Latest Clinical Trials
Vismodegib, FAK Inhibitor GSK2256098, Capivasertib, and Abemaciclib in Treating Patients With Progressive Meningiomas Alliance for Clinical Trials in Oncology NA
RECRUITING
(Sep 1, 2026)
PHASE2 TAPUR: Testing the Use of Food and Drug Administration (FDA) Approved Drugs That Target a Specific Abnormality in a Tumor Gene in People With Advanced Stage Cancer American Society of Clinical Oncology NA
RECRUITING
(Sep 1, 2026)
PHASE2 A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Patients With Metastatic or Locally Advanced Breast Cancer Hoffmann-La Roche NA
RECRUITING
(Sep 1, 2026)
PHASE1, PHASE2 Fulvestrant Plus Abemaciclib in Women With Advanced Low Grade Serous Carcinoma M.D. Anderson Cancer Center NA
ACTIVE NOT RECRUITING
(Sep 1, 2026)
PHASE2 Testing the Addition of Copanlisib to Usual Treatment (Fulvestrant and Abemaciclib) in Metastatic Breast Cancer National Cancer Institute (NCI) NA
ACTIVE NOT RECRUITING
(Sep 1, 2026)
PHASE1 A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Participants With Breast Cancer Hoffmann-La Roche NA
RECRUITING
(Sep 1, 2026)
PHASE1, PHASE2 SRS & Abemaciclib w/wo Imlunestrant in the Management of HR+/HER2- Breast CA Brain Metastases H. Lee Moffitt Cancer Center and Research Institute NA
RECRUITING
(Sep 1, 2026)
PHASE1, PHASE2 A Study Evaluating the Efficacy and Safety of Biomarker-Driven Therapies in Patients With Persistent or Recurrent Rare Epithelial Ovarian Tumors Hoffmann-La Roche NA
ACTIVE NOT RECRUITING
(Sep 1, 2026)
PHASE2 Phase III Study to Assess AZD9833+ CDK4/6 Inhibitor in HR+/HER2-MBC With Detectable ESR1m Before Progression (SERENA-6) AstraZeneca NA
ACTIVE NOT RECRUITING
(Sep 1, 2026)
PHASE3 A Study of LOXO-783 in Patients With Breast Cancer/Other Solid Tumors Eli Lilly and Company NA
RECRUITING
(Sep 1, 2026)
PHASE1 Study of Abemaciclib and Elacestrant in Participants With Brain Metastasis Due to ER+/HER-2- Breast Cancer Stemline Therapeutics, Inc. NA
RECRUITING
(Sep 1, 2026)
PHASE1, PHASE2 A PoC Study to Evaluate Treatments' Efficacy by Monitoring MRD Using ctDNA in HR-positive/HER2-negative EBC Population MedSIR NA
ACTIVE NOT RECRUITING
(Sep 1, 2026)
PHASE2 A Study of Ruxolitinib in Combination With Abemaciclib for the Treatment of Myelofibrosis Memorial Sloan Kettering Cancer Center NA
RECRUITING
(Sep 1, 2026)
PHASE1 CB-103 With Either Lenvatinib or Abemaciclib in Patients With NOTCH ACC Michael J. Dennis, MD NA
RECRUITING
(Sep 1, 2026)
PHASE1, PHASE2 A Phase 1 Study of Neoadjuvant Abemaciclib in Combination With Radiation Therapy for Liposarcomas University of Washington NA
RECRUITING
(Sep 1, 2026)
PHASE1 Elacestrant vs Elacestrant Plus a CDK4/6 Inhibitor in Patients With ERpositive/HER2-negative Advanced or Metastatic Breast Cancer Northwestern University NA
RECRUITING
(Sep 1, 2026)
PHASE2 A Study to Evaluate Efficacy and Safety of Giredestrant Compared With Fulvestrant (Plus a CDK4/6 Inhibitor), in Participants With ER-Positive, HER2-Negative Advanced Breast Cancer Resistant to Adjuvant Endocrine Therapy (pionERA Breast Cancer) Hoffmann-La Roche NA
ACTIVE NOT RECRUITING
(Sep 1, 2026)
PHASE3 ALPINE: Maintenance Letrozole/Abemaciclib Dana-Farber Cancer Institute NA
RECRUITING
(Sep 1, 2026)
PHASE2 A Study to Evaluate the Effect of GDC-4198 Alone and in Combination With Giredestrant Versus Abemaciclib and Giredestrant in Participants With Locally Advanced or Metastatic Estrogen Receptor-Positive (ER+), Human Epidermal Growth Factor Receptor-Negative (HER2-) Breast Cancer Genentech, Inc. NA
