Beone Medicines Drug Patent Portfolio

Beone Medicines owns 2 orange book drugs protected by 14 US patents Given below is the list of Beone Medicines's drug patents along with their expiration dates.

Drug Patent Number Drug Patent Title Drug Patent Expiry Status
US11786531 Methods of treating B-cell proliferative disorder 19 Jan, 2043
Active
US11896596 Methods of treating B-cell proliferative disorder 19 Jan, 2043
Active
US11911386 Methods of treating B-cell proliferative disorder 19 Jan, 2043
Active
US12233069 Oral solid tablet comprising Bruton's Tyrosine Kinase inhibitor and preparation method therefor 10 Jun, 2040
Active
US11701357 Treatment of B cell cancers using a combination comprising Btk inhibitors 24 Jun, 2039
Active
US11420968 Bcl-2 Inhibitors 29 Apr, 2039
Active
US10927117 Crystalline form of (S)-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetra-hydropyrazolo[1,5-a]pyrimidine-3-carboxamide, preparation, and uses thereof 15 Aug, 2037
Active
US11591340 Crystalline form of (S)-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetra- hydropyrazolo[1,5-a]pyrimidine-3-carboxamide, preparation, and uses thereof 15 Aug, 2037
Active
US11851437 Crystalline form of (S)-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetra-hydropyrazolo[1,5-a]pyrimidine-3-carboxamide, preparation, and uses thereof 15 Aug, 2037
Active
US11884674 Crystalline form of (S)-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetra- hydropyrazolo[1,5-a]pyrimidine-3-carboxamide, preparation, and uses thereof 15 Aug, 2037
Active
US11970500 Crystalline form of (s)-7-(1-acryloylpiperidin-4-yl)- 2-(4-phenoxyphenyl)-4,5,6,7-tetra- hydropyrazolo[1,5-a]pyrimidine-3-carboxamide, preparation, and uses thereof 15 Aug, 2037
Active
US10570139 Substituted pyrazolo[1,5-a]pyrimidines as Bruton's tyrosine kinase modulators 22 Apr, 2034
Active
US11142528 Substituted pyrazolo[1,5-a]pyrimidines as Bruton's tyrosine kinase modulators 22 Apr, 2034
Active
US9447106 Substituted pyrazolo[1,5-a]pyrimidines as bruton's tyrosine kinase modulators 22 Apr, 2034
Active


Given below is the list of recent legal activities going on the following drug patents of Beone Medicines.

Activity Date Patent Number
Patent litigations
Payment of Maintenance Fee, 4th Year, Large Entity 25 Mar, 2025 US11142528
Patent Issue Date Used in PTA Calculation 25 Feb, 2025 US12233069
Patent eGrant Notification 25 Feb, 2025 US12233069
Recordation of Patent Grant Mailed 25 Feb, 2025 US12233069
Mail Patent eGrant Notification 25 Feb, 2025 US12233069
Recordation of Patent eGrant 25 Feb, 2025 US12233069
Email Notification 25 Feb, 2025 US12233069
Change in Power of Attorney (May Include Associate POA) 20 Feb, 2025 US11142528
Email Notification 20 Feb, 2025 US11142528
Issue Notification Mailed 05 Feb, 2025 US12233069
Email Notification 05 Feb, 2025 US12233069
Dispatch to FDC 21 Jan, 2025 US12233069
Application Is Considered Ready for Issue 21 Jan, 2025 US12233069
Issue Fee Payment Received 16 Jan, 2025 US12233069
Issue Fee Payment Verified 16 Jan, 2025 US12233069


Beone Medicines's Family Patents

Beone Medicines drugs have patent protection in a total of 28 countries. It's US patent count contributes only to 23.0% of its total global patent coverage. 1 country has all of their patents expired or invalidated which has opened up potential generic launch opportunities in this particular country. Click below to unlock the full patent family tree.

Family Patents





Clinical Trials

Recent Clinical Trials by Beone Medicines:

