Binimetinib Patent Expiration

Binimetinib is Used for treating melanoma and non-small cell lung cancer in combination with encorafenib for patients with a BRAF mutation. It was first introduced by Array Biopharma Inc in its drug Mektovi on Jun 27, 2018.


Binimetinib Patents

Given below is the list of patents protecting Binimetinib, along with the drug name that holds that patent and the company name owning that drug.

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Drug Used in Drug Patent Number Drug Patent Title Drug Patent Expiry Drug Owner
Mektovi US9562016 Preparation of and formulation comprising a MEK inhibitor Oct 18, 2033 Array Biopharma Inc
Mektovi US9598376 Preparation of and formulation comprising a MEK inhibitor Oct 18, 2033 Array Biopharma Inc
Mektovi US9980944 Preparation of and formulation comprising a MEK inhibitor Oct 18, 2033 Array Biopharma Inc
Mektovi US9314464 Compounds and compositions as protein kinase inhibitors Jul 04, 2031 Array Biopharma Inc
Mektovi US10005761 Compounds and compositions as protein kinase inhibitors Aug 27, 2030 Array Biopharma Inc
Mektovi US9593100 Compounds and compositions as protein kinase inhibitors Aug 27, 2030 Array Biopharma Inc
Mektovi US9850229 Compounds and compositions as protein kinase inhibitors Aug 27, 2030 Array Biopharma Inc
Mektovi US7777050 N3 alkylated benzimidazole derivatives as MEK inhibitors Mar 13, 2027 Array Biopharma Inc
Mektovi US8178693 N3 alkylated benzimidazole derivatives as MEK inhibitors Mar 13, 2023

(Expired)

Array Biopharma Inc
Mektovi US8193229 Method of treatment using N3 alkylated benzimidazole derivatives as MEK inhibitors Mar 13, 2023

(Expired)

Array Biopharma Inc
Mektovi US8513293 Methods of treating a hyperproliferative disorder or inhibiting cell growth in a mammal Mar 13, 2023

(Expired)

Array Biopharma Inc



Binimetinib's Family Patents

Family Patents

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Clinical Trials

Recent Clinical Trials on Binimetinib:

Sometimes companies keep conducting clinical trials even after the drug's approval to discover new formulations, methods of use, or new treatment indications, so they could file for additional patents or receive regulatory exclusivity extensions, such as pediatric exclusivity, potentially delaying generic competition. Based on these recent clinical trials, generic companies need to consider the potential for new intellectual property or regulatory hurdles. These strategic moves by the drug owner might delay generic substitution or lead to additional sales of the brand drug, even after patent expiry.

