Aspirin Patent Expiration

Aspirin is Used for targeting release to the small intestine, reducing fever, and relieving minor aches and pains. It was first introduced by Bayer Healthcare Llc in its drug 8-Hour Bayer on Approved Prior to Jan 1, 1982. Other drugs containing Aspirin are Durlaza, Measurin, Vazalore, Bayer Extra Strength Aspirin For Migraine Pain. 3 different companies have introduced drugs containing Aspirin.


Aspirin Patents

Given below is the list of patents protecting Aspirin, along with the drug name that holds that patent and the company name owning that drug.

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Drug Used in Drug Patent Number Drug Patent Title Drug Patent Expiry Drug Owner
Vazalore US10646431 PH dependent carriers for targeted release of pharmaceuticals along the gastrointestinal tract, compositions therefrom, and making and using same Sep 29, 2032 Plx Pharma
Vazalore US10786444 PH dependent carriers for targeted release of pharmaceuticals along the gastrointestinal tract, compositions therefrom, and making and using same Sep 29, 2032 Plx Pharma
Vazalore US9216150 pH dependent carriers for targeted release of pharmaceuticals along the gastrointestinal tract, compositions therefrom, and making and using same Sep 29, 2032 Plx Pharma
Vazalore US9226892 pH dependent carriers for targeted release of pharmaceuticals along the gastrointestinal tract, compositions therefrom, and making and using same Sep 29, 2032 Plx Pharma
Vazalore US8865187 Compositions comprising lecithin oils and NSAIDs for protecting the gastrointestinal tract and providing enhanced therapeutic activity Mar 23, 2022

(Expired)

Plx Pharma
Vazalore US9101637 Methods of treating inflammation with compositions comprising lecithin oils and NSAIDS for protecting the gastrointestinal tract and providing enhanced therapeutic activity Mar 23, 2022

(Expired)

Plx Pharma
Vazalore US9351984 Compositions comprising lecithin oils and NSAIDs for protecting the gastrointestinal tract and providing enhanced therapeutic activity Dec 19, 2021

(Expired)

Plx Pharma



A patent's expiry date may change depending upon legal activities going on that patent. Critical activities like abandoning of a patent, term extension of a patent or amendment of its claims can increase or decrease the life of a patent hence affecting its expiry date and in turn affecting the generic launch date of that drug. Tracking these ongoing activities on a patent application helps to keep an eye on the latest developments in the patent process of the drug which can give an idea of how early a drug's generic could be available. The next section provides a list of recent legal activities on Aspirin's patents.

Given below is the list recent legal activities going on the following patents of Aspirin.

Activity Date Patent Number
Patent litigations
Payment of Maintenance Fee, 4th Yr, Small Entity 14 Mar, 2024 US10786444
Payment of Maintenance Fee, 4th Yr, Small Entity 25 Oct, 2023 US10646431
Expire Patent 18 Sep, 2023 US9101637
Payment of Maintenance Fee, 8th Yr, Small Entity 02 Aug, 2023 US9226892
7.5 yr surcharge - late pmt w/in 6 mo, Small Entity 02 Aug, 2023 US9226892
Payment of Maintenance Fee, 8th Yr, Small Entity 07 Jun, 2023 US9216150
Maintenance Fee Reminder Mailed 03 Apr, 2023 US9101637
Expire Patent 28 Nov, 2022 US8865187
Maintenance Fee Reminder Mailed 13 Jun, 2022 US8865187
Recordation of Patent Grant Mailed 29 Sep, 2020 US10786444


Aspirin's Family Patents

Family Patents

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Clinical Trials

Recent Clinical Trials on Aspirin:

Sometimes companies keep conducting clinical trials even after the drug's approval to discover new formulations, methods of use, or new treatment indications, so they could file for additional patents or receive regulatory exclusivity extensions, such as pediatric exclusivity, potentially delaying generic competition. Based on these recent clinical trials, generic companies need to consider the potential for new intellectual property or regulatory hurdles. These strategic moves by the drug owner might delay generic substitution or lead to additional sales of the brand drug, even after patent expiry.

