Horizon Drug Patent Portfolio

Horizon owns 5 orange book drugs protected by 80 US patents with Duexis having the least patent protection, holding only 6 patents. And Procysbi with maximum patent protection, holding 25 patents. Given below is the list of Horizon's drug patents along with their expiration dates.

Drug Patent Number Drug Patent Title Drug Patent Expiry Status
US10143665 Methods for storing cysteamine formulations and related methods of treatment 16 Feb, 2037
Active
US10328037 Methods for storing cysteamine formulations and related methods of treatment 16 Feb, 2037
Active
US10548859 Methods for storing Cysteamine formulations and related methods of treatment 16 Feb, 2037
Active
US10905662 Methods for storing cysteamine formulations and related methods of treatment 16 Feb, 2037
Active
US10143665 Methods for storing cysteamine formulations and related methods of treatment 16 Aug, 2036
Active
US10328037 Methods for storing cysteamine formulations and related methods of treatment 16 Aug, 2036
Active
US10548859 Methods for storing Cysteamine formulations and related methods of treatment 16 Aug, 2036
Active
US10905662 Methods for storing cysteamine formulations and related methods of treatment 16 Aug, 2036
Active
US9173851 Delayed release cysteamine bead formulation, and methods of making and using same 17 Dec, 2034
Active
US9233077 Delayed release cysteamine bead formulation, and methods of making and using same 17 Dec, 2034
Active
US9173851 Delayed release cysteamine bead formulation, and methods of making and using same 17 Jun, 2034
Active
US9233077 Delayed release cysteamine bead formulation, and methods of making and using same 17 Jun, 2034
Active
US8945621 Method for treating a patient at risk for developing an NSAID-associated ulcer 17 Oct, 2031
Active
US9220698 Method for delivering a pharmaceutical composition to patient in need thereof 10 Mar, 2031
Active
US8546450 Treatment of pain with topical diclofenac compounds 09 Aug, 2030
Active
US9393208 Method for delivering a pharmaceutical composition to patient in need thereof 03 Sep, 2029
Active
US8217078 Treatment of pain with topical diclofenac 10 Jul, 2029
Active
US8618164 Treatment of pain with topical diclofenac compounds 10 Jul, 2029
Active
US8741956 Treatment of pain with topical diclofenac 10 Jul, 2029
Active
US9370501 Treatment of pain with topical diclofenac 10 Jul, 2029
Active
US9375412 Treatment of pain with topical diclofenac 10 Jul, 2029
Active
US9415029 Treatment of pain with topical diclofenac 10 Jul, 2029
Active
US8252838 Diclofenac topical formulation 21 Apr, 2028
Active
US8026284 Enterically coated cystamine, cysteamine and derivatives thereof 22 Mar, 2028
Active
US8168218 Delayed release tablet with defined core geometry 07 Jan, 2028
Active
US8563613 Diclofenac topical formulation 17 Oct, 2027
Active
US8871809 Diclofenac topical formulation 17 Oct, 2027
Active
US9066913 Diclofenac topical formulation 17 Oct, 2027
Active
US9101591 Diclofenac topical formulation 17 Oct, 2027
Active
US9132110 Treatment of pain with topical diclofenac 17 Oct, 2027
Active
US9168304 Diclofenac topical formulation 17 Oct, 2027
Active
US9168305 Diclofenac topical formulation 17 Oct, 2027
Active
US9220784 Diclofenac topical formulation 17 Oct, 2027
Active
US9339551 Diclofenac topical formulation 17 Oct, 2027
Active
US9339552 Diclofenac topical formulation 17 Oct, 2027
Active
US9539335 Diclofenac topical formulation 17 Oct, 2027
Active
US8026284 Enterically coated cystamine, cysteamine and derivatives thereof 22 Sep, 2027
Active
