Bupivacaine Patent Expiration

Bupivacaine is Used for providing local or regional analgesia in various surgical procedures and postoperative pain management. It was first introduced by Pacira Pharmaceuticals Inc in its drug Exparel on Oct 28, 2011. Another drug containing Bupivacaine is Posimir. 3 different companies have introduced drugs containing Bupivacaine.


Bupivacaine Patents

Given below is the list of patents protecting Bupivacaine, along with the drug name that holds that patent and the company name owning that drug.

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Drug Used in Drug Patent Number Drug Patent Title Drug Patent Expiry Drug Owner
Exparel US12156940 Manufacturing of bupivacaine multivesicular liposomes Jul 02, 2044 Pacira Pharms Inc
Exparel US12251468 Manufacturing of bupivacaine multivesicular liposomes Jul 02, 2044 Pacira Pharms Inc
Exparel US12318483 Manufacturing of bupivacaine multivesicular liposomes Jul 02, 2044 Pacira Pharms Inc
Exparel US12370142 Jul 02, 2044 Pacira Pharms Inc
Exparel US11918565 Treatment of post-operative pain via sciatic nerve block with sustained-release liposomal anesthetic compositions Feb 02, 2043 Pacira Pharms Inc
Exparel US12226610 Treatment of pain associated with total knee arthroplasty with sustained-release liposomal anesthetic compositions Feb 02, 2043 Pacira Pharms Inc
Exparel US11931459 Treatment of pain in pediatric patients by administration of sustained-release liposomal anesthetic compositions Mar 17, 2042 Pacira Pharms Inc
Exparel US11033495 Manufacturing of bupivacaine multivesicular liposomes Jan 22, 2041 Pacira Pharms Inc
Exparel US11179336 Manufacturing of bupivacaine multivesicular liposomes Jan 22, 2041 Pacira Pharms Inc
Exparel US11278494 Manufacturing of bupivacaine multivesicular liposomes Jan 22, 2041 Pacira Pharms Inc
Exparel US11304904 Manufacturing of bupivacaine multivesicular liposomes Jan 22, 2041 Pacira Pharms Inc
Exparel US11311486 Manufacturing of bupivacaine multivesicular liposomes Jan 22, 2041 Pacira Pharms Inc
Exparel US11357727 Manufacturing of bupivacaine multivesicular liposomes Jan 22, 2041 Pacira Pharms Inc
Exparel US11426348 Compositions of bupivacaine multivesicular liposomes Jan 22, 2041 Pacira Pharms Inc
Exparel US11452691 Compositions of bupivacaine multivesicular liposomes Jan 22, 2041 Pacira Pharms Inc
Exparel US11819574 Manufacturing of bupivacaine multivesicular liposomes Jan 22, 2041 Pacira Pharms Inc
Exparel US11819575 Manufacturing of bupivacaine multivesicular liposomes Jan 22, 2041 Pacira Pharms Inc
Exparel US11925706 Manufacturing of bupivacaine multivesicular liposomes Jan 22, 2041 Pacira Pharms Inc
Exparel US12144890 Manufacturing of bupivacaine multivesicular liposomes Jan 22, 2041 Pacira Pharms Inc
Exparel US12151024 Manufacturing of bupivacaine multivesicular liposomes Jan 22, 2041 Pacira Pharms Inc
Exparel US12296047 Manufacturing of bupivacaine multivesicular liposomes Jan 22, 2041 Pacira Pharms Inc
Posimir US11400019 Sustained release drug delivery systems with reduced impurities and related methods Jan 12, 2041 Innocoll
Posimir US11771624 Sustained release drug delivery systems with reduced impurities and related methods Jan 12, 2041 Innocoll
Posimir US8153149 Controlled delivery system Sep 15, 2025

(Expired)

Innocoll
Posimir US8153661 Controlled delivery system Sep 15, 2025

(Expired)

Innocoll
Posimir US8753665 Controlled delivery system Sep 15, 2025

(Expired)

Innocoll
Posimir US8846072 Controlled delivery system Sep 15, 2025

(Expired)

Innocoll
Exparel US9585838 Production of multivesicular liposomes Dec 24, 2021

(Expired)

Pacira Pharms Inc
Exparel US8182835 Sustained-release liposomal anesthetic compositions Sep 18, 2018

(Expired)

Pacira Pharms Inc
Exparel US8834921 Sustained-release liposomal anesthetic compositions Sep 18, 2018

(Expired)

Pacira Pharms Inc
Exparel US9205052 Sustained-release liposomal anesthetic compositions Sep 18, 2018

(Expired)

Pacira Pharms Inc
Exparel US6132766 Multivesicular liposomes with controlled release of encapsulated biologically active substances Nov 16, 2013

(Expired)

Pacira Pharms Inc



About Veterinary Bupivacaine

Bupivacaine is used in a drug marketed by 1 company: Elanco Us Inc.

