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Amantadine Hydrochloride Patent Expiration

Amantadine Hydrochloride is used for managing motor complications in patients with Parkinson's disease receiving levodopa-based therapy. It was first introduced by Endo Pharmaceuticals Inc in its drug Symmetrel on Approved Prior to Jan 1, 1982. Other drugs containing Amantadine Hydrochloride are Osmolex Er, Gocovri. 33 different companies have introduced drugs containing Amantadine Hydrochloride.


Amantadine Hydrochloride Patents

Given below is the list of patents protecting Amantadine Hydrochloride, along with the drug name that holds that patent and the company name owning that drug.

Drug Used in Drug Patent Number Drug Patent Title Drug Patent Expiry Drug Owner
Gocovri US11065213 Amantadine compositions and preparations thereof Aug 23, 2038 Supernus Pharms
Gocovri US11077073 Methods of using amantadine compositions Aug 23, 2038 Supernus Pharms
Osmolex Er US10213393 Composition and method for treating neurological disease Feb 15, 2038 Supernus Pharms
Osmolex Er US10213394 Composition and method for treating neurological disease Feb 15, 2038 Supernus Pharms
Osmolex Er US10500170 Composition and method for treating neurological disease Feb 15, 2038 Supernus Pharms
Osmolex Er US10500171 Composition and method for treating neurological disease Feb 15, 2038 Supernus Pharms
Osmolex Er US10500172 Composition and method for treating neurological disease Feb 15, 2038 Supernus Pharms
Osmolex Er US10512617 Composition and method for treating neurological disease Feb 15, 2038 Supernus Pharms
Osmolex Er US11890261 Composition and method for treating neurological disease Feb 15, 2038 Supernus Pharms
Gocovri US10154971 Methods of administering amantadine Dec 04, 2034 Supernus Pharms
Gocovri US10646456 Methods of administering amantadine Jun 17, 2034 Supernus Pharms
Gocovri US11903908 Methods of administering amantadine Jun 17, 2034 Supernus Pharms
Gocovri US11197835 Method of administering amantadine prior to a sleep period Dec 02, 2030 Supernus Pharms
Gocovri US8741343 Method of administering amantadine prior to a sleep period Dec 02, 2030 Supernus Pharms
Gocovri US9867791 Method of administering amantadine prior to a sleep period Dec 02, 2030 Supernus Pharms
Gocovri US9867792 Method of administering amantadine prior to a sleep period Dec 02, 2030 Supernus Pharms
Gocovri US9867793 Method of administering amantadine prior to a sleep period Dec 02, 2030 Supernus Pharms
Gocovri US9877933 Method of administering amantadine prior to a sleep period Dec 02, 2030 Supernus Pharms
Osmolex Er US8252331 Osmotic device containing amantadine and an osmotic salt Mar 13, 2030 Supernus Pharms
Gocovri US8389578 Composition and method for treating neurological disease Jan 22, 2028 Supernus Pharms
Osmolex Er US8389578 Composition and method for treating neurological disease Jan 22, 2028 Supernus Pharms
Osmolex Er US8574626 Osmotic device containing amantadine and an osmotic salt Nov 28, 2025 Supernus Pharms
Gocovri US8796337 Composition and method for treating neurological disease Nov 23, 2025 Supernus Pharms
Gocovri US8889740 Composition and method for treating neurological disease Nov 23, 2025 Supernus Pharms
Gocovri US8895614 Composition and method for treating neurological disease Nov 23, 2025 Supernus Pharms
Gocovri US8895615 Composition and method for treating neurological disease Nov 23, 2025 Supernus Pharms
Gocovri US8895616 Composition and method for treating neurological disease Nov 23, 2025 Supernus Pharms
Gocovri US8895617 Composition and method for treating neurological disease Nov 23, 2025 Supernus Pharms
Gocovri US8895618 Composition and method for treating neurological disease Nov 23, 2025 Supernus Pharms
Osmolex Er US8796337 Composition and method for treating neurological disease Nov 23, 2025 Supernus Pharms
Osmolex Er US8889740 Composition and method for treating neurological disease Nov 23, 2025 Supernus Pharms
Osmolex Er US8895614 Composition and method for treating neurological disease Nov 23, 2025 Supernus Pharms
Osmolex Er US8895615 Composition and method for treating neurological disease Nov 23, 2025 Supernus Pharms
Osmolex Er US8895616 Composition and method for treating neurological disease Nov 23, 2025 Supernus Pharms
Osmolex Er US8895617 Composition and method for treating neurological disease Nov 23, 2025 Supernus Pharms
Osmolex Er US8895618 Composition and method for treating neurological disease Nov 23, 2025 Supernus Pharms
Osmolex Er US8987333 Composition and method for treating neurological disease Nov 23, 2025 Supernus Pharms
Osmolex Er US9072697 Composition and method for treating neurological disease Nov 23, 2025 Supernus Pharms
Osmolex Er USRE39069 Multi-layered osmotic device May 29, 2018