US9504699 Delayed-release glucocorticoid treatment of rheumatoid disease 03 Aug, 2027
Active
US9192590 Enterically coated cysteamine, cystamine and derivatives thereof 26 Jul, 2027
Active
US9198882 Enterically coated cysteamine, cystamine and derivatives thereof 26 Jul, 2027
Active
US9925156 Enterically coated cysteamine, cystamine and derivatives thereof 26 Jul, 2027
Active
US9925157 Enterically coated cysteamine, cystamine and derivatives thereof 26 Jul, 2027
Active
US9925158 Enterically coated cysteamine, cystamine and derivatives thereof 26 Jul, 2027
Active
US8129433 Enterically coated cysteamine, cystamine and derivatives thereof 26 Jan, 2027
Active
US9192590 Enterically coated cysteamine, cystamine and derivatives thereof 26 Jan, 2027
Active
US9198882 Enterically coated cysteamine, cystamine and derivatives thereof 26 Jan, 2027
Active
US9925156 Enterically coated cysteamine, cystamine and derivatives thereof 26 Jan, 2027
Active
US9925157 Enterically coated cysteamine, cystamine and derivatives thereof 26 Jan, 2027
Active
US9925158 Enterically coated cysteamine, cystamine and derivatives thereof 26 Jan, 2027
Active
US8067033 Stable compositions of famotidine and ibuprofen 18 Jul, 2026
Active
US8067451 Methods and medicaments for administration of ibuprofen 18 Jul, 2026
Active
US8309127 Stable compositions of famotidine and ibuprofen 18 Jul, 2026
Active
US8318202 Stable compositions of famotidine and ibuprofen 18 Jul, 2026
Active
US8449910 Stable compositions of famotidine and ibuprofen 18 Jul, 2026
Active
US8501228 Stable compositions of famotidine and ibuprofen 18 Jul, 2026
Active
US8309124 Delayed release tablet with defined core geometry 23 Apr, 2024 Expired
US8394407 Delayed release tablet with defined core geometry 23 Apr, 2024 Expired
US9040085 Delayed release tablet with defined core geometry 23 Apr, 2024 Expired
US9186332 Delayed release tablet with defined core geometry 23 Apr, 2024 Expired
US6926907 Pharmaceutical compositions for the coordinated delivery of NSAIDs 28 Feb, 2023 Expired
US8557285 Pharmaceutical compositions for the coordinated delivery of NSAIDs 31 May, 2022 Expired
US8852636 Pharmaceutical compositions for the coordinated delivery of NSAIDs 31 May, 2022 Expired
US8858996 Pharmaceutical compositions for the coordinated delivery of NSAIDS 31 May, 2022 Expired
US9161920 Pharmaceutical compositions for the coordinated delivery of NSAIDs 31 May, 2022 Expired
US9198888 Pharmaceutical compositions for the coordinated delivery of NSAIDs 31 May, 2022 Expired
US9345695 Pharmaceutical compositions for the coordinated delivery of NSAIDs 31 May, 2022 Expired
US9707181 Pharmaceutical compositions for the coordinated delivery of NSAIDs 31 May, 2022 Expired
US6488960 Corticosteroid formulation 14 Mar, 2020 Expired
US6677326 Corticosteroid formulation comprising less than 2.5 mg prednisolone for once daily administration 14 Mar, 2020 Expired
US6369085 Form of S-omeprazole 25 Nov, 2018 Expired
US7411070 Form of S-omeprazole 25 Nov, 2018 Expired
US7745466 Form of S-omeprazole 13 Oct, 2018 Expired
US6369085 Form of S-omeprazole 25 May, 2018 Expired
US7411070 Form of S-omeprazole 25 May, 2018 Expired
US5900424 Omeprazole magnesium salt form 04 Nov, 2016 Expired
US5900424 Omeprazole magnesium salt form 04 May, 2016 Expired
US5714504 Compositions 03 Aug, 2015 Expired
US5714504 Compositions 03 Feb, 2015 Expired
US6875872 Compounds 27 Nov, 2014 Expired
US6875872 Compounds 27 May, 2014 Expired


Given below is the list of recent legal activities going on the following drug patents of Horizon.