RECRUITING
(Sep 1, 2026)
PHASE1, PHASE2 A Study of LY4257496 in Participants With Cancer (OMNIRAY) Eli Lilly and Company NA
RECRUITING
(Sep 1, 2026)
PHASE1 Evolutionary Clinical Trial for Novel Biomarker-Driven Therapies UNC Lineberger Comprehensive Cancer Center NA
RECRUITING
(Sep 1, 2026)
PHASE2 BGB-43395 Plus Letrozole Versus CDK4/6i Plus Letrozole for Patients With Advanced or Metastatic HR+/HER2- Breast Cancer Who Have Not Received Prior Treatment for Advanced or Metastatic Disease BeOne Medicines NA
RECRUITING
(Sep 1, 2026)
PHASE3 Abiraterone With Dalpiciclib in Salivary Gland Carcinoma Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University NA
RECRUITING
(Sep 1, 2026)
PHASE2 A Study of Abemaciclib (LY2835219) in Healthy Participants Eli Lilly and Company NA
RECRUITING
(Sep 1, 2026)
PHASE1 Chemotherapy Exemption in Elderly Women With Node-Positive ER+/HER2- Breast Cancer Fudan University NA
NOT YET RECRUITING
(Sep 1, 2026)
PHASE2 A Study to Learn How Well Participants With a Specific Type of Early Breast Cancer (ER-Positive, HER2-Negative) Tolerate and Stay on Treatment With Giredestrant and How They Feel During Treatment Hoffmann-La Roche NA
NOT YET RECRUITING
(Sep 1, 2026)
PHASE3 Imlunestrant/Abemaciclib/Selinexor in Ovarian and Endometrial Dana-Farber Cancer Institute NA
NOT YET RECRUITING
(Sep 1, 2026)
PHASE2 Cyclin-Dependent Kinase (CDK)4/6 Inhibitor Abemaciclib for Neurofibromatosis Type I (NF1) Related Atypical Neurofibromas National Cancer Institute (NCI) NA
RECRUITING
(Aug 21, 2026)
PHASE1, PHASE2 Abemaciclib in Patients With HIV-associated and HIV-negative Kaposi Sarcoma National Cancer Institute (NCI) NA
RECRUITING
(Aug 21, 2026)
PHASE1, PHASE2 INdividualized Screening Trial of Innovative Glioblastoma Therapy (INSIGhT) David Reardon, MD NA
RECRUITING
(Aug 1, 2026)
PHASE2 A Study of Abemaciclib in Recurrent Glioblastoma Dana-Farber Cancer Institute NA
ACTIVE NOT RECRUITING
(Aug 1, 2026)
PHASE2 Study of AZD9833 Alone or in Combination in Women With Advanced Breast Cancer. AstraZeneca NA
ACTIVE NOT RECRUITING
(Aug 1, 2026)
PHASE1 Capivasertib + CDK4/6i + Fulvestrant for Advanced/Metastatic HR+/HER2- Breast Cancer (CAPItello-292) AstraZeneca NA
ACTIVE NOT RECRUITING
(Aug 1, 2026)
PHASE3 Abemaciclib Plus Ramucirumab for Esophageal/Gastroesophageal Junction Ca Baylor Research Institute NA
COMPLETED
(Aug 1, 2026)
PHASE1, PHASE2 ETHAN - ET for Male BC Jose Pablo Leone NA
RECRUITING
(Aug 1, 2026)
PHASE2 TACTIVE-U: A Study to Learn About the Study Medicine (Vepdegestrant) When Given With Other Medicines in People With Advanced or Metastatic Breast Cancer (Sub-Study A) Pfizer NA
ACTIVE NOT RECRUITING
(Aug 1, 2026)
PHASE1, PHASE2 An Adjuvant Endocrine-based Therapy Study of Camizestrant (AZD9833) in ER+/HER2- Early Breast Cancer (CAMBRIA-2) AstraZeneca NA
ACTIVE NOT RECRUITING
(Aug 1, 2026)
PHASE3 A Master Protocol (LY900023) That Includes Several Clinical Trials of Drugs for Children and Young Adults With Cancer Eli Lilly and Company NA
RECRUITING
(Aug 1, 2026)
PHASE2 A First-in-human Dose Escalation and Expansion Study to Evaluate the Safety, and Tolerability of AZD8421 Alone or in Combination in Participants With Selected Advanced or Metastatic Solid Tumors AstraZeneca NA
