA SUSPENDED
(Jul 1, 2026)
PHASE1, PHASE2
A Study to Evaluate Adverse Events and Change in Disease Activity With Injected Etentamig Plus Oral Pomalidomide Versus Standard Therapies in Adults With Relapsed or Refractory Multiple Myeloma AbbVie NA NOT YET RECRUITING
(Jul 1, 2026)
PHASE3
A Study of Carfilzomib, Lenalidomide, Dexamethasone and Daratumumab for Patients With Relapsed/Refractory Myeloma With Salvage Autologous Hematopoietic Cell Transplantation Memorial Sloan Kettering Cancer Center NA ACTIVE NOT RECRUITING
(Jun 1, 2026)
PHASE2
Daratumumab, Carfilzomib, Pomalidomide, Dexamethasone In MM Andrew Yee, MD NA ACTIVE NOT RECRUITING
(Jun 1, 2026)
PHASE2
A Study to Assess Change in Disease Activity and Adverse Events (AE)s in Adult Participants With Multiple Myeloma Receiving T Cell Engaging Bi/Tri-specific Antibodies Intravenously (IV)/Subcutaneously (SC) Alone or in Combinations AbbVie NA RECRUITING
(Jun 1, 2026)
PHASE1, PHASE2
KCD (Carfilzomib/Cyclophosphamide/Dexamethasone) Regimen for the Treatment of Newly Diagnosed POEMS Syndrome Shanghai Changzheng Hospital NA RECRUITING
(Jun 1, 2026)
PHASE2
Evaluation iNduction, Consolidation and Maintenance Treatment With Isatuximab , Carfilzomib, LEnalidomide and Dexamethasone Universitätsklinikum Hamburg-Eppendorf NA ACTIVE NOT RECRUITING
(May 1, 2026)
PHASE2
Efficacy and Safety of Carfilzomib in Combination With Ibrutinib vs Ibrutinib in Waldenström's Macroglobulinemia Christian Buske NA ACTIVE NOT RECRUITING
(May 1, 2026)
PHASE2
KRDI in Transplant-Eligible MM Massachusetts General Hospital NA ACTIVE NOT RECRUITING
(May 1, 2026)
PHASE2
Study of Belantamab Mafodotin in Combination With Kd for the Treatment of Relapsed Myeloma Patients, Refractory to Lenalidomide PETHEMA Foundation NA ACTIVE NOT RECRUITING
(May 1, 2026)
PHASE1, PHASE2
COMbination Regimens in MM Post AHCT to elimiNate MRD Utilizing IbERdomide University of Alabama at Birmingham NA ACTIVE NOT RECRUITING
(May 1, 2026)
PHASE1, PHASE2
Combination Treatment Therapy Approaches for the Treatment of High-Risk Multiple Myeloma, REACH Trial Mayo Clinic NA ACTIVE NOT RECRUITING
(May 1, 2026)
PHASE2
Selvigaltin With Standard of Care Treatment for the Treatment of Relapsed/Refractory Multiple Myeloma Roswell Park Cancer Institute NA WITHDRAWN
(May 1, 2026)
PHASE1
Evaluation of the Safety and the Efficacy of Carfilzomib Combined With Cyclophosphamide and Dexamethasone (CCyd) or Lenalidomide and Dex (CRd) Followed by ASCT or 12 Cycles of Carf Combined With Dex and Len for Patients Eligible for ASCT With Newly Diagnosed Multiple Myeloma. Mario Boccadoro NA COMPLETED
(Apr 1, 2026)
PHASE2
Study of Carfilzomib Weekly Plus Melphalan and Prednisone in Untreated Symptomatic Elderly Multiple Myeloma University Hospital, Lille NA COMPLETED
(Apr 1, 2026)
PHASE2
Front-line Therapy With Carfilzomib, Lenalidomide, and Dexamethasone Induction University Hospital, Toulouse NA COMPLETED
(Apr 1, 2026)
PHASE2
Daratumumab, Carfilzomib, Lenalidomide and Low Dose Dexamethasone (DKRd) in Newly Diagnosed, Multiple Myeloma University of Chicago NA ACTIVE NOT RECRUITING
(Apr 1, 2026)
PHASE2
Carfilzomib and Belatacept for Desensitization National Institute of Allergy and Infectious Diseases (NIAID) NA ACTIVE NOT RECRUITING
(Apr 1, 2026)
PHASE1, PHASE2
Carfilzomib in Combination With Sotorasib for the Treatment of Patients With KRAS G12C Mutated Advanced or Metastatic Non-small Cell Lung Cancer City of Hope Medical Center NA RECRUITING
(Apr 1, 2026)
PHASE1
A Phase II Study of Carfilzomib in Relapsed Waldenström's Macroglobulinemia (WM) IST-CAR-531 Hackensack Meridian Health NA COMPLETED
(Mar 1, 2026)
PHASE2
Carfilzomib, Lenalidomide, and Dexamethasone Before and After Stem Cell Transplant in Treating Patients With Newly Diagnosed Multiple Myeloma University of Chicago NA COMPLETED
(Mar 1, 2026)
PHASE2
Phase Ib Study of SAR650984 in Combination With Carfilzomib for Treatment of Relapsed or Refractory Multiple Myeloma Thomas Martin, MD NA COMPLETED
(Mar 1, 2026)
PHASE1
Personalized Selinexor-based Therapy for Relapsed/Refractory Multiple Myeloma University of Colorado, Denver NA ACTIVE NOT RECRUITING
(Mar 1, 2026)
PHASE2


Carfilzomib Generic API Manufacturers

Several generic applications have been filed for Carfilzomib. The first generic version for Carfilzomib was by Dr Reddys Laboratories Ltd and was approved on Sep 9, 2019. And the latest generic version is by Msn Laboratories Private Ltd and was approved on Jul 20, 2026.

Given below is the list of companies who have filed for Carfilzomib generic, along with the locations of their manufacturing plants worldwide.