Activity Date Patent Number
Patent litigations
Maintenance Fee Reminder Mailed 15 Jul, 2024 US8318202 (Litigated)
Maintenance Fee Reminder Mailed 01 Jul, 2024 US8309127 (Litigated)
Expire Patent 24 Jun, 2024 US9339552 (Litigated)
Expire Patent 24 Jun, 2024 US9339551 (Litigated)
Payment of Maintenance Fee, 12th Year, Large Entity 24 May, 2024 US8309124 (Litigated)
11.5 yr surcharge- late pmt w/in 6 mo, Large Entity 24 May, 2024 US8309124 (Litigated)
Payment of Maintenance Fee, 8th Year, Large Entity 23 May, 2024 US9504699
Maintenance Fee Reminder Mailed 15 Apr, 2024 US8252838 (Litigated)
Maintenance Fee Reminder Mailed 08 Apr, 2024 US9415029
Maintenance Fee Reminder Mailed 26 Feb, 2024 US8217078 (Litigated)
Maintenance Fee Reminder Mailed 19 Feb, 2024 US9375412
Maintenance Fee Reminder Mailed 12 Feb, 2024 US9370501
Payment of Maintenance Fee, 8th Year, Large Entity 19 Jan, 2024 US9393208
Maintenance Fee Reminder Mailed 08 Jan, 2024 US9339551 (Litigated)
Maintenance Fee Reminder Mailed 08 Jan, 2024 US9339552 (Litigated)


Horizon's Drug Patent Litigations

Horizon's drugs have been subject to various legal proceedings, including patent litigations. The earliest legal proceeding was initiated on Feb 24, 2015, against patent number US8557285. The petitioner Dr. Reddy's Lab., Inc., challenged the validity of this patent, with Pozen Inc. as the respondent. Click below to track the latest information on how companies are challenging Horizon's patents.

Patent Proceeding Filing Date Status Respondent Petitioner
Patent litigations
US9220698 April, 2018 Terminated
(09 Sep, 2019)
Horizon Pharma USA, Inc. et al. Dr. Reddy's Laboratories, Inc.
US9393208 December, 2017 Final Written Decision
(06 Sep, 2019)
Horizon Pharma USA, Inc. et al. Mylan Pharmaceuticals Inc. et al.
US9393208 July, 2018 Terminated
(01 Apr, 2019)
Pozen Inc. et al. Dr. Reddy's Lab., Inc. et al.
US9220698 August, 2017 Terminated
(27 Mar, 2019)
Horizon Pharma USA, Inc. et al. Mylan Pharmaceuticals Inc. et al.
US8858996 August, 2015 Final Written Decision
(28 Feb, 2017)
Pozen Inc. et al. Lupin Pharmaceuticals Inc. et al.
US8945621 August, 2015 FWD Entered
(21 Feb, 2017)
Pozen Inc Coalition for Affordable Drugs VII LLC
US8852636 August, 2015 Terminated-Denied
(01 Mar, 2016)
Pozen Inc. Lupin Pharmaceuticals Inc
US8852636 August, 2015 Terminated-Denied
(11 Feb, 2016)
Pozen Inc. Coalition for Affordable Drugs VII LLC
US8858996 June, 2015 Terminated-Denied
(17 Dec, 2015)
Pozen Inc. Coalition for Affordable Drugs VII LLC
US6926907 May, 2015 Terminated-Denied
(08 Dec, 2015)
POZEN Inc. Coalition for Affordable Drugs VII LLC
US8557285 February, 2015 Terminated-Denied
(09 Oct, 2015)
Pozen Inc. Dr. Reddy's Lab., Inc.


Horizon Drug Patents' Oppositions Filed in EPO

Horizon drug patents have faced multiple oppositions in the European Patent Office. The earliest opposition was filed on Apr 15, 2011, by Strawman Limited. This opposition was filed on patent number EP02734602A. Click below to reveal the latest opposition data.