Title Lead Sponsor Collaborators Status Phases
Clinical Trials
A Study to Learn About How Safe BAY3389934 is and How it Affects Blood Clotting When Given Alone or With Aspirin in Healthy Participants Bayer NA RECRUITING
(Sep 22, 2026)
PHASE1
Pomalidomide and Nivolumab in People With Virus-Associated Malignancies With or Without HIV National Cancer Institute (NCI) NA RECRUITING
(Sep 10, 2026)
PHASE1
Aspirin in Preventing Disease Recurrence in Patients With Barrett Esophagus After Successful Elimination by Radiofrequency Ablation National Cancer Institute (NCI) NA ACTIVE NOT RECRUITING
(Sep 1, 2026)
PHASE2
Study to Evaluate the Efficacy & Safety of the INTERCEPT Blood System for RBCs in Complex Cardiac Surgery Patients Cerus Corporation NA COMPLETED
(Sep 1, 2026)
PHASE3
Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis University of Florida NA ACTIVE NOT RECRUITING
(Sep 1, 2026)
PHASE3
Polypill in Acute Coronary Syndrome University of Texas Southwestern Medical Center NA COMPLETED
(Sep 1, 2026)
PHASE2
APPLE: Aspirin to Prevent Pregnancy Loss and Preeclampsia University of Pennsylvania NA RECRUITING
(Sep 1, 2026)
PHASE3
Early Antiplatelet Administration After Intravenous Thrombolysis for Acute Ischemic Stroke (TREND-IVT) Capital Medical University NA RECRUITING
(Sep 1, 2026)
PHASE3
Reduce Opiate Exposure With ACL Surgery Campbell Clinic NA ENROLLING BY INVITATION
(Sep 1, 2026)
PHASE3
Study Targeting Myocardial Perfusion and Symptom Relief in Women With SGLT2 Inhibitors (STRONG) University of Virginia NA RECRUITING
(Sep 1, 2026)
PHASE1
Aspirin in Acute Pneumonia in the Elderly: a Multicenter, Double-blind, Randomized, Placebo-controlled Trial. Centre Hospitalier Universitaire Dijon NA NOT YET RECRUITING
(Sep 1, 2026)
PHASE3
Thrombolysis in Factor Xa-inhibitors Trial Guri Hagberg NA RECRUITING
(Sep 1, 2026)
PHASE3
A Polypill for Acute Coronary Syndrome University of Texas Southwestern Medical Center NA RECRUITING
(Sep 1, 2026)
PHASE2
Reducing the Burden of Cardiovascular Events With Antiplatelet Therapy in Patients With IntraCerebral Haemorrhage Christian Medical College and Hospital, Ludhiana, India NA RECRUITING
(Sep 1, 2026)
PHASE3
Aspirin in Subclinical Coronary Artery Disease: A Pilot Randomised Controlled Trial Montreal Heart Institute NA RECRUITING
(Sep 1, 2026)
PHASE3
Intravenous Recombinant Human Prourokinase for Acute Medium Vessel Occlusion 4.5-24 Hours After Ischemic Stroke The First Affiliated Hospital of Anhui Medical University NA NOT YET RECRUITING
(Sep 1, 2026)
PHASE3
The Efficacy and Safety of Tirofiban Enhanced Antiplatelet Therapy in the Treatment of Ruptured Intracranial Aneurysms With Stent First Affiliated Hospital of Fujian Medical University NA NOT YET RECRUITING
(Sep 1, 2026)
PHASE3
TicAgreLor Versus Placebo to Prevent Cerebral ISCHemia in anEuRysmal Low Grade SAH A Double Blinded Randomised Controlled Study University Hospital, Toulouse NA NOT YET RECRUITING
(Sep 1, 2026)
PHASE3
Pomalidomide in Combination With Liposomal Doxorubicin in People With Advanced or Refractory Kaposi Sarcoma National Cancer Institute (NCI) NA ACTIVE NOT RECRUITING
(Aug 21, 2026)
PHASE1
Gemcitabine, Carboplatin, and Lenalidomide for Treatment of Advanced/Metastatic Urothelial Cancer and Other Solid Tumors National Cancer Institute (NCI) NA COMPLETED
(Aug 6, 2026)
PHASE1
Aspirin in Preventing Recurrence of Cancer in Patients With HER2 Negative Stage II-III Breast Cancer After Chemotherapy, Surgery, and/or Radiation Therapy Alliance for Clinical Trials in Oncology NA TERMINATED
(Aug 1, 2026)
PHASE3
Aspirin in Preventing Colorectal Cancer in Patients With Colorectal Adenoma National Cancer Institute (NCI) NA ACTIVE NOT RECRUITING