Other drugs containing Bupivacaine are: Nocita .

Veterinary Bupivacaine Patents

Given below is the list of patents protecting Bupivacaine, along with the drug name that holds that patent and the company owning that drug.

Filter patents by

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Drug Used In Drug Patent Number Drug Patent Expiry Drug Owner
Patent Data
Nocita US9205052 18 Sep, 2018 ELANCO US INC.

Bupivacaine's Family Patents

Family Patents

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Clinical Trials

Recent Clinical Trials on Bupivacaine:

Sometimes companies keep conducting clinical trials even after the drug's approval to discover new formulations, methods of use, or new treatment indications, so they could file for additional patents or receive regulatory exclusivity extensions, such as pediatric exclusivity, potentially delaying generic competition. Based on these recent clinical trials, generic companies need to consider the potential for new intellectual property or regulatory hurdles. These strategic moves by the drug owner might delay generic substitution or lead to additional sales of the brand drug, even after patent expiry.

Title Lead Sponsor Collaborators Status Phases
Clinical Trials
Nebulized Bupivacaine Analgesia for Cleft Palate Repair Assiut University NA RECRUITING
(Sep 1, 2026)
PHASE3
Peri-operative Oral Pain Control Following Buccal Graft Urethroplasty University of California, San Francisco NA COMPLETED
(Sep 1, 2026)
PHASE3
Optimal Anesthetic for Corticosteroid Injections for Knee Osteoarthritis Foundation for Orthopaedic Research and Education NA COMPLETED
(Sep 1, 2026)
PHASE1
Analgesic Requirement for Post-Operative Pain Control in TLIP Interbody Fusion Foundation for Orthopaedic Research and Education NA ENROLLING BY INVITATION
(Sep 1, 2026)
PHASE2, PHASE3
Liposomal Bupivacaine Plus Plain Bupivacaine Versus Dexamethasone Plus Plain Bupivacaine in the Supraclavicular Brachial Plexus Block in Patients With Risk Factors for Severe Acute Postoperative Pain The University of Hong Kong NA RECRUITING
(Sep 1, 2026)
PHASE3
A Clinical Study to Compare BupiZenge With Lidocaine for Pain Due to Oral Mucositis in Patients With Head and Neck Cancer. OncoZenge AB NA RECRUITING
(Sep 1, 2026)
PHASE3
Greater Occipital Nerve Blockade in Veterans With Post-concussion Headache: Sub-study 2 Yale University NA RECRUITING
(Sep 1, 2026)
PHASE2
Intrathecal Dexmedetomidine and Postoperative Delirium in Elderly Hip Fracture Surgery Assiut University NA NOT YET RECRUITING
(Sep 1, 2026)
PHASE2, PHASE3
Comparison of Dexmedetomidine Versus Dexamethasone as Adjuvants to Bupivacaine in Ultrasound-Guided Erector Spinae Plane Block for Acute Pain Management in Patients With Traumatic Rib Fractures Assiut University NA NOT YET RECRUITING
(Sep 1, 2026)
PHASE2, PHASE3
Effect of Post-Radiofrequency Corticosteroid Injection on the Incidence of Post-Neurotomy Neuritis Siriraj Hospital NA ENROLLING BY INVITATION
(Sep 1, 2026)
PHASE2
Bupivacaine vs Placebo for Unilateral Mastectomy Surgical Site Post-operative Pain Control Memorial Sloan Kettering Cancer Center NA ACTIVE NOT RECRUITING
(Aug 1, 2026)
PHASE3
Greater Occipital Nerve Blockade in Veterans With Post-concussion Headache: Sub-study 1 Yale University NA COMPLETED
(Aug 1, 2026)
PHASE1
Transnasal Sphenopalatine Ganglion Block for Treatment of Acute Subarachnoid Hemorrhage Associated Headache University of California, Davis NA RECRUITING
(Aug 1, 2026)
PHASE2, PHASE3
Liposomal Bupivacaine vs Standard Bupivacaine for Post-Rhinoplasty Analgesia Washington University School of Medicine NA RECRUITING
(Aug 1, 2026)
PHASE2
Pharmacokinetic and Safety Study of HYR-PB21 vs Bupivacaine Hydrochloric Acid in Healthy Participants Fruithy Holdings Limited NA NOT YET RECRUITING
(Aug 1, 2026)
PHASE1