Application Filing Date Opposition Party Legal Status
Patent litigations
EP12169866A Sep, 2020 Alfred E. Tiefenbacher (GmbH & Co. KG) Granted and Under Opposition
EP07801510A Jul, 2013 Laboratorios Liconsa, S.A. Patent maintained as amended
EP02734602A Apr, 2011 CHATFIELD PHARMACEUTICALS LIMITED Patent maintained as amended
EP02734602A Apr, 2011 STRAWMAN LIMITED Patent maintained as amended


Horizon's Family Patents

Horizon drugs have patent protection in a total of 45 countries. It's US patent count contributes only to 41.5% of its total global patent coverage. 8 countries have all of their patents expired or invalidated which has opened up potential generic launch opportunities in these countries. Click below to unlock the full patent family tree.

Family Patents



Horizon Drug List

Given below is the complete list of Horizon's drugs and the patents protecting them.


1. Duexis

Duexis is protected by 6 patents, out of which none have expired yet. Check out its patent list below.

Drug Patent Number Drug Patent Title Drug Patent Expiry Status
US8067033 Stable compositions of famotidine and ibuprofen 18 Jul, 2026
(1 year, 6 months from now)
Active
US8067451 Methods and medicaments for administration of ibuprofen 18 Jul, 2026
(1 year, 6 months from now)
Active
US8309127 Stable compositions of famotidine and ibuprofen 18 Jul, 2026
(1 year, 6 months from now)
Active
US8318202 Stable compositions of famotidine and ibuprofen 18 Jul, 2026
(1 year, 6 months from now)
Active
US8449910 Stable compositions of famotidine and ibuprofen 18 Jul, 2026
(1 year, 6 months from now)
Active
US8501228 Stable compositions of famotidine and ibuprofen 18 Jul, 2026
(1 year, 6 months from now)
Active

Discover which of these patents contain the active ingredient(API) of the drug, their family patents, along with litigation and legal activity details of these patents on Duexis's drug page


2. Pennsaid

Pennsaid is protected by 19 patents, out of which none have expired yet. Check out its patent list below.

Drug Patent Number Drug Patent Title Drug Patent Expiry Status
US8546450 Treatment of pain with topical diclofenac compounds 09 Aug, 2030
(5 years from now)
Active
US8217078 Treatment of pain with topical diclofenac 10 Jul, 2029
(4 years from now)
Active
US8618164 Treatment of pain with topical diclofenac compounds 10 Jul, 2029
(4 years from now)
Active
US8741956 Treatment of pain with topical diclofenac 10 Jul, 2029
(4 years from now)
Active
US9370501 Treatment of pain with topical diclofenac 10 Jul, 2029
(4 years from now)
Active
US9375412 Treatment of pain with topical diclofenac 10 Jul, 2029
(4 years from now)
Active
US9415029 Treatment of pain with topical diclofenac 10 Jul, 2029
(4 years from now)
Active
US8252838 Diclofenac topical formulation 21 Apr, 2028
(3 years from now)
Active
US8563613 Diclofenac topical formulation 17 Oct, 2027
(2 years from now)
Active
US8871809 Diclofenac topical formulation 17 Oct, 2027
(2 years from now)
Active
US9066913 Diclofenac topical formulation 17 Oct, 2027
(2 years from now)
Active
US9101591 Diclofenac topical formulation 17 Oct, 2027
(2 years from now)
Active
US9132110 Treatment of pain with topical diclofenac 17 Oct, 2027
(2 years from now)
Active
US9168304 Diclofenac topical formulation 17 Oct, 2027
(2 years from now)
Active
US9168305 Diclofenac topical formulation 17 Oct, 2027
(2 years from now)
Active
US9220784 Diclofenac topical formulation 17 Oct, 2027
(2 years from now)
Active
US9339551 Diclofenac topical formulation 17 Oct, 2027
(2 years from now)
Active
US9339552 Diclofenac topical formulation 17 Oct, 2027
(2 years from now)
Active
US9539335 Diclofenac topical formulation 17 Oct, 2027
(2 years from now)
Active

Discover which of these patents contain the active ingredient(API) of the drug, their family patents, along with litigation and legal activity details of these patents on Pennsaid's drug page


3. Procysbi

Procysbi is protected by 25 patents, out of which none have expired yet. Check out its patent list below.