Title Lead Sponsor Collaborators Status Phases
Clinical Trials
A Study of BGB-11417 in Participants With Myeloid Malignancies BeOne Medicines NA RECRUITING
(Sep 1, 2026)
PHASE1, PHASE2
A Phase 1b/2 Study of Sonrotoclax (BGB-11417) as Monotherapy and in Various Combinations With Dexamethasone Plus Carfilzomib, Dexamethasone Plus Daratumumab, and Dexamethasone Plus Pomalidomide in Multiple Myeloma BeOne Medicines NA RECRUITING
(Sep 1, 2026)
PHASE1, PHASE2
A Study of Zanubrutinib Plus Anti-CD20 Versus Lenalidomide Plus Rituximab in Participants With Relapsed/Refractory Follicular or Marginal Zone Lymphoma BeOne Medicines NA ACTIVE NOT RECRUITING
(Sep 1, 2026)
PHASE3
A Study to Examine the Efficacy and Safety of Zanubrutinib Given to Adults With Primary Membranous Nephropathy BeOne Medicines NA ACTIVE NOT RECRUITING
(Sep 1, 2026)
PHASE2, PHASE3
BGB-43395 Alone or as Part of Combination Therapies in Participants With Breast Cancer and Other Advanced Solid Tumors BeOne Medicines NA RECRUITING
(Sep 1, 2026)
PHASE1
An Investigational Study of BGB-58067 As a Single Agent and in Combination With Anticancer Agents in Participants With Advanced Solid Tumors BeOne Medicines NA RECRUITING
(Sep 1, 2026)
PHASE1
A Study to Investigate Safety and Effectiveness of Tacabrutideg (BGB-16673) in Combination With Other Agents in Participants With Relapsed or Refractory B-Cell Malignancies BeOne Medicines NA RECRUITING
(Sep 1, 2026)
PHASE1, PHASE2
A Study to Investigate the Efficacy and Safety of Sonrotoclax Plus Zanubrutinib Compared With Placebo Plus Zanubrutinib in Adults With Relapsed/Refractory Mantle Cell Lymphoma (CELESTIAL-RRMCL) BeOne Medicines NA RECRUITING
(Sep 1, 2026)
PHASE3
A Study to Evaluate the Safety and Efficacy of Tacabrutideg (BGB-16673) Compared to Pirtobrutinib in Adults With Relapsed/Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma BeOne Medicines NA RECRUITING
(Sep 1, 2026)
PHASE3
A Study of BG-75098 Alone and in Combination With Other Agents in Adults With Advanced Solid Tumors BeOne Medicines NA RECRUITING
(Sep 1, 2026)
PHASE1
A Study to Investigate Sonrotoclax (BGB-11417) Plus Zanubrutinib (BGB-3111) Compared With Venetoclax Plus Acalabrutinib in Adults With Previously Untreated Chronic Lymphocytic Leukemia BeOne Medicines NA RECRUITING
(Sep 1, 2026)
PHASE3
BGB-43395 Plus Letrozole Versus CDK4/6i Plus Letrozole for Patients With Advanced or Metastatic HR+/HER2- Breast Cancer Who Have Not Received Prior Treatment for Advanced or Metastatic Disease BeOne Medicines NA RECRUITING
(Sep 1, 2026)
PHASE3
A Study Investigating Alternate Schedules of Tislelizumab Plus Chemotherapy in Japanese Patients With First-line Advanced ESCC BeOne Medicines NA RECRUITING
(Sep 1, 2026)
PHASE2
A Trial in Healthy Participants to Assess Drug Interaction Potential of BGB-43395 BeOne Medicines NA NOT YET RECRUITING
(Sep 1, 2026)
PHASE1
A Study to Evaluate Long-term Safety of Zanubrutinib Regimens in Participants With B-Cell Malignancies Who Participated in BeiGene Parent Studies of Zanubrutinib BeOne Medicines NA ACTIVE NOT RECRUITING
(Aug 1, 2026)
PHASE3
Study of Sonrotoclax (BGB-11417) Monotherapy in Participants With Relapsed or Refractory Mantle Cell Lymphoma BeOne Medicines NA ACTIVE NOT RECRUITING
(Aug 1, 2026)
PHASE1, PHASE2
Study of Sonrotoclax (BGB-11417) Plus Zanubrutinib (BGB-3111) Compared With Venetoclax Plus Obinutuzumab in Participants With Chronic Lymphocytic Leukemia (CLL) BeOne Medicines NA ACTIVE NOT RECRUITING
(Aug 1, 2026)
PHASE3
A Study to Investigate the Safety of Novel Dose Ramp-up Schedule(s) When Initiating Sonrotoclax in Participants Treated for Blood Cancers. BeOne Medicines NA RECRUITING
(Aug 1, 2026)
PHASE1, PHASE2
A Study of Tacabrutideg (BGB-16673) Compared to Investigator's Choice in Participants With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Previously Exposed to Both Bruton Tyrosine Kinase (BTK) and B-cell Leukemia/Lymphoma 2 Protein (BCL2) Inhibitors BeOne Medicines NA RECRUITING
(Aug 1, 2026)
PHASE3
A Study of BGB-16673 Compared to Investigator's Choice in Participants With Relapsed/Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Previously Exposed to Covalent Bruton Tyrosine Kinase (BTK) Inhibitors BeOne Medicines NA ACTIVE NOT RECRUITING
(Aug 1, 2026)
PHASE3
A Study to Evaluate Efficacy and Safety of Tislelizumab Plus Chemotherapy for Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Adenocarcinoma and Esophageal Squamous Cell Carcinoma in Racial and Ethnic Minority Patients in the United States BeOne Medicines NA RECRUITING
(Aug 1, 2026)
PHASE2
A Study of Sonrotoclax (BGB-11417) in Children With Relapsed or Refractory Acute Myeloid Leukemia and B-cell Acute Lymphoblastic Leukemia BeOne Medicines NA NOT YET RECRUITING
(Aug 1, 2026)
PHASE1, PHASE2
A Study to Investigate Sonrotoclax Combined With Zanubrutinib Versus Zanubrutinib Alone in Participants With Previously Untreated Chronic Lymphocytic Leukemia BeOne Medicines NA ACTIVE NOT RECRUITING
(Jul 1, 2026)
PHASE2
A Study to Investigate the Effect of the CYP3A Inducer Phenytoin and the CYP3A Inhibitor Itraconazole on the Pharmacokinetics of BGB-58067 in Healthy Participants BeOne Medicines NA RECRUITING
(Jul 1, 2026)
PHASE1
A Study to Investigate the Relative Bioavailability and Food Effect of Tablet for Oral Suspension of Sonrotoclax in Healthy Adults BeOne Medicines NA RECRUITING
(Jul 1, 2026)
PHASE1
Study of Bcl-2 Inhibitor Sonrotoclax (BGB-11417) in Participants With Mature B-Cell Malignancies BeOne Medicines NA ACTIVE NOT RECRUITING
(Jun 1, 2026)
PHASE1
BGB-43395 Alone or as Part of Combination Therapies in Chinese Participants With HR+/HER2- Breast Cancer and Other Advanced Solid Tumors BeOne Medicines NA COMPLETED
(Jun 1, 2026)
PHASE1
A Study to Investigate the Efficacy of Zanubrutinib Plus Rituximab Compared With Bendamustine Plus Rituximab in Adults With Previously Untreated Mantle Cell Lymphoma Who Are Ineligible for Stem Cell Transplantation BeOne Medicines NA ACTIVE NOT RECRUITING
(May 1, 2026)
PHASE3
A Study to Investigate the Relative Bioavailability and Food Effect of a Fixed-Dose Combination Tablet Containing Zanubrutinib and Sonrotoclax (BG-71332) in Healthy Adults BeOne Medicines NA COMPLETED
(Apr 1, 2026)
PHASE1
A Study to Investigate Progression-Free Survival With Sonrotoclax Plus Obinutuzumab Or Sonrotoclax Plus Rituximab Compared With Venetoclax Plus Rituximab Treatment In Patients With Relapsed and/or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CELESTIAL-RRCLL) BeOne Medicines NA RECRUITING
(Mar 1, 2026)
PHASE3