Effect of Height Based vs Conventional Dose of Spinal Anesthesia in Lower Limb Surgeries Liaquat National Hospital & Medical College NA NOT YET RECRUITING
(Aug 1, 2026)
PHASE1, PHASE2
THIS STUDY AIMS TO COMPARE TWO DRUGS KETAMINE AND TRAMAL IN PREVENTION OF SHIVERING IN PATIENTS UNDERGOING SPINAL ANESTHESIA STUDY POPULATION IS PT UNDERGOING C SECTION . DOSE OF KETAMINE IS 0.25mg/kg and That of TRAMAL 0.5mg/kg. KRL Hospital, Islamabad NA COMPLETED
(Aug 1, 2026)
PHASE2
Postoperative Pain Management for Hip Surgeries: UltrasoundGuided Suprainguinal Fascia Iliaca Compartment Block Versus Suprainguinal Fascia Iliaca Compartment Block in Combination With Sciatic Nerve Block Ain Shams University NA COMPLETED
(Aug 1, 2026)
PHASE1
This Study Aims to Determine Whether Lower Doses (4 µg) of Intrathecal Dexmedetomidine Can Provide Comparable Analgesic Benefits While Minimizing Adverse Hemodynamic Effects in Patients Encountered in Our Setup( Shifa International Hospital Islamabad). Shifa International Hospital NA ENROLLING BY INVITATION
(Aug 1, 2026)
PHASE1, PHASE2
Thoracic Epidural Analgesia or Four-Quadrant Transversus Abdominus Plane Block in Reducing Pain in Patients Undergoing Liver Surgery M.D. Anderson Cancer Center NA ACTIVE NOT RECRUITING
(Jul 1, 2026)
PHASE3
Yale Steroid Enhanced Versus Exparel Nerveblock TKA RCT Study Yale University NA RECRUITING
(Jul 1, 2026)
PHASE2
Pectoral Nerve Blocks (PECs) for Cardiovascular Implantable Electronic Device Placement Beth Israel Deaconess Medical Center NA COMPLETED
(Jul 1, 2026)
PHASE2, PHASE3
A Study of Stellate Ganglion Block for Prevention of Atrial Fibrillation Mayo Clinic NA COMPLETED
(Jul 1, 2026)
PHASE2, PHASE3
Yale Steroid Enhanced Versus Exparel Nerveblock TKA Part 2 Yale University NA RECRUITING
(Jul 1, 2026)
PHASE2
A Randomized Comparison Between 0.67 mcg/kg, 1 mcg/kg, and 1.33 mcg/kg of Perineural Dexmedetomidine for Ultrasound-Guided Infraclavicular Block McGill University Health Centre/Research Institute of the McGill University Health Centre NA COMPLETED
(Jul 1, 2026)
PHASE2
Adductor Canal Block: Efficacy in Postoperative Pain Management for Cardiac Surgery Montreal Heart Institute NA NOT YET RECRUITING
(Jul 1, 2026)
PHASE2, PHASE3
Comparing Suprascapular Nerve Block and Interscalene Block for Post-thoracotomy Pain in Pediatric Patients. Children's Cancer Hospital Egypt 57357 NA RECRUITING
(Jul 1, 2026)
PHASE2, PHASE3
Efficacy of Nerve Blocks for Episodic Migraine Mayo Clinic NA RECRUITING
(Jun 1, 2026)
PHASE2
Influence of Superficial Parasternal Intercostal Plane Block on Internal Thoracic Artery Caliber to Facilitate Surgical Harvesting in CABG Ain Shams University NA NOT YET RECRUITING
(Jun 1, 2026)
PHASE3
Continuous ESP Block in Patients Undergoing CABG Surgery. Instituto do Coracao NA RECRUITING
(Jun 1, 2026)
PHASE3
Pediatric Postoperative Analgesia Herniorrhaphy Study Heron Therapeutics NA WITHDRAWN
(May 1, 2026)
PHASE2
Dexmedetomidine in Postoperative Analgesia New Valley University NA ENROLLING BY INVITATION
(May 1, 2026)
PHASE2, PHASE3
Spinal Nalbuphine for Analgesia in Total Hip Arthroplasty Asklepieion Voulas General Hospital NA COMPLETED
(May 1, 2026)
PHASE2
Clinical Observation of Bupivacaine Liposome for Lower Extremity Nerve Block Hainan Medical College NA COMPLETED
(May 1, 2026)
PHASE2
Sciatic Nerve Block With ALX006 in Subjects Undergoing Bunionectomy Rebel Medicine Inc NA RECRUITING
(May 1, 2026)
PHASE2
"Dexa vs Dexmedetomidine With Bupivacaine in TAP Block for Laparotomy Analgesia Sahiwal medical college sahiwal NA RECRUITING
(May 1, 2026)
PHASE2, PHASE3
Comparison of Hemodynamic Effects of Bupivacaine in Spinal Anesthesia Liaquat National Hospital & Medical College NA NOT YET RECRUITING
(May 1, 2026)
PHASE2
Resiniferatoxin for the Management of Refractory Morton s Neuroma Pain National Institutes of Health Clinical Center (CC) NA COMPLETED