Drug Patent Number Drug Patent Title Drug Patent Expiry Status
US10143665
(Pediatric)
Methods for storing cysteamine formulations and related methods of treatment 16 Feb, 2037
(12 years from now)
Active
US10328037
(Pediatric)
Methods for storing cysteamine formulations and related methods of treatment 16 Feb, 2037
(12 years from now)
Active
US10548859
(Pediatric)
Methods for storing Cysteamine formulations and related methods of treatment 16 Feb, 2037
(12 years from now)
Active
US10905662
(Pediatric)
Methods for storing cysteamine formulations and related methods of treatment 16 Feb, 2037
(12 years from now)
Active
US10143665 Methods for storing cysteamine formulations and related methods of treatment 16 Aug, 2036
(11 years from now)
Active
US10328037 Methods for storing cysteamine formulations and related methods of treatment 16 Aug, 2036
(11 years from now)
Active
US10548859 Methods for storing Cysteamine formulations and related methods of treatment 16 Aug, 2036
(11 years from now)
Active
US10905662 Methods for storing cysteamine formulations and related methods of treatment 16 Aug, 2036
(11 years from now)
Active
US9173851
(Pediatric)
Delayed release cysteamine bead formulation, and methods of making and using same 17 Dec, 2034
(9 years from now)
Active
US9233077
(Pediatric)
Delayed release cysteamine bead formulation, and methods of making and using same 17 Dec, 2034
(9 years from now)
Active
US9173851 Delayed release cysteamine bead formulation, and methods of making and using same 17 Jun, 2034
(9 years from now)
Active
US9233077 Delayed release cysteamine bead formulation, and methods of making and using same 17 Jun, 2034
(9 years from now)
Active
US8026284
(Pediatric)
Enterically coated cystamine, cysteamine and derivatives thereof 22 Mar, 2028
(3 years from now)
Active
US8026284 Enterically coated cystamine, cysteamine and derivatives thereof 22 Sep, 2027
(2 years from now)
Active
US9192590
(Pediatric)
Enterically coated cysteamine, cystamine and derivatives thereof 26 Jul, 2027
(2 years from now)
Active
US9198882
(Pediatric)
Enterically coated cysteamine, cystamine and derivatives thereof 26 Jul, 2027
(2 years from now)
Active
US9925156
(Pediatric)
Enterically coated cysteamine, cystamine and derivatives thereof 26 Jul, 2027
(2 years from now)
Active
US9925157
(Pediatric)
Enterically coated cysteamine, cystamine and derivatives thereof 26 Jul, 2027
(2 years from now)
Active
US9925158
(Pediatric)
Enterically coated cysteamine, cystamine and derivatives thereof 26 Jul, 2027
(2 years from now)
Active
US8129433 Enterically coated cysteamine, cystamine and derivatives thereof 26 Jan, 2027
(2 years from now)
Active
US9192590 Enterically coated cysteamine, cystamine and derivatives thereof 26 Jan, 2027
(2 years from now)
Active
US9198882 Enterically coated cysteamine, cystamine and derivatives thereof 26 Jan, 2027
(2 years from now)
Active
US9925156 Enterically coated cysteamine, cystamine and derivatives thereof 26 Jan, 2027
(2 years from now)
Active
US9925157 Enterically coated cysteamine, cystamine and derivatives thereof 26 Jan, 2027
(2 years from now)
Active
US9925158 Enterically coated cysteamine, cystamine and derivatives thereof 26 Jan, 2027
(2 years from now)
Active

Discover which of these patents contain the active ingredient(API) of the drug, their family patents, along with litigation and legal activity details of these patents on Procysbi's drug page


4. Rayos

Rayos is protected by 8 patents, out of which 6 have expired. Check out its patent list below.