(Expired)

 Supernus Pharms



Amantadine Hydrochloride's Family Patents

Family Patents

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Amantadine Hydrochloride Generic API Manufacturers

Several generic applications have been filed for Amantadine Hydrochloride. The first generic version for Amantadine Hydrochloride was by Upsher Smith Laboratories Llc and was approved on Aug 5, 1986. And the latest generic version is by Zhejiang Jutai Pharmaceutical Co Ltd and was approved on Sep 26, 2024.

Given below is the list of companies who have filed for Amantadine Hydrochloride generic, along with the locations of their manufacturing plants worldwide.


1. ACTAVIS ELIZABETH

Actavis Elizabeth Llc has filed for 1 generic for Amantadine Hydrochloride. Given below are the details of the strengths of this generic introduced by Actavis Elizabeth.

Strength Dosage Form Availability Application Pathway TE code Launch Date
100MG

capsule Discontinued ORAL N/A Feb 23, 2006


Manufacturing Plant Locations
New

Actavis Elizabeth's manufacturing plants are situated in 1 country - United States. Given below are the details of these plant locations as well as the firm names of Actavis Elizabeth as present at those locations.

Country City Firm Name
United States
Elizabeth Actavis Elizabeth LLC, A Company of Teva





2. ADAPTIS

Adaptis Pharma Private Ltd has filed for 1 generic for Amantadine Hydrochloride. Given below are the details of the strengths of this generic introduced by Adaptis.

Strength Dosage Form Availability Application Pathway TE code Launch Date
100MG

tablet Discontinued ORAL N/A May 27, 2022





3. ALEMBIC

Alembic Pharmaceuticals Ltd has filed for 1 generic for Amantadine Hydrochloride. Given below are the details of the strengths of this generic introduced by Alembic.

Strength Dosage Form Availability Application Pathway TE code Launch Date
100MG

tablet Prescription ORAL AB Oct 15, 2020


Manufacturing Plant Locations
New

Alembic's manufacturing plants are situated in 1 country - India. Given below are the details of these plant locations as well as the firm names of Alembic as present at those locations.

Country City Firm Name
India
Vadodara Alembic Pharmaceuticals Limited
Panchmahal Alembic Pharmaceuticals Limited
Vadodara Alembic Pharmaceuticals Ltd
Vadodara Alembic Pharmaceuticals, Ltd
Panelav Alembic Pharmaceuticals Limited
Vadodara Alembic Pharmaceuticals Ltd (API Division, Karakhadi)
Panchmahal Alembic Pharmaceuticals Limited (Units I and II)





4. ATHEM

Athem Holdings Llc has filed for 1 generic for Amantadine Hydrochloride. Given below are the details of the strengths of this generic introduced by Athem.

Strength Dosage Form Availability Application Pathway TE code Launch Date
100MG

tablet Prescription ORAL AB Mar 10, 2020





5. AUROBINDO PHARMA USA

Aurobindo Pharma Usa Inc has filed for 1 generic for Amantadine Hydrochloride. Given below are the details of the strengths of this generic introduced by Aurobindo Pharma Usa.

Strength Dosage Form Availability Application Pathway TE code Launch Date
50MG/5ML

(reference standard)

syrup Prescription ORAL AA Oct 28, 1994


Manufacturing Plant Locations
New

Aurobindo Pharma Usa's manufacturing plants are situated in 1 country - United States. Given below are the details of these plant locations as well as the firm names of Aurobindo Pharma Usa as present at those locations.

Country City Firm Name
United States
East Windsor Aurobindo Pharma USA Inc





6. BAJAJ

Bajaj Medical Llc has filed for 1 generic for Amantadine Hydrochloride. Given below are the details of the strengths of this generic introduced by Bajaj.

Strength Dosage Form Availability Application Pathway TE code Launch Date
50MG/5ML

syrup Discontinued ORAL N/A Sep 11, 2002


Manufacturing Plant Locations
New

Bajaj's manufacturing plants are situated in 1 country - United States. Given below are the details of these plant locations as well as the firm names of Bajaj as present at those locations.