(Aug 1, 2026)
PHASE2
Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial - Hemodynamics (CREST-H) Columbia University NA COMPLETED
(Aug 1, 2026)
PHASE3
Comparative Pharmacokinetic, Pharmacodynamic, and Safety Study of 1 Dose Level of Aspirin for Injection and Oral Aspirin Tablets in Healthy Adult Human Subjects Rhoshan Pharmaceuticals Inc NA COMPLETED
(Aug 1, 2026)
PHASE1
The Efficacy of Aspirin Combined With Hydroxychloroquine Treatment in High Risk Pregnancies for Preeclampsia Yoo-min Kim NA RECRUITING
(Aug 1, 2026)
PHASE3
Low Dose Aspirin for the Prevention of Postpartum Related Breast Cancer Mayo Clinic NA RECRUITING
(Aug 1, 2026)
PHASE2
Mechanisms of Benefit of IL4RA Inhibition in Aspirin-Exacerbated Respiratory Disease Brigham and Women's Hospital NA ACTIVE NOT RECRUITING
(Aug 1, 2026)
PHASE2
Addition of Antibiotics to Upfront Treatment Regimen for Colorectal Cancer Virginia Commonwealth University NA RECRUITING
(Aug 1, 2026)
PHASE2
Combination Antithrombotic Treatment for Prevention of Recurrent Ischemic Stroke in IntraCranial Atherosclerotic diseaSe (CATIS- ICAS) Population Health Research Institute NA NOT YET RECRUITING
(Aug 1, 2026)
PHASE3
Combination Immunotherapy Treatment for Locally Advanced Unresectable or Metastatic, PD-L1 Negative (CPS<10), gBRCA Negative, Triple Negative Breast Cancer Including BreakVax ImmunoTreatment (Designed and Manufactured Per Patient), Chemotherapy and Anti PD-1 Therapy BreakBio Corp NA NOT YET RECRUITING
(Aug 1, 2026)
PHASE1, PHASE2
Combination Immunotherapy Treatment for Glioblastoma Including BreakVax ImmunoTreatment (Designed and Manufactured Per Patient), Chemotherapy and Anti PD-1 Therapy BreakBio Corp NA NOT YET RECRUITING
(Aug 1, 2026)
PHASE1, PHASE2
APEX-STROKE Adaptive Platform Trial for Stroke Fudan University NA NOT YET RECRUITING
(Aug 1, 2026)
PHASE3
Stroke Minimization Through Additive Anti-atherosclerotic Agents in Routine Treatment II Study (SMAART II) Northern California Institute of Research and Education NA RECRUITING
(Jul 1, 2026)
PHASE3
ACT-GLOBAL Adaptive Platform Trial for Stroke The George Institute NA RECRUITING
(Jul 1, 2026)
PHASE3
LEARNER- Low dosE AspiRiN prEterm tRial (Angola) Instituto Nacional de Investigacao em Saude, Angola NA ACTIVE NOT RECRUITING
(Jul 1, 2026)
PHASE1, PHASE2
Percutaneous Embolectomy, Low Dose Thrombolysis or Heparin for Intermediate High Risk Pulmonary Embolism (STRATIFY II) Jesper Kjaergaard NA RECRUITING
(Jul 1, 2026)
PHASE3
Clopidogrel Plus Aspirin in Acute Ischemic Stroke Following Thrombectomy and/or Intravenous Thrombolysis (CoPrime) University of Alberta NA COMPLETED
(Jul 1, 2026)
PHASE2
Comparing High and lOw-dose asPirin With Dual anTIplatelet Therapy for Three Months Using prasUgrel and aSpirin Following Coronary Artery Bypass Grafting. (OPTIMUS-CABG Trial) Dolnośląskie Centrum Chorób Serca im.prof. Zbigniewa Religi MEDINET Sp. z o.o. NA RECRUITING
(Jul 1, 2026)
PHASE3
Efficacy and Safety of Immunoglobulin Plus Firsekibart in Patients With Kawasaki Disease Children's Hospital of Fudan University NA NOT YET RECRUITING
(Jul 1, 2026)
PHASE2, PHASE3
Y-6 Sublingual Tablets for Acute Penetrating Artery Infarction Neurodawn Pharmaceutical Co., Ltd. NA NOT YET RECRUITING
(Jul 1, 2026)
PHASE2, PHASE3
Study on Aspirin Versus Placebo in Resected Colon Cancer With PI3K Mutation Stage III or II High Risk University Hospital, Rouen NA ACTIVE NOT RECRUITING
(Jun 1, 2026)
PHASE3
Aspirin and Rintatolimod With or Without Interferon-alpha 2b in Treating Patients With Prostate Cancer Before Surgery Roswell Park Cancer Institute NA ACTIVE NOT RECRUITING
