Alprostadil was first introduced by Pfizer Inc in its drug Prostin Vr Pediatric on Approved Prior to Jan 1, 1982. Other drugs containing Alprostadil are Edex, Muse, Caverject, Caverject Impulse. 5 different companies have introduced drugs containing Alprostadil.

Alprostadil Patents

Given below is the list of patents protecting Alprostadil, along with the drug name that holds that patent and the company name owning that drug.

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Drug Used in	Drug Patent Number	Drug Patent Title	Drug Patent Expiry	Drug Owner
Muse	US5886039	Method and composition for treating erectile dysfunction	Mar 23, 2016 (Expired)	Viatris
Caverject	US5741523	Stabilized prostaglandin E1	Apr 21, 2015 (Expired)	Pfizer
Caverject Impulse	US5716338	Dual-chamber type injection cartridge with bypass connection	Feb 10, 2015 (Expired)	Pfizer
Caverject Impulse	US5501673	Injection cartridge	Apr 16, 2013 (Expired)	Pfizer
Muse	US5474535	Dosage and inserter for treatment of erectile dysfunction	Dec 12, 2012 (Expired)	Viatris

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Alprostadil's Family Patents

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Alprostadil Generic API Manufacturers

Several generic applications have been filed for Alprostadil. The first generic version for Alprostadil was by Hikma Pharmaceuticals Usa Inc and was approved on Jan 20, 1998. And the latest generic version is by Meitheal Pharmaceuticals Inc and was approved on Apr 30, 1999.

Given below is the list of companies who have filed for Alprostadil generic, along with the locations of their manufacturing plants worldwide.