Beone Medicines Drug List

Given below is the complete list of Beone Medicines's drugs and the patents protecting them.


1. Beqalzi

Beqalzi is protected by 1 patent, which is still active. Check out its patent list below.

Drug Patent Number Drug Patent Title Drug Patent Expiry Status
US11420968 Bcl-2 Inhibitors 29 Apr, 2039
(12 years from now)
Active

Discover which of these patents contain the active ingredient(API) of the drug, their family patents, along with litigation and legal activity details of these patents on Beqalzi's drug page


2. Brukinsa

Brukinsa is protected by 13 patents, out of which none have expired yet. Check out its patent list below.

Drug Patent Number Drug Patent Title Drug Patent Expiry Status
US11786531 Methods of treating B-cell proliferative disorder 19 Jan, 2043
(16 years from now)
Active
US11896596 Methods of treating B-cell proliferative disorder 19 Jan, 2043
(16 years from now)
Active
US11911386 Methods of treating B-cell proliferative disorder 19 Jan, 2043
(16 years from now)
Active
US12233069 Oral solid tablet comprising Bruton's Tyrosine Kinase inhibitor and preparation method therefor 10 Jun, 2040
(13 years from now)
Active
US11701357 Treatment of B cell cancers using a combination comprising Btk inhibitors 24 Jun, 2039
(12 years from now)
Active
US10927117 Crystalline form of (S)-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetra-hydropyrazolo[1,5-a]pyrimidine-3-carboxamide, preparation, and uses thereof 15 Aug, 2037
(10 years from now)
Active
US11591340 Crystalline form of (S)-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetra- hydropyrazolo[1,5-a]pyrimidine-3-carboxamide, preparation, and uses thereof 15 Aug, 2037
(10 years from now)
Active
US11851437 Crystalline form of (S)-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetra-hydropyrazolo[1,5-a]pyrimidine-3-carboxamide, preparation, and uses thereof 15 Aug, 2037
(10 years from now)
Active
US11884674 Crystalline form of (S)-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetra- hydropyrazolo[1,5-a]pyrimidine-3-carboxamide, preparation, and uses thereof 15 Aug, 2037
(10 years from now)
Active
US11970500 Crystalline form of (s)-7-(1-acryloylpiperidin-4-yl)- 2-(4-phenoxyphenyl)-4,5,6,7-tetra- hydropyrazolo[1,5-a]pyrimidine-3-carboxamide, preparation, and uses thereof 15 Aug, 2037
(10 years from now)
Active
US10570139 Substituted pyrazolo[1,5-a]pyrimidines as Bruton's tyrosine kinase modulators 22 Apr, 2034
(7 years from now)
Active
US11142528 Substituted pyrazolo[1,5-a]pyrimidines as Bruton's tyrosine kinase modulators 22 Apr, 2034
(7 years from now)
Active
US9447106 Substituted pyrazolo[1,5-a]pyrimidines as bruton's tyrosine kinase modulators 22 Apr, 2034
(7 years from now)
Active

Discover which of these patents contain the active ingredient(API) of the drug, their family patents, along with litigation and legal activity details of these patents on Brukinsa's drug page


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