Title Lead Sponsor Collaborators Status Phases
Clinical Trials
Binimetinib for People With Relapsed/Refractory BRAF Wild Type Hairy Cell Leukemia and Variant National Cancer Institute (NCI) NA RECRUITING
(Sep 14, 2026)
PHASE2
Identification and Treatment Of Micrometastatic Disease in Stage III Colon Cancer Massachusetts General Hospital NA ACTIVE NOT RECRUITING
(Sep 1, 2026)
PHASE3
A Study to Compare the Administration of Encorafenib + Binimetinib + Nivolumab Versus Ipilimumab + Nivolumab in BRAF-V600 Mutant Melanoma With Brain Metastases SWOG Cancer Research Network NA RECRUITING
(Sep 1, 2026)
PHASE2
A Clinical Trial of Three Study Medicines (Encorafenib, Binimetinib, and Pembrolizumab) in Patients With Advanced or Metastatic Melanoma Pfizer NA ACTIVE NOT RECRUITING
(Sep 1, 2026)
PHASE3
Binimetinib and Imatinib for Unresectable Stage III-IV KIT-Mutant Melanoma University of California, San Francisco NA RECRUITING
(Aug 1, 2026)
PHASE2
A Study to Learn About the Study Medicine Called PF-07799933 in People With Advanced Solid Tumors With BRAF Alterations. Pfizer NA ACTIVE NOT RECRUITING
(Aug 1, 2026)
PHASE1
Palbociclib and Binimetinib in RAS-Mutant Cancers, A ComboMATCH Treatment Trial National Cancer Institute (NCI) NA ACTIVE NOT RECRUITING
(Aug 1, 2026)
PHASE2
Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial) National Cancer Institute (NCI) NA ACTIVE NOT RECRUITING
(Jul 1, 2026)
PHASE2
Testing Treatment With Encorafenib and Binimetinib Before Surgery for Melanoma With Lymph Node Involvement ECOG-ACRIN Cancer Research Group NA TERMINATED
(Jul 1, 2026)
PHASE2
ENCOrafenib With Binimetinib in bRAF NSCLC Intergroupe Francophone de Cancerologie Thoracique NA ACTIVE NOT RECRUITING
(Jul 1, 2026)
PHASE2
Testing the Combination of the Anticancer Drugs ZEN003694 and Binimetinib in Patients With Advanced/Metastatic or Unresectable Solid Tumors With RAS Alterations and Triple Negative Breast Cancer National Cancer Institute (NCI) NA RECRUITING
(Jul 1, 2026)
PHASE1
Encorafenib Plus Binimetinib for People With BRAF V600 Mutated Relapsed/Refractory HCL National Cancer Institute (NCI) NA ACTIVE NOT RECRUITING
(Jun 10, 2026)
PHASE2
Nivolumab With Trametinib and Dabrafenib, or Encorafenib and Binimetinib in Treating Patients With BRAF Mutated Metastatic or Unresectable Stage III-IV Melanoma M.D. Anderson Cancer Center NA ACTIVE NOT RECRUITING
(Jun 1, 2026)
PHASE2
Encorafenib, Binimetinib and Cetuximab in Subjects With Previously Untreated BRAF-mutant ColoRectal Cancer Pierre Fabre Medicament NA COMPLETED
(Jun 1, 2026)
PHASE2
Binimetinib and Encorafenib for the Treatment of Advanced Solid Tumors With Non-V600E BRAF Mutations University Health Network, Toronto NA ACTIVE NOT RECRUITING
(Jun 1, 2026)
PHASE2
Study of IDE196 in Patients With Solid Tumors Harboring GNAQ/11 Mutations or PRKC Fusions IDEAYA Biosciences NA RECRUITING
(Jun 1, 2026)
PHASE1, PHASE2
Study of Binimetinib in Combination With Pembrolizumab in Advanced Non-Small Cell Lung Cancer University Health Network, Toronto NA ACTIVE NOT RECRUITING
(Jun 1, 2026)
PHASE1
Testing Binimetinib as a Potential Targeted Treatment in Cancers With NRAS Genetic Changes (MATCH-Subprotocol Z1A) National Cancer Institute (NCI) NA ACTIVE NOT RECRUITING
(May 1, 2026)
PHASE2
Avelumab With Binimetinib, Sacituzumab Govitecan, or Liposomal Doxorubicin in Treating Stage IV or Unresectable, Recurrent Triple Negative Breast Cancer Laura Huppert, MD, BA NA ACTIVE NOT RECRUITING
(Apr 1, 2026)
PHASE2
Encorafenib and Binimetinib With or Without Nivolumab in Treating Patients With Metastatic Radioiodine Refractory BRAF V600 Mutant Thyroid Cancer Providence Health & Services NA ACTIVE NOT RECRUITING
(Apr 1, 2026)
PHASE2
Study of Inlexisertib (DCC-3116) in Participants With RAS/MAPK Pathway Mutant Solid Tumors Deciphera Pharmaceuticals, LLC NA TERMINATED
(Apr 1, 2026)
PHASE1
Binimetinib and Encorafenib for the Treatment of Metastatic Melanoma and Central Nervous System Metastases M.D. Anderson Cancer Center NA RECRUITING
(Apr 1, 2026)
PHASE2
Phase II Study Investigating the Combination of Encorafenib and Binimetinib in BRAF V600E Mutated Chinese Patients With Metastatic Non-Small Cell Lung Cancer Pierre Fabre Medicament NA ACTIVE NOT RECRUITING
(Apr 1, 2026)
PHASE2
MEKTOVIĀ® for the Treatment of Pediatric Adamantinomatous Craniopharyngioma Nationwide Children's Hospital NA RECRUITING
(Apr 1, 2026)
PHASE2
Study of Chemotherapy, With or Without Binimetinib in Advanced Biliary Tract Cancers in 2nd Line Setting (A ComboMATCH Treatment Trial) National Cancer Institute (NCI) NA ACTIVE NOT RECRUITING
(Apr 1, 2026)
PHASE2
Personalized Medicine for Advanced Biliary Cancer Patients UNICANCER NA RECRUITING
(Apr 1, 2026)
PHASE3
An Open-label Study of Encorafenib + Binimetinib in Patients With BRAFV600-mutant Non-small Cell Lung Cancer Pfizer NA COMPLETED
(Mar 1, 2026)
PHASE2
Binimetinib and Hydroxychloroquine in Treating Patients With KRAS Mutant Metastatic Pancreatic Cancer M.D. Anderson Cancer Center NA COMPLETED
(Mar 1, 2026)
PHASE1
A Study Comparing 3 Study Medicines (Encorafenib, Binimetinib, Pembrolizumab) to 2 Study Medicines (Ipilimumab and Nivolumab) in Patients With Advanced Melanoma Pfizer NA TERMINATED
(Mar 1, 2026)
PHASE2


Binimetinib Generic API Manufacturers

Given below is the list of companies who have filed for Binimetinib generic, along with the locations of their manufacturing plants worldwide.