Bortezomib Patent Expiration

Bortezomib is Used for treating multiple myeloma patients who have not responded to previous therapies. It was first introduced by Takeda Pharmaceuticals Usa Inc in its drug Velcade on May 13, 2003. Another drug containing Bortezomib is Bortezomib. 25 different companies have introduced drugs containing Bortezomib.


Bortezomib Patents

Given below is the list of patents protecting Bortezomib, along with the drug name that holds that patent and the company name owning that drug.

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Drug Used in Drug Patent Number Drug Patent Title Drug Patent Expiry Drug Owner
Bortezomib US11679119 Bortezomib compositions Sep 23, 2042 Maia Pharms Inc
Bortezomib US11752164 Bortezomib compositions Sep 23, 2042 Maia Pharms Inc
Bortezomib US12005069 Bortezomib compositions Sep 23, 2042 Maia Pharms Inc
Bortezomib US8962572 Bortezomib formulations Nov 03, 2032 Fresenius Kabi Usa
Velcade US6713446

(Pediatric)

Formulation of boronic acid compounds Jul 25, 2022

(Expired)

Takeda Pharms Usa
Velcade US6958319

(Pediatric)

Formulation of boronic acid compounds Jul 25, 2022

(Expired)

Takeda Pharms Usa
Velcade US6713446 Formulation of boronic acid compounds Jan 25, 2022

(Expired)

Takeda Pharms Usa
Velcade US6958319 Formulation of boronic acid compounds Jan 25, 2022

(Expired)

Takeda Pharms Usa
Velcade US5780454

(Pediatric)

Boronic ester and acid compounds Nov 03, 2017

(Expired)

Takeda Pharms Usa
Velcade US5780454 Boronic ester and acid compounds May 03, 2017

(Expired)

Takeda Pharms Usa
Velcade US6083903 Boronic ester and acid compounds, synthesis and uses Oct 28, 2014

(Expired)

Takeda Pharms Usa
Velcade US6297217 Boronic ester and acid compounds, synthesis and uses Oct 28, 2014

(Expired)

Takeda Pharms Usa
Velcade US6617317 Boronic ester and acid compositions Oct 28, 2014

(Expired)

Takeda Pharms Usa
Velcade US6747150 Boronic ester and acid compounds, synthesis and uses Oct 28, 2014

(Expired)

Takeda Pharms Usa
Velcade US7119080 Boronic ester and acid compounds, synthesis and uses Oct 28, 2014

(Expired)

Takeda Pharms Usa



A patent's expiry date may change depending upon legal activities going on that patent. Critical activities like abandoning of a patent, term extension of a patent or amendment of its claims can increase or decrease the life of a patent hence affecting its expiry date and in turn affecting the generic launch date of that drug. Tracking these ongoing activities on a patent application helps to keep an eye on the latest developments in the patent process of the drug which can give an idea of how early a drug's generic could be available. The next section provides a list of recent legal activities on Bortezomib's patents.

Given below is the list recent legal activities going on the following patents of Bortezomib.

Activity Date Patent Number
Patent litigations
Patent Issue Date Used in PTA Calculation 11 Jun, 2024 US12005069
Email Notification 11 Jun, 2024 US12005069
Patent eGrant Notification 11 Jun, 2024 US12005069
Mail Patent eGrant Notification 11 Jun, 2024 US12005069
Recordation of Patent eGrant 11 Jun, 2024 US12005069
Recordation of Patent Grant Mailed 11 Jun, 2024 US12005069
Email Notification 23 May, 2024 US12005069
Issue Notification Mailed 22 May, 2024 US12005069
Application Is Considered Ready for Issue 09 May, 2024 US12005069
Dispatch to FDC 09 May, 2024 US12005069


Bortezomib's Family Patents

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Clinical Trials

Recent Clinical Trials on Bortezomib:

Sometimes companies keep conducting clinical trials even after the drug's approval to discover new formulations, methods of use, or new treatment indications, so they could file for additional patents or receive regulatory exclusivity extensions, such as pediatric exclusivity, potentially delaying generic competition. Based on these recent clinical trials, generic companies need to consider the potential for new intellectual property or regulatory hurdles. These strategic moves by the drug owner might delay generic substitution or lead to additional sales of the brand drug, even after patent expiry.

