Drug Patent List
Litigation OpportunitiesNew
Newsletter
Weekly Digest

Pharsight

Mannkind Drug Patent Portfolio

Mannkind owns 1 orange book drug protected by 48 US patents Given below is the list of Mannkind's drug patents along with their expiration dates.

Drug Patent Number Drug Patent Title Drug Patent Expiry Status
US8636001 Dry powder inhaler and system for drug delivery 12 Jul, 2032
Active
US8499757 Dry powder inhaler and system for drug delivery 19 Feb, 2032
Active
US8424518 Dry powder inhaler and system for drug delivery 17 Oct, 2031
Active
US9597374 Use of ultrarapid acting insulin 08 Oct, 2031
Active
US8227409 Diketopiperazine microparticles with defined isomer contents 08 Mar, 2031
Active
US9358352 Dry powder drug delivery system and methods 15 Feb, 2031
Active
US10500159 Apparatus and method for cryogranulating a pharmaceutical composition 02 Nov, 2030
Active
US10201672 Dry powder inhaler and system for drug delivery 02 Aug, 2030
Active
US8551528 Diketopiperazine microparticles with defined specific surface areas 11 Jun, 2030
Active
US8734845 Diketopiperazine microparticles with defined specific surface areas 11 Jun, 2030
Active
US8778403 Diketopiperazine microparticles with defined specific surface areas 11 Jun, 2030
Active
US8485180 Dry powder drug delivery system 25 Mar, 2030
Active
US9511198 Dry powder inhaler and system for drug delivery 16 Feb, 2030
Active
US9339615 Dry powder inhaler and system for drug delivery 20 Oct, 2029
Active
US8623817 Method of treating diabetes type 2 by administering ultrarapid acting insulin 18 Sep, 2029
Active
US10046031 Use of ultrarapid acting insulin 11 Aug, 2029
Active
US8119593 Method of treating diabetes type 2 by metformin and an ultrarapid acting insulin 11 Aug, 2029
Active
US8258095 Method of controlling glycemia by ultrarapid acting insulin without adjusting an insulin dose for meal content 11 Aug, 2029
Active
US9943571 Use of ultrarapid acting insulin 11 Aug, 2029
Active
US9393372 Dry powder drug delivery system 04 Jul, 2029
Active
US10342938 Dry powder drug delivery system 12 Jun, 2029
Active
US8912193 Dry powder inhaler and system for drug delivery 12 Jun, 2029
Active
US9192675 Dry powder inhaler and system for drug delivery 12 Jun, 2029
Active
US9446133 Dry powder inhaler and system for drug delivery 12 Jun, 2029
Active
US9662461 Dry powder drug delivery system and methods 12 Jun, 2029
Active
US8729019 Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents 26 Dec, 2028
Active
US9283193 Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents 14 Sep, 2026
Active
US9717689 Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents 14 Sep, 2026
Active
US7943572 Superior control of blood glucose in diabetes treatment 10 Aug, 2026
Active
US8146588 Unit dose capsules and dry powder inhaler 24 Apr, 2023 Expired
US7464706 Unit dose cartridge and dry powder inhaler 02 Mar, 2023 Expired
US7305986 Unit dose capsules for use in a dry powder inhaler 16 Jan, 2023 Expired
US8156936 Unit dose capsules and dry powder inhaler 16 Jan, 2023 Expired
US8215300 Unit dose cartridge and dry powder inhaler 24 Nov, 2022 Expired
US8950397 Unit dose cartridge and dry powder inhaler 20 Jul, 2021 Expired
US6444226 Purification and stabilization of peptide and protein pharmaceutical agents 29 Jun, 2020 Expired
US6652885 Purification and stabilization of peptide and protein pharmaceutical agents 29 Jun, 2020 Expired
US7648960 Method for delivery of monomeric or dimeric insulin complexed to diketopiperazine microparticles 29 Jun, 2020 Expired
US7943178 Methods and compositions for delivering peptides 29 Jun, 2020 Expired
US8389470 Methods and compositions for delivering peptides 29 Jun, 2020 Expired
US8889099 Methods and compositions for delivering peptides 29 Jun, 2020 Expired
US6071497 Microparticles for lung delivery comprising diketopiperazine 15 May, 2015 Expired
US6428771 Method for drug delivery to the pulmonary system 15 May, 2015 Expired
US8394414 Method for drug delivery to the pulmonary system 15 May, 2015 Expired
US6663898 Carbon-substituted diketopiperazine delivery systems 30 Sep, 2014 Expired
US6906030 Carbon-substituted diketopiperazine delivery systems 30 Sep, 2014 Expired
US7276534 Carbon-substituted diketopiperazine delivery systems 30 Sep, 2014 Expired
US8133514 Carbon-substituted diketopiperazine delivery systems 30 Sep, 2014 Expired


Given below is the list of recent legal activities going on the following drug patents of Mannkind.