RECRUITING
(Aug 1, 2026)
PHASE1, PHASE2 Saruparib (AZD5305) Plus Camizestrant or Plus Endocrine Therapy, Compared With CDK4/6 Inhibitor Plus Endocrine Therapy or Plus Camizestrant in HR-Positive, HER2-Negative (IHC 0, 1+, 2+/ ISH Non-amplified), BRCA1, BRCA2, or PALB2m Advanced Breast Cancer AstraZeneca NA
RECRUITING
(Aug 1, 2026)
PHASE3 Imlunestrant and Abemaciclib for the Treatment of Estrogen Receptor Positive Breast Cancer in Patients With Minimal Residual Disease, MIRI Trial Jonsson Comprehensive Cancer Center NA
RECRUITING
(Aug 1, 2026)
PHASE2 Marker - Adjusted Therapy Comparing Adjuvant Elacestrant With Standard Endocrine Treatment in Genomically and/or Clinically High-risk ER+/HER2- eBC Women's Cancer Study Group GmbH NA
RECRUITING
(Aug 1, 2026)
PHASE3 A Study to Evaluate ATX-898 in Participants With Advanced Solid Tumors Antares Therapeutics, Inc NA
NOT YET RECRUITING
(Aug 1, 2026)
PHASE1, PHASE2 QL1706 Plus Neoadjuvant Endocrine Therapy in HR-Positive/HER2-Negative Breast Cancer With a Poor Response to Neoadjuvant Chemotherapy Hebei Medical University Fourth Hospital NA
NOT YET RECRUITING
(Aug 1, 2026)
PHASE2 Abemaciclib (LY2835219) in Patients With Recurrent Primary Brain Tumors Memorial Sloan Kettering Cancer Center NA
ACTIVE NOT RECRUITING
(Jul 1, 2026)
PHASE2 A Study of Abiraterone Acetate Plus Prednisone With or Without Abemaciclib (LY2835219) in Participants With Prostate Cancer Eli Lilly and Company NA
ACTIVE NOT RECRUITING
(Jul 1, 2026)
PHASE2, PHASE3 Abemaciclib for Bone and Soft Tissue Sarcoma With Cyclin-Dependent Kinase (CDK) Pathway Alteration Medical College of Wisconsin NA
RECRUITING
(Jul 1, 2026)
PHASE2 Endocrine Therapy With Abemaciclib or Chemotherapy as Initial Metastatic Treatment in ER+/HER2- Breast Cancer UNICANCER NA
ACTIVE NOT RECRUITING
(Jul 1, 2026)
PHASE3 Abemaciclib for the Treatment of Recurrent Ovarian or Endometrial Cancer Jonsson Comprehensive Cancer Center NA
RECRUITING
(Jul 1, 2026)
PHASE2 A Study of Imlunestrant, Investigator's Choice of Endocrine Therapy, and Imlunestrant Plus Abemaciclib in Participants With ER+, HER2- Advanced Breast Cancer Eli Lilly and Company NA
ACTIVE NOT RECRUITING
(Jul 1, 2026)
PHASE3 Abemaciclib Before 177Lu-PSMA-617 for the Treatment of Metastatic Castrate Resistant Prostate Cancer Vadim S Koshkin NA
RECRUITING
(Jul 1, 2026)
PHASE1, PHASE2 First-in-Human Study of Tersolisib (STX-478) as Monotherapy and in Combination With Other Antineoplastic Agents in Participants With Advanced Solid Tumors Eli Lilly and Company NA
RECRUITING
(Jul 1, 2026)
PHASE1, PHASE2 A Study Comparing Abemaciclib Plus Temozolomide to Temozolomide Monotherapy in Children and Young Adults With High-grade Glioma Following Radiotherapy Eli Lilly and Company NA
ACTIVE NOT RECRUITING
(Jul 1, 2026)
PHASE2 A Study of Elacestrant Alone or in Combination With Abemaciclib in People With Endometrial Cancer Memorial Sloan Kettering Cancer Center NA
RECRUITING
(Jul 1, 2026)
PHASE2 Abemaciclib Combined With FOLFOX/FOLFIRI Regimen in Patients With Advanced Colorectal Liver Metastases Cancer Fudan University NA
ENROLLING BY INVITATION
(Jul 1, 2026)
PHASE2 Study of Abemaciclib in Dedifferentiated Liposarcoma Memorial Sloan Kettering Cancer Center NA
ACTIVE NOT RECRUITING
(Jun 1, 2026)
PHASE2 RESOLVE: Abemaciclib + Letrozole +/- Metformin or Gedatolisib in Endometrial Cancer Dana-Farber Cancer Institute NA