Title Lead Sponsor Collaborators Status Phases
Clinical Trials
Trial of Allogeneic Reduced-Intensity, HLA-Haploidentical Allogeneic Hematopoietic Cell Bone Marrow Transplantation Followed by Graft-versus-Host-Disease (GVHD) Prophylaxis With Cyclophosphamide, Bortezomib and Maraviroc for Hematologic Malignancies ... National Cancer Institute (NCI) NA RECRUITING
(Sep 16, 2026)
PHASE1, PHASE2
Alisertib, Bortezomib, and Rituximab in Treating Patients With Relapsed or Refractory Mantle Cell Lymphoma or B-cell Low Grade Non-Hodgkin Lymphoma National Cancer Institute (NCI) NA ACTIVE NOT RECRUITING
(Sep 1, 2026)
PHASE1
Bortezomib, Sorafenib Tosylate, and Decitabine in Treating Patients With Acute Myeloid Leukemia National Cancer Institute (NCI) NA ACTIVE NOT RECRUITING
(Sep 1, 2026)
PHASE1
2015-12: A Study Exploring the Use of Early and Late Consolidation/Maintenance Therapy University of Arkansas NA ACTIVE NOT RECRUITING
(Sep 1, 2026)
PHASE2
Stibium Metallicum Praeparatum D6 Versus Placebo in the Reduction of Paclitaxel-induced Peripheral Neurotoxicity University of Bern NA NOT YET RECRUITING
(Sep 1, 2026)
PHASE3
Study to Evaluate Combined Treatment of Daratumumab, Bortezomib and Dexamethasone in PBL Patients. Fondazione Italiana Linfomi - ETS NA RECRUITING
(Sep 1, 2026)
PHASE2
Sequential Therapy in Multiple Myeloma Guided by MRD Assessments University of Alabama at Birmingham NA ACTIVE NOT RECRUITING
(Sep 1, 2026)
PHASE2
A Study to Evaluate Mezigdomide, Bortezomib and Dexamethasone (MEZIVd) Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM) Celgene NA RECRUITING
(Sep 1, 2026)
PHASE3
Testing the Investigational Agent Combination of Daratumumab, Bortezomib, and Dexamethasone Compared to the Usual Treatment of Cyclophosphamide, Bortezomib, and Dexamethasone in Newly Diagnosed Multiple Myeloma Patients With Kidney Failure Eastern Cooperative Oncology Group NA RECRUITING
(Sep 1, 2026)
PHASE2
Isatuximab, Iberdomide, Bortezomib, Dexamethasone in Transplant Ineligible/Deferred Newly Diagnosed Myeloma Dana-Farber Cancer Institute NA NOT YET RECRUITING
(Sep 1, 2026)
PHASE1, PHASE2
A Study in Participants With Relapsed or Refractory Multiple Myeloma for IBI3003 Innovent Biologics (Suzhou) Co. Ltd. NA RECRUITING
(Sep 1, 2026)
PHASE3
D2 - Isa-Iber-VD Induction, Followed by Risk & Response Adapted Consolidation & Maintenance, in Transplant-Eligible NDMM Dana-Farber Cancer Institute NA NOT YET RECRUITING
(Sep 1, 2026)
PHASE3
Virotherapy and Natural History Study of KHSV-Associated Multricentric Castleman s Disease With Correlates of Disease Activity National Cancer Institute (NCI) NA ACTIVE NOT RECRUITING
(Aug 20, 2026)
PHASE2
A Phase II Study of Velcade® in Patients Stage IIIB OR IV Non-Small Cell Lung Cancer Gustave Roussy, Cancer Campus, Grand Paris NA TERMINATED
(Aug 1, 2026)
PHASE2
A Study of Carfilzomib, Lenalidomide, Vorinostat, and Dexamethasone in Relapsed and/or Refractory Multiple Myeloma Hackensack Meridian Health NA ACTIVE NOT RECRUITING
(Aug 1, 2026)
PHASE1, PHASE2
Carfilzomib, Rituximab, Ifosfamide, Carboplatin, and Etoposide in Treating Patients With Relapsed or Refractory Stage I-IV Diffuse Large B-cell Lymphoma Roswell Park Cancer Institute NA ACTIVE NOT RECRUITING
(Aug 1, 2026)
PHASE1
Combination Chemotherapy in Treating Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia, Lymphoblastic Lymphoma, Burkitt Lymphoma/Leukemia, or Double-Hit Lymphoma/Leukemia M.D. Anderson Cancer Center NA RECRUITING
(Aug 1, 2026)
PHASE2
A Study of JNJ-68284528, a Chimeric Antigen Receptor T Cell (CAR-T) Therapy Directed Against B-cell Maturation Antigen (BCMA) in Participants With Multiple Myeloma Janssen Research & Development, LLC NA ACTIVE NOT RECRUITING
(Aug 1, 2026)