Country City Firm Name
United States
Chicago Bajaj Medical, LLC





7. BIONPHARMA

Bionpharma Inc has filed for 1 generic for Amantadine Hydrochloride. Given below are the details of the strengths of this generic introduced by Bionpharma.

Strength Dosage Form Availability Application Pathway TE code Launch Date
100MG

(reference standard)

capsule Prescription ORAL AB May 29, 2008


Manufacturing Plant Locations
New

Bionpharma's manufacturing plants are situated in 1 country - United States. Given below are the details of these plant locations as well as the firm names of Bionpharma as present at those locations.

Country City Firm Name
United States
Princeton Bionpharma Inc.





8. CHARTWELL MOLECULAR

Chartwell Molecular Holdings Llc has filed for 1 generic for Amantadine Hydrochloride. Given below are the details of the strengths of this generic introduced by Chartwell Molecular.

Strength Dosage Form Availability Application Pathway TE code Launch Date
100MG

capsule Discontinued ORAL N/A Jun 15, 2017





9. CHARTWELL RX

Chartwell Rx Sciences Llc has filed for 1 generic for Amantadine Hydrochloride. Given below are the details of the strengths of this generic introduced by Chartwell Rx.

Strength Dosage Form Availability Application Pathway TE code Launch Date
50MG/5ML

syrup Discontinued ORAL N/A Sep 10, 2004





10. ELYSIUM

Elysium Pharmaceuticals Ltd has filed for 1 generic for Amantadine Hydrochloride. Given below are the details of the strengths of this generic introduced by Elysium.

Strength Dosage Form Availability Application Pathway TE code Launch Date
50MG/5ML

syrup Prescription ORAL AA Aug 20, 2021


Manufacturing Plant Locations
New

Elysium's manufacturing plants are situated in 1 country - India. Given below are the details of these plant locations as well as the firm names of Elysium as present at those locations.

Country City Firm Name
India
Dabhasa Elysium Pharmaceuticals Limited





11. ENDO OPERATIONS

Endo Operations Ltd has filed for 1 generic for Amantadine Hydrochloride. Given below are the details of the strengths of this generic introduced by Endo Operations.

Strength Dosage Form Availability Application Pathway TE code Launch Date
50MG/5ML

syrup Discontinued ORAL N/A Dec 12, 2006





12. G AND W LABS INC

G And W Laboratories Inc has filed for 1 generic for Amantadine Hydrochloride. Given below are the details of the strengths of this generic introduced by G And W Labs Inc.

Strength Dosage Form Availability Application Pathway TE code Launch Date
50MG/5ML

syrup Discontinued ORAL N/A Oct 30, 1990





13. HERITAGE PHARMA

Heritage Pharma Labs Inc has filed for 1 generic for Amantadine Hydrochloride. Given below are the details of the strengths of this generic introduced by Heritage Pharma.

Strength Dosage Form Availability Application Pathway TE code Launch Date
100MG

capsule Prescription ORAL AB Jun 12, 2017


Manufacturing Plant Locations
New

Heritage Pharma's manufacturing plants are situated in 1 country - United States. Given below are the details of these plant locations as well as the firm names of Heritage Pharma as present at those locations.

Country City Firm Name
United States
East Brunswick Heritage Pharmaceuticals, Inc. DBA AVET Pharmaceutical LABS
East Brunswick Heritage Pharmaceuticals Inc





14. HUMANWELL PURACAP

Humanwell Puracap Pharmaceutical Wuhan Co Ltd has filed for 1 generic for Amantadine Hydrochloride. Given below are the details of the strengths of this generic introduced by Humanwell Puracap.

Strength Dosage Form Availability Application Pathway TE code Launch Date
100MG

capsule Prescription ORAL AB Dec 20, 2022


Manufacturing Plant Locations
New

Humanwell Puracap's manufacturing plants are situated in 1 country - China. Given below are the details of these plant locations as well as the firm names of Humanwell Puracap as present at those locations.

Country City Firm Name
China
Wuhan Humanwell PuraCap Pharmaceuticals (Wuhan) Co., Ltd.





15. INVAGEN PHARMS

Invagen Pharmaceuticals Inc has filed for 1 generic for Amantadine Hydrochloride. Given below are the details of the strengths of this generic introduced by Invagen Pharms.

Strength Dosage Form Availability Application Pathway TE code Launch Date
100MG

tablet Discontinued ORAL N/A Jan 31, 2017





16. JUBILANT GENERICS

Jubilant Generics Ltd has filed for 1 generic for Amantadine Hydrochloride. Given below are the details of the strengths of this generic introduced by Jubilant Generics.