(Jun 1, 2026)
PHASE2
The Value of Screening for HPR in Patients Undergoing Lower Extremity Arterial Endovascular Interventions Marissa Jarosinski NA TERMINATED
(Jun 1, 2026)
PHASE3
Intensified Tuberculosis Treatment to Reduce the Mortality of Patients With Tuberculous Meningitis ANRS, Emerging Infectious Diseases NA RECRUITING
(Jun 1, 2026)
PHASE3
Poly-unsaturated Fats for Improving Nasal Polyps and Asthma Norfolk and Norwich University Hospitals NHS Foundation Trust NA COMPLETED
(Jun 1, 2026)
PHASE3
The Seven Trial: Exploiting the Unfolded Protein Response HonorHealth Research Institute NA TERMINATED
(Jun 1, 2026)
PHASE1
The PARTUM Trial: Postpartum Aspirin to Reduce Thromboembolism Undue Morbidity University of Calgary NA RECRUITING
(Jun 1, 2026)
PHASE3
Efficacy and Safety of Early Combined Therapy With PCSK9 Inhibitors and Statins in Acute Ischemic Stroke Xiang Luo NA COMPLETED
(Jun 1, 2026)
PHASE2, PHASE3
CiLostAzol for pReventIon of Recurrent sTroke in Africa Northern California Institute of Research and Education NA NOT YET RECRUITING
(Jun 1, 2026)
PHASE3
Comparative Pharmacokinetic, Pharmacodynamic, and Safety Study of 1 Dose of Aspirin for Injection and Oral Aspirin Tablets in Healthy Adult Subjects Rhoshan Pharmaceuticals Inc NA COMPLETED
(Jun 1, 2026)
PHASE1
HR-MRI-Directed Tirofiban Therapy for Late-Window Acute Ischemic Stroke (TIAN) Weifang Medical University NA RECRUITING
(Jun 1, 2026)
PHASE3
Duration of Dual Anti-Platelet Therapy in Chronic Limb Threatening Ischemia After Distal Revascularization Fondation Hôpital Saint-Joseph NA RECRUITING
(Jun 1, 2026)
PHASE3
Evaluating Bu Yang Huanwu Decoction For Early Diabetic Vascular Disease Xuanwu Hospital, Beijing NA NOT YET RECRUITING
(Jun 1, 2026)
PHASE3
Optimizing the Use of Aspirin for the Prevention of Preeclampsia Hospital Universitari Vall d'Hebron Research Institute NA NOT YET RECRUITING
(Jun 1, 2026)
PHASE3
Sodium Bicarbonate to Treat Severe Acidosis in the Critically Ill University Hospital, Montpellier NA COMPLETED
(May 1, 2026)
PHASE3
T Cells Expressing a Novel Fully-Human Anti-BCMA CAR for Treating Multiple Myeloma National Cancer Institute (NCI) NA COMPLETED
(May 1, 2026)
PHASE1
A Phase IIa Randomized, Double-Blinded Clinical Trial of Naproxen or Aspirin for Cancer Immune Interception in Lynch Syndrome M.D. Anderson Cancer Center NA RECRUITING
(May 1, 2026)
PHASE2
Testing a Combination of Vaccines for Cancer Prevention in Lynch Syndrome National Cancer Institute (NCI) NA ACTIVE NOT RECRUITING
(May 1, 2026)
PHASE2
Aspirin for the Prevention of Preeclampsia and Pregnancy Outcomes After Assisted Reproductive Technology University Hospital, Toulouse NA RECRUITING
(May 1, 2026)
PHASE3
Best Antithrombotic Therapy in Patients With Acute Venous ThromboEmbolism While Taking Antiplatelets Centre Hospitalier Universitaire de Saint Etienne NA RECRUITING
(May 1, 2026)
PHASE3
A Study to Evaluate Safety, Pharmacokinetics and Pharmacodynamics of RBD4059 in Participants With Stable Coronary Artery Disease Ribocure Pharmaceuticals AB NA COMPLETED
(May 1, 2026)
PHASE2
Precision Antiplatelet Therapy Guided by Platelet Aggregation Function in Patients With Acute Ischemic STROKE Sichuan Provincial People's Hospital NA RECRUITING
(May 1, 2026)
PHASE3
Aspirin Versus Clopidogrel in Chronic Coronary Syndrome in Arabian Gulf Countries Khalid F Alhabib NA NOT YET RECRUITING
(May 1, 2026)
PHASE3
Pro-urokinase for Extended-Window Posterior Circulation Stroke The First Affiliated Hospital of Zhengzhou University NA NOT YET RECRUITING
(May 1, 2026)
PHASE3
Lenalidomide and Dexamethasone With or Without Thalidomide in Treating Patients With Multiple Myeloma National Cancer Institute (NCI) NA ACTIVE NOT RECRUITING