PHASE2
A Study Comparing JNJ-68284528, a CAR-T Therapy Directed Against B-cell Maturation Antigen (BCMA), Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) or Daratumumab, Pomalidomide and Dexamethasone (DPd) in Participants With Relapsed and Lenalidomide-Refractory Multiple Myeloma Janssen Research & Development, LLC NA ACTIVE NOT RECRUITING
(Aug 1, 2026)
PHASE3
A Study of Teclistamab With Other Anticancer Therapies in Participants With Multiple Myeloma Janssen Research & Development, LLC NA ACTIVE NOT RECRUITING
(Aug 1, 2026)
PHASE1
Ixazomib-pomalidomide-dexamethasone as Second or Third-line Combination Treatment for Patients With Relapsed and Refractory Multiple Myeloma Previously Treated With Daratumumab, Lenalidomide and Bortezomib Tel-Aviv Sourasky Medical Center NA ACTIVE NOT RECRUITING
(Aug 1, 2026)
PHASE2
A Study of Bortezomib, Lenalidomide and Dexamethasone (VRd) Followed by Cilta-cel, a CAR-T Therapy Directed Against BCMA Versus VRd Followed by Lenalidomide and Dexamethasone (Rd) Therapy in Participants With Newly Diagnosed Multiple Myeloma for Whom ASCT is Not Planned as Initial Therapy Janssen Research & Development, LLC NA ACTIVE NOT RECRUITING
(Aug 1, 2026)
PHASE3
A Study of Teclistamab in Combination With Daratumumab Subcutaneously (SC) (Tec-Dara) Versus Daratumumab SC, Pomalidomide, and Dexamethasone (DPd) or Daratumumab SC, Bortezomib, and Dexamethasone (DVd) in Participants With Relapsed or Refractory Multiple Myeloma Janssen Research & Development, LLC NA ACTIVE NOT RECRUITING
(Aug 1, 2026)
PHASE3
A Study of Daratumumab-Based Therapies in Participants With Amyloid Light Chain (AL) Amyloidosis Janssen Research & Development, LLC NA ACTIVE NOT RECRUITING
(Aug 1, 2026)
PHASE2
Study of Iberdomide, Bortezomib, Dexamethasone With Isatuximab Added on Demand for ND-NTE MM Patients Canadian Myeloma Research Group NA RECRUITING
(Aug 1, 2026)
PHASE2
A Study to Learn About the Effects of the Combination of Elranatamab, Daratumumab and Lenalidomide Compared With Daratumumab, Bortezomib, Lenalidomide, and Dexamethasone in Patients With Newly Diagnosed Multiple Myeloma Who Are Not Candidates for Transplant Pfizer NA RECRUITING
(Aug 1, 2026)
PHASE3
Safety, Efficacy, and Pharmacokinetics of Continuous Subcutaneous Lenalidomide in Multiple Myeloma (MM) Starton Therapeutics, Inc NA RECRUITING
(Aug 1, 2026)
PHASE1, PHASE2
MagnetisMM-32: A Study to Learn About the Study Medicine Called Elranatamab in People With Multiple Myeloma (MM) That Has Come Back After Taking Other Treatments (Including Prior Treatment With an Anti-CD38 Antibody and Lenalidomide) Pfizer NA RECRUITING
(Aug 1, 2026)
PHASE3
Study Assessing Activity of Intravenous (IV) Etentamig Monotherapy Versus Standard Available Therapies in Adult Participants With Relapsed or Refractory Multiple Myeloma AbbVie NA ACTIVE NOT RECRUITING
(Aug 1, 2026)
PHASE3
A Study Comparing Talquetamab Plus Pomalidomide, Talquetamab Plus Teclistamab, and Elotuzumab, Pomalidomide, and Dexamethasone or Pomalidomide, Bortezomib, and Dexamethasone in Participants With Relapsed or Refractory Myeloma Who Have Received an Anti-CD38 Antibody and Lenalidomide Janssen Research & Development, LLC NA ACTIVE NOT RECRUITING
(Aug 1, 2026)
PHASE3
Adding Dasatinib Or Venetoclax To Improve Responses In Children With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia (ALL) Or Lymphoma (T-LLY) Or Mixed Phenotype Acute Leukemia (MPAL) St. Jude Children's Research Hospital NA RECRUITING
(Aug 1, 2026)
PHASE2
A Study of Different Sequences of Cilta-cel, Talquetamab in Combination With Daratumumab and Teclistamab in Combination With Daratumumab Following Induction With Daratumumab, Bortezomib, Lenalidomide and Dexamethasone in Participants With Standard-risk Newly Diagnosed Multiple Myeloma Janssen Research & Development, LLC NA ACTIVE NOT RECRUITING