RECRUITING
(Jun 1, 2026)
PHASE2 A Study of LY3484356 in Participants With Advanced or Metastatic Breast Cancer or Endometrial Cancer Eli Lilly and Company NA
ACTIVE NOT RECRUITING
(Jun 1, 2026)
PHASE1 LY3214996 and Cetuximab Alone or in Combination With Abemaciclib for the Treatment of Unresectable or Metastatic Colorectal Cancer M.D. Anderson Cancer Center NA
ACTIVE NOT RECRUITING
(Jun 1, 2026)
PHASE1, PHASE2 Testing the Safety and Efficacy of the Combination of Two Anti-cancer Drugs, ZEN003694 and Abemaciclib, for Adult and Pediatric Patients (12-17 Years) With Metastatic or Unresectable NUT Carcinoma, Breast Cancer and Other Solid Tumors National Cancer Institute (NCI) NA
RECRUITING
(Jun 1, 2026)
PHASE1 Open-Label Umbrella Study To Evaluate Safety And Efficacy Of Elacestrant In Various Combination In Participants With Metastatic Breast Cancer Stemline Therapeutics, Inc. NA
ACTIVE NOT RECRUITING
(Jun 1, 2026)
PHASE1, PHASE2 Neo-DAB: Darolutamide and Abemaciclib in Prostate Cancer Praful Ravi, MB BCHir, MRCP NA
COMPLETED
(Jun 1, 2026)
PHASE1 Safety and Efficacy of T-DXd vs. CDK4/6i-based ET as First-line Therapy of HR-positive and HER2-low/Ultralow Advanced Breast Cancer Patients Classified as Non-luminal Subtype MedSIR NA
RECRUITING
(Jun 1, 2026)
PHASE2 ONO-4578-06:Phase I Study of ONO-4578 and Letrozole Plus CDK4 /6 Inhibitors in Breast Cancer Ono Pharmaceutical Co., Ltd. NA
COMPLETED
(Jun 1, 2026)
PHASE1 Using Tumor Models to Determine Treatments University Health Network, Toronto NA
RECRUITING
(Jun 1, 2026)
PHASE2 A Study of Abemaciclib and Cabozantinib in People With Clear Cell Renal Cell Carcinoma (ccRCC) Memorial Sloan Kettering Cancer Center NA
RECRUITING
(Jun 1, 2026)
PHASE1, PHASE2 Rising ctDNA to Tailor Endocrine Therapy Switch in Patients With ER+/HER2- Metastatic Breast Cancer. UNICANCER NA
NOT YET RECRUITING
(Jun 1, 2026)
PHASE3 I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer QuantumLeap Healthcare Collaborative NA
RECRUITING
(May 1, 2026)
PHASE2 Targeted Therapy With CDK4/6 Inhibitors in Chemo-Refractory, Rb Wild-Type Extensive SCLC Case Comprehensive Cancer Center NA
COMPLETED
(May 1, 2026)
PHASE2 Immune Modulation by Abemaciclib in Head and Neck Squamous Cell Carcinoma (HNSCC). (AIM Trial) University of Arizona NA
TERMINATED
(May 1, 2026)
PHASE2 ABemacicliB or Abemaciclib and HydroxYchloroquine to Target Minimal Residual Disease in Breast Cancer Abramson Cancer Center at Penn Medicine NA
RECRUITING
(May 1, 2026)
PHASE2 Single Cell Immune and Non-immune Correlates of Response to Neoadjuvant Abemaciclib University of Texas Southwestern Medical Center NA
RECRUITING
(May 1, 2026)
PHASE2 Testing the Addition of Abemaciclib to Olaparib for Women With Recurrent Ovarian Cancer National Cancer Institute (NCI) NA
RECRUITING
(May 1, 2026)
PHASE1 Abemaciclib With or Without Atezolizumab for mCRPC Dana-Farber Cancer Institute NA
COMPLETED
(May 1, 2026)
PHASE2 Drug Screening Using Novel IMD in Renal Cell Carcinoma Oliver Jonas NA
RECRUITING
(May 1, 2026)
PHASE1 A Study of Abemaciclib and Radiation Therapy in People With Metastatic Breast Cancer Memorial Sloan Kettering Cancer Center NA
RECRUITING
(May 1, 2026)
PHASE1 Study of PF-07220060 With Letrozole in Adults With HR-positive HER2-negative Breast Cancer Who Have Not Received Anticancer Treatment for Advanced/Metastatic Disease Pfizer NA
ACTIVE NOT RECRUITING