Activity Date Patent Number
Patent litigations
Payment of Maintenance Fee, 8th Year, Large Entity 06 Jun, 2024 US9511198
Expire Patent
Critical
20 May, 2024 US8156936
Expire Patent
Critical
06 May, 2024 US8146588
Payment of Maintenance Fee, 8th Year, Large Entity 20 Mar, 2024 US9446133
Payment of Maintenance Fee, 12th Yr, Small Entity 04 Mar, 2024 US8258095
Maintenance Fee Reminder Mailed
Critical
26 Feb, 2024 US8215300
Payment of Maintenance Fee, 12th Year, Large Entity 24 Jan, 2024 US8227409
Payment of Maintenance Fee, 8th Year, Large Entity 19 Jan, 2024 US9393372
Payment of Maintenance Fee, 8th Year, Large Entity 07 Dec, 2023 US9358352
Maintenance Fee Reminder Mailed
Critical
04 Dec, 2023 US8156936
Maintenance Fee Reminder Mailed
Critical
20 Nov, 2023 US8146588
Payment of Maintenance Fee, 8th Year, Large Entity 17 Nov, 2023 US9339615
Payment of Maintenance Fee, 8th Year, Large Entity 15 Sep, 2023 US9283193
Payment of Maintenance Fee, 12th Yr, Small Entity 21 Aug, 2023 US8119593
Expire Patent
Critical
19 Jun, 2023 US7943178


Mannkind's Drug Patent Litigations

Mannkind's drugs have been subject to various legal proceedings, including patent litigations. The earliest legal proceeding was initiated on Nov 17, 1997, against patent number US6428771. The petitioner , challenged the validity of this patent, with STEINER et al as the respondent. Click below to track the latest information on how companies are challenging Mannkind's patents.

Patent Proceeding Filing Date Status Respondent Petitioner
Patent litigations
US9597374 June, 2014 Decision
(17 Aug, 2016)
Anders Hasager Boss et al
US7305986 December, 2006 Decision
(30 Apr, 2007)
Solomon S. Steiner et al
US6428771 November, 1997 Decision
(29 May, 2001)
STEINER et al


Mannkind's Family Patents


Family Patents



Mannkind Drug List

Given below is the complete list of Mannkind's drugs and the patents protecting them.


1. Afrezza

Afrezza is protected by 48 patents, out of which 19 have expired. Check out its patent list below.