(Aug 1, 2026)
PHASE2
Elranatamab/Lenalidomide Consolidation and/or Elranatamab Maintenance Versus Standard of Care After D-VRd Induction in Transplant-eligible NDMM Patients Intergroupe Francophone du Myelome NA RECRUITING
(Aug 1, 2026)
PHASE3
A Study to Evaluate Efficacy and Safety of Ciltacabtagene Autoleucel Janssen Research & Development, LLC NA RECRUITING
(Aug 1, 2026)
PHASE2
A Study to Evaluate the Efficacy and Safety of Belantamab Mafodotin in Combination With Standard of Care in Participants With Relapsed-Refractory Multiple Myeloma (RRMM) GlaxoSmithKline NA RECRUITING
(Aug 1, 2026)
PHASE2
Belantamab Mafodotin or Daratumumab With Bortezomib, Lenalidomide and Dexamethasone for Newly Diagnosed Multiple Myeloma PrECOG, LLC. NA RECRUITING
(Aug 1, 2026)
PHASE3
Systemic Anti-Cancer Therapy Dose Modifications for Individuals With Duffy Null Phenotype Andrew Hantel, MD NA RECRUITING
(Aug 1, 2026)
PHASE1
A Study Comparing AZD0120, a Dual-targeted CAR-T Against B-cell Maturation Antigen (BCMA) and CD19, Versus Standard Regimens in Participants With Relapsed Refractory Multiple Myeloma (DURGA-4) AstraZeneca NA RECRUITING
(Aug 1, 2026)
PHASE3
Venetoclax, Dexamethasone, Bortezomib, and Daratumumab For The Treatment Of Adolescent And Young Adults With Relapsed Or Refractory T-Cell Acute Lymphoblastic Leukemia And T-cell Acute Lymphoblastic Lymphoma M.D. Anderson Cancer Center NA RECRUITING
(Aug 1, 2026)
PHASE1
CM336 Plus Isa-VR in Newly Diagnosed Primary Plasma Cell Leukemia Institute of Hematology & Blood Diseases Hospital, China NA RECRUITING
(Aug 1, 2026)
PHASE2
A Study of Ramantamig Plus Daratumumab Versus Daratumumab, Bortezomib, Lenalidomide, and Dexamethasone (DVRd) or Daratumumab, Lenalidomide, and Dexamethasone (DRd) in Participants With NDMM For Whom Stem Cell Transplant is Not Planned Janssen Research & Development, LLC NA NOT YET RECRUITING
(Aug 1, 2026)
PHASE3
BCMA/GPRC5D Trispecific Antibody Treatment for Newly Diagnosed Amyloidosis (AL-004) Institute of Hematology & Blood Diseases Hospital, China NA NOT YET RECRUITING
(Aug 1, 2026)
PHASE2
Study to Evaluate Change in Disease Activity and Adverse Events of Subcutaneous Etentamig Compared With Daratumumab Plus Cyclophosphamide Plus Bortezomib Plus Dexamethasone (Dara-CyBorD) in Adults With Amyloid Light Chain (AL) Amyloidosis AbbVie NA NOT YET RECRUITING
(Aug 1, 2026)
PHASE3
Lenalidomide and Dexamethasone With or Without Bortezomib in Treating Patients With Previously Untreated Multiple Myeloma National Cancer Institute (NCI) NA ACTIVE NOT RECRUITING
(Jul 1, 2026)
PHASE3
Carfilzomib, Clarithromycin (Biaxin®), Lenalidomide (Revlimid®), and Dexamethasone (Decadron®) [Car-BiRD] Therapy for Subjects With Multiple Myeloma Weill Medical College of Cornell University NA COMPLETED
(Jul 1, 2026)
PHASE2
Selinexor and Backbone Treatments of Multiple Myeloma Patients Karyopharm Therapeutics Inc NA RECRUITING
(Jul 1, 2026)
PHASE1, PHASE2
Daratumumab-bortezomib-dexamethasone (Dara-VCd) vs Bortezomib-Thalidomide-Dexamethasone (VTd), Then Maintenance With Ixazomib (IXA) or IXA-Dara European Myeloma Network B.V. NA ACTIVE NOT RECRUITING
(Jul 1, 2026)
PHASE2
Study of Daratumumab Combined With Carfilzomib, Lenalidomide and Dexamethasone for Newly Diagnosed Multiple Myeloma Wake Forest University Health Sciences NA ACTIVE NOT RECRUITING
(Jul 1, 2026)
PHASE2
Phase 2 Study With Minimal Residual Disease (MRD) Driven Adaptive Strategy in Treatment for Newly Diagnosed Multiple Myeloma (MM) With Upfront Daratumumab-based Therapy University of Michigan Rogel Cancer Center NA ACTIVE NOT RECRUITING