Strength Dosage Form Availability Application Pathway TE code Launch Date
100MG

tablet Discontinued ORAL N/A Feb 7, 2018


Manufacturing Plant Locations
New

Jubilant Generics's manufacturing plants are situated in 1 country - India. Given below are the details of these plant locations as well as the firm names of Jubilant Generics as present at those locations.

Country City Firm Name
India
Roorkee Jubilant Generics Limited





17. PHARM ASSOC

Pharmaceutical Associates Inc has filed for 1 generic for Amantadine Hydrochloride. Given below are the details of the strengths of this generic introduced by Pharm Assoc.

Strength Dosage Form Availability Application Pathway TE code Launch Date
50MG/5ML

(reference standard)

syrup Prescription ORAL AA Jul 17, 1995





18. RISING

Rising Pharma Holdings Inc has filed for 1 generic for Amantadine Hydrochloride. Given below are the details of the strengths of this generic introduced by Rising.

Strength Dosage Form Availability Application Pathway TE code Launch Date
100MG

capsule Prescription ORAL AB Mar 2, 2020


Manufacturing Plant Locations
New

Rising's manufacturing plants are situated in 3 countries - United States, Mexico, India. Given below are the details of these plant locations as well as the firm names of Rising as present at those locations.

Country City Firm Name
United States
Saddle Brook Rising Pharmaceuticals, Inc.
Mount Morris Rising Creek Bakery LLC
Phoenix Rising Sun Farms Inc
East Brunswick Rising Pharma Holding, Inc.
Rising Sun Rising Sun Veterinary Clinic
Flagstaff Rising High Enterprises, LLC (DBA RisingHy)
Livingston Risingsun Iodine Products Corp.
Decatur Rising Pharma Holdings, Inc
Fort Bragg Rising Tide Sea Vegetables
Mexico
Pueblo San Clemente RISING FARMS SAPI DE CV
India
Ahmedabad Rising Retina Clinic





19. RUBICON

Rubicon Research Private Ltd has filed for 1 generic for Amantadine Hydrochloride. Given below are the details of the strengths of this generic introduced by Rubicon.

Strength Dosage Form Availability Application Pathway TE code Launch Date
100MG

capsule Prescription ORAL AB May 21, 2020


Manufacturing Plant Locations
New

Rubicon's manufacturing plants are situated in 3 countries - United States, Canada, India. Given below are the details of these plant locations as well as the firm names of Rubicon as present at those locations.

Country City Firm Name
United States
Geismar Rubicon, LLC
Indianapolis Rubicon Foods LLC
Canada
Concord Rubicon Research Canada Limited
India
Ambarnath Rubicon Research Private Limited





20. SANDOZ

Sandoz Inc has filed for 1 generic for Amantadine Hydrochloride. Given below are the details of the strengths of this generic introduced by Sandoz.

Strength Dosage Form Availability Application Pathway TE code Launch Date
100MG

capsule Prescription ORAL AB Feb 18, 1987


Manufacturing Plant Locations
New

Sandoz's manufacturing plants are situated in 4 countries - Austria, United States, Spain, India. Given below are the details of these plant locations as well as the firm names of Sandoz as present at those locations.

Country City Firm Name
Austria
Langkampfen Sandoz GmbH
Kundl Sandoz GmbH
United States
East Hanover Sandoz Incorporated
Princeton Sandoz Inc
Spain
Palafolls Sandoz Industrial Products, S.A.
Les Franqueses Del Valles Sandoz Industrial Products S.A.
India
Navi Mumbai Sandoz Private Limited





21. SOLVAY

Solvay Pharmaceuticals has filed for 1 generic for Amantadine Hydrochloride. This 100mg version comes by the name SYMADINE. Given below are the details of the strengths of this generic introduced by Solvay.

Strength Dosage Form Availability Application Pathway TE code Launch Date
100MG

capsule Discontinued ORAL N/A Sep 4, 1986


Manufacturing Plant Locations
New

Solvay's manufacturing plants are situated in 1 country - United States. Given below are the details of these plant locations as well as the firm names of Solvay as present at those locations.

Country City Firm Name
United States
Spartanburg Solvay USA Inc
Chicago Heights Solvay USA Inc.
Longview Solvay Chemicals Inc
Willow Island Solvay, Inc





22. STRIDES PHARMA

Strides Pharma Global Pte Ltd has filed for 1 generic for Amantadine Hydrochloride. Given below are the details of the strengths of this generic introduced by Strides Pharma.