(Apr 9, 2026)
PHASE1
Thoracic Epidural Analgesia vs Surgical Site Infiltration With Liposomal Bupivacaine Following Open Gynecologic Surgery Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins NA COMPLETED
(Apr 1, 2026)
PHASE3
Repeat or Single Quadratus Lumborum Block for the Reduction of Opioid Prescriptions After Surgery in Retroperitoneal Sarcoma Patients ("RESQU-SARC" Trial) M.D. Anderson Cancer Center NA ACTIVE NOT RECRUITING
(Apr 1, 2026)
PHASE2
Video-assisted Thoracoscopic Surgery - Exparel Study Nada Sadek NA COMPLETED
(Apr 1, 2026)
PHASE2
Clinical Trial of Endoscopically Guided Injection of Exparel (Bupivacaine) for the Treatment of Craniofacial Pain Stanford University NA RECRUITING
(Apr 1, 2026)
PHASE2
The Role of Peripheral Afferents in Modulating Post-stroke Central Pain Institut National de la Santé Et de la Recherche Médicale, France NA RECRUITING
(Apr 1, 2026)
PHASE3
IV vs Epidural Opioids + Epidural Local Anesthetic for Laparotomy Analgesia University of Iowa NA RECRUITING
(Apr 1, 2026)
PHASE2, PHASE3
Ketamine, SGB and Combination Treatment for TBI-associated Headache or PTSD Northwestern University NA RECRUITING
(Apr 1, 2026)
PHASE2
Supplemental Postoperative Bupivacaine Following Non-Surgical Endodontic Treatment New York University NA RECRUITING
(Apr 1, 2026)
PHASE2
COntralateral CorticoSTeroid Injection in Total Knee Arthroplasty Unity Health Toronto NA RECRUITING
(Apr 1, 2026)
PHASE1, PHASE2
Erector Spinae Versus Intercostal Nerve Blocks With Liposomal Bupivacaine for Analgesia in Thoracic Surgery George Washington University NA RECRUITING
(Apr 1, 2026)
PHASE3
Intraoperative Placement of Vancomycin-impregnated Calcium Sulfate Beads Conjugated With Analgesics to Improve Spine Surgery Outcomes Ganesh M. Shankar NA NOT YET RECRUITING
(Apr 1, 2026)
PHASE2
Improving Postoperative Analgesia After Functional Endoscopic Surgery South Egypt Cancer Institute NA NOT YET RECRUITING
(Apr 1, 2026)
PHASE2, PHASE3
Ultrasound Guided Erectror Spinae Block Versus Intracavitary During Medical Thoracoscopy Kafrelsheikh University NA NOT YET RECRUITING
(Apr 1, 2026)
PHASE2, PHASE3
Liposomal Bupivacaine With Standard Bupivacaine Versus Dexmedetomidine With Standard Bupivacaine The University of Hong Kong NA COMPLETED
(Mar 1, 2026)
PHASE3
MgSO4 as Adjuvants to Bupivacaine vs Neostigmine in TAP Block in Cesarean Section Assiut University NA COMPLETED
(Mar 1, 2026)
PHASE2, PHASE3
A Study of Bupivacaine Liposome Injection in the Treatment of Pain After Thoracoscopic Surgery Jiangsu HengRui Medicine Co., Ltd. NA RECRUITING
(Mar 1, 2026)
PHASE2
Peritumoral and Periganglionic Infiltration of Levobupivacaine Prior to Conservative Surgery for Triple-negative Breast Cancer Institut Jean-Godinot NA NOT YET RECRUITING
(Mar 1, 2026)
PHASE2
Anterior Iliopsoas Space Block Versus PENG Block on Ease of Positioning for Spinal Anathesia in Patients Undergoing Hip Surgeries Benha University NA RECRUITING
(Mar 1, 2026)
PHASE3
Comparison Between Tranversus Abdominis Plane (TAP) Block With Only Bupivacaine and TAP Block With Bupivacaine Plus Ketamine in Reducing Postoperative Pain After Total Abdominal Hystrectomy Liaquat National Hospital & Medical College NA RECRUITING
(Mar 1, 2026)
PHASE1, PHASE2
Hernia Abd Wall Recons - BDE vs Exparel Baylor Research Institute NA ENROLLING BY INVITATION
(Mar 1, 2026)
PHASE2


Bupivacaine Generic API Manufacturers

Several generic applications have been filed for Bupivacaine.

Given below is the list of companies who have filed for Bupivacaine generic, along with the locations of their manufacturing plants worldwide.


Bupivacaine News

ANDA Litigation Settlement Updates for Q2 2025 | Robins Kaplan LLP - JDSupra

13 Aug, 2025

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