(Jul 1, 2026)
PHASE2
Daratumumab Based Response Adapted Therapy for Older Adults With Newly Diagnosed Multiple Myeloma H. Lee Moffitt Cancer Center and Research Institute NA COMPLETED
(Jul 1, 2026)
PHASE2
Bortezomib in Patients With Metastatic Castration-Resistant Prostate Cancer With PTEN Deletion University of Utah NA ACTIVE NOT RECRUITING
(Jul 1, 2026)
PHASE2
A Study of CyBorD (Cyclophosphamide, Bortezomib, Dexamethasone) Plus Daratumumab in People With Monoclonal Gammopathy of Renal Significance (MGRS) Memorial Sloan Kettering Cancer Center NA RECRUITING
(Jul 1, 2026)
PHASE2
A Study Comparing Anitocabtagene Autoleucel to Standard of Care Therapy in Participants With Relapsed/ Refractory Multiple Myeloma Kite, A Gilead Company NA ACTIVE NOT RECRUITING
(Jul 1, 2026)
PHASE3
Phase I/II Clinical Trial of Proteasome Inhibitor in Combination With CPX-351 for the Treatment of Newly-Diagnosed TP53-mutated Acute Myeloid Leukemia (AML) Masonic Cancer Center, University of Minnesota NA RECRUITING
(Jul 1, 2026)
PHASE1, PHASE2
A Study of Dara-RVd and Teclistamab-RVd in People With Multiple Myeloma Memorial Sloan Kettering Cancer Center NA RECRUITING
(Jul 1, 2026)
PHASE1, PHASE2
A Study to Evaluate the Efficacy and Safety of Belantamab Mafodotin in Combination With Cyclophosphamide, Bortezomib, and Dexamethasone in Adult Participants With Newly Diagnosed Amyloid Light Chain (AL) Amyloidosis GlaxoSmithKline NA RECRUITING
(Jul 1, 2026)
PHASE2
Sonrotoclax Plus Dexamethasone With or Without Daratumumab Regimen in Patients With t(11;14) Primary AL Amyloidosis Peking University People's Hospital NA RECRUITING
(Jul 1, 2026)
PHASE2
A Randomized Phase 3 Study to Evaluate the Efficacy and Safety of NXC-201 Compared With Daratumumab With Cyclophosphamide, Bortezomib and Dexamethasone (CyBorD) in Newly Diagnosed Systemic AL Amyloidosis Nexcella Inc. NA NOT YET RECRUITING
(Jul 1, 2026)
PHASE3
Isa-VRdlite for of Frail and/or Much Older Patients With High Risk Newly Diagnosed Multiple Myeloma Base on Circulating Plasma Cells The Affiliated People's Hospital of Ningbo University NA NOT YET RECRUITING
(Jul 1, 2026)
PHASE2, PHASE3
Natural Killer Cells and Bortezomib to Treat Cancer National Heart, Lung, and Blood Institute (NHLBI) NA COMPLETED
(Jun 25, 2026)
PHASE1
Busulfan & Melphalan Conditioning for Autologous Stem Cell Transplant (ASCT) and Lenalidomide Maintenance University Health Network, Toronto NA COMPLETED
(Jun 1, 2026)
PHASE2
Total Therapy for Infants With Acute Lymphoblastic Leukemia (ALL) I St. Jude Children's Research Hospital NA ACTIVE NOT RECRUITING
(Jun 1, 2026)
PHASE1, PHASE2
Total Therapy XVII for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia and Lymphoma St. Jude Children's Research Hospital NA ACTIVE NOT RECRUITING
(Jun 1, 2026)
PHASE2, PHASE3
A Study of Ixazomib and Ibrutinib in Relapsed/Refractory Mantle Cell Lymphoma PrECOG, LLC. NA COMPLETED
(Jun 1, 2026)
PHASE1, PHASE2
Bortezomib and Temozolomide in Recurrent Grade-4 Glioma Unmethylated MGMT Promoter (BORTEM-17) Haukeland University Hospital NA RECRUITING
(Jun 1, 2026)
PHASE1, PHASE2
Efficacy and Safety Study of bb2121 Versus Standard Regimens in Subjects With Relapsed and Refractory Multiple Myeloma (RRMM) Celgene NA COMPLETED
(Jun 1, 2026)
PHASE3
Testing the Use of Combination Therapy in Adult Patients With Newly Diagnosed Multiple Myeloma, the EQUATE Trial ECOG-ACRIN Cancer Research Group NA RECRUITING
(Jun 1, 2026)
PHASE3
A Study to Examine the Effects of Novel Therapy Linvoseltamab in Combination With Other Cancer Treatments for Adult Participants With Multiple Myeloma That is Resistant to Current Standard of Care Treatments Regeneron Pharmaceuticals NA RECRUITING
(Jun 1, 2026)
PHASE1
