Amphotericin B was first introduced by Apothecon Inc Div Bristol Myers Squibb in its drug Fungizone on Approved Prior to Jan 1, 1982. Other drugs containing Amphotericin B are Amphotec, Abelcet, Ambisome. 13 different companies have introduced drugs containing Amphotericin B.

Amphotericin B Patents

Given below is the list of patents protecting Amphotericin B, along with the drug name that holds that patent and the company name owning that drug.

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Drug Used in	Drug Patent Number	Drug Patent Title	Drug Patent Expiry	Drug Owner
Abelcet	US6406713	Methods of preparing low-toxicity drug-lipid complexes	Jun 18, 2019 (Expired)	Leadiant Biosci Inc
Ambisome	US5965156	Amphotericin B liposome preparation	Oct 12, 2016 (Expired)	Astellas
Ambisome	US5874104	Treatment of systemic fungal infections with phospholipid particles encapsulating polyene antibiotics	Feb 23, 2016 (Expired)	Astellas
Abelcet	US5616334	Low toxicity drug-lipid systems	Apr 01, 2014 (Expired)	Leadiant Biosci Inc

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Amphotericin B's Family Patents

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Amphotericin B Generic API Manufacturers

Several generic applications have been filed for Amphotericin B. The first generic version for Amphotericin B was by Apothecon Inc Div Bristol Myers Squibb and was approved on Approved Prior to Jan 1, 1982. And the latest generic version is by Mylan Laboratories Ltd and was approved on Jun 30, 2025.

Given below is the list of companies who have filed for Amphotericin B generic, along with the locations of their manufacturing plants worldwide.