(May 1, 2026)
PHASE3 Probiotics for Abemaciclib-Induced Abdominal Discomfort. Leeuwenhoek Laboratories Co. Ltd. NA
RECRUITING
(May 1, 2026)
PHASE2 Endocrine Therapy With or Without Abemaciclib (LY2835219) Following Surgery in Participants With Breast Cancer Eli Lilly and Company NA
ACTIVE NOT RECRUITING
(Apr 1, 2026)
PHASE3 Study of the CDK4/6 Inhibitor Abemaciclib in Solid Tumors Harboring Genetic Alterations in Genes Encoding D-Type Cyclins or Amplification of CDK4 or CDK6 Dana-Farber Cancer Institute NA
RECRUITING
(Apr 1, 2026)
PHASE2 Genetic Testing in Guiding Treatment for Patients With Brain Metastases Alliance for Clinical Trials in Oncology NA
ACTIVE NOT RECRUITING
(Apr 1, 2026)
PHASE2 Abemaciclib and Endocrine Therapy in Older Patients With Breast Cancer. City of Hope Medical Center NA
RECRUITING
(Apr 1, 2026)
PHASE2 Fulvestrant, Ipatasertib and CDK4/6 Inhibition in Metastatic ER+/HER2- Breast Cancer Patients Without ctDNA Suppression Royal Marsden NHS Foundation Trust NA
ACTIVE NOT RECRUITING
(Apr 1, 2026)
PHASE2 Abemaciclib in Combination With Bicalutamide for Androgen Receptor-positive, HER2-negative Metastatic Breast Cancer Icahn School of Medicine at Mount Sinai NA
RECRUITING
(Apr 1, 2026)
PHASE1, PHASE2 VS-6766+Abema+Fulv in Met HR+/HER- BC Adrienne G. Waks NA
RECRUITING
(Apr 1, 2026)
PHASE1, PHASE2 Evaluation of Lasofoxifene Combined With Abemaciclib Compared With Fulvestrant Combined With Abemaciclib in Locally Advanced or Metastatic ER+/HER2- Breast Cancer With an ESR1 Mutation LeonaBio NA
RECRUITING
(Apr 1, 2026)
PHASE3 Abemaciclib and Letrozole in Patients With Estrogen Receptor-positive Rare Ovarian Cancer Universitaire Ziekenhuizen KU Leuven NA
RECRUITING
(Apr 1, 2026)
PHASE2 Functional Imaging in Prediction of Response to Abemaciclib for Advanced Hormone Receptor-Positive, HER2-Negative Breast Cancer University of Washington NA
RECRUITING
(Apr 1, 2026)
PHASE2 A Precision Medicine Approach (SMMART-ACT) for the Treatment of Patients With Advanced Sarcoma, Prostate, Breast, Ovarian or Pancreatic Cancer OHSU Knight Cancer Institute NA
TERMINATED
(Apr 1, 2026)
PHASE2 Testing the Addition of an Anti-Cancer Drug, Abemaciclib, to the Usual Chemotherapy Treatment (5-Fluorouracil) for Metastatic, Refractory Colorectal Cancer National Cancer Institute (NCI) NA
RECRUITING
(Apr 1, 2026)
PHASE1 Safety and Tolerability of TNG456 Alone and in Combination With Abemaciclib in Patients With Solid Tumors With MTAP Loss Tango Therapeutics, Inc. NA
RECRUITING
(Apr 1, 2026)
PHASE1, PHASE2 Evaluating Cancer Response to Treatment With Abemaciclib and Fulvestrant in Women With Recurrent Endometrial Cancer Memorial Sloan Kettering Cancer Center NA
COMPLETED
(Mar 1, 2026)
PHASE2 Abemaciclib and Letrozole to Treat Endometrial Cancer Gynecologic Oncology Group NA
ACTIVE NOT RECRUITING
(Mar 1, 2026)
PHASE2 Abemaciclib in Newly Diagnosed Meningioma Patients Nader Sanai NA
RECRUITING
(Mar 1, 2026)
PHASE2 Testing the Addition of an Anti-cancer Drug, Abemaciclib, to the Usual Chemotherapy Treatment (Gemcitabine) for Soft Tissue Sarcoma National Cancer Institute (NCI) NA
RECRUITING
(Mar 1, 2026)
PHASE1, PHASE2 Multigene Risk Score Combined With Ki-67 Dynamic Assessment in Stratified Neoadjuvant Endocrine Therapy Treatment With or Without CDK4/6 Inhibitors in HR+/HER2- Breast Cancer Peking University NA
ENROLLING BY INVITATION
(Mar 1, 2026)
PHASE2