NDMM Patients Candidates for ASCT Comparing Extended VRD Plus vs. Isa-VRD vs. Isa-V-Iberdomide PETHEMA Foundation NA RECRUITING
(Jun 1, 2026)
PHASE3
Comparing Combinations of Drugs to Treat Newly Diagnosed Multiple Myeloma (NDMM) When a Stem Cell Transplant is Not a Medically Suitable Treatment SWOG Cancer Research Network NA RECRUITING
(Jun 1, 2026)
PHASE3
A Study of Immune Suppression Treatment for People With Sickle Cell Disease or β-Thalassemia Who Are Going to Receive an Allogeneic Hematopoietic Cell Transplantation (HCT) Memorial Sloan Kettering Cancer Center NA RECRUITING
(Jun 1, 2026)
PHASE2
Comparing the Combination of Selinexor-Daratumumab-Velcade-Dexamethasone (Dara-SVD) With the Usual Treatment (Dara-RVD) for High-Risk Newly Diagnosed Multiple Myeloma National Cancer Institute (NCI) NA ACTIVE NOT RECRUITING
(Jun 1, 2026)
PHASE2
Phase II Study of QLS32015 Combination Therapy in the Treatment of Multiple Myeloma Qilu Pharmaceutical Co., Ltd. NA RECRUITING
(Jun 1, 2026)
PHASE2
Testing the Addition of Daratumumab to Chemotherapy for Treating Patients With Newly-Diagnosed T-Cell Lymphoblastic Leukemia (T-ALL) and T-Cell Lymphoblastic Lymphoma (T-LL) Children's Oncology Group NA NOT YET RECRUITING
(Jun 1, 2026)
PHASE2, PHASE3
ELDORADO: Elranatamab Versus Daratumumab in Combination With RVd Lite for Newly Diagnosed Transplant Ineligible/Deferred Multiple Myeloma Massachusetts General Hospital NA NOT YET RECRUITING
(Jun 1, 2026)
PHASE2
A Study of Linvo-VR vs DVRd in Transplant-Eligible Adult Participants With Newly Diagnosed Multiple Myeloma (NDMM) Regeneron Pharmaceuticals NA WITHDRAWN
(Jun 1, 2026)
PHASE2, PHASE3
Study of Alternative and Approved Dosing Regimens of Belantamab Mafodotin, Bortezomib, and Dexamethasone (BVd) in Participants With Relapsed/Refractory Multiple Myeloma GlaxoSmithKline NA NOT YET RECRUITING
(Jun 1, 2026)
PHASE2
Study of Bortezomib and Docetaxel for Patients With Hormone Refractory Prostate Cancer University of Southern California NA TERMINATED
(May 1, 2026)
PHASE2
Trial for Patients Not Qualifying for TT4 and TT5 Protocols Because of Prior Therapy University of Arkansas NA ACTIVE NOT RECRUITING
(May 1, 2026)
PHASE2
Bortezomib and Sorafenib Tosylate in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia National Cancer Institute (NCI) NA COMPLETED
(May 1, 2026)
PHASE3
Ixazomib Citrate in Treating Patients With Relapsed Multiple Myeloma That Is Not Refractory to Bortezomib Mayo Clinic NA COMPLETED
(May 1, 2026)
PHASE2
A Study Comparing Daratumumab, VELCADE (Bortezomib), Lenalidomide, and Dexamethasone (D-VRd) With VELCADE, Lenalidomide, and Dexamethasone (VRd) in Participants With Untreated Multiple Myeloma and for Whom Hematopoietic Stem Cell Transplant is Not Planned as Initial Therapy Janssen Research & Development, LLC NA COMPLETED
(May 1, 2026)
PHASE3
Belantamab Mafodotin Plus Pomalidomide and Dexamethasone (Pd) Versus Bortezomib Plus Pd in Relapsed/Refractory Multiple Myeloma GlaxoSmithKline NA ACTIVE NOT RECRUITING
(May 1, 2026)
PHASE3
A Study of Evaluating the Safety and Efficacy of ATG-010, Bortezomib, and Dexamethasone (SVd) Versus Bortezomib and Dexamethasone (Vd) in Patients With Relapsed or Refractory Multiple Myeloma (RRMM) Antengene Corporation NA COMPLETED
(May 1, 2026)
PHASE3
Post-Transplant Cyclophosphamide, Bortezomib and Abatacept for the Prevention of Graft-versus-Host-Disease (GvHD) Northwell Health NA RECRUITING
(May 1, 2026)
PHASE1, PHASE2
Bortezomib and Pembrolizumab With or Without Pelareorep for the Treatment of Relapsed or Refractory Multiple Myeloma, AMBUSH Trial University of Southern California NA ACTIVE NOT RECRUITING
(May 1, 2026)
PHASE1, PHASE2
TINI 2: Total Therapy for Infants With Acute Lymphoblastic Leukemia II Tanja Andrea Gruber NA RECRUITING