Strength Dosage Form Availability Application Pathway TE code Launch Date
100MG

tablet Prescription ORAL AB Jun 9, 2017


Manufacturing Plant Locations
New

Strides Pharma's manufacturing plants are situated in 2 countries - United States, India. Given below are the details of these plant locations as well as the firm names of Strides Pharma as present at those locations.

Country City Firm Name
United States
East Brunswick Strides Pharma Inc.
Chestnut Ridge Strides Pharma, Inc.
India
Puducherry Strides Pharma Science Limited
Bangalore Strides Pharma Science Limited





23. STRIDES SOFTGELS

Strides Softgels Pte Ltd has filed for 1 generic for Amantadine Hydrochloride. Given below are the details of the strengths of this generic introduced by Strides Softgels.

Strength Dosage Form Availability Application Pathway TE code Launch Date
100MG

capsule Prescription ORAL AB Feb 18, 2022





24. TEVA PHARMS

Teva Pharmaceuticals Usa has filed for 1 generic for Amantadine Hydrochloride. Given below are the details of the strengths of this generic introduced by Teva Pharms.

Strength Dosage Form Availability Application Pathway TE code Launch Date
50MG/5ML

syrup Discontinued ORAL N/A Aug 23, 1991





25. UPSHER SMITH LABS

Upsher Smith Laboratories Llc has filed for 1 generic for Amantadine Hydrochloride. Given below are the details of the strengths of this generic introduced by Upsher Smith Labs.

Strength Dosage Form Availability Application Pathway TE code Launch Date
100MG

(reference standard)

tablet Prescription ORAL AB Dec 16, 2002





26. WATSON LABS

Watson Laboratories Inc has filed for 1 generic for Amantadine Hydrochloride. Given below are the details of the strengths of this generic introduced by Watson Labs.

Strength Dosage Form Availability Application Pathway TE code Launch Date
100MG

capsule Discontinued ORAL N/A Jan 21, 1987





27. WATSON LABS INC

Watson Laboratories Inc has filed for 1 generic for Amantadine Hydrochloride. Given below are the details of the strengths of this generic introduced by Watson Labs Inc.

Strength Dosage Form Availability Application Pathway TE code Launch Date
100MG

tablet Prescription ORAL AB Dec 15, 2016





28. XTTRIUM LABS INC

Xttrium Laboratories Inc has filed for 1 generic for Amantadine Hydrochloride. Given below are the details of the strengths of this generic introduced by Xttrium Labs Inc.

Strength Dosage Form Availability Application Pathway TE code Launch Date
50MG/5ML

syrup Prescription ORAL AA Dec 24, 1998





29. ZHEJIANG JUTAI PHARM

Zhejiang Jutai Pharmaceutical Co Ltd has filed for 1 generic for Amantadine Hydrochloride. Given below are the details of the strengths of this generic introduced by Zhejiang Jutai Pharm.

Strength Dosage Form Availability Application Pathway TE code Launch Date
100MG

tablet Prescription ORAL AB Sep 26, 2024





30. ZYDUS

Zydus Worldwide Dmcc has filed for 1 generic for Amantadine Hydrochloride. Given below are the details of the strengths of this generic introduced by Zydus.

Strength Dosage Form Availability Application Pathway TE code Launch Date
EQ 68.5MG BASE

capsule, extended release Prescription ORAL AB Aug 26, 2024


Manufacturing Plant Locations
New

Zydus's manufacturing plants are situated in 2 countries - India, United States. Given below are the details of these plant locations as well as the firm names of Zydus as present at those locations.

Country City Firm Name
India
Moraiya, Ahmedabad Zydus Lifesciences Limited
Matoda, Ahmedabad Zydus Animal Health and Investments Limited
Ankleshwar Zydus Lifesciences Limited
Matoda Zydus Lifesciences Limited
Matoda Zydus Hospira Oncology Private Ltd.
Ahmedabad ZYDUS LIFESCIENCES LIMITED
Dabhasa Zydus Lifesciences Limited
Thane Zydus Lifesciences Limited
Jarod Zydus Lifesciences Limited
Ahmedabad Zydus Lifesciences Limited
District Solan Zydus Lifesciences Limited
United States
Pennington Zydus Pharmaceuticals (USA) Inc





31. ZYDUS PHARMS

Zydus Pharmaceuticals Usa Inc has filed for 1 generic for Amantadine Hydrochloride. Given below are the details of the strengths of this generic introduced by Zydus Pharms.

Strength Dosage Form Availability Application Pathway TE code Launch Date
100MG

capsule Prescription ORAL AB May 31, 2016