Drug Patent Number Drug Patent Title Drug Patent Expiry Status
US8168218 Delayed release tablet with defined core geometry 07 Jan, 2028
(3 years from now)
Active
US9504699 Delayed-release glucocorticoid treatment of rheumatoid disease 03 Aug, 2027
(2 years from now)
Active
US8309124 Delayed release tablet with defined core geometry 23 Apr, 2024
(7 months ago)
Expired
US8394407 Delayed release tablet with defined core geometry 23 Apr, 2024
(7 months ago)
Expired
US9040085 Delayed release tablet with defined core geometry 23 Apr, 2024
(7 months ago)
Expired
US9186332 Delayed release tablet with defined core geometry 23 Apr, 2024
(7 months ago)
Expired
US6488960 Corticosteroid formulation 14 Mar, 2020
(4 years ago)
Expired
US6677326 Corticosteroid formulation comprising less than 2.5 mg prednisolone for once daily administration 14 Mar, 2020
(4 years ago)
Expired

Discover which of these patents contain the active ingredient(API) of the drug, their family patents, along with litigation and legal activity details of these patents on Rayos's drug page


5. Vimovo

Vimovo is protected by 22 patents, out of which 19 have expired. Check out its patent list below.

Drug Patent Number Drug Patent Title Drug Patent Expiry Status
US8945621 Method for treating a patient at risk for developing an NSAID-associated ulcer 17 Oct, 2031
(6 years from now)
Active
US9220698 Method for delivering a pharmaceutical composition to patient in need thereof 10 Mar, 2031
(6 years from now)
Active
US9393208 Method for delivering a pharmaceutical composition to patient in need thereof 03 Sep, 2029
(4 years from now)
Active
US6926907 Pharmaceutical compositions for the coordinated delivery of NSAIDs 28 Feb, 2023
(1 year, 9 months ago)
Expired
US8557285 Pharmaceutical compositions for the coordinated delivery of NSAIDs 31 May, 2022
(2 years ago)
Expired
US8852636 Pharmaceutical compositions for the coordinated delivery of NSAIDs 31 May, 2022
(2 years ago)
Expired
US8858996 Pharmaceutical compositions for the coordinated delivery of NSAIDS 31 May, 2022
(2 years ago)
Expired
US9161920 Pharmaceutical compositions for the coordinated delivery of NSAIDs 31 May, 2022
(2 years ago)
Expired
US9198888 Pharmaceutical compositions for the coordinated delivery of NSAIDs 31 May, 2022
(2 years ago)
Expired
US9345695 Pharmaceutical compositions for the coordinated delivery of NSAIDs 31 May, 2022
(2 years ago)
Expired
US9707181 Pharmaceutical compositions for the coordinated delivery of NSAIDs 31 May, 2022
(2 years ago)
Expired
US6369085
(Pediatric)
Form of S-omeprazole 25 Nov, 2018
(6 years ago)
Expired
US7411070
(Pediatric)
Form of S-omeprazole 25 Nov, 2018
(6 years ago)
Expired
US7745466 Form of S-omeprazole 13 Oct, 2018
(6 years ago)
Expired
US6369085 Form of S-omeprazole 25 May, 2018
(6 years ago)
Expired
US7411070 Form of S-omeprazole 25 May, 2018
(6 years ago)
Expired
US5900424
(Pediatric)
Omeprazole magnesium salt form 04 Nov, 2016
(8 years ago)
Expired
US5900424 Omeprazole magnesium salt form 04 May, 2016
(8 years ago)
Expired
US5714504
(Pediatric)
Compositions 03 Aug, 2015
(9 years ago)
Expired
US5714504 Compositions 03 Feb, 2015
(9 years ago)
Expired
US6875872
(Pediatric)
Compounds 27 Nov, 2014
(10 years ago)
Expired
US6875872 Compounds 27 May, 2014
(10 years ago)
Expired

Discover which of these patents contain the active ingredient(API) of the drug, their family patents, along with litigation and legal activity details of these patents on Vimovo's drug page


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Horizon News

Amgen sees benefits from Horizon acquisition in third quarter and prepares to launch biosimilars

31 Oct, 2024

Amgen sees a 6% increase in quarterly revenue and surpasses profit expectations from analysts familiar with the matter, according to Yahoo Lifestyle

06 May, 2024

The US Federal Trade Commission files lawsuit to prevent Amgen's acquisition of Horizon Therapeutics for $27.8 billion.

05 May, 2024

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25 Jan, 2024

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