(May 1, 2026)
PHASE1, PHASE2
Teclistamab-Daratumumab and Talquestamab-Daratumumab in Newly Diagnosed High-risk Multiple Myeloma PETHEMA Foundation NA ACTIVE NOT RECRUITING
(May 1, 2026)
PHASE2
Dara-RVd Induction for Newly Diagnosed Multiple Myeloma With Autologous Stem Cell Transplantation UNC Lineberger Comprehensive Cancer Center NA WITHDRAWN
(May 1, 2026)
PHASE2
All Japanese Population: Belantamab Mafodotin Plus Pomalidomide and Dexamethasone (Pd) Versus Bortezomib Plus Pd in Relapsed/Refractory Multiple Myeloma GlaxoSmithKline NA ACTIVE NOT RECRUITING
(May 1, 2026)
PHASE3
Etenta-Isa-VRd in Newly Diagnosed High-Risk Multiple Myeloma Universitätsklinikum Hamburg-Eppendorf NA NOT YET RECRUITING
(May 1, 2026)
PHASE1, PHASE2
A Study of the Combination of Belantamab Mafodotin, Bortezomib, and Dexamethasone (BVd) in Participants With Multiple Myeloma and Moderate Hepatic Impairment GlaxoSmithKline NA NOT YET RECRUITING
(May 1, 2026)
PHASE1
Bortezomib With Gemcitabine/Doxorubicin in Patients With Urothelial Cancer and Other Solid Tumors M.D. Anderson Cancer Center NA ACTIVE NOT RECRUITING
(Apr 1, 2026)
PHASE1
IV Busulfan Plus Bortezomib Conditioning Regimen for Second Autologous Stem Cell Transplant in Multiple Myeloma Patients Otsuka Pharmaceutical Development & Commercialization, Inc. NA COMPLETED
(Apr 1, 2026)
PHASE2
S1211 Bortezomib, Dexamethasone, and Lenalidomide With or Without Elotuzumab in Treating Patients With Newly Diagnosed High-Risk Multiple Myeloma SWOG Cancer Research Network NA COMPLETED
(Apr 1, 2026)
PHASE1, PHASE2
Trial of the Combination of Bortezomib and Clofarabine in Adults With Relapsed Solid Tumors National Cancer Institute (NCI) NA COMPLETED
(Apr 1, 2026)
PHASE1
Trial of Duvelisib in Combination With Either Romidepsin or Bortezomib in Relapsed/Refractory T-cell Lymphomas Memorial Sloan Kettering Cancer Center NA COMPLETED
(Apr 1, 2026)
PHASE1
A Study to Investigate the Clinical Benefit of Isatuximab in Combination With Bortezomib, Lenalidomide and Dexamethasone in Adults With Newly Diagnosed Multiple Myeloma Not Eligible for Transplant Sanofi NA ACTIVE NOT RECRUITING
(Apr 1, 2026)
PHASE3
Daratumumab, Bortezomib, and Dexamethasone Followed by Daratumumab, Ixazomib, and Dexamethasone in Treating Patients With Relapsed or Refractory Multiple Myeloma M.D. Anderson Cancer Center NA ACTIVE NOT RECRUITING
(Apr 1, 2026)
PHASE2
Paclitaxel in Patients With GIST With Low P-glycoprotein Expression After Failure of at Least Imatinib and Sunitinib, and Regorafenib. Asan Medical Center NA COMPLETED
(Apr 1, 2026)
PHASE2
A Study to Evaluate Subcutaneous TAK-079 Added to Standard of Care Regimens in Participants With Newly Diagnosed Multiple Myeloma (NDMM) Takeda NA COMPLETED
(Apr 1, 2026)
PHASE1
Evaluation of Efficacy and Safety of Belantamab Mafodotin, Bortezomib and Dexamethasone Versus Daratumumab, Bortezomib and Dexamethasone in Participants With Relapsed/Refractory Multiple Myeloma GlaxoSmithKline NA ACTIVE NOT RECRUITING
(Apr 1, 2026)
PHASE3
VR-CAP in the First-line Treatment for Patients With Marginal Zone Lymphoma Henan Cancer Hospital NA COMPLETED
(Apr 1, 2026)
PHASE2
Isatuximab, Lenalidomide, Bortezomib, and Dexamethasone in NDMM Jacob Laubach, MD NA ACTIVE NOT RECRUITING
(Apr 1, 2026)
PHASE2
Palbociclib in Combo w/Chemotherapy in Peds Relapsed/Refractory Acute Lymphoblastic Leukemia Tanja Andrea Gruber NA COMPLETED
(Apr 1, 2026)
PHASE1
Iberdomide, Daratumumab, Bortezomib, and Dexamethasone for Treatment of Newly Diagnosed Multiple Myeloma, IDEAL Study Mayo Clinic NA ACTIVE NOT RECRUITING
(Apr 1, 2026)
PHASE1, PHASE2