(Apr 1, 2026)
PHASE3
Oxaliplatin, Leucovorin Calcium, and Fluorouracil With or Without Celecoxib in Treating Patients With Stage III Colon Cancer Previously Treated With Surgery Alliance for Clinical Trials in Oncology NA COMPLETED
(Apr 1, 2026)
PHASE3
Efficacy of Immunoglobulin Plus Prednisolone in Reducing Coronary Artery Lesion in Patients With Kawasaki Disease Children's Hospital of Fudan University NA COMPLETED
(Apr 1, 2026)
PHASE3
Randomised Evaluation of COVID-19 Therapy University of Oxford NA RECRUITING
(Apr 1, 2026)
PHASE3
AERIAL Trial: Antiplatelet Therapy in Heart Transplantation Ottawa Heart Institute Research Corporation NA RECRUITING
(Apr 1, 2026)
PHASE3
Mechanisms of Dupilumab in AERD Scripps Clinic NA COMPLETED
(Apr 1, 2026)
PHASE2
Comparison of the Effect of Medication Therapy in Alleviating Migraine With Patent Foramen Ovale Chinese Academy of Medical Sciences, Fuwai Hospital NA COMPLETED
(Apr 1, 2026)
PHASE2
Anti-Platelets in Chronic Obstructive Pulmonary Disease Brigham and Women's Hospital NA COMPLETED
(Apr 1, 2026)
PHASE2
Concomitant Use of Clopidogrel With Atorvastatin or Rosuvastatin in Patients With Small Vessel Stroke Kafrelsheikh University NA RECRUITING
(Apr 1, 2026)
PHASE3
Pomalidomide as an Immune-enhancing Agent for the Control of HIV University of Aarhus NA ACTIVE NOT RECRUITING
(Apr 1, 2026)
PHASE1, PHASE2
Aspirin Dose Escalation for the Prevention of Recurrent Preterm Delivery Trial The George Washington University Biostatistics Center NA RECRUITING
(Apr 1, 2026)
PHASE3
A Study of SRSD107 in Participants With Chronic Coronary and/or Peripheral Arterial Disease Sirius Therapeutics Co., Ltd. NA RECRUITING
(Apr 1, 2026)
PHASE2
Can Aspirin Reduce the Risk of HCC in Cirrhosis: The AspiRe HCC Trial Curtin University NA NOT YET RECRUITING
(Apr 1, 2026)
PHASE3
Tenecteplase for Late-Window Stroke Guided by DWI-FLAIR Mismatch The First Affiliated Hospital of Zhengzhou University NA NOT YET RECRUITING
(Apr 1, 2026)
PHASE3
Spatiotemporal Evolution of Traditional Chinese Medicine Mechanisms in Acute Ischemic Stroke Treated With Dengzhan Xixin and Dengzhan Shengmai Guangdong Provincial Hospital of Traditional Chinese Medicine NA NOT YET RECRUITING
(Apr 1, 2026)
PHASE2, PHASE3
Aspirin to Target Arterial Events in Chronic Kidney Disease University of Southampton NA TERMINATED
(Mar 1, 2026)
PHASE3
Tenecteplase Reperfusion Therapy in Acute Ischemic Cerebrovascular Events-BEYOND Beijing Tiantan Hospital NA RECRUITING
(Mar 1, 2026)
PHASE3
Aspirin Continuation or Interruption in Patients at Moderate Risk for Cardiovascular Events Undergoing Colonoscopy and/or Polypectomy Chinese University of Hong Kong NA RECRUITING
(Mar 1, 2026)
PHASE3
Rivaroxaban vs Warfarin in Patients With Mechanical Heart Valves Rawalpindi Institute of Cardiology NA ENROLLING BY INVITATION
(Mar 1, 2026)
PHASE3
Counterpain PXM Versus Diclofenac Versus Piroxicam Taisho Pharmaceutical Indonesia NA COMPLETED
(Mar 1, 2026)
PHASE3


Aspirin Generic API Manufacturers

Given below is the list of companies who have filed for Aspirin generic, along with the locations of their manufacturing plants worldwide.


Aspirin News

Aspire Biopharma Shares Business Update for Q3 2025 - BioSpace

05 Dec, 2025

Aspire Biopharma Releases Business Update for the Third Quarter of 2025 - PharmiWeb.com

04 Dec, 2025

Federal Circuit Rules That the Phrase 'Clinically Proven Effective' Does Not Confer Patentability

26 Sep, 2025

Ongoing Discussion Surrounding Patents for Second Medical Uses - Mondaq

22 Apr, 2025

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