Bexarotene Patent Expiration

Bexarotene is Used for treating cutaneous lesions in patients with refractory or persistent stage IA and IB cutaneous T-cell lymphoma. It was first introduced by Bausch Health Ireland Ltd in its drug Targretin on Dec 29, 1999. 10 different companies have introduced drugs containing Bexarotene.


Bexarotene Patents

Given below is the list of patents protecting Bexarotene, along with the drug name that holds that patent and the company name owning that drug.

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Drug Used in Drug Patent Number Drug Patent Title Drug Patent Expiry Drug Owner
Targretin US5962731 Compounds having selective activity for retinoid X receptors, and means for modulation of processes mediated by retinoid X receptors Oct 05, 2016

(Expired)

Bausch
Targretin US5780676 Compounds having selective activity for Retinoid X Receptors, and means for modulation of processes mediated by Retinoid X Receptors Jul 14, 2015

(Expired)

Bausch



Bexarotene's Family Patents

Family Patents

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Clinical Trials

Recent Clinical Trials on Bexarotene:

Sometimes companies keep conducting clinical trials even after the drug's approval to discover new formulations, methods of use, or new treatment indications, so they could file for additional patents or receive regulatory exclusivity extensions, such as pediatric exclusivity, potentially delaying generic competition. Based on these recent clinical trials, generic companies need to consider the potential for new intellectual property or regulatory hurdles. These strategic moves by the drug owner might delay generic substitution or lead to additional sales of the brand drug, even after patent expiry.

Title Lead Sponsor Collaborators Status Phases
Clinical Trials
A Phase I/II Study of Bexarotene in Combination With ZD1839 (IRESSA®) in the Treatment of Non-Small Cell Lung Cancer Stanford University NA COMPLETED
(Jun 1, 2026)
PHASE1, PHASE2


Bexarotene Generic API Manufacturers

Several generic applications have been filed for Bexarotene. The first generic version for Bexarotene was by Bionpharma Inc and was approved on Aug 12, 2014. And the latest generic version is by Cipla Ltd and was approved on Dec 10, 2024.

Given below is the list of companies who have filed for Bexarotene generic, along with the locations of their manufacturing plants worldwide.