A Study Comparing Teclistamab Monotherapy Versus Pomalidomide, Bortezomib, Dexamethasone (PVd) or Carfilzomib, Dexamethasone (Kd) in Participants With Relapsed or Refractory Multiple Myeloma Janssen Research & Development, LLC NA ACTIVE NOT RECRUITING
(Apr 1, 2026)
PHASE3
A Study of VRd-based Regimen Combined With CART-ASCT-CART2 Treatment in NDMM Patients With P53 Abnormalities Institute of Hematology & Blood Diseases Hospital, China NA ACTIVE NOT RECRUITING
(Apr 1, 2026)
PHASE2
Rivoceranib Plus Paclitaxel in Patients With Gastrointestinal Stromal Tumor Asan Medical Center NA RECRUITING
(Apr 1, 2026)
PHASE2
GIST Oral Paclitaxel(Liporaxel) Asan Medical Center NA RECRUITING
(Apr 1, 2026)
PHASE2
China Subpopulation: Evaluation of Efficacy and Safety of Belantamab Mafodotin, Bortezomib and Dexamethasone Versus Daratumumab, Bortezomib and Dexamethasone in Participants With Relapsed/Refractory Multiple Myeloma GlaxoSmithKline NA ACTIVE NOT RECRUITING
(Apr 1, 2026)
PHASE3
Japan Expansion Cohort: Evaluation of Efficacy and Safety of Belantamab Mafodotin, Bortezomib and Dexamethasone Versus Daratumumab, Bortezomib and Dexamethasone in Participants With Relapsed/Refractory Multiple Myeloma GlaxoSmithKline NA ACTIVE NOT RECRUITING
(Apr 1, 2026)
PHASE3
Study Comparing Conventional Dose Combination RVD to High-Dose Treatment With ASCT in the Initial Myeloma up to 65 Years University Hospital, Toulouse NA COMPLETED
(Mar 1, 2026)
PHASE3
Escalating Doses of Thalidomide in Conjunction With Bortezomib and HIgh Dose Melphalan for BSCT Hackensack Meridian Health NA COMPLETED
(Mar 1, 2026)
PHASE1, PHASE2
Auto Transplant High Dose Melphalan vs High Dose Melphalan+Bortezomib in Pts With Multiple Myeloma Age 65 Years or Older Hackensack Meridian Health NA TERMINATED
(Mar 1, 2026)
PHASE2
Allogeneic Hematopoietic Stem Cell Transplantation for Multiple Myeloma Hackensack Meridian Health NA COMPLETED
(Mar 1, 2026)
PHASE2
Vorinostat,Lenalinomide and Dexamethasone in Multiple Myeloma Refractory to Previous Lenalinomide Containing Regimens Hackensack Meridian Health NA COMPLETED
(Mar 1, 2026)
PHASE1, PHASE2
Combination Chemotherapy With or Without Bortezomib in Treating Younger Patients With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia or Stage II-IV T-Cell Lymphoblastic Lymphoma National Cancer Institute (NCI) NA ACTIVE NOT RECRUITING
(Mar 1, 2026)
PHASE3
A Study to Determine Dose, Safety, Tolerability and Efficacy of CC-220 Monotherapy, and in Combination With Other Treatments in Subjects With Multiple Myeloma Celgene NA ACTIVE NOT RECRUITING
(Mar 1, 2026)
PHASE1, PHASE2
International Study for Treatment of High Risk Childhood Relapsed ALL 2010 Charite University, Berlin, Germany NA RECRUITING
(Mar 1, 2026)
PHASE2
Daratumumab Combined With Bortezomib, Cyclophosphamide and Dexamethasone for the Treatment of Multiple Myeloma Patients Presenting With Extramedullary Disease Stichting European Myeloma Network NA ACTIVE NOT RECRUITING
(Mar 1, 2026)
PHASE2
Open-label Study Comparing Iberdomide, Daratumumab and Dexamethasone (IberDd) Versus Daratumumab, Bortezomib, and Dexamethasone (DVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM) Celgene NA ACTIVE NOT RECRUITING
(Mar 1, 2026)
PHASE3
Nemtabrutinib, Bortezomib, and Rituximab for WM Seoul National University Hospital NA NOT YET RECRUITING
(Mar 1, 2026)
PHASE2


Bortezomib Generic API Manufacturers

Several generic applications have been filed for Bortezomib. The first generic version for Bortezomib was by Qilu Pharmaceutical Hainan Co Ltd and was approved on May 2, 2022. And the latest generic version is by Gland Pharma Ltd and was approved on Jan 6, 2026.

Given below is the list of companies who have filed for Bortezomib generic, along with the locations of their manufacturing plants worldwide.