Drug Patent Number Drug Patent Title Drug Patent Expiry Status
US8636001 Dry powder inhaler and system for drug delivery 12 Jul, 2032
(7 years from now)
Active
US8499757 Dry powder inhaler and system for drug delivery 19 Feb, 2032
(7 years from now)
Active
US8424518 Dry powder inhaler and system for drug delivery 17 Oct, 2031
(6 years from now)
Active
US9597374 Use of ultrarapid acting insulin 08 Oct, 2031
(6 years from now)
Active
US8227409 Diketopiperazine microparticles with defined isomer contents 08 Mar, 2031
(6 years from now)
Active
US9358352 Dry powder drug delivery system and methods 15 Feb, 2031
(6 years from now)
Active
US10500159 Apparatus and method for cryogranulating a pharmaceutical composition 02 Nov, 2030
(5 years from now)
Active
US10201672 Dry powder inhaler and system for drug delivery 02 Aug, 2030
(5 years from now)
Active
US8551528 Diketopiperazine microparticles with defined specific surface areas 11 Jun, 2030
(5 years from now)
Active
US8734845 Diketopiperazine microparticles with defined specific surface areas 11 Jun, 2030
(5 years from now)
Active
US8778403 Diketopiperazine microparticles with defined specific surface areas 11 Jun, 2030
(5 years from now)
Active
US8485180 Dry powder drug delivery system 25 Mar, 2030
(5 years from now)
Active
US9511198 Dry powder inhaler and system for drug delivery 16 Feb, 2030
(5 years from now)
Active
US9339615 Dry powder inhaler and system for drug delivery 20 Oct, 2029
(4 years from now)
Active
US8623817 Method of treating diabetes type 2 by administering ultrarapid acting insulin 18 Sep, 2029
(4 years from now)
Active
US10046031 Use of ultrarapid acting insulin 11 Aug, 2029
(4 years from now)
Active
US8119593 Method of treating diabetes type 2 by metformin and an ultrarapid acting insulin 11 Aug, 2029
(4 years from now)
Active
US8258095 Method of controlling glycemia by ultrarapid acting insulin without adjusting an insulin dose for meal content 11 Aug, 2029
(4 years from now)
Active
US9943571 Use of ultrarapid acting insulin 11 Aug, 2029
(4 years from now)
Active
US9393372 Dry powder drug delivery system 04 Jul, 2029
(4 years from now)
Active
US10342938 Dry powder drug delivery system 12 Jun, 2029
(4 years from now)
Active
US8912193 Dry powder inhaler and system for drug delivery 12 Jun, 2029
(4 years from now)
Active
US9192675 Dry powder inhaler and system for drug delivery 12 Jun, 2029
(4 years from now)
Active
US9446133 Dry powder inhaler and system for drug delivery 12 Jun, 2029
(4 years from now)
Active
US9662461 Dry powder drug delivery system and methods 12 Jun, 2029
(4 years from now)
Active
US8729019 Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents 26 Dec, 2028
(4 years from now)
Active
US9283193 Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents 14 Sep, 2026
(1 year, 9 months from now)
Active
US9717689 Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents 14 Sep, 2026
(1 year, 9 months from now)
Active
US7943572 Superior control of blood glucose in diabetes treatment 10 Aug, 2026
(1 year, 8 months from now)
Active
US8146588 Unit dose capsules and dry powder inhaler 24 Apr, 2023
(1 year, 7 months ago)
Expired
US7464706 Unit dose cartridge and dry powder inhaler 02 Mar, 2023
(1 year, 8 months ago)
Expired
US7305986 Unit dose capsules for use in a dry powder inhaler 16 Jan, 2023
(1 year, 10 months ago)
Expired
US8156936 Unit dose capsules and dry powder inhaler 16 Jan, 2023
(1 year, 10 months ago)
Expired
US8215300 Unit dose cartridge and dry powder inhaler 24 Nov, 2022
(2 years ago)
Expired
US8950397 Unit dose cartridge and dry powder inhaler 20 Jul, 2021
(3 years ago)
Expired
US6444226 Purification and stabilization of peptide and protein pharmaceutical agents 29 Jun, 2020
(4 years ago)
Expired
US6652885 Purification and stabilization of peptide and protein pharmaceutical agents 29 Jun, 2020
(4 years ago)
Expired
US7648960 Method for delivery of monomeric or dimeric insulin complexed to diketopiperazine microparticles 29 Jun, 2020
(4 years ago)
Expired
US7943178 Methods and compositions for delivering peptides 29 Jun, 2020
(4 years ago)
Expired
US8389470 Methods and compositions for delivering peptides 29 Jun, 2020
(4 years ago)
Expired
US8889099 Methods and compositions for delivering peptides 29 Jun, 2020
(4 years ago)
Expired
US6071497 Microparticles for lung delivery comprising diketopiperazine 15 May, 2015
(9 years ago)
Expired
US6428771 Method for drug delivery to the pulmonary system 15 May, 2015
(9 years ago)
Expired
US8394414 Method for drug delivery to the pulmonary system 15 May, 2015
(9 years ago)
Expired
US6663898 Carbon-substituted diketopiperazine delivery systems 30 Sep, 2014
(10 years ago)
Expired
US6906030 Carbon-substituted diketopiperazine delivery systems 30 Sep, 2014
(10 years ago)
Expired
US7276534 Carbon-substituted diketopiperazine delivery systems 30 Sep, 2014
(10 years ago)
Expired
US8133514 Carbon-substituted diketopiperazine delivery systems 30 Sep, 2014
(10 years ago)
Expired

Discover which of these patents contain the active ingredient(API) of the drug, their family patents, along with litigation and legal activity details of these patents on Afrezza's drug page


Explore Our Curated Drug Screens

Drugs Generating Over $1 Billion in Annual Revenue
Explore the top-performing drugs that dominate the pharmaceutical industry
View List
NCE-1 Patent Expiry in the Next 1 Year
Identify opportunities as new chemical entity (NCE-1) patents approach expiry
View List
Recently Granted Patents in EP
Find the opportunity